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Items: 25


Pharmacokinetics and distribution of 2-hydroxypropyl-β-cyclodextrin following a single intrathecal dose to cats.

Kao ML, Stellar S, Solon E, Lordi A, Kasica N, Swain G, Bagel JH, Gurda BL, Vite CH.

J Inherit Metab Dis. 2019 Nov 9. doi: 10.1002/jimd.12189. [Epub ahead of print]


In Situ Hybridization for Detection of AAV-Mediated Gene Expression.

Hunter JE, Gurda BL, Yoon SY, Castle MJ, Wolfe JH.

Methods Mol Biol. 2019;1950:107-122. doi: 10.1007/978-1-4939-9139-6_6.


LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss.

Gurda BL, Bagel JH, Fisher SJ, Schultz ML, Lieberman AP, Hand P, Vite CH, Swain GP.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):229-245. doi: 10.1093/jnen/nlx119.


Canine and Feline Models of Human Genetic Diseases and Their Contributions to Advancing Clinical Therapies

Gurda BL, Bradbury AM, Vite CH.

Yale J Biol Med. 2017 Sep 25;90(3):417-431. eCollection 2017 Sep. Review.


Wnt10b and Dkk-1 gene therapy differentially influenced trabecular bone architecture, soft tissue integrity, and osteophytosis in a skeletally mature rat model of osteoarthritis.

Mason JB, Gurda BL, Hankenson KD, Harper LR, Carlson CS, Wilson JM, Richardson DW.

Connect Tissue Res. 2017 Nov;58(6):542-552. doi: 10.1080/03008207.2016.1267153. Epub 2016 Dec 9.


Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis.

Mason JB, Gurda BL, Van Wettere A, Engiles JB, Wilson JM, Richardson DW.

Equine Vet J. 2017 Jan;49(1):79-86. doi: 10.1111/evj.12547. Epub 2016 Jan 16.


Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII.

Gurda BL, De Guilhem De Lataillade A, Bell P, Zhu Y, Yu H, Wang P, Bagel J, Vite CH, Sikora T, Hinderer C, Calcedo R, Yox AD, Steet RA, Ruane T, O'Donnell P, Gao G, Wilson JM, Casal M, Ponder KP, Haskins ME.

Mol Ther. 2016 Feb;24(2):206-216. doi: 10.1038/mt.2015.189. Epub 2015 Oct 8.


Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

Hinderer C, Bell P, Louboutin JP, Zhu Y, Yu H, Lin G, Choa R, Gurda BL, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Tarantal AF, Casal ML, Haskins ME, Wilson JM.

Mol Ther. 2015 Aug;23(8):1298-1307. doi: 10.1038/mt.2015.99. Epub 2015 May 29.


A review of gene therapy in canine and feline models of lysosomal storage disorders.

Bradbury AM, Gurda BL, Casal ML, Ponder KP, Vite CH, Haskins ME.

Hum Gene Ther Clin Dev. 2015 Mar;26(1):27-37. doi: 10.1089/humc.2015.002. Epub 2015 Feb 11. Review.


Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity.

Tseng YS, Gurda BL, Chipman P, McKenna R, Afione S, Chiorini JA, Muzyczka N, Olson NH, Baker TS, Kleinschmidt J, Agbandje-McKenna M.

J Virol. 2015 Feb;89(3):1794-808. doi: 10.1128/JVI.02710-14. Epub 2014 Nov 19.


Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14894-9. doi: 10.1073/pnas.1413645111. Epub 2014 Sep 29.


Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM.

Mol Ther. 2014 Dec;22(12):2018-27. doi: 10.1038/mt.2014.135. Epub 2014 Jul 16.


Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain.

Swain GP, Prociuk M, Bagel JH, O'Donnell P, Berger K, Drobatz K, Gurda BL, Haskins ME, Sands MS, Vite CH.

Gene Ther. 2014 Jan;21(1):28-36. doi: 10.1038/gt.2013.54. Epub 2013 Oct 17.


Structural insights into adeno-associated virus serotype 5.

Govindasamy L, DiMattia MA, Gurda BL, Halder S, McKenna R, Chiorini JA, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

J Virol. 2013 Oct;87(20):11187-99. doi: 10.1128/JVI.00867-13. Epub 2013 Aug 7.


Capsid antibodies to different adeno-associated virus serotypes bind common regions.

Gurda BL, DiMattia MA, Miller EB, Bennett A, McKenna R, Weichert WS, Nelson CD, Chen WJ, Muzyczka N, Olson NH, Sinkovits RS, Chiorini JA, Zolotutkhin S, Kozyreva OG, Samulski RJ, Baker TS, Parrish CR, Agbandje-McKenna M.

J Virol. 2013 Aug;87(16):9111-24. doi: 10.1128/JVI.00622-13. Epub 2013 Jun 12.


Multiple recombinant adeno-associated viral vector serotypes display persistent in vivo gene expression in vector-transduced rat stifle joints.

Mason JB, Gurda BL, Engiles JB, Hankenson KD, Wilson JM, Richardson DW.

Hum Gene Ther Methods. 2013 Jun;24(3):185-94. doi: 10.1089/hgtb.2012.199.


The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing.

Raupp C, Naumer M, Müller OJ, Gurda BL, Agbandje-McKenna M, Kleinschmidt JA.

J Virol. 2012 Sep;86(17):9396-408. doi: 10.1128/JVI.00209-12. Epub 2012 Jun 20.


Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8.

Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M.

J Virol. 2012 Aug;86(15):7739-51. doi: 10.1128/JVI.00218-12. Epub 2012 May 16.


Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid.

Bell CL, Gurda BL, Van Vliet K, Agbandje-McKenna M, Wilson JM.

J Virol. 2012 Jul;86(13):7326-33. doi: 10.1128/JVI.00448-12. Epub 2012 Apr 18.


Structural insight into the unique properties of adeno-associated virus serotype 9.

DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, Agbandje-McKenna M.

J Virol. 2012 Jun;86(12):6947-58. doi: 10.1128/JVI.07232-11. Epub 2012 Apr 11.


Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.

Harbison CE, Weichert WS, Gurda BL, Chiorini JA, Agbandje-McKenna M, Parrish CR.

J Gen Virol. 2012 Feb;93(Pt 2):347-355. doi: 10.1099/vir.0.035113-0. Epub 2011 Nov 9.


Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.

Nam HJ, Gurda BL, McKenna R, Potter M, Byrne B, Salganik M, Muzyczka N, Agbandje-McKenna M.

J Virol. 2011 Nov;85(22):11791-9. doi: 10.1128/JVI.05305-11. Epub 2011 Sep 7.


Structural characterization of the dual glycan binding adeno-associated virus serotype 6.

Ng R, Govindasamy L, Gurda BL, McKenna R, Kozyreva OG, Samulski RJ, Parent KN, Baker TS, Agbandje-McKenna M.

J Virol. 2010 Dec;84(24):12945-57. doi: 10.1128/JVI.01235-10. Epub 2010 Sep 22.


Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae.

Gurda BL, Parent KN, Bladek H, Sinkovits RS, DiMattia MA, Rence C, Castro A, McKenna R, Olson N, Brown K, Baker TS, Agbandje-McKenna M.

J Virol. 2010 Jun;84(12):5880-9. doi: 10.1128/JVI.02719-09. Epub 2010 Apr 7.

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