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MiR-152 inhibits neuronal axon growth after spinal cord injury through regulating P38 MAPK signaling pathway.

Zhang T, Wang K, Luo J, Guo L.

Minerva Med. 2019 Jul 17. doi: 10.23736/S0026-4806.19.06224-4. [Epub ahead of print] No abstract available.


Successful recanalisation of coronary chronic total occlusions is not associated with improved cardiovascular survival compared with initial medical therapy.

Guo L, Zhang S, Wu J, Zhong L, Ding H, Xu J, Zhou X, Huang R.

Scand Cardiovasc J. 2019 Jul 18:1-23. doi: 10.1080/14017431.2019.1645351. [Epub ahead of print]


Downregulated Long Noncoding RNA GAS5 Fails to Function as Decoy of CEBPB, Resulting in Increased GDF15 Expression and Rapid Ovarian Cancer Cell Proliferation.

Guo LL, Wang SF.

Cancer Biother Radiopharm. 2019 Jul 16. doi: 10.1089/cbr.2019.2889. [Epub ahead of print]


Generation and characterization of Lhx4tdT reporter knock-in and Lhx4loxP conditional knockout mice.

Dong X, Xie X, Guo L, Xu J, Xu M, Liang G, Gan L.

Genesis. 2019 Jul 17:e23328. doi: 10.1002/dvg.23328. [Epub ahead of print]


Survival prediction of high-grade glioma patients with diffusion kurtosis imaging.

Zhang J, Jiang J, Zhao L, Zhang J, Shen N, Li S, Guo L, Su C, Jiang R, Zhu W.

Am J Transl Res. 2019 Jun 15;11(6):3680-3688. eCollection 2019.


Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization.

Boakye AA, Zhang D, Guo L, Zheng Y, Hoetker D, Zhao J, Posa DK, Ng CK, Zheng H, Kumar A, Kumar V, Wempe MF, Bhatnagar A, Conklin DJ, Baba SP.

Front Physiol. 2019 Jul 2;10:751. doi: 10.3389/fphys.2019.00751. eCollection 2019.


Systematic analysis of the lysine succinylome in the model medicinal mushroom Ganoderma lucidum.

Wang G, Xu L, Yu H, Gao J, Guo L.

BMC Genomics. 2019 Jul 16;20(1):585. doi: 10.1186/s12864-019-5962-0.


Engineering Pore Size of Pillared-Layer Coordination Polymers Enables Highly Efficient Adsorption Separation of Acetylene from Ethylene.

Zheng F, Guo L, Gao B, Li L, Zhang Z, Yang Q, Yang Y, Su B, Ren Q, Bao Z.

ACS Appl Mater Interfaces. 2019 Jul 16. doi: 10.1021/acsami.9b09231. [Epub ahead of print]


Enantioselective Total Syntheses of Pallambins A-D.

Jia Y, Zhang X, Cai X, Huang B, Guo L, Gao Z.

Angew Chem Int Ed Engl. 2019 Jul 16. doi: 10.1002/anie.201907523. [Epub ahead of print]


Beta-sarcoglycan-deficient muscular dystrophy presenting as chronic bronchopneumonia in a young cat.

Bouillon J, Taylor SM, Vargo C, Lange M, Zwicker LA, Sukut SL, Guo LT, Shelton GD.

JFMS Open Rep. 2019 Jul 1;5(2):2055116919856457. doi: 10.1177/2055116919856457. eCollection 2019 Jul-Dec.


Whole genome analysis reveals new insights into the molecular characteristics of Clostridioides difficile NAP1/BI/027/ST1 clinical isolates in the People's Republic of China.

Lv T, Chen Y, Guo L, Xu Q, Gu S, Shen P, Quan J, Fang Y, Chen L, Gui Q, Ye G, Li L.

Infect Drug Resist. 2019 Jul 1;12:1783-1794. doi: 10.2147/IDR.S203238. eCollection 2019.


A novel integrin αvβ3-specific ligand for the sensitive diagnosis of glioblastoma.

Zhang L, Shan X, Meng X, Gu T, Guo L, An X, Jiang Q, Ge H, Ning X.

Mol Pharm. 2019 Jul 15. doi: 10.1021/acs.molpharmaceut.9b00602. [Epub ahead of print]


A network meta-analysis protocol of adjuvant chemotherapy for unresectable patients with advanced gastric cancer.

Li L, Guo LY, Mao J.

Medicine (Baltimore). 2019 Jul;98(28):e16108. doi: 10.1097/MD.0000000000016108.


Regulation of cytochrome P450 expression by microRNAs and long non coding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.

Li D, Tolleson WH, Yu D, Chen S, Guo L, Xiao W, Tong W, Ning B.

J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019 Jul 15:1-35. doi: 10.1080/10590501.2019.1639481. [Epub ahead of print]


NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development.

Li YY, Guo L, Li H, Li J, Dong F, Yi ZY, Ouyang YC, Hou Y, Wang ZB, Sun QY, Lu SS, Han Z.

Mol Reprod Dev. 2019 Jul 15. doi: 10.1002/mrd.23234. [Epub ahead of print]


Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors.

Zheng X, Liang C, Wang L, Miao K, Wang B, Zhang W, Chen D, Wu G, Zhu W, Guo L, Feng S, Gao L, Shen HC, Yun H.

Medchemcomm. 2019 May 6;10(6):970-973. doi: 10.1039/c9md00178f. eCollection 2019 Jun 1.


Evaluation of therapeutic efficacy with CytoSorter® circulating tumor cell-capture system in patients with locally advanced head and neck squamous cell carcinoma.

Zheng W, Zhang Y, Guo L, Wang S, Fang M, Mao W, Lou J.

Cancer Manag Res. 2019 Jun 27;11:5857-5869. doi: 10.2147/CMAR.S208409. eCollection 2019.


Enhanced Raman scattering on lead iodide film.

Zhu L, Ma H, Wang H, Li P, Guo L, Zhao B.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 4;223:117336. doi: 10.1016/j.saa.2019.117336. [Epub ahead of print]


Antiphospholipid antibodies predict post-stroke depression after acute ischemic stroke.

Wang G, Zhou Y, Bu X, Peng H, Xu T, Wang A, Guo L, Liu J, Zhang J, Li D, Zhang J, Ju Z, Chen CS, Chen J, He J, Zhang Y, Zhong C.

J Affect Disord. 2019 Jul 4;257:160-165. doi: 10.1016/j.jad.2019.07.013. [Epub ahead of print]


Separating the effects of climate change and human activity on water use efficiency over the Beijing-Tianjin Sand Source Region of China.

Guo L, Shan N, Zhang Y, Sun F, Liu W, Shi Z, Zhang Q.

Sci Total Environ. 2019 Jul 5;690:584-595. doi: 10.1016/j.scitotenv.2019.07.067. [Epub ahead of print]


Total Synthesis of Dapholdhamine B and Dapholdhamine B Lactone.

Guo LD, Hou J, Tu W, Zhang Y, Zhang Y, Chen L, Xu J.

J Am Chem Soc. 2019 Jul 12. doi: 10.1021/jacs.9b05641. [Epub ahead of print]


Study of e^{+}e^{-}→γωJ/ψ and Observation of X(3872)→ωJ/ψ.

Ablikim M, Achasov MN, Adlarson P, Ahmed S, Albrecht M, Alekseev M, Amoroso A, An FF, An Q, Bai Y, Bakina O, Ferroli RB, Ban Y, Begzsuren K, Bennett JV, Berger N, Bertani M, Bettoni D, Bianchi F, Biernat J, Bloms J, Boyko I, Briere RA, Cai H, Cai X, Calcaterra A, Cao GF, Cao N, Cetin SA, Chai J, Chang JF, Chang WL, Chelkov G, Chen DY, Chen G, Chen HS, Chen JC, Chen ML, Chen SJ, Chen YB, Cheng W, Cibinetto G, Cossio F, Cui XF, Dai HL, Dai JP, Dai XC, Dbeyssi A, Dedovich D, Deng ZY, Denig A, Denysenko I, Destefanis M, De Mori F, Ding Y, Dong C, Dong J, Dong LY, Dong MY, Dou ZL, Du SX, Fan JZ, Fang J, Fang SS, Fang Y, Farinelli R, Fava L, Feldbauer F, Felici G, Feng CQ, Fritsch M, Fu CD, Fu Y, Gao Q, Gao XL, Gao Y, Gao Y, Gao YG, Gao Z, Garillon B, Garzia I, Gersabeck EM, Gilman A, Goetzen K, Gong L, Gong WX, Gradl W, Greco M, Gu LM, Gu MH, Gu S, Gu YT, Guo AQ, Guo LB, Guo RP, Guo YP, Guskov A, Han S, Hao XQ, Harris FA, He KL, Heinsius FH, Held T, Heng YK, Hou YR, Hou ZL, Hu HM, Hu JF, Hu T, Hu Y, Huang GS, Huang JS, Huang XT, Huang XZ, Huesken N, Hussain T, Andersson WI, Imoehl W, Irshad M, Ji Q, Ji QP, Ji XB, Ji XL, Jiang HL, Jiang XS, Jiang XY, Jiao JB, Jiao Z, Jin DP, Jin S, Jin Y, Johansson T, Kalantar-Nayestanaki N, Kang XS, Kappert R, Kavatsyuk M, Ke BC, Keshk IK, Khan T, Khoukaz A, Kiese P, Kiuchi R, Kliemt R, Koch L, Kolcu OB, Kopf B, Kuemmel M, Kuessner M, Kupsc A, Kurth M, Kurth MG, Kühn W, Lange JS, Larin P, Lavezzi L, Leithoff H, Lenz T, Li C, Li C, Li DM, Li F, Li FY, Li G, Li HB, Li HJ, Li JC, Li JW, Li K, Li LK, Li L, Li PL, Li PR, Li QY, Li WD, Li WG, Li XH, Li XL, Li XN, Li XQ, Li ZB, Liang H, Liang H, Liang YF, Liang YT, Liao GR, Liao LZ, Libby J, Lin CX, Lin DX, Lin YJ, Liu B, Liu BJ, Liu CX, Liu D, Liu DY, Liu FH, Liu F, Liu F, Liu HB, Liu HM, Liu H, Liu H, Liu JB, Liu JY, Liu KY, Liu K, Liu Q, Liu SB, Liu T, Liu X, Liu XY, Liu YB, Liu ZA, Liu Z, Long YF, Lou XC, Lu HJ, Lu JD, Lu JG, Lu Y, Lu YP, Luo CL, Luo MX, Luo PW, Luo T, Luo XL, Lusso S, Lyu XR, Ma FC, Ma HL, Ma LL, Ma MM, Ma QM, Ma XN, Ma XX, Ma XY, Ma YM, Maas FE, Maggiora M, Maldaner S, Malde S, Malik QA, Mangoni A, Mao YJ, Mao ZP, Marcello S, Meng ZX, Messchendorp JG, Mezzadri G, Min J, Min TJ, Mitchell RE, Mo XH, Mo YJ, Morales CM, Muchnoi NY, Muramatsu H, Mustafa A, Nakhoul S, Nefedov Y, Nerling F, Nikolaev IB, Ning Z, Nisar S, Niu SL, Olsen SL, Ouyang Q, Pacetti S, Pan Y, Papenbrock M, Patteri P, Pelizaeus M, Peng HP, Peters K, Pettersson J, Ping JL, Ping RG, Pitka A, Poling R, Prasad V, Qi M, Qi TY, Qian S, Qiao CF, Qin N, Qin XP, Qin XS, Qin ZH, Qiu JF, Qu SQ, Rashid KH, Ravindran K, Redmer CF, Richter M, Ripka M, Rivetti A, Rodin V, Rolo M, Rong G, Rosner C, Rump M, Sarantsev A, Savri M, Schoenning K, Shan W, Shan XY, Shao M, Shen CP, Shen PX, Shen XY, Sheng HY, Shi X, Shi XD, Song JJ, Song QQ, Song XY, Sosio S, Sowa C, Spataro S, Sui FF, Sun GX, Sun JF, Sun L, Sun SS, Sun XH, Sun YJ, Sun YK, Sun YZ, Sun ZJ, Sun ZT, Tan YT, Tang CJ, Tang GY, Tang X, Thoren V, Tsednee B, Uman I, Wang B, Wang BL, Wang CW, Wang DY, Wang HH, Wang K, Wang LL, Wang LS, Wang M, Wang MZ, Wang M, Wang PL, Wang RM, Wang WP, Wang X, Wang XF, Wang XL, Wang Y, Wang YF, Wang Z, Wang ZG, Wang ZY, Wang Z, Weber T, Wei DH, Weidenkaff P, Wen HW, Wen SP, Wiedner U, Wilkinson G, Wolke M, Wu LH, Wu LJ, Wu Z, Xia L, Xia Y, Xiao SY, Xiao YJ, Xiao ZJ, Xie YG, Xie YH, Xing TY, Xiong XA, Xiu QL, Xu GF, Xu JJ, Xu L, Xu QJ, Xu W, Xu XP, Yan F, Yan L, Yan WB, Yan WC, Yan YH, Yang HJ, Yang HX, Yang L, Yang RX, Yang SL, Yang YH, Yang YX, Yang Y, Yang ZQ, Ye M, Ye MH, Yin JH, You ZY, Yu BX, Yu CX, Yu JS, Yuan CZ, Yuan XQ, Yuan Y, Yuncu A, Zafar AA, Zeng Y, Zhang BX, Zhang BY, Zhang CC, Zhang DH, Zhang HH, Zhang HY, Zhang J, Zhang JL, Zhang JQ, Zhang JW, Zhang JY, Zhang JZ, Zhang K, Zhang L, Zhang SF, Zhang TJ, Zhang XY, Zhang Y, Zhang YH, Zhang YT, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhang ZH, Zhang ZP, Zhang ZY, Zhao G, Zhao JW, Zhao JY, Zhao JZ, Zhao L, Zhao L, Zhao MG, Zhao Q, Zhao SJ, Zhao TC, Zhao YB, Zhao ZG, Zhemchugov A, Zheng B, Zheng JP, Zheng Y, Zheng YH, Zhong B, Zhou L, Zhou LP, Zhou Q, Zhou X, Zhou XK, Zhou XR, Zhou X, Zhou X, Zhu AN, Zhu J, Zhu J, Zhu K, Zhu KJ, Zhu SH, Zhu WJ, Zhu XL, Zhu YC, Zhu YS, Zhu ZA, Zhuang J, Zou BS, Zou JH; BESIII Collaboration.

Phys Rev Lett. 2019 Jun 14;122(23):232002. doi: 10.1103/PhysRevLett.122.232002.


Predictive Factors of Recurrence for Multifocal Papillary Thyroid Microcarcinoma With Brafv600e Mutation: A Single Center Study of 1,207 Chinese Patients.

Xue S, Zhang L, Wang P, Liu J, Yin Y, Jin M, Guo L, Zhou Y, Chen G.

Front Endocrinol (Lausanne). 2019 Jun 26;10:407. doi: 10.3389/fendo.2019.00407. eCollection 2019.


Prescription practices in the treatment of agitation in newly hospitalized Chinese schizophrenia patients: data from a non-interventional naturalistic study.

Zhang SZ, Mu YG, Liu Q, Shi Y, Guo LH, Li LZ, Yang FD, Wang Y, Li T, Mei QY, He HB, Chen ZY, Su ZH, Liu TB, Xie SP, Tan QR, Zhang JB, Zhang CP, Sang H, Mi WF, Zhang HY.

BMC Psychiatry. 2019 Jul 10;19(1):216. doi: 10.1186/s12888-019-2192-6.


Underliquid Superlyophobic Copper-coated Meshes for the Separation of Immiscible Organic Liquid Mixtures.

Zhao Z, Shen Y, Yang H, Li J, Guo L.

ACS Appl Mater Interfaces. 2019 Jul 10. doi: 10.1021/acsami.9b05812. [Epub ahead of print]


Oxide Neuromorphic Transistors Gated by Polyvinyl Alcohol Solid Electrolyte with Ultralow Power Consumption.

Guo L, Han H, Zhu LQ, Guo YB, Yu F, Ren ZY, Xiao H, Ge Z, Ding J.

ACS Appl Mater Interfaces. 2019 Jul 11. doi: 10.1021/acsami.9b05717. [Epub ahead of print]


The effects of tranylcypromine on osteoclastogenesis in vitro and in vivo.

Liu Z, Yang K, Yan X, Wang T, Jiang T, Zhou Q, Qi J, Qian N, Zhou H, Chen B, Huang P, Guo L, Zhang X, Xu X, Jiang M, Deng L.

FASEB J. 2019 Jul 10:fj201802242RR. doi: 10.1096/fj.201802242RR. [Epub ahead of print]


A potent free fatty acid receptor 1 agonist with a glucose-dependent antihyperglycemic effect.

Wang X, Xu Y, Feng S, Huang X, Meng X, Chen J, Guo L, Ge J, Zhang J, Chen J, Cheng L, Gu K, Zhang Y, Jiang Q, Ning X.

Chem Commun (Camb). 2019 Jul 10. doi: 10.1039/c9cc04040d. [Epub ahead of print]


Expression and clinical significance of miRNA-145 and miRNA-218 in laryngeal cancer.

Guo L, Cai X, Hu W, Hua W, Yan W, Lin Y, Yin S, Chen Y.

Oncol Lett. 2019 Jul;18(1):764-770. doi: 10.3892/ol.2019.10353. Epub 2019 May 13.


Prevalence and antimicrobial susceptibilities of bacterial pathogens in Chinese pig farms from 2013 to 2017.

Zhang B, Ku X, Yu X, Sun Q, Wu H, Chen F, Zhang X, Guo L, Tang X, He Q.

Sci Rep. 2019 Jul 9;9(1):9908. doi: 10.1038/s41598-019-45482-8.


Comparison and Discrimination of Artemisia argyi and Artemisia lavandulifolia by Gas Chromatography-Mass Spectrometry-Based Metabolomic Approach.

Guo L, Zhang D, Wang L, Xue Z, Guo M, Duan L, Zheng Y.

J AOAC Int. 2019 Jul 9. doi: 10.5740/jaoacint.19-0080. [Epub ahead of print]


Validation of the 8th edition UICC/AJCC TNM staging system for HPV associated oropharyngeal cancer patients managed with contemporary chemo-radiotherapy.

van Gysen K, Stevens M, Guo L, Jayamanne D, Veivers D, Wignall A, Pang L, Guminski A, Lee A, Hruby G, Macleod P, Taylor A, Eade T.

BMC Cancer. 2019 Jul 9;19(1):674. doi: 10.1186/s12885-019-5894-8.


Multi-purpose barbituric acid derivatives with aggregation induced emission.

Zhang H, Cui Y, Tao F, Zhang D, Xu Z, Guo L.

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 27;223:117320. doi: 10.1016/j.saa.2019.117320. [Epub ahead of print]


A fast and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry method for determining mefentrifluconazole in plant- and animal-derived foods.

Zhang Y, Wu X, Li X, Duan T, Xu J, Dong F, Liu X, Guo L, Zheng Y.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Jul 9:1-10. doi: 10.1080/19440049.2019.1628361. [Epub ahead of print]


Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice.

Snider B, Geiser A, Yu XP, Beebe EC, Willency JA, Qing K, Guo L, Lu J, Wang X, Yang Q, Efanov A, Adams AC, Coskun T, Emmerson PJ, Alsina-Fernandez J, Ai M.

J Endocr Soc. 2019 May 16;3(7):1423-1444. doi: 10.1210/js.2019-00004. eCollection 2019 Jul 1.


Genome assembly of Nannochloropsis oceanica provides evidence of host nucleus overthrow by the symbiont nucleus during speciation.

Guo L, Liang S, Zhang Z, Liu H, Wang S, Pan K, Xu J, Ren X, Pei S, Yang G.

Commun Biol. 2019 Jul 3;2:249. doi: 10.1038/s42003-019-0500-9. eCollection 2019.


Transcriptional Analysis of the Early Ripening of 'Kyoho' Grape in Response to the Treatment of Riboflavin.

Wang ZG, Guo LL, Ji XR, Yu YH, Zhang GH, Guo DL.

Genes (Basel). 2019 Jul 6;10(7). pii: E514. doi: 10.3390/genes10070514.


Development of novel ST68/PLA-PEG stabilized ultrasound nanobubbles for potential tumor imaging and theranostic.

Shang M, Wang K, Guo L, Duan S, Lu Z, Li J.

Ultrasonics. 2019 Jul 2;99:105947. doi: 10.1016/j.ultras.2019.105947. [Epub ahead of print]


A folic acid-functionalized dual-emissive nanoprobe for "double-check" luminescence imaging of cancer cells.

Liu C, Liu J, Ma H, Zhang W, Song B, Guo L, Zhang R, Yuan J.

Methods. 2019 Jul 5. pii: S1046-2023(19)30042-8. doi: 10.1016/j.ymeth.2019.07.001. [Epub ahead of print]


S-Petasin isolated from Petasites japonicus exerts anti-adipogenic activity in the 3T3-L1 cell line by inhibiting PPAR-γ pathway signaling.

Guo L, Li K, Cui ZW, Kang JS, Son BG, Choi YW.

Food Funct. 2019 Jul 17;10(7):4396-4406. doi: 10.1039/c9fo00549h.


Crystal structure of the glycoside hydrolase PssZ from Listeria monocytogenes.

Wu H, Qiao S, Li D, Guo L, Zhu M, Ma LZ.

Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):501-506. doi: 10.1107/S2053230X19008100. Epub 2019 Jun 28.


High-performance Large-scale Flexible Optoelectronics using Ultra-thin Silver Films with Tunable Properties.

Zhang C, Huang Q, Cui Q, Ji C, Zhang Z, Chen X, George T, Zhao S, Guo LJ.

ACS Appl Mater Interfaces. 2019 Jul 8. doi: 10.1021/acsami.9b08289. [Epub ahead of print]


Water-soluble conjugated polymer with near-infrared absorption for synergistic tumor therapy using photothermal and photodynamic activity.

Zhou S, Yang C, Guo L, Wang Y, Zhang G, Feng L.

Chem Commun (Camb). 2019 Jul 18;55(59):8615-8618. doi: 10.1039/c9cc03744f.


The Background Structure of Entrepreneurial Team and Strategic Investment Decisions: A Collective Psychological Capital Perspective.

Guo LX, Lu KH, Cheng YF, Liu CF.

Front Psychol. 2019 Jun 20;10:1416. doi: 10.3389/fpsyg.2019.01416. eCollection 2019.


Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine.

Yang F, Wang D, Tong Y, Qin C, Yang L, Yu F, Huang X, Liu S, Cao Z, Guo L, Li W, Wu Y, Zhao X.

J Proteomics. 2019 Jul 4;206:103435. doi: 10.1016/j.jprot.2019.103435. [Epub ahead of print]


Oleuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats.

Yin M, Jiang N, Guo L, Ni Z, Al-Brakati AY, Othman MS, Abdel Moneim AE, Kassab RB.

Life Sci. 2019 Jul 4:116634. doi: 10.1016/j.lfs.2019.116634. [Epub ahead of print]


Biophysical and Biological Characterization of PEGylated Recombinant Human Endostatin (M2 ES).

Guo L, Xu B, Zhou D, Chang G, Fu Y, Liu L, Luo Y.

Clin Exp Pharmacol Physiol. 2019 Jul 6. doi: 10.1111/1440-1681.13134. [Epub ahead of print]


Cross-sectional study on influence of the family environment on the lifetime non-medical use of prescription drugs among Chinese adolescents in Guangdong: an analysis of sex differences.

Wang W, Luo M, Xi C, Lei Y, Pan S, Gao X, Xu Y, Huang G, Deng X, Guo L, Lu C.

BMJ Open. 2019 Jul 4;9(7):e026758. doi: 10.1136/bmjopen-2018-026758.

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