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Items: 1 to 50 of 112

1.

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T.

Nat Immunol. 2018 Oct 29. doi: 10.1038/s41590-018-0237-5. [Epub ahead of print]

PMID:
30374128
2.

Neutrophils instruct homeostatic and pathological states in naive tissues.

Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A.

J Exp Med. 2018 Nov 5;215(11):2778-2795. doi: 10.1084/jem.20181468. Epub 2018 Oct 3.

PMID:
30282719
3.

Role of polymorphonuclear neutrophils in the reperfused ischemic brain: insights from cell-type-specific immunodepletion and fluorescence microscopy studies.

Hermann DM, Kleinschnitz C, Gunzer M.

Ther Adv Neurol Disord. 2018 Sep 14;11:1756286418798607. doi: 10.1177/1756286418798607. eCollection 2018. Review.

4.

A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells.

Sokolova V, Loza K, Knuschke T, Heinen-Weiler J, Jastrow H, Hasenberg M, Buer J, Westendorf AM, Gunzer M, Epple M.

Acta Biomater. 2018 Oct 15;80:352-363. doi: 10.1016/j.actbio.2018.09.026. Epub 2018 Sep 18.

PMID:
30240952
5.

Modeling Hemolytic-Uremic Syndrome: In-Depth Characterization of Distinct Murine Models Reflecting Different Features of Human Disease.

Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amann K, Coldewey SM.

Front Immunol. 2018 Jun 25;9:1459. doi: 10.3389/fimmu.2018.01459. eCollection 2018.

6.

Nanoparticle decoration impacts airborne fungal pathobiology.

Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L, Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M, Hasenberg M, Knauer SK, Stauber RH.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7087-7092. doi: 10.1073/pnas.1804542115. Epub 2018 Jun 20.

PMID:
29925597
7.

Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components.

Lin Y, Wu C, Wang X, Kemper T, Squire A, Gunzer M, Zhang J, Chen X, Lu M.

Protein Cell. 2018 Jun 6. doi: 10.1007/s13238-018-0555-2. [Epub ahead of print] No abstract available.

PMID:
29876903
8.

Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target.

Hermann DM, Kleinschnitz C, Gunzer M.

J Neuroimmunol. 2018 Aug 15;321:138-143. doi: 10.1016/j.jneuroim.2018.04.015. Epub 2018 Apr 24. Review.

PMID:
29729895
9.

[New insights into the function of bone marrow].

Schett G, Bozec A, Bekeredjian-Ding I, Chang HD, David JP, Dörner T, Grässel S, Gunzer M, Manz R, Mei H, Mielenz D, Müller-Ladner U, Neumann E, Radbruch A, Richter W, Straub RH.

Z Rheumatol. 2018 May;77(Suppl 1):4-7. doi: 10.1007/s00393-018-0456-z. Review. German. No abstract available.

PMID:
29691692
10.

[Mutual influence of immune system and bones].

Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A.

Z Rheumatol. 2018 May;77(Suppl 1):8-11. doi: 10.1007/s00393-018-0454-1. Review. German. No abstract available.

PMID:
29675686
11.

How Safe Is the Administration of Long-Acting Granulocyte Colony-Stimulating Factor in Cancer Patients?

Geissler K, Gunzer M, Ostermann H.

Oncol Res Treat. 2018;41(5):316-326. doi: 10.1159/000486681. Epub 2018 Mar 23.

PMID:
29562228
12.

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

Neumann J, Henneberg S, von Kenne S, Nolte N, Müller AJ, Schraven B, Görtler MW, Reymann KG, Gunzer M, Riek-Burchardt M.

PLoS One. 2018 Mar 15;13(3):e0193970. doi: 10.1371/journal.pone.0193970. eCollection 2018.

13.

Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation via Toll-Like Receptor 7.

Stegemann-Koniszewski S, Behrens S, Boehme JD, Hochnadel I, Riese P, Guzmán CA, Kröger A, Schreiber J, Gunzer M, Bruder D.

Front Immunol. 2018 Feb 13;9:245. doi: 10.3389/fimmu.2018.00245. eCollection 2018.

14.

Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research.

Otto L, Zelinskyy G, Schuster M, Dittmer U, Gunzer M.

J Mol Med (Berl). 2018 Apr;96(3-4):349-360. doi: 10.1007/s00109-018-1628-7. Epub 2018 Feb 19.

PMID:
29460050
15.

ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis.

Whittaker Hawkins RF, Patenaude A, Dumas A, Jain R, Tesfagiorgis Y, Kerfoot S, Matsui T, Gunzer M, Poubelle PE, Larochelle C, Pelletier M, Vallières L.

JCI Insight. 2017 Dec 7;2(23). pii: 96882. doi: 10.1172/jci.insight.96882. [Epub ahead of print]

16.

Escaping the traps of your own hunters.

Gunzer M.

Science. 2017 Dec 1;358(6367):1126-1127. doi: 10.1126/science.aar2428. No abstract available.

PMID:
29191890
17.

Visualizing the function and fate of neutrophils in sterile injury and repair.

Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P.

Science. 2017 Oct 6;358(6359):111-116. doi: 10.1126/science.aam9690.

PMID:
28983053
18.

Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.

Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarten D, Opitz CA, Brakhage AA, Sitek B, Hasenberg M, Gunzer M.

Mol Cell Proteomics. 2017 Dec;16(12):2184-2198. doi: 10.1074/mcp.RA117.000072. Epub 2017 Sep 26.

PMID:
28951444
19.

Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo.

Davies G, Rolle AM, Maurer A, Spycher PR, Schillinger C, Solouk-Saran D, Hasenberg M, Weski J, Fonslet J, Dubois A, Boschetti F, Denat F, Gunzer M, Eichner M, Ryder LS, Jensen M, Schibli R, Pichler BJ, Wiehr S, Thornton CR.

Theranostics. 2017 Aug 11;7(14):3398-3414. doi: 10.7150/thno.20919. eCollection 2017.

20.

Three-Dimensional Cross-Sectional Light-Sheet Microscopy Imaging of the Inflamed Mouse Gut.

Zundler S, Klingberg A, Schillinger D, Fischer S, Neufert C, Atreya I, Gunzer M, Neurath MF.

Gastroenterology. 2017 Oct;153(4):898-900. doi: 10.1053/j.gastro.2017.07.022. Epub 2017 Sep 4. No abstract available.

PMID:
28870528
21.

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation.

Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N.

J Allergy Clin Immunol. 2018 Jan;141(1):416-419.e10. doi: 10.1016/j.jaci.2017.06.048. Epub 2017 Aug 19. No abstract available.

PMID:
28826775
22.

Irf4-dependent CD103+CD11b+ dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus.

Pohl JM, Gutweiler S, Thiebes S, Volke JK, Klein-Hitpass L, Zwanziger D, Gunzer M, Jung S, Agace WW, Kurts C, Engel DR.

Gut. 2017 Dec;66(12):2110-2120. doi: 10.1136/gutjnl-2017-313856. Epub 2017 Jun 14. Erratum in: Gut. 2018 Feb;67(2):379.

23.

Quantitative Visualization of Leukocyte Infiltrate in a Murine Model of Fulminant Myocarditis by Light Sheet Microscopy.

Männ L, Klingberg A, Gunzer M, Hasenberg M.

J Vis Exp. 2017 May 31;(123). doi: 10.3791/55450.

PMID:
28605364
24.

3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy.

Lugo-Hernandez E, Squire A, Hagemann N, Brenzel A, Sardari M, Schlechter J, Sanchez-Mendoza EH, Gunzer M, Faissner A, Hermann DM.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3355-3367. doi: 10.1177/0271678X17698970. Epub 2017 Mar 28.

25.

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy.

Klingberg A, Hasenberg A, Ludwig-Portugall I, Medyukhina A, Männ L, Brenzel A, Engel DR, Figge MT, Kurts C, Gunzer M.

J Am Soc Nephrol. 2017 Feb;28(2):452-459. doi: 10.1681/ASN.2016020232. Epub 2016 Aug 3.

26.

CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin.

Männ L, Kochupurakkal N, Martin C, Verjans E, Klingberg A, Sody S, Kraus A, Dalimot J, Bergmüller E, Jung S, Voortman S, Winterhager E, Brandau S, Garbi N, Kurrer M, Eriksson U, Gunzer M, Hasenberg M.

Eur J Immunol. 2016 Aug;46(8):2028-42. doi: 10.1002/eji.201546245. Epub 2016 Jun 8.

27.

Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals.

Stegemann-Koniszewski S, Jeron A, Gereke M, Geffers R, Kröger A, Gunzer M, Bruder D.

MBio. 2016 May 3;7(3). pii: e00276-16. doi: 10.1128/mBio.00276-16.

28.

Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages.

Zec K, Volke J, Vijitha N, Thiebes S, Gunzer M, Kurts C, Engel DR.

Pathogens. 2016 Feb 4;5(1). pii: E15. doi: 10.3390/pathogens5010015.

29.

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice.

Moses K, Klein JC, Männ L, Klingberg A, Gunzer M, Brandau S.

J Leukoc Biol. 2016 Jun;99(6):811-23. doi: 10.1189/jlb.1HI0715-289R. Epub 2016 Jan 27.

PMID:
26819319
30.

ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo.

Rolle AM, Hasenberg M, Thornton CR, Solouk-Saran D, Männ L, Weski J, Maurer A, Fischer E, Spycher PR, Schibli R, Boschetti F, Stegemann-Koniszewski S, Bruder D, Severin GW, Autenrieth SE, Krappmann S, Davies G, Pichler BJ, Gunzer M, Wiehr S.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1026-33. doi: 10.1073/pnas.1518836113. Epub 2016 Jan 19.

31.

Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.

Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J.

Sci Transl Med. 2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278. Erratum in: Sci Transl Med. 2015 Dec 23;7(319):319er8. Lehy, Julia [corrected to Leyh, Julia].

PMID:
26659573
32.

Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.

Herz J, Sabellek P, Lane TE, Gunzer M, Hermann DM, Doeppner TR.

Stroke. 2015 Oct;46(10):2916-25. doi: 10.1161/STROKEAHA.115.010620. Epub 2015 Sep 3.

33.

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes.

Hasenberg A, Hasenberg M, Männ L, Neumann F, Borkenstein L, Stecher M, Kraus A, Engel DR, Klingberg A, Seddigh P, Abdullah Z, Klebow S, Engelmann S, Reinhold A, Brandau S, Seeling M, Waisman A, Schraven B, Göthert JR, Nimmerjahn F, Gunzer M.

Nat Methods. 2015 May;12(5):445-52. doi: 10.1038/nmeth.3322. Epub 2015 Mar 16.

PMID:
25775045
34.

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke.

Neumann J, Riek-Burchardt M, Herz J, Doeppner TR, König R, Hütten H, Etemire E, Männ L, Klingberg A, Fischer T, Görtler MW, Heinze HJ, Reichardt P, Schraven B, Hermann DM, Reymann KG, Gunzer M.

Acta Neuropathol. 2015 Feb;129(2):259-77. doi: 10.1007/s00401-014-1355-2. Epub 2014 Nov 13.

PMID:
25391494
35.

Human dendritic cell subsets display distinct interactions with the pathogenic mould Aspergillus fumigatus.

Lother J, Breitschopf T, Krappmann S, Morton CO, Bouzani M, Kurzai O, Gunzer M, Hasenberg M, Einsele H, Loeffler J.

Int J Med Microbiol. 2014 Nov;304(8):1160-8. doi: 10.1016/j.ijmm.2014.08.009. Epub 2014 Aug 18.

PMID:
25200858
36.

Automated characterization and parameter-free classification of cell tracks based on local migration behavior.

Mokhtari Z, Mech F, Zitzmann C, Hasenberg M, Gunzer M, Figge MT.

PLoS One. 2013 Dec 6;8(12):e80808. doi: 10.1371/journal.pone.0080808. eCollection 2013. Erratum in: PLoS One. 2014;9(12):e115158.

37.

Traps and hyper inflammation - new ways that neutrophils promote or hinder survival.

Gunzer M.

Br J Haematol. 2014 Jan;164(2):189-99. doi: 10.1111/bjh.12608. Epub 2013 Oct 21. Review.

PMID:
24138538
38.

Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.

Etemire E, Krull M, Hasenberg M, Reichardt P, Gunzer M.

PLoS One. 2013 Jul 11;8(7):e68378. doi: 10.1371/journal.pone.0068378. Print 2013.

39.

Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters.

Philipsen L, Engels T, Schilling K, Gurbiel S, Fischer KD, Tedford K, Schraven B, Gunzer M, Reichardt P.

Mol Cell Proteomics. 2013 Sep;12(9):2551-67. doi: 10.1074/mcp.M112.025205. Epub 2013 Jun 10.

40.

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation.

De Filippo K, Dudeck A, Hasenberg M, Nye E, van Rooijen N, Hartmann K, Gunzer M, Roers A, Hogg N.

Blood. 2013 Jun 13;121(24):4930-7. doi: 10.1182/blood-2013-02-486217. Epub 2013 May 3.

41.

A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.

Reichardt P, Patzak I, Jones K, Etemire E, Gunzer M, Hogg N.

EMBO J. 2013 Mar 20;32(6):829-43. doi: 10.1038/emboj.2013.33. Epub 2013 Feb 26.

42.

T cell activation results in conformational changes in the Src family kinase Lck to induce its activation.

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Merten C, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B.

Sci Signal. 2013 Feb 19;6(263):ra13. doi: 10.1126/scisignal.2003607.

PMID:
23423439
43.

Cellular immune reactions in the lung.

Hasenberg M, Stegemann-Koniszewski S, Gunzer M.

Immunol Rev. 2013 Jan;251(1):189-214. doi: 10.1111/imr.12020. Review.

PMID:
23278750
44.

Pilus adhesin RrgA interacts with complement receptor 3, thereby affecting macrophage function and systemic pneumococcal disease.

Orrskog S, Rounioja S, Spadafina T, Gallotta M, Norman M, Hentrich K, Fälker S, Ygberg-Eriksson S, Hasenberg M, Johansson B, Uotila LM, Gahmberg CG, Barocchi M, Gunzer M, Normark S, Henriques-Normark B.

MBio. 2012 Dec 26;4(1):e00535-12. doi: 10.1128/mBio.00535-12.

45.

TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.

Stegemann-Koniszewski S, Gereke M, Orrskog S, Lienenklaus S, Pasche B, Bader SR, Gruber AD, Akira S, Weiss S, Henriques-Normark B, Bruder D, Gunzer M.

J Innate Immun. 2013;5(1):84-96. doi: 10.1159/000345112. Epub 2012 Nov 15.

46.

White-opaque switching of Candida albicans allows immune evasion in an environment-dependent fashion.

Sasse C, Hasenberg M, Weyler M, Gunzer M, Morschhäuser J.

Eukaryot Cell. 2013 Jan;12(1):50-8. doi: 10.1128/EC.00266-12. Epub 2012 Nov 2.

47.

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.

Florian MC, Dörr K, Niebel A, Daria D, Schrezenmeier H, Rojewski M, Filippi MD, Hasenberg A, Gunzer M, Scharffetter-Kochanek K, Zheng Y, Geiger H.

Cell Stem Cell. 2012 May 4;10(5):520-30. doi: 10.1016/j.stem.2012.04.007.

48.

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.

Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, Madhu M, Arnett JL, Santho RA, Dunn SK, Fishman GI, Gutstein DE, Civitelli R, Barrio LC, Gunzer M, Cancelas JA.

Blood. 2012 May 31;119(22):5144-54. doi: 10.1182/blood-2011-07-368506. Epub 2012 Apr 12.

49.

Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.

Schmidt A, Oberle N, Weiss EM, Vobis D, Frischbutter S, Baumgrass R, Falk CS, Haag M, Brügger B, Lin H, Mayr GW, Reichardt P, Gunzer M, Suri-Payer E, Krammer PH.

Sci Signal. 2011 Dec 20;4(204):ra90. doi: 10.1126/scisignal.2002179.

PMID:
22375050
50.

Vaccine adjuvants: Tailor-made mast-cell granules.

Gunzer M.

Nat Mater. 2012 Feb 21;11(3):181-2. doi: 10.1038/nmat3257. No abstract available.

PMID:
22349854

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