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Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations.

Flanagan DJ, Barker N, Costanzo NSD, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Ernst M, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E.

Cancer Res. 2019 Mar 1;79(5):970-981. doi: 10.1158/0008-5472.CAN-18-2095. Epub 2019 Jan 8.


Social stress shortens lifespan in mice.

Razzoli M, Nyuyki-Dufe K, Gurney A, Erickson C, McCallum J, Spielman N, Marzullo M, Patricelli J, Kurata M, Pope EA, Touma C, Palme R, Largaespada DA, Allison DB, Bartolomucci A.

Aging Cell. 2018 Aug;17(4):e12778. doi: 10.1111/acel.12778. Epub 2018 May 28.


Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells.

Eid BG, Gurney AM.

PLoS One. 2018 Feb 23;13(2):e0192699. doi: 10.1371/journal.pone.0192699. eCollection 2018.


Susceptibility to unconscious influences is unaffected by a challenging inhibitory task or mental exhaustion.

Gurney A, Lagos AL, Manning A, Scott RB.

Conscious Cogn. 2018 Feb;58:111-123. doi: 10.1016/j.concog.2017.10.016. Epub 2017 Nov 7.


WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death.

Fischer MM, Cancilla B, Yeung VP, Cattaruzza F, Chartier C, Murriel CL, Cain J, Tam R, Cheng CY, Evans JW, O'Young G, Song X, Lewicki J, Kapoun AM, Gurney A, Yen WC, Hoey T.

Sci Adv. 2017 Jun 21;3(6):e1700090. doi: 10.1126/sciadv.1700090. eCollection 2017 Jun.


Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults.

Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C.

N Engl J Med. 2017 May 18;376(20):1943-1955. doi: 10.1056/NEJMoa1616338.


Atrioventricular Node Dysfunction and Ion Channel Transcriptome in Pulmonary Hypertension.

Temple IP, Logantha SJ, Absi M, Zhang Y, Pervolaraki E, Yanni J, Atkinson A, Petkova M, Quigley GM, Castro S, Drinkhill M, Schneider H, Monfredi O, Cartwright E, Zi M, Yamanushi TT, Mahadevan VS, Gurney AM, White E, Zhang H, Hart G, Boyett MR, Dobrzynski H.

Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e003432.


Shoulder Electromyography Measurements During Activities of Daily Living and Routine Rehabilitation Exercises.

Gurney AB, Mermier C, LaPlante M, Majumdar A, O'Neill K, Shewman T, Gurney JG.

J Orthop Sports Phys Ther. 2016 May;46(5):375-83. doi: 10.2519/jospt.2016.6090. Epub 2016 Apr 6.


Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis.

Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A.

Mol Metab. 2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005. eCollection 2016 Jan.


Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.

Chartier C, Raval J, Axelrod F, Bond C, Cain J, Dee-Hoskins C, Ma S, Fischer MM, Shah J, Wei J, Ji M, Lam A, Stroud M, Yen WC, Yeung P, Cancilla B, O'Young G, Wang M, Kapoun AM, Lewicki J, Hoey T, Gurney A.

Cancer Res. 2016 Feb 1;76(3):713-23. doi: 10.1158/0008-5472.CAN-15-0561. Epub 2015 Dec 30.


Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.

Yen WC, Fischer MM, Axelrod F, Bond C, Cain J, Cancilla B, Henner WR, Meisner R, Sato A, Shah J, Tang T, Wallace B, Wang M, Zhang C, Kapoun AM, Lewicki J, Gurney A, Hoey T.

Clin Cancer Res. 2015 May 1;21(9):2084-95. doi: 10.1158/1078-0432.CCR-14-2808.


Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice.

Razzoli M, McCallum J, Gurney A, Engeland WC, Bartolomucci A.

Genes Nutr. 2015 May;10(3):458. doi: 10.1007/s12263-015-0458-2. Epub 2015 Mar 20.


Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of "humanized" knockin mice expressing full-length or truncated VGF.

Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR.

Endocrinology. 2015 May;156(5):1724-38. doi: 10.1210/en.2014-1826. Epub 2015 Feb 12.


The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.

Cero C, Vostrikov VV, Verardi R, Severini C, Gopinath T, Braun PD, Sassano MF, Gurney A, Roth BL, Vulchanova L, Possenti R, Veglia G, Bartolomucci A.

Structure. 2014 Dec 2;22(12):1744-1753. doi: 10.1016/j.str.2014.10.001. Epub 2014 Nov 13.


Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.

Sedivy V, Joshi S, Ghaly Y, Mizera R, Zaloudikova M, Brennan S, Novotna J, Herget J, Gurney AM.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L48-57. doi: 10.1152/ajplung.00362.2013. Epub 2014 Oct 31.


Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex.

Sharma J, Baker ST, Turgeon SM, Gurney AM, Opperman KJ, Grill B.

J Biol Chem. 2014 Dec 12;289(50):34654-66. doi: 10.1074/jbc.M114.614065. Epub 2014 Oct 17.


Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome.

Sanghez V, Razzoli M, Carobbio S, Campbell M, McCallum J, Cero C, Ceresini G, Cabassi A, Govoni P, Franceschini P, de Santis V, Gurney A, Ninkovic I, Parmigiani S, Palanza P, Vidal-Puig A, Bartolomucci A.

Psychoneuroendocrinology. 2013 Dec;38(12):2933-42. doi: 10.1016/j.psyneuen.2013.07.022. Epub 2013 Sep 2.


Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.

Agnusdei V, Minuzzo S, Frasson C, Grassi A, Axelrod F, Satyal S, Gurney A, Hoey T, Seganfreddo E, Basso G, Valtorta S, Moresco RM, Amadori A, Indraccolo S.

Leukemia. 2014 Feb;28(2):278-88. doi: 10.1038/leu.2013.183. Epub 2013 Jun 18.


Canonical wnt signaling is required for pancreatic carcinogenesis.

Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M.

Cancer Res. 2013 Aug 1;73(15):4909-22. doi: 10.1158/0008-5472.CAN-12-4384. Epub 2013 Jun 12.


Palm Cooling and Heating Delays Fatigue During Resistance Exercise in Women.

Kwon YS, Robergs RA, Mermier CM, Schneider SM, Gurney AB.

J Strength Cond Res. 2015 Aug;29(8):2261-9. doi: 10.1519/JSC.0b013e31829cef4e.


Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity.

Anderson UA, Carson C, Johnston L, Joshi S, Gurney AM, McCloskey KD.

Br J Pharmacol. 2013 Jul;169(6):1290-304. doi: 10.1111/bph.12210.


Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands.

Mitchell C, Syed NI, Tengah A, Gurney AM, Kennedy C.

J Pharmacol Exp Ther. 2012 Dec;343(3):755-62. doi: 10.1124/jpet.112.198051. Epub 2012 Sep 18.


Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.

Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T.

Clin Cancer Res. 2012 Oct 1;18(19):5374-86. doi: 10.1158/1078-0432.CCR-12-0736. Epub 2012 Sep 5.


Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors.

Gurney A, Axelrod F, Bond CJ, Cain J, Chartier C, Donigan L, Fischer M, Chaudhari A, Ji M, Kapoun AM, Lam A, Lazetic S, Ma S, Mitra S, Park IK, Pickell K, Sato A, Satyal S, Stroud M, Tran H, Yen WC, Lewicki J, Hoey T.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22. doi: 10.1073/pnas.1120068109. Epub 2012 Jul 2.


A Ca²⁺-dependent chloride current and Ca²⁺ influx via Ca(v)1.2 ion channels play major roles in P2Y receptor-mediated pulmonary vasoconstriction.

Mitchell C, Syed NI, Gurney AM, Kennedy C.

Br J Pharmacol. 2012 Jun;166(4):1503-12. doi: 10.1111/j.1476-5381.2012.01892.x.


PPM-1, a PP2Cα/β phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans.

Tulgren ED, Baker ST, Rapp L, Gurney AM, Grill B.

Genetics. 2011 Dec;189(4):1297-307. doi: 10.1534/genetics.111.134791. Epub 2011 Oct 3.


Anti-DLL4, a cancer therapeutic with multiple mechanisms of action.

Gurney A, Hoey T.

Vasc Cell. 2011 Aug 10;3:18. doi: 10.1186/2045-824X-3-18.


Absorption of hydrocortisone acetate in human connective tissue using phonophoresis.

Gurney AB, Wascher D, Schenck R, Tennison A, Jaramillo B.

Sports Health. 2011 Jul;3(4):346-51.


Contractile and electrophysiological properties of pulmonary artery smooth muscle are not altered in TASK-1 knockout mice.

Manoury B, Lamalle C, Oliveira R, Reid J, Gurney AM.

J Physiol. 2011 Jul 1;589(Pt 13):3231-46. doi: 10.1113/jphysiol.2011.206748. Epub 2011 Apr 11.


Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.

Fischer M, Yen WC, Kapoun AM, Wang M, O'Young G, Lewicki J, Gurney A, Hoey T.

Cancer Res. 2011 Mar 1;71(5):1520-5. doi: 10.1158/0008-5472.CAN-10-2817. Epub 2010 Dec 30.


KCNQ potassium channels: new targets for pulmonary vasodilator drugs?

Gurney AM, Joshi S, Manoury B.

Adv Exp Med Biol. 2010;661:405-17. doi: 10.1007/978-1-60761-500-2_26. Review.


Design parameters to control synthetic gene expression in Escherichia coli.

Welch M, Govindarajan S, Ness JE, Villalobos A, Gurney A, Minshull J, Gustafsson C.

PLoS One. 2009 Sep 14;4(9):e7002. doi: 10.1371/journal.pone.0007002.


Organ culture mimics the effects of hypoxia on membrane potential, K(+) channels and vessel tone in pulmonary artery.

Manoury B, Etheridge SL, Reid J, Gurney AM.

Br J Pharmacol. 2009 Oct;158(3):848-61. doi: 10.1111/j.1476-5381.2009.00353.x. Epub 2009 Aug 19.


DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.

Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, Fitch-Bruhns M, Lazetic S, Park IK, Sato A, Satyal S, Wang X, Clarke MF, Lewicki J, Gurney A.

Cell Stem Cell. 2009 Aug 7;5(2):168-77. doi: 10.1016/j.stem.2009.05.019.


Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells.

McElroy SP, Drummond RM, Gurney AM.

Cell Calcium. 2009 Aug;46(2):99-106. doi: 10.1016/j.ceca.2009.05.006. Epub 2009 Jul 1.


Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.

Morecroft I, Murray A, Nilsen M, Gurney AM, MacLean MR.

Br J Pharmacol. 2009 Aug;157(7):1241-9. doi: 10.1111/j.1476-5381.2009.00283.x. Epub 2009 Jun 5.


Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries.

Gurney AM, Howarth FC.

Cardiovasc Diabetol. 2009 Jan 21;8:4. doi: 10.1186/1475-2840-8-4.


KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.

Joshi S, Sedivy V, Hodyc D, Herget J, Gurney AM.

J Pharmacol Exp Ther. 2009 Apr;329(1):368-76. doi: 10.1124/jpet.108.147785. Epub 2009 Jan 16.


Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.

Dylla SJ, Beviglia L, Park IK, Chartier C, Raval J, Ngan L, Pickell K, Aguilar J, Lazetic S, Smith-Berdan S, Clarke MF, Hoey T, Lewicki J, Gurney AL.

PLoS One. 2008 Jun 18;3(6):e2428. doi: 10.1371/journal.pone.0002428. Erratum in: PLoS ONE. 2008;3(8). doi: 10.1371/annotation/2aa6a20a-e63c-49b6-aeea-aae62435617f.


Two-pore potassium channels in the cardiovascular system.

Gurney A, Manoury B.

Eur Biophys J. 2009 Mar;38(3):305-18. doi: 10.1007/s00249-008-0326-8. Epub 2008 May 1. Review.


Pharmacological profile of store-operated Ca(2+) entry in intrapulmonary artery smooth muscle cells.

McElroy SP, Gurney AM, Drummond RM.

Eur J Pharmacol. 2008 Apr 14;584(1):10-20. doi: 10.1016/j.ejphar.2008.01.018. Epub 2008 Jan 26.


Absorption of dexamethasone sodium phosphate in human connective tissue using iontophoresis.

Gurney AB, Wascher DC.

Am J Sports Med. 2008 Apr;36(4):753-9. doi: 10.1177/0363546507311597. Epub 2008 Jan 11.


Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors.

Cho RW, Wang X, Diehn M, Shedden K, Chen GY, Sherlock G, Gurney A, Lewicki J, Clarke MF.

Stem Cells. 2008 Feb;26(2):364-71. Epub 2007 Nov 1.


Object-relations and spirituality: revisiting a clinical dialogue.

Gurney AG, Rogers SA.

J Clin Psychol. 2007 Oct;63(10):961-77.


Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system.

Case RM, Eisner D, Gurney A, Jones O, Muallem S, Verkhratsky A.

Cell Calcium. 2007 Oct-Nov;42(4-5):345-50. Epub 2007 Jun 14. Review.


Phenotypic characterization of human colorectal cancer stem cells.

Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63. Epub 2007 Jun 4.


The prognostic role of a gene signature from tumorigenic breast-cancer cells.

Liu R, Wang X, Chen GY, Dalerba P, Gurney A, Hoey T, Sherlock G, Lewicki J, Shedden K, Clarke MF.

N Engl J Med. 2007 Jan 18;356(3):217-26.


The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes.

Ma YL, Bates S, Gurney AM.

Eur J Pharmacol. 2006 Sep 18;545(2-3):87-92. Epub 2006 Jul 1.


The role of twin pore domain and other K+ channels in hypoxic pulmonary vasoconstriction.

Gurney AM, Joshi S.

Novartis Found Symp. 2006;272:218-28; discussion 228-33, 274-9. Review.


Pulmonary vasoconstrictor action of KCNQ potassium channel blockers.

Joshi S, Balan P, Gurney AM.

Respir Res. 2006 Feb 20;7:31.

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