Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 51

1.

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis.

Jankute M, Alderwick LJ, Moorey AR, Joe M, Gurcha SS, Eggeling L, Lowary TL, Dell A, Pang PC, Yang T, Haslam S, Besra GS.

Cell Surf. 2018 Jun;2:38-53. doi: 10.1016/j.tcsw.2018.06.003.

2.

Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes.

Ivanova IM, Nepogodiev SA, Saalbach G, O'Neill EC, Urbaniak MD, Ferguson MA, Gurcha SS, Besra GS, Field RA.

Carbohydr Res. 2017 Jan 13;438:26-38. doi: 10.1016/j.carres.2016.11.017. Epub 2016 Nov 30.

3.

Identification of KasA as the cellular target of an anti-tubercular scaffold.

Abrahams KA, Chung CW, Ghidelli-Disse S, Rullas J, Rebollo-López MJ, Gurcha SS, Cox JA, Mendoza A, Jiménez-Navarro E, Martínez-Martínez MS, Neu M, Shillings A, Homes P, Argyrou A, Casanueva R, Loman NJ, Moynihan PJ, Lelièvre J, Selenski C, Axtman M, Kremer L, Bantscheff M, Angulo-Barturen I, Izquierdo MC, Cammack NC, Drewes G, Ballell L, Barros D, Besra GS, Bates RH.

Nat Commun. 2016 Sep 1;7:12581. doi: 10.1038/ncomms12581.

4.

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.

Cox JA, Abrahams KA, Alemparte C, Ghidelli-Disse S, Rullas J, Angulo-Barturen I, Singh A, Gurcha SS, Nataraj V, Bethell S, Remuiñán MJ, Encinas L, Jervis PJ, Cammack NC, Bhatt A, Kruse U, Bantscheff M, Fütterer K, Barros D, Ballell L, Drewes G, Besra GS.

Nat Microbiol. 2016 Jan 18;1:15006. doi: 10.1038/nmicrobiol.2015.6.

PMID:
27571973
5.

Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target.

Gurcha SS, Usha V, Cox JA, Fütterer K, Abrahams KA, Bhatt A, Alderwick LJ, Reynolds RC, Loman NJ, Nataraj V, Alemparte C, Barros D, Lloyd AJ, Ballell L, Hobrath JV, Besra GS.

PLoS One. 2014 Nov 19;9(11):e113568. doi: 10.1371/journal.pone.0113568. eCollection 2014.

6.

Selectfluor and NFSI exo-glycal fluorination strategies applied to the enhancement of the binding affinity of galactofuranosyltransferase GlfT2 inhibitors.

Dumitrescu L, Eppe G, Tikad A, Pan W, El Bkassiny S, Gurcha SS, Ardá A, Jiménez-Barbero J, Besra GS, Vincent SP.

Chemistry. 2014 Nov 10;20(46):15208-15. doi: 10.1002/chem.201404180. Epub 2014 Sep 24.

PMID:
25251918
7.

Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

Sambandan D, Dao DN, Weinrick BC, Vilchèze C, Gurcha SS, Ojha A, Kremer L, Besra GS, Hatfull GF, Jacobs WR Jr.

MBio. 2013 May 7;4(3):e00222-13. doi: 10.1128/mBio.00222-13.

8.

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.

Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher A.

J Immunol. 2013 Jun 1;190(11):5722-30. doi: 10.4049/jimmunol.1203343. Epub 2013 Apr 29.

9.

Ppm1-encoded polyprenyl monophosphomannose synthase activity is essential for lipoglycan synthesis and survival in mycobacteria.

Rana AK, Singh A, Gurcha SS, Cox LR, Bhatt A, Besra GS.

PLoS One. 2012;7(10):e48211. doi: 10.1371/journal.pone.0048211. Epub 2012 Oct 31.

10.

Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.

Usha V, Hobrath JV, Gurcha SS, Reynolds RC, Besra GS.

PLoS One. 2012;7(3):e33886. doi: 10.1371/journal.pone.0033886. Epub 2012 Mar 29.

11.

Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component.

Stoop EJ, Schipper T, Rosendahl Huber SK, Nezhinsky AE, Verbeek FJ, Gurcha SS, Besra GS, Vandenbroucke-Grauls CM, Bitter W, van der Sar AM.

Dis Model Mech. 2011 Jul;4(4):526-36. doi: 10.1242/dmm.006676. Epub 2011 Mar 3.

12.

Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.

Usha V, Gurcha SS, Lovering AL, Lloyd AJ, Papaemmanouil A, Reynolds RC, Besra GS.

Microbiology. 2011 Jan;157(Pt 1):290-9. doi: 10.1099/mic.0.042549-0. Epub 2010 Nov 16.

PMID:
21081761
13.

Modular approach to triazole-linked 1,6-α-D-oligomannosides to the discovery of inhibitors of Mycobacterium tuberculosis cell wall synthetase.

Lo Conte M, Marra A, Chambery A, Gurcha SS, Besra GS, Dondoni A.

J Org Chem. 2010 Oct 1;75(19):6326-36. doi: 10.1021/jo100928g.

14.

Mycobacterium marinum MMAR_2380, a predicted transmembrane acyltransferase, is essential for the presence of the mannose cap on lipoarabinomannan.

Driessen NN, Stoop EJ, Ummels R, Gurcha SS, Mishra AK, Larrouy-Maumus G, Nigou J, Gilleron M, Puzo G, Maaskant JJ, Sparrius M, Besra GS, Bitter W, Vandenbroucke-Grauls CM, Appelmelk BJ.

Microbiology. 2010 Nov;156(Pt 11):3492-502. doi: 10.1099/mic.0.037507-0. Epub 2010 Aug 5.

15.

Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics.

Trunkfield AE, Gurcha SS, Besra GS, Bugg TD.

Bioorg Med Chem. 2010 Apr 1;18(7):2651-63. doi: 10.1016/j.bmc.2010.02.026. Epub 2010 Feb 19.

16.

3-Ketosteroid 9alpha-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis.

Hu Y, van der Geize R, Besra GS, Gurcha SS, Liu A, Rohde M, Singh M, Coates A.

Mol Microbiol. 2010 Jan;75(1):107-21. doi: 10.1111/j.1365-2958.2009.06957.x. Epub 2009 Nov 10.

17.

Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN.

Driessen NN, Ummels R, Maaskant JJ, Gurcha SS, Besra GS, Ainge GD, Larsen DS, Painter GF, Vandenbroucke-Grauls CM, Geurtsen J, Appelmelk BJ.

Infect Immun. 2009 Oct;77(10):4538-47. doi: 10.1128/IAI.01256-08. Epub 2009 Aug 3.

18.

Inactivation of Mycobacterium tuberculosis mannosyltransferase pimB reduces the cell wall lipoarabinomannan and lipomannan content and increases the rate of bacterial-induced human macrophage cell death.

Torrelles JB, DesJardin LE, MacNeil J, Kaufman TM, Kutzbach B, Knaup R, McCarthy TR, Gurcha SS, Besra GS, Clegg S, Schlesinger LS.

Glycobiology. 2009 Jul;19(7):743-55. doi: 10.1093/glycob/cwp042. Epub 2009 Mar 24.

19.

Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.

Pathak AK, Pathak V, Suling WJ, Riordan JR, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem. 2009 Jan 15;17(2):872-81. doi: 10.1016/j.bmc.2008.11.027. Epub 2008 Nov 18.

20.

Glycosylation of the phosphate binding protein, PstS, in Streptomyces coelicolor by a pathway that resembles protein O-mannosylation in eukaryotes.

Wehmeier S, Varghese AS, Gurcha SS, Tissot B, Panico M, Hitchen P, Morris HR, Besra GS, Dell A, Smith MC.

Mol Microbiol. 2009 Jan;71(2):421-33. doi: 10.1111/j.1365-2958.2008.06536.x. Epub 2008 Nov 10.

21.

Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall.

Lucas R, Balbuena P, Errey JC, Squire MA, Gurcha SS, McNeil M, Besra GS, Davis BG.

Chembiochem. 2008 Sep 22;9(14):2197-9. doi: 10.1002/cbic.200800189. No abstract available.

PMID:
18780384
22.

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

Dao DN, Sweeney K, Hsu T, Gurcha SS, Nascimento IP, Roshevsky D, Besra GS, Chan J, Porcelli SA, Jacobs WR.

PLoS Pathog. 2008 Jun 6;4(6):e1000081. doi: 10.1371/journal.ppat.1000081.

23.

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB' mutant.

Mishra AK, Klein C, Gurcha SS, Alderwick LJ, Babu P, Hitchen PG, Morris HR, Dell A, Besra GS, Eggeling L.

Antonie Van Leeuwenhoek. 2008 Aug;94(2):277-87. doi: 10.1007/s10482-008-9243-1. Epub 2008 Apr 18.

24.

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.

Alderwick LJ, Dover LG, Veerapen N, Gurcha SS, Kremer L, Roper DL, Pathak AK, Reynolds RC, Besra GS.

Protein Expr Purif. 2008 Apr;58(2):332-41. doi: 10.1016/j.pep.2007.11.012. Epub 2007 Dec 8.

PMID:
18248822
25.

A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.

Hu Y, Henderson B, Lund PA, Tormay P, Ahmed MT, Gurcha SS, Besra GS, Coates AR.

Infect Immun. 2008 Apr;76(4):1535-46. doi: 10.1128/IAI.01078-07. Epub 2008 Jan 28.

26.

The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium-host interaction.

Appelmelk BJ, den Dunnen J, Driessen NN, Ummels R, Pak M, Nigou J, Larrouy-Maumus G, Gurcha SS, Movahedzadeh F, Geurtsen J, Brown EJ, Eysink Smeets MM, Besra GS, Willemsen PT, Lowary TL, van Kooyk Y, Maaskant JJ, Stoker NG, van der Ley P, Puzo G, Vandenbroucke-Grauls CM, Wieland CW, van der Poll T, Geijtenbeek TB, van der Sar AM, Bitter W.

Cell Microbiol. 2008 Apr;10(4):930-44. Epub 2007 Dec 5.

PMID:
18070119
27.

Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.

Pathak AK, Pathak V, Riordan JR, Suling WJ, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4527-30. Epub 2007 Jun 6.

28.

Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.

Pathak AK, Pathak V, Seitz L, Gurcha SS, Besra GS, Riordan JM, Reynolds RC.

Bioorg Med Chem. 2007 Aug 15;15(16):5629-50. Epub 2007 Apr 10.

29.

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.

Bhatt A, Fujiwara N, Bhatt K, Gurcha SS, Kremer L, Chen B, Chan J, Porcelli SA, Kobayashi K, Besra GS, Jacobs WR Jr.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5157-62. Epub 2007 Mar 12.

30.

Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis.

Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR Jr.

Microbiology. 2007 Feb;153(Pt 2):513-20.

PMID:
17259623
31.
33.

Synthesis and biological evaluation of new inhibitors of UDP-Galf transferase--a key enzyme in M. tuberculosis cell wall biosynthesis.

Cren S, Gurcha SS, Blake AJ, Besra GS, Thomas NR.

Org Biomol Chem. 2004 Sep 7;2(17):2418-20. Epub 2004 Aug 9.

PMID:
15326520
34.

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Guy MR, Illarionov PA, Gurcha SS, Dover LG, Gibson KJ, Smith PW, Minnikin DE, Besra GS.

Biochem J. 2004 Sep 15;382(Pt 3):905-12.

35.

Synthesis of mannopyranose disaccharides as photoaffinity probes for mannosyltransferases in Mycobacterium tuberculosis.

Pathak AK, Pathak V, Riordan JM, Gurcha SS, Besra GS, Reynolds RC.

Carbohydr Res. 2004 Feb 25;339(3):683-91.

PMID:
15013406
36.

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):373-6.

PMID:
14698162
37.

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3685-8.

PMID:
14552758
38.

Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum.

Gibson KJ, Eggeling L, Maughan WN, Krumbach K, Gurcha SS, Nigou J, Puzo G, Sahm H, Besra GS.

J Biol Chem. 2003 Oct 17;278(42):40842-50. Epub 2003 Aug 6.

39.
40.

Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile.

Kremer L, Guérardel Y, Gurcha SS, Locht C, Besra GS.

Microbiology. 2002 Oct;148(Pt 10):3145-54.

PMID:
12368448
41.

Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.

McLean KJ, Marshall KR, Richmond A, Hunter IS, Fowler K, Kieser T, Gurcha SS, Besra GS, Munro AW.

Microbiology. 2002 Oct;148(Pt 10):2937-49.

PMID:
12368427
42.

Synthesis of an arabinofuranosyl disaccharide photoaffinity probe for arabinosyltransferase activity in Mycobacterium tuberculosis.

Pathak AK, Pathak V, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem Lett. 2002 Oct 7;12(19):2749-52.

PMID:
12217368
43.

Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay.

Cooper HN, Gurcha SS, Nigou J, Brennan PJ, Belisle JT, Besra GS, Young D.

Glycobiology. 2002 Jul;12(7):427-34.

PMID:
12122024
44.

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Kremer L, Gurcha SS, Bifani P, Hitchen PG, Baulard A, Morris HR, Dell A, Brennan PJ, Besra GS.

Biochem J. 2002 May 1;363(Pt 3):437-47.

45.

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Gurcha SS, Baulard AR, Kremer L, Locht C, Moody DB, Muhlecker W, Costello CE, Crick DC, Brennan PJ, Besra GS.

Biochem J. 2002 Jul 15;365(Pt 2):441-50.

46.

Studies on n-octyl-5-(alpha-D-arabinofuranosyl)-beta-D-galactofuranosides for mycobacterial glycosyltransferase activity.

Pathak AK, Pathak V, Suling WJ, Gurcha SS, Morehouse CB, Besra GS, Maddry JA, Reynolds RC.

Bioorg Med Chem. 2002 Apr;10(4):923-8.

PMID:
11836099
47.
48.

Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.

Pathak AK, Pathak V, Maddry JA, Suling WJ, Gurcha SS, Besra GS, Reynolds RC.

Bioorg Med Chem. 2001 Dec;9(12):3145-51.

PMID:
11711289
49.

Studies on (beta,1-->5) and (beta,1-->6) linked octyl Gal(f) disaccharides as substrates for mycobacterial galactosyltransferase activity.

Pathak AK, Pathak V, Seitz L, Maddry JA, Gurcha SS, Besra GS, Suling WJ, Reynolds RC.

Bioorg Med Chem. 2001 Dec;9(12):3129-43.

PMID:
11711288
50.

CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection.

Moody DB, Ulrichs T, Mühlecker W, Young DC, Gurcha SS, Grant E, Rosat JP, Brenner MB, Costello CE, Besra GS, Porcelli SA.

Nature. 2000 Apr 20;404(6780):884-8.

PMID:
10786796

Supplemental Content

Loading ...
Support Center