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Items: 1 to 50 of 111

1.

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.

Janco M, Rynkiewicz MJ, Li L, Hook J, Eiffe E, Ghosh A, Böcking T, Lehman WJ, Hardeman EC, Gunning PW.

Sci Rep. 2019 Aug 2;9(1):11262. doi: 10.1038/s41598-019-47592-9.

2.

Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres.

Meiring JCM, Bryce NS, Lastra Cagigas M, Benda A, Whan RM, Ariotti N, Parton RG, Stear JH, Hardeman EC, Gunning PW.

J Cell Sci. 2019 Aug 8;132(15). pii: jcs228916. doi: 10.1242/jcs.228916.

PMID:
31331962
3.

Actin-tropomyosin distribution in non-muscle cells.

Manstein DJ, Meiring JCM, Hardeman EC, Gunning PW.

J Muscle Res Cell Motil. 2019 May 4. doi: 10.1007/s10974-019-09514-0. [Epub ahead of print]

PMID:
31054005
4.

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments.

Meiring JCM, Bryce NS, Niño JLG, Gabriel A, Tay SS, Hardeman EC, Biro M, Gunning PW.

Sci Rep. 2019 Apr 24;9(1):6504. doi: 10.1038/s41598-019-42977-2.

5.

Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening.

Bryce NS, Hardeman EC, Gunning PW, Lock JG.

Curr Opin Chem Biol. 2019 Aug;51:40-47. doi: 10.1016/j.cbpa.2019.02.013. Epub 2019 Mar 19. Review.

PMID:
30901618
6.

Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms.

Sao K, Jones TM, Doyle AD, Maity D, Schevzov G, Chen Y, Gunning PW, Petrie RJ.

Mol Biol Cell. 2019 May 1;30(10):1170-1181. doi: 10.1091/mbc.E18-06-0355. Epub 2019 Mar 13.

7.

Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function.

Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC.

FASEB J. 2019 Mar;33(3):3997-4006. doi: 10.1096/fj.201801429RR. Epub 2018 Dec 3.

PMID:
30509116
8.

Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton.

Meiring JCM, Bryce NS, Wang Y, Taft MH, Manstein DJ, Liu Lau S, Stear J, Hardeman EC, Gunning PW.

Curr Biol. 2018 Jul 23;28(14):2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Epub 2018 Jul 5.

9.

Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells.

Stefen H, Suchowerska AK, Chen BJ, Brettle M, Kuschelewski J, Gunning PW, Janitz M, Fath T.

FEBS Open Bio. 2018 Feb 19;8(4):570-583. doi: 10.1002/2211-5463.12386. eCollection 2018 Apr.

10.

On-target action of anti-tropomyosin drugs regulates glucose metabolism.

Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC.

Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x.

11.

Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis.

Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2018 Apr;75(4):147-149. doi: 10.1002/cm.21441. Epub 2018 Mar 14. No abstract available.

PMID:
29514407
12.

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.

Masedunskas A, Appaduray MA, Lucas CA, Lastra Cagigas M, Heydecker M, Holliday M, Meiring JCM, Hook J, Kee A, White M, Thomas P, Zhang Y, Adelstein RS, Meckel T, Böcking T, Weigert R, Bryce NS, Gunning PW, Hardeman EC.

J Cell Sci. 2018 Mar 19;131(6). pii: jcs212654. doi: 10.1242/jcs.212654.

13.

Fundamental differences.

Gunning PW, Hardeman EC.

Elife. 2018 Feb 1;7. pii: e34477. doi: 10.7554/eLife.34477.

14.

Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.

Suchowerska AK, Fok S, Stefen H, Gunning PW, Hardeman EC, Power J, Fath T.

Front Cell Neurosci. 2017 Dec 22;11:421. doi: 10.3389/fncel.2017.00421. eCollection 2017.

15.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

16.

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments.

Elam WA, Cao W, Kang H, Huehn A, Hocky GM, Prochniewicz E, Schramm AC, Negrón K, Garcia J, Bonello TT, Gunning PW, Thomas DD, Voth GA, Sindelar CV, De La Cruz EM.

J Biol Chem. 2017 Dec 1;292(48):19565-19579. doi: 10.1074/jbc.M117.808378. Epub 2017 Sep 22.

17.

ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.

Kee AJ, Bryce NS, Yang L, Polishchuk E, Schevzov G, Weigert R, Polishchuk R, Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2017 Oct;74(10):379-389. doi: 10.1002/cm.21405. Epub 2017 Aug 31.

PMID:
28834398
18.

Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.

Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP.

Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18.

19.

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM.

Oncotarget. 2017 May 16;8(20):33544-33559. doi: 10.18632/oncotarget.16825.

20.

Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins.

Desouza-Armstrong M, Gunning PW, Stehn JR.

Cytoskeleton (Hoboken). 2017 Jun;74(6):233-248. doi: 10.1002/cm.21367. Epub 2017 Apr 26.

PMID:
28378936
21.

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro.

Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, Gunning PW, Manstein DJ, Michelot A, Lappalainen P.

Curr Biol. 2017 Mar 6;27(5):705-713. doi: 10.1016/j.cub.2017.01.018. Epub 2017 Feb 16.

22.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

23.

Tropomyosins.

Gunning PW, Hardeman EC.

Curr Biol. 2017 Jan 9;27(1):R8-R13. doi: 10.1016/j.cub.2016.11.033.

24.

Recruitment Kinetics of Tropomyosin Tpm3.1 to Actin Filament Bundles in the Cytoskeleton Is Independent of Actin Filament Kinetics.

Appaduray MA, Masedunskas A, Bryce NS, Lucas CA, Warren SC, Timpson P, Stear JH, Gunning PW, Hardeman EC.

PLoS One. 2016 Dec 15;11(12):e0168203. doi: 10.1371/journal.pone.0168203. eCollection 2016.

25.

Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces.

Nicovich PR, Janco M, Sobey T, Gajwani M, Obeidy P, Whan R, Gaus K, Gunning PW, Coster AC, Böcking T.

Cytoskeleton (Hoboken). 2016 Dec;73(12):729-738. doi: 10.1002/cm.21342. Epub 2016 Nov 23.

PMID:
27783462
26.

Emergence of Form from Function - Mechanical Engineering Approaches to Probe the Role of Stem Cell Mechanoadaptation in Sealing Cell Fate.

Knothe Tate ML, Gunning PW, Sansalone V.

Bioarchitecture. 2016;6(5):85-103. doi: 10.1080/19490992.2016.1229729. Epub 2016 Oct 14.

27.

Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and γ-actin in epithelial cells.

Dugina V, Alieva I, Khromova N, Kireev I, Gunning PW, Kopnin P.

Oncotarget. 2016 Nov 8;7(45):72699-72715. doi: 10.18632/oncotarget.12236.

28.

The impact of tropomyosins on actin filament assembly is isoform specific.

Janco M, Bonello TT, Byun A, Coster AC, Lebhar H, Dedova I, Gunning PW, Böcking T.

Bioarchitecture. 2016 Jul 3;6(4):61-75. doi: 10.1080/19490992.2016.1201619. Epub 2016 Jul 15.

29.

Dense small molecule labeling enables activator-dependent STORM by proximity mapping.

Chen Y, Gu M, Gunning PW, Russell SM.

Histochem Cell Biol. 2016 Sep;146(3):255-66. doi: 10.1007/s00418-016-1451-6. Epub 2016 May 31.

PMID:
27246003
30.

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge.

Brayford S, Bryce NS, Schevzov G, Haynes EM, Bear JE, Hardeman EC, Gunning PW.

Curr Biol. 2016 May 23;26(10):1312-8. doi: 10.1016/j.cub.2016.03.028. Epub 2016 Apr 21.

31.

A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics.

Bonello TT, Janco M, Hook J, Byun A, Appaduray M, Dedova I, Hitchcock-DeGregori S, Hardeman EC, Stehn JR, Böcking T, Gunning PW.

Sci Rep. 2016 Jan 25;6:19816. doi: 10.1038/srep19816.

32.

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.

33.

An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake.

Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC.

Traffic. 2016 Jan;17(1):80-1. doi: 10.1111/tra.12342. No abstract available.

34.

Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells.

Glass JJ, Phillips PA, Gunning PW, Stehn JR.

BMC Cancer. 2015 Oct 16;15:712. doi: 10.1186/s12885-015-1741-8.

35.

Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.

Coombes JD, Schevzov G, Kan CY, Petti C, Maritz MF, Whittaker S, Mackenzie KL, Gunning PW.

Cell Mol Biol Lett. 2015 Dec;20(4):626-46. doi: 10.1515/cmble-2015-0037.

PMID:
26274783
36.

Tropomyosin - master regulator of actin filament function in the cytoskeleton.

Gunning PW, Hardeman EC, Lappalainen P, Mulvihill DP.

J Cell Sci. 2015 Aug 15;128(16):2965-74. doi: 10.1242/jcs.172502. Epub 2015 Aug 3. Review.

37.

Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton.

Jalilian I, Heu C, Cheng H, Freittag H, Desouza M, Stehn JR, Bryce NS, Whan RM, Hardeman EC, Fath T, Schevzov G, Gunning PW.

PLoS One. 2015 May 15;10(5):e0126214. doi: 10.1371/journal.pone.0126214. eCollection 2015.

38.

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments.

Schevzov G, Kee AJ, Wang B, Sequeira VB, Hook J, Coombes JD, Lucas CA, Stehn JR, Musgrove EA, Cretu A, Assoian R, Fath T, Hanoch T, Seger R, Pleines I, Kile BT, Hardeman EC, Gunning PW.

Mol Biol Cell. 2015 Jul 1;26(13):2475-90. doi: 10.1091/mbc.E14-10-1453. Epub 2015 May 13.

39.

The evolution of compositionally and functionally distinct actin filaments.

Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC.

J Cell Sci. 2015 Jun 1;128(11):2009-19. doi: 10.1242/jcs.165563. Epub 2015 Mar 18. Review.

40.

An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake.

Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC.

Traffic. 2015 Jul;16(7):691-711. doi: 10.1111/tra.12282. Epub 2015 Apr 29. Erratum in: Traffic. 2016 Jan;17(1):80-1.

41.

Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.

Lim CY, Bi X, Wu D, Kim JB, Gunning PW, Hong W, Han W.

Nat Commun. 2015 Jan 9;6:5951. doi: 10.1038/ncomms6951.

42.

Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens.

Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS, Gomez GA.

Cytoskeleton (Hoboken). 2014 Dec;71(12):663-76. doi: 10.1002/cm.21202. Epub 2015 Jan 31.

PMID:
25545457
43.

A systematic nomenclature for mammalian tropomyosin isoforms.

Geeves MA, Hitchcock-DeGregori SE, Gunning PW.

J Muscle Res Cell Motil. 2015 Apr;36(2):147-53. doi: 10.1007/s10974-014-9389-6. Epub 2014 Nov 5. Review.

44.

The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome.

Canales CP, Wong AC, Gunning PW, Housley GD, Hardeman EC, Palmer SJ.

Eur J Hum Genet. 2015 Jun;23(6):774-80. doi: 10.1038/ejhg.2014.188. Epub 2014 Sep 24.

45.

Lighting up microtubule cytoskeleton dynamics in skeletal muscle.

Masedunskas A, Appaduray M, Gunning PW, Hardeman EC.

Intravital. 2014 May 30;3(1):e29293. doi: 10.4161/intv.29293. eCollection 2014.

46.

Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells.

Curthoys NM, Freittag H, Connor A, Desouza M, Brettle M, Poljak A, Hall A, Hardeman E, Schevzov G, Gunning PW, Fath T.

Mol Cell Neurosci. 2014 Jan;58:11-21. doi: 10.1016/j.mcn.2013.10.011. Epub 2013 Nov 6.

PMID:
24211701
47.

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells.

Stehn JR, Haass NK, Bonello T, Desouza M, Kottyan G, Treutlein H, Zeng J, Nascimento PR, Sequeira VB, Butler TL, Allanson M, Fath T, Hill TA, McCluskey A, Schevzov G, Palmer SJ, Hardeman EC, Winlaw D, Reeve VE, Dixon I, Weninger W, Cripe TP, Gunning PW.

Cancer Res. 2013 Aug 15;73(16):5169-82. doi: 10.1158/0008-5472.CAN-12-4501. Erratum in: Cancer Res. 2013 Oct 1;73(19):6094.

48.

Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.

Koestler SA, Steffen A, Nemethova M, Winterhoff M, Luo N, Holleboom JM, Krupp J, Jacob S, Vinzenz M, Schur F, Schlüter K, Gunning PW, Winkler C, Schmeiser C, Faix J, Stradal TE, Small JV, Rottner K.

Mol Biol Cell. 2013 Sep;24(18):2861-75. doi: 10.1091/mbc.E12-12-0857. Epub 2013 Jul 24.

49.

Aged skeletal muscle retains the ability to fully regenerate functional architecture.

Lee AS, Anderson JE, Joya JE, Head SI, Pather N, Kee AJ, Gunning PW, Hardeman EC.

Bioarchitecture. 2013 Mar-Apr;3(2):25-37. doi: 10.4161/bioa.24966. Epub 2013 Jul 1.

50.

SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation.

Widagdo J, Taylor KM, Gunning PW, Hardeman EC, Palmer SJ.

PLoS One. 2012;7(11):e49283. doi: 10.1371/journal.pone.0049283. Epub 2012 Nov 8.

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