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Items: 39

1.

Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models.

Deb S, Pham S, Ming DS, Chin MY, Adomat H, Hurtado-Coll A, Gleave ME, Guns EST.

Cancers (Basel). 2018 Sep 20;10(10). pii: E343. doi: 10.3390/cancers10100343.

2.

Neuropeptide Y and orexin immunoreactivity in the sparrow brain coincide with seasonal changes in energy balance and steroids.

Fokidis HB, Ma C, Radin B, Prior NH, Adomat HH, Guns ES, Soma KK.

J Comp Neurol. 2018 Sep 17. doi: 10.1002/cne.24535. [Epub ahead of print]

PMID:
30225913
3.

Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation.

Lallous N, Leblanc E, Munuganti RS, Hassona MD, Nakouzi NA, Awrey S, Morin H, Roshan-Moniri M, Singh K, Lawn S, Yamazaki T, Adomat HH, Andre C, Daugaard M, Young RN, Guns ES, Rennie PS, Cherkasov A.

Mol Cancer Ther. 2016 Dec;15(12):2936-2945. Epub 2016 Oct 7.

4.

Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment.

Lubik AA, Nouri M, Truong S, Ghaffari M, Adomat HH, Corey E, Cox ME, Li N, Guns ES, Yenki P, Pham S, Buttyan R.

Int J Cancer. 2017 Jan 15;140(2):358-369. doi: 10.1002/ijc.30450. Epub 2016 Oct 20.

5.

DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis.

Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G.

PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. eCollection 2016.

6.

Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions.

Ben-Eltriki M, Deb S, Guns ES.

J Cancer. 2016 Jan 15;7(4):391-407. doi: 10.7150/jca.13470. eCollection 2016. Review.

7.

Sex steroid profiles in zebra finches: Effects of reproductive state and domestication.

Prior NH, Yap KN, Mainwaring MC, Adomat HH, Crino OL, Ma C, Guns ES, Griffith SC, Buchanan KL, Soma KK.

Gen Comp Endocrinol. 2017 Apr 1;244:108-117. doi: 10.1016/j.ygcen.2016.02.018. Epub 2016 Feb 17.

PMID:
26899721
8.

Sex steroid profiles and pair-maintenance behavior of captive wild-caught zebra finches (Taeniopygia guttata).

Prior NH, Yap KN, Adomat HH, Mainwaring MC, Fokidis HB, Guns ES, Buchanan KL, Griffith SC, Soma KK.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2016 Jan;202(1):35-44. doi: 10.1007/s00359-015-1050-3. Epub 2015 Nov 26.

PMID:
26610331
9.

Oral simvastatin administration delays castration-resistant progression and reduces intratumoral steroidogenesis of LNCaP prostate cancer xenografts.

Gordon JA, Midha A, Szeitz A, Ghaffari M, Adomat HH, Guo Y, Klassen TL, Guns ES, Wasan KM, Cox ME.

Prostate Cancer Prostatic Dis. 2016 Mar;19(1):21-7. doi: 10.1038/pcan.2015.37. Epub 2015 Aug 4.

PMID:
26238234
10.

The effect of pomegranate fruit extract on testosterone-induced BPH in rats.

Ammar AE, Esmat A, Hassona MD, Tadros MG, Abdel-Naim AB, Guns ES.

Prostate. 2015 May;75(7):679-92. doi: 10.1002/pros.22951. Epub 2015 Jan 25.

PMID:
25620586
11.

Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer.

Toren PJ, Kim S, Pham S, Mangalji A, Adomat H, Guns ES, Zoubeidi A, Moore W, Gleave ME.

Mol Cancer Ther. 2015 Jan;14(1):59-69. doi: 10.1158/1535-7163.MCT-14-0521. Epub 2014 Oct 28.

12.

Regulation of local steroidogenesis in the brain and in prostate cancer: lessons learned from interdisciplinary collaboration.

Fokidis HB, Adomat HH, Kharmate G, Hosseini-Beheshti E, Guns ES, Soma KK.

Front Neuroendocrinol. 2015 Jan;36:108-29. doi: 10.1016/j.yfrne.2014.08.005. Epub 2014 Sep 16. Review.

PMID:
25223867
13.

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro.

Pham S, Deb S, Ming DS, Adomat H, Hosseini-Beheshti E, Zoubeidi A, Gleave M, Guns ES.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt B:436-44. doi: 10.1016/j.jsbmb.2014.09.004. Epub 2014 Sep 6.

PMID:
25201454
14.

A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis.

Ho VW, Hamilton MJ, Dang NH, Hsu BE, Adomat HH, Guns ES, Weljie A, Samudio I, Bennewith KL, Krystal G.

Carcinogenesis. 2014 Oct;35(10):2291-9. doi: 10.1093/carcin/bgu147. Epub 2014 Jul 14.

15.

Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro.

Deb S, Chin MY, Adomat H, Guns ES.

J Steroid Biochem Mol Biol. 2014 May;141:94-103. doi: 10.1016/j.jsbmb.2014.01.007. Epub 2014 Jan 30.

PMID:
24486455
16.

Tenth International Conference of the Society for Integrative Oncology Translational Science in Integrative Oncology: from bedside to bench to best practices.

Balneaves LG, Lee RT, Guns ES, Zick SM, Bauer-Wu S, Greenlee H.

Integr Cancer Ther. 2014 Jan;13(1):5-11. doi: 10.1177/1534735413517743. No abstract available.

PMID:
24420529
17.

Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro.

Deb S, Chin MY, Adomat H, Guns ES.

J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:50-8. doi: 10.1016/j.jsbmb.2013.10.027. Epub 2013 Nov 20. Review.

PMID:
24269662
18.

Validation of a sequential extraction and liquid chromatography-tandem mass spectrometric method for determination of dihydrotestosterone, androstanediol and androstanediol-glucuronide in prostate tissues.

Adomat HH, Bains OS, Lubieniecka JM, Gleave ME, Guns ES, Grigliatti TA, Reid RE, Riggs KW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:84-95. doi: 10.1016/j.jchromb.2012.06.031. Epub 2012 Jul 1.

PMID:
22818945
19.

Cytochrome P450 3A-mediated microsomal biotransformation of 1α,25-dihydroxyvitamin D3 in mouse and human liver: drug-related induction and inhibition of catabolism.

Deb S, Pandey M, Adomat H, Guns ES.

Drug Metab Dispos. 2012 May;40(5):907-18. doi: 10.1124/dmd.111.041681. Epub 2012 Feb 2.

20.

Fluorescent adducts formed by reaction of oxidized unsaturated fatty acids with amines increase macrophage viability.

Riazy M, Lougheed M, Adomat HH, Guns ES, Eigendorf GK, Duronio V, Steinbrecher UP.

Free Radic Biol Med. 2011 Nov 15;51(10):1926-36. doi: 10.1016/j.freeradbiomed.2011.08.029. Epub 2011 Sep 1.

PMID:
21930200
21.

Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.

Axerio-Cilies P, Lack NA, Nayana MR, Chan KH, Yeung A, Leblanc E, Guns ES, Rennie PS, Cherkasov A.

J Med Chem. 2011 Sep 22;54(18):6197-205. doi: 10.1021/jm200532b. Epub 2011 Aug 29.

PMID:
21846139
22.

Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model.

Leon CG, Locke JA, Adomat HH, Etinger SL, Twiddy AL, Neumann RD, Nelson CC, Guns ES, Wasan KM.

Prostate. 2010 Mar 1;70(4):390-400. doi: 10.1002/pros.21072.

PMID:
19866465
23.

Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance.

Locke JA, Guns ES, Lehman ML, Ettinger S, Zoubeidi A, Lubik A, Margiotti K, Fazli L, Adomat H, Wasan KM, Gleave ME, Nelson CC.

Prostate. 2010 Feb 15;70(3):239-51. doi: 10.1002/pros.21057.

PMID:
19790237
24.

Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.

Locke JA, Nelson CC, Adomat HH, Hendy SC, Gleave ME, Guns ES.

J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):126-36. doi: 10.1016/j.jsbmb.2009.03.011. Epub 2009 Apr 5.

PMID:
19442514
25.

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.

Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, Wood CA, Ettinger SL, Gleave ME, Nelson CC.

Cancer Res. 2008 Aug 1;68(15):6407-15. doi: 10.1158/0008-5472.CAN-07-5997.

27.

Evaluation of the antiproliferative effects of Essiac on in vitro and in vivo models of prostate cancer compared to paclitaxel.

Eberding A, Madera C, Xie S, Wood CA, Brown PN, Guns ES.

Nutr Cancer. 2007;58(2):188-96.

PMID:
17640165
28.

Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.

Ivanov NI, Cowell SP, Brown P, Rennie PS, Guns ES, Cox ME.

Clin Nutr. 2007 Apr;26(2):252-63. Epub 2007 Mar 6.

PMID:
17337101
29.

Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts.

Low JC, Wasan KM, Fazli L, Eberding A, Adomat H, Guns ES.

Cancer Chemother Pharmacol. 2007 Nov;60(6):821-9.

PMID:
17294190
30.

Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models.

Xie X, Eberding A, Madera C, Fazli L, Jia W, Goldenberg L, Gleave M, Guns ES.

J Urol. 2006 May;175(5):1926-31.

PMID:
16600800
31.

Drug Insight: lycopene in the prevention and treatment of prostate cancer.

Guns ES, Cowell SP.

Nat Clin Pract Urol. 2005 Jan;2(1):38-43. Review.

PMID:
16474575
32.

Bioactive compounds from Rhodiola rosea (Crassulaceae).

Ming DS, Hillhouse BJ, Guns ES, Eberding A, Xie S, Vimalanathan S, Towers GH.

Phytother Res. 2005 Sep;19(9):740-3.

PMID:
16220564
33.

pH modulation using CsCl enhances therapeutic effects of vitamin D in LNCaP tumor bearing mice.

Guns ES, Xie X, Fedoruk M, Madera C, Cowell S, Mayer LD, Skov K, Gleave ME, Kozlowski P.

Prostate. 2005 Aug 1;64(3):316-22.

PMID:
15754319
34.

P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells.

Fedoruk MN, Giménez-Bonafé P, Guns ES, Mayer LD, Nelson CC.

Prostate. 2004 Apr 1;59(1):77-90.

PMID:
14991868
35.

Mass spectral analysis of PC-SPES confirms the presence of diethylstilbestrol.

Guns ES, Goldenberg SL, Brown PN.

Can J Urol. 2002 Dec;9(6):1684-8; discussion 1689.

PMID:
12517310
36.

Drug interaction studies between paclitaxel (Taxol) and OC144-093--a new modulator of MDR in cancer chemotherapy.

Guns ES, Denyssevych T, Dixon R, Bally MB, Mayer L.

Eur J Drug Metab Pharmacokinet. 2002 Apr-Jun;27(2):119-26.

PMID:
12064370
37.

Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes.

Guns ES, Bullock PL, Reimer ML, Dixon R, Bally M, Mayer LD.

Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):273-82.

PMID:
11808870
38.

Tumor-specific and photodependent cytotoxicity of hypericin in the human LNCaP prostate tumor model.

Xie X, Hudson JB, Guns ES.

Photochem Photobiol. 2001 Aug;74(2):221-5.

PMID:
11547559
39.

Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.

Newman MJ, Rodarte JC, Benbatoul KD, Romano SJ, Zhang C, Krane S, Moran EJ, Uyeda RT, Dixon R, Guns ES, Mayer LD.

Cancer Res. 2000 Jun 1;60(11):2964-72.

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