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Items: 1 to 50 of 79

1.

"A Step and a Ceiling": mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure-induced oxidative activation of PKG.

Csato V, Kadir SZSA, Khavandi K, Bennett H, Sugden S, Gurney AM, Pritchard HT, Hill-Eubanks D, Eaton P, Nelson MT, Greenstein AS.

Physiol Rep. 2019 Nov;7(22):e14260. doi: 10.14814/phy2.14260.

2.

Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.

Absi M, Eid BG, Ashton N, Hart G, Gurney AM.

PLoS One. 2019 Aug 1;14(8):e0220473. doi: 10.1371/journal.pone.0220473. eCollection 2019.

3.

Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells.

Eid BG, Gurney AM.

PLoS One. 2018 Feb 23;13(2):e0192699. doi: 10.1371/journal.pone.0192699. eCollection 2018.

4.

Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.

Temple IP, Logantha SJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, Yamanushi TT, Mahadevan VS, Gurney AM, White E, Zhang H, Hart G, Boyett MR, Dobrzynski H.

Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e003432.

5.

Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.

Sedivy V, Joshi S, Ghaly Y, Mizera R, Zaloudikova M, Brennan S, Novotna J, Herget J, Gurney AM.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L48-57. doi: 10.1152/ajplung.00362.2013. Epub 2014 Oct 31.

6.

Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex.

Sharma J, Baker ST, Turgeon SM, Gurney AM, Opperman KJ, Grill B.

J Biol Chem. 2014 Dec 12;289(50):34654-66. doi: 10.1074/jbc.M114.614065. Epub 2014 Oct 17.

7.

Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity.

Anderson UA, Carson C, Johnston L, Joshi S, Gurney AM, McCloskey KD.

Br J Pharmacol. 2013 Jul;169(6):1290-304. doi: 10.1111/bph.12210.

8.

Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands.

Mitchell C, Syed NI, Tengah A, Gurney AM, Kennedy C.

J Pharmacol Exp Ther. 2012 Dec;343(3):755-62. doi: 10.1124/jpet.112.198051. Epub 2012 Sep 18.

PMID:
22991416
9.

A Ca²⁺-dependent chloride current and Ca²⁺ influx via Ca(v)1.2 ion channels play major roles in P2Y receptor-mediated pulmonary vasoconstriction.

Mitchell C, Syed NI, Gurney AM, Kennedy C.

Br J Pharmacol. 2012 Jun;166(4):1503-12. doi: 10.1111/j.1476-5381.2012.01892.x.

10.

PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans.

Tulgren ED, Baker ST, Rapp L, Gurney AM, Grill B.

Genetics. 2011 Dec;189(4):1297-307. doi: 10.1534/genetics.111.134791. Epub 2011 Oct 3.

11.

Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice.

Manoury B, Lamalle C, Oliveira R, Reid J, Gurney AM.

J Physiol. 2011 Jul 1;589(Pt 13):3231-46. doi: 10.1113/jphysiol.2011.206748. Epub 2011 Apr 11.

12.

KCNQ potassium channels: new targets for pulmonary vasodilator drugs?

Gurney AM, Joshi S, Manoury B.

Adv Exp Med Biol. 2010;661:405-17. doi: 10.1007/978-1-60761-500-2_26. Review.

PMID:
20204745
13.

Organ culture mimics the effects of hypoxia on membrane potential, K(+) channels and vessel tone in pulmonary artery.

Manoury B, Etheridge SL, Reid J, Gurney AM.

Br J Pharmacol. 2009 Oct;158(3):848-61. doi: 10.1111/j.1476-5381.2009.00353.x. Epub 2009 Aug 19.

14.

Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells.

McElroy SP, Drummond RM, Gurney AM.

Cell Calcium. 2009 Aug;46(2):99-106. doi: 10.1016/j.ceca.2009.05.006. Epub 2009 Jul 1.

PMID:
19573912
15.

Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.

Morecroft I, Murray A, Nilsen M, Gurney AM, MacLean MR.

Br J Pharmacol. 2009 Aug;157(7):1241-9. doi: 10.1111/j.1476-5381.2009.00283.x. Epub 2009 Jun 5.

16.

Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries.

Gurney AM, Howarth FC.

Cardiovasc Diabetol. 2009 Jan 21;8:4. doi: 10.1186/1475-2840-8-4.

17.

KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.

Joshi S, Sedivy V, Hodyc D, Herget J, Gurney AM.

J Pharmacol Exp Ther. 2009 Apr;329(1):368-76. doi: 10.1124/jpet.108.147785. Epub 2009 Jan 16.

18.

Pharmacological profile of store-operated Ca(2+) entry in intrapulmonary artery smooth muscle cells.

McElroy SP, Gurney AM, Drummond RM.

Eur J Pharmacol. 2008 Apr 14;584(1):10-20. doi: 10.1016/j.ejphar.2008.01.018. Epub 2008 Jan 26.

PMID:
18308301
19.

The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes.

Ma YL, Bates S, Gurney AM.

Eur J Pharmacol. 2006 Sep 18;545(2-3):87-92. Epub 2006 Jul 1.

PMID:
16876781
20.

The role of twin pore domain and other K+ channels in hypoxic pulmonary vasoconstriction.

Gurney AM, Joshi S.

Novartis Found Symp. 2006;272:218-28; discussion 228-33, 274-9. Review.

PMID:
16686438
21.

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers.

Joshi S, Balan P, Gurney AM.

Respir Res. 2006 Feb 20;7:31.

22.

Going with the flow: smooth muscle TRPM7 channels and the vascular response to blood flow.

Gurney AM.

Circ Res. 2006 Feb 3;98(2):163-4. No abstract available.

PMID:
16456106
23.

Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells.

del Corsso C, Ostrovskaya O, McAllister CE, Murray K, Hatton WJ, Gurney AM, Spencer NJ, Wilson SM.

Mech Ageing Dev. 2006 Apr;127(4):315-23. Epub 2006 Jan 18.

PMID:
16413046
25.

In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance.

Zinselmeyer BH, Dempster J, Gurney AM, Wokosin D, Miller M, Ho H, Millington OR, Smith KM, Rush CM, Parker I, Cahalan M, Brewer JM, Garside P.

J Exp Med. 2005 Jun 6;201(11):1815-23. Epub 2005 May 31.

26.

The use of small interfering RNA to elucidate the activity and function of ion channel genes in an intact tissue.

Gurney AM, Hunter E.

J Pharmacol Toxicol Methods. 2005 May-Jun;51(3):253-62.

PMID:
15862470
27.

Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells.

Gurney AM, Osipenko ON, MacMillan D, McFarlane KM, Tate RJ, Kempsill FE.

Circ Res. 2003 Nov 14;93(10):957-64. Epub 2003 Oct 9.

PMID:
14551239
28.

Two-photon microscopy of fura-2-loaded cardiac myocytes with an all-solid-state tunable and visible femtosecond laser source.

McConnell G, Smith GL, Girkin JM, Gurney AM, Ferguson AI.

Opt Lett. 2003 Oct 1;28(19):1742-4.

PMID:
14514086
29.

Involvement of Rho-kinase in contraction of guinea-pig aorta induced by prostanoid EP3 receptor agonists.

Shum WW, Le GY, Jones RL, Gurney AM, Sasaki Y.

Br J Pharmacol. 2003 Aug;139(8):1449-61.

30.

Mechanisms of endothelial dysfunction after ionized radiation: selective impairment of the nitric oxide component of endothelium-dependent vasodilation.

Soloviev AI, Tishkin SM, Parshikov AV, Ivanova IV, Goncharov EV, Gurney AM.

Br J Pharmacol. 2003 Mar;138(5):837-44.

31.

Synergism between prostanoids and other vasoactive agents.

Jones RL, Shum WW, Gurney AM.

J Card Surg. 2002 Sep-Oct;17(5):436-8.

PMID:
12630545
32.

Saline containing phosphatidylcholine liposomes possess the ability to restore endothelial function damaged resulting from gamma-irradiation.

Soloviev AI, Stefanov AV, Tishkin SM, Khromov AS, Parshikov AV, Ivanova IV, Gurney AM.

J Physiol Pharmacol. 2002 Dec;53(4 Pt 1):701-12.

33.

Regional variation in P2 receptor expression in the rat pulmonary arterial circulation.

Chootip K, Ness KF, Wang Y, Gurney AM, Kennedy C.

Br J Pharmacol. 2002 Nov;137(5):637-46.

34.

Kit positive cells in the guinea pig bladder.

McCloskey KD, Gurney AM.

J Urol. 2002 Aug;168(2):832-6.

PMID:
12131376
35.

Multiple sites of oxygen sensing and their contributions to hypoxic pulmonary vasoconstriction.

Gurney AM.

Respir Physiol Neurobiol. 2002 Aug 22;132(1):43-53. Review.

PMID:
12126694
36.

Potassium channels underlying the resting potential of pulmonary artery smooth muscle cells.

Gurney AM, Osipenko ON, MacMillan D, Kempsill FE.

Clin Exp Pharmacol Physiol. 2002 Apr;29(4):330-3. Review.

PMID:
11985545
37.
38.

Mechanisms of hydralazine induced vasodilation in rabbit aorta and pulmonary artery.

Ellershaw DC, Gurney AM.

Br J Pharmacol. 2001 Oct;134(3):621-31.

39.

Electrophysiological recording methods used in vascular biology.

Gurney AM.

J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):409-20. Review.

PMID:
11325583
40.

Regional distribution of potassium currents in the rabbit pulmonary arterial circulation.

McCulloch KM, Kempsill FE, Buchanan KJ, Gurney AM.

Exp Physiol. 2000 Sep;85(5):487-96.

PMID:
11038399
41.
42.
43.

Potential role for kv3.1b channels as oxygen sensors.

Osipenko ON, Tate RJ, Gurney AM.

Circ Res. 2000 Mar 17;86(5):534-40.

PMID:
10720415
45.

Oxygen-sensing potassium currents in pulmonary artery.

McCulloch KM, Osipenko ON, Gurney AM.

Gen Pharmacol. 1999 Apr;32(4):403-11. Review.

PMID:
10323480
46.

Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells.

Evans AM, Osipenko ON, Haworth SG, Gurney AM.

Am J Physiol. 1998 Sep;275(3):H887-99. doi: 10.1152/ajpheart.1998.275.3.H887.

PMID:
9724293
48.
49.

The channel-blocking action of methonium compounds on rat submandibular ganglion cells. 1983.

Gurney AM, Rang HP.

Br J Pharmacol. 1997 Feb;120(4 Suppl):471-90; discussion 468-9. No abstract available.

50.

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