Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 333

1.

Regulation of Differentiation of HC11 Mouse Breast Epithelial Cells by the Signal Transducer and Activator of Transcription-3.

Niit M, Geletu M, Taha Z, Arulanandam R, Cass J, Hoskin V, Elliott B, Gunning P, Raptis L.

Anticancer Res. 2019 Jun;39(6):2749-2756. doi: 10.21873/anticanres.13401.

PMID:
31177110
2.

Structural and functional consequences of the STAT5BN642H driver mutation.

de Araujo ED, Erdogan F, Neubauer HA, Meneksedag-Erol D, Manaswiyoungkul P, Eram MS, Seo HS, Qadree AK, Israelian J, Orlova A, Suske T, Pham HTT, Boersma A, Tangermann S, Kenner L, Rülicke T, Dong A, Ravichandran M, Brown PJ, Audette GF, Rauscher S, Dhe-Paganon S, Moriggl R, Gunning PT.

Nat Commun. 2019 Jun 7;10(1):2517. doi: 10.1038/s41467-019-10422-7.

3.

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.

Maurer B, Nivarthi H, Wingelhofer B, Pham HTT, Schlederer M, Suske T, Grausenburger R, Schiefer AI, Prchal-Murphy M, Chen D, Winkler S, Merkel O, Kornauth C, Hofbauer M, Hochgatterer B, Hoermann G, Hoelbl-Kovacic A, Prochazkova J, Lobello C, Cumaraswamy AA, Latzka J, Kitzwögerer M, Chott A, Janikova A, Pospíšilova Š, Loizou JI, Kubicek S, Valent P, Kolbe T, Grebien F, Kenner L, Gunning PT, Kralovics R, Herling M, Müller M, Rülicke T, Sexl V, Moriggl R.

Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986. [Epub ahead of print]

4.

Actin-tropomyosin distribution in non-muscle cells.

Manstein DJ, Meiring JCM, Hardeman EC, Gunning PW.

J Muscle Res Cell Motil. 2019 May 4. doi: 10.1007/s10974-019-09514-0. [Epub ahead of print]

PMID:
31054005
5.

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments.

Meiring JCM, Bryce NS, Niño JLG, Gabriel A, Tay SS, Hardeman EC, Biro M, Gunning PW.

Sci Rep. 2019 Apr 24;9(1):6504. doi: 10.1038/s41598-019-42977-2.

6.

Effect of Caveolin-1 upon Stat3-ptyr705 levels in breast and lung carcinoma cells.

Geletu M, Taha Z, Arulanandam R, Mohan R, Assi HH, Castro MG, Nabi IR, Gunning PT, Raptis L PhD.

Biochem Cell Biol. 2019 Apr 15. doi: 10.1139/bcb-2018-0367. [Epub ahead of print]

7.

Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening.

Bryce NS, Hardeman EC, Gunning PW, Lock JG.

Curr Opin Chem Biol. 2019 Mar 19;51:40-47. doi: 10.1016/j.cbpa.2019.02.013. [Epub ahead of print] Review.

PMID:
30901618
8.

Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms.

Sao K, Jones TM, Doyle AD, Maity D, Schevzov G, Chen Y, Gunning PW, Petrie RJ.

Mol Biol Cell. 2019 May 1;30(10):1170-1181. doi: 10.1091/mbc.E18-06-0355. Epub 2019 Mar 13.

PMID:
30865560
9.

Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception.

Linher-Melville K, Sharma M, Nakhla P, Kum E, Ungard R, Park J, Rosa D, Gunning P, Singh G.

Mol Pain. 2019 Jan-Dec;15:1744806918823477. doi: 10.1177/1744806918823477.

10.

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, O'Hare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT.

J Med Chem. 2019 Mar 14;62(5):2651-2665. doi: 10.1021/acs.jmedchem.8b01957. Epub 2019 Mar 6.

PMID:
30776234
11.

PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication.

Geletu M, Taha Z, Gunning PT, Raptis L.

Cancers (Basel). 2019 Feb 1;11(2). pii: E167. doi: 10.3390/cancers11020167. Review.

12.

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.

Kosack L, Wingelhofer B, Popa A, Orlova A, Agerer B, Vilagos B, Majek P, Parapatics K, Lercher A, Ringler A, Klughammer J, Smyth M, Khamina K, Baazim H, de Araujo ED, Rosa DA, Park J, Tin G, Ahmar S, Gunning PT, Bock C, Siddle HV, Woods GM, Kubicek S, Murchison EP, Bennett KL, Moriggl R, Bergthaler A.

Cancer Cell. 2019 Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018.

13.

Predictors of involuntary patients' satisfaction with care: prospective study.

Bainbridge E, Hallahan B, McGuinness D, Gunning P, Newell J, Higgins A, Murphy K, McDonald C.

BJPsych Open. 2018 Nov 16;4(6):492-500. doi: 10.1192/bjo.2018.65. eCollection 2018 Nov.

14.

Stress hormone signaling through β-adrenergic receptors regulates macrophage mechanotype and function.

Kim TH, Ly C, Christodoulides A, Nowell CJ, Gunning PW, Sloan EK, Rowat AC.

FASEB J. 2019 Mar;33(3):3997-4006. doi: 10.1096/fj.201801429RR. Epub 2018 Dec 3.

PMID:
30509116
15.

A methodological inter-comparison study on the detection of surface contaminant sodium dodecyl sulfate applying ambient- and vacuum-based techniques.

Giovannozzi AM, Hornemann A, Pollakowski-Herrmann B, Green FM, Gunning P, Salter TL, Steven RT, Bunch J, Portesi C, Tyler BJ, Beckhoff B, Rossi AM.

Anal Bioanal Chem. 2019 Jan;411(1):217-229. doi: 10.1007/s00216-018-1431-x. Epub 2018 Nov 6.

PMID:
30402675
16.

Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium.

Whelan A, Duffy J, Gaul RT, O'Reilly D, Nolan DR, Gunning P, Lally C, Murphy BP.

J Mech Behav Biomed Mater. 2019 Feb;90:54-60. doi: 10.1016/j.jmbbm.2018.09.038. Epub 2018 Sep 26.

PMID:
30343171
17.

A functional in vitro assay for screening inhibitors of STAT5B phosphorylation.

de Araujo ED, Manaswiyoungkul P, Erdogan F, Qadree AK, Sina D, Tin G, Toutah K, Yuen K, Gunning PT.

J Pharm Biomed Anal. 2019 Jan 5;162:60-65. doi: 10.1016/j.jpba.2018.08.036. Epub 2018 Aug 18.

PMID:
30223143
18.

The impact of implantation depth of the Lotus™ valve on mechanical stress in close proximity to the bundle of His.

McGee OM, Gunning PS, McNamara A, McNamara LM.

Biomech Model Mechanobiol. 2019 Feb;18(1):79-88. doi: 10.1007/s10237-018-1069-9. Epub 2018 Aug 20.

PMID:
30128675
19.

Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton.

Meiring JCM, Bryce NS, Wang Y, Taft MH, Manstein DJ, Liu Lau S, Stear J, Hardeman EC, Gunning PW.

Curr Biol. 2018 Jul 23;28(14):2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Epub 2018 Jul 5.

PMID:
29983319
20.

Pectin Conformation in Solution.

Alba K, Bingham RJ, Gunning PA, Wilde PJ, Kontogiorgos V.

J Phys Chem B. 2018 Jul 26;122(29):7286-7294. doi: 10.1021/acs.jpcb.8b04790. Epub 2018 Jul 13.

PMID:
29965758
21.

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer.

Wingelhofer B, Neubauer HA, Valent P, Han X, Constantinescu SN, Gunning PT, Müller M, Moriggl R.

Leukemia. 2018 Aug;32(8):1713-1726. doi: 10.1038/s41375-018-0117-x. Epub 2018 Mar 27. Review.

22.

Tropomyosin isoforms have specific effects on the transcriptome of undifferentiated and differentiated B35 neuroblastoma cells.

Stefen H, Suchowerska AK, Chen BJ, Brettle M, Kuschelewski J, Gunning PW, Janitz M, Fath T.

FEBS Open Bio. 2018 Feb 19;8(4):570-583. doi: 10.1002/2211-5463.12386. eCollection 2018 Apr.

23.

On-target action of anti-tropomyosin drugs regulates glucose metabolism.

Kee AJ, Chagan J, Chan JY, Bryce NS, Lucas CA, Zeng J, Hook J, Treutlein H, Laybutt DR, Stehn JR, Gunning PW, Hardeman EC.

Sci Rep. 2018 Mar 15;8(1):4604. doi: 10.1038/s41598-018-22946-x.

24.

Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis.

Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2018 Apr;75(4):147-149. doi: 10.1002/cm.21441. Epub 2018 Mar 14. No abstract available.

PMID:
29514407
25.

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice.

Masedunskas A, Appaduray MA, Lucas CA, Lastra Cagigas M, Heydecker M, Holliday M, Meiring JCM, Hook J, Kee A, White M, Thomas P, Zhang Y, Adelstein RS, Meckel T, Böcking T, Weigert R, Bryce NS, Gunning PW, Hardeman EC.

J Cell Sci. 2018 Mar 19;131(6). pii: jcs212654. doi: 10.1242/jcs.212654.

26.

Pharmacologic inhibition of STAT5 in acute myeloid leukemia.

Wingelhofer B, Maurer B, Heyes EC, Cumaraswamy AA, Berger-Becvar A, de Araujo ED, Orlova A, Freund P, Ruge F, Park J, Tin G, Ahmar S, Lardeau CH, Sadovnik I, Bajusz D, Keserű GM, Grebien F, Kubicek S, Valent P, Gunning PT, Moriggl R.

Leukemia. 2018 May;32(5):1135-1146. doi: 10.1038/s41375-017-0005-9. Epub 2018 Feb 2.

27.

Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells.

Geletu M, Mohan R, Arulanandam R, Berger-Becvar A, Nabi IR, Gunning PT, Raptis L.

Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):794-802. doi: 10.1016/j.bbamcr.2018.02.004. Epub 2018 Feb 16.

PMID:
29458077
28.

Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.

Leclaire C, Lecointe K, Gunning PA, Tribolo S, Kavanaugh DW, Wittmann A, Latousakis D, MacKenzie DA, Kawasaki N, Juge N.

FASEB J. 2018 Jun;32(6):3301-3320. doi: 10.1096/fj.201700619R. Epub 2018 Jan 29.

29.

Fundamental differences.

Gunning PW, Hardeman EC.

Elife. 2018 Feb 1;7. pii: e34477. doi: 10.7554/eLife.34477.

30.

Developmental Profiling of Tropomyosin Expression in Mouse Brain Reveals Tpm4.2 as the Major Post-synaptic Tropomyosin in the Mature Brain.

Suchowerska AK, Fok S, Stefen H, Gunning PW, Hardeman EC, Power J, Fath T.

Front Cell Neurosci. 2017 Dec 22;11:421. doi: 10.3389/fncel.2017.00421. eCollection 2017.

31.

A calibration procedure for a traceable contamination analysis on medical devices by combined X-ray spectrometry and ambient spectroscopic techniques.

Pollakowski-Herrmann B, Hornemann A, Giovannozzi AM, Green F, Gunning P, Portesi C, Rossi A, Seim C, Steven R, Tyler B, Beckhoff B.

J Pharm Biomed Anal. 2018 Feb 20;150:308-317. doi: 10.1016/j.jpba.2017.12.007. Epub 2017 Dec 7.

PMID:
29272815
32.

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.

Orlova A, Wingelhofer B, Neubauer HA, Maurer B, Berger-Becvar A, Keserű GM, Gunning PT, Valent P, Moriggl R.

Expert Opin Ther Targets. 2018 Jan;22(1):45-57. doi: 10.1080/14728222.2018.1406924. Epub 2017 Nov 24. Review.

33.

ProxyPhos sensors for the detection of negatively charged membranes.

Murcar-Evans BI, Cabral AD, Toutah K, de Araujo ED, Lai A, Macdonald PM, Berger-Becvar A, Kraskouskaya D, Gunning PT.

Analyst. 2017 Nov 20;142(23):4511-4521. doi: 10.1039/c7an00568g.

PMID:
29098228
34.

Regulation of HC11 mouse breast epithelial cell differentiation by the E-cadherin/Rac axis.

Niit M, Arulanandam R, Cass J, Geletu M, Hoskin V, Côté G, Gunning P, Elliott B, Raptis L.

Exp Cell Res. 2017 Dec 1;361(1):112-125. doi: 10.1016/j.yexcr.2017.10.008. Epub 2017 Oct 13.

PMID:
29031557
35.

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.

36.

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments.

Elam WA, Cao W, Kang H, Huehn A, Hocky GM, Prochniewicz E, Schramm AC, Negrón K, Garcia J, Bonello TT, Gunning PW, Thomas DD, Voth GA, Sindelar CV, De La Cruz EM.

J Biol Chem. 2017 Dec 1;292(48):19565-19579. doi: 10.1074/jbc.M117.808378. Epub 2017 Sep 22.

37.

Structure-activity relationship study of ProxyPhos chemosensors for the detection of proximal phosphorylation and other phosphate species.

Cabral AD, Murcar-Evans BI, Toutah K, Bancerz M, Rosa D, Yuen K, Radu TB, Ali M, Penkul A, Kraskouskaya D, Gunning PT.

Analyst. 2017 Oct 9;142(20):3922-3933. doi: 10.1039/c7an00722a.

PMID:
28930308
38.

ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.

Kee AJ, Bryce NS, Yang L, Polishchuk E, Schevzov G, Weigert R, Polishchuk R, Gunning PW, Hardeman EC.

Cytoskeleton (Hoboken). 2017 Oct;74(10):379-389. doi: 10.1002/cm.21405. Epub 2017 Aug 31.

PMID:
28834398
39.

MicroRNA-337-3p controls hepatobiliary gene expression and transcriptional dynamics during hepatic cell differentiation.

Demarez C, Gérard C, Cordi S, Poncy A, Achouri Y, Dauguet N, Rosa DA, Gunning PT, Manfroid I, Lemaigre FP.

Hepatology. 2018 Jan;67(1):313-327. doi: 10.1002/hep.29475. Epub 2017 Nov 16.

PMID:
28833283
40.

High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains.

de Araujo ED, Manaswiyoungkul P, Israelian J, Park J, Yuen K, Farhangi S, Berger-Becvar A, Abu-Jazar L, Gunning PT.

J Pharm Biomed Anal. 2017 Sep 5;143:159-167. doi: 10.1016/j.jpba.2017.04.052. Epub 2017 May 1.

PMID:
28600954
41.

Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia.

Gleixner KV, Schneeweiss M, Eisenwort G, Berger D, Herrmann H, Blatt K, Greiner G, Byrgazov K, Hoermann G, Konopleva M, Waliul I, Cumaraswamy AA, Gunning PT, Maeda H, Moriggl R, Deininger M, Lion T, Andreeff M, Valent P.

Haematologica. 2017 Sep;102(9):1519-1529. doi: 10.3324/haematol.2016.163436. Epub 2017 Jun 8.

42.

Characterization and application studies of ProxyPhos, a chemosensor for the detection of proximally phosphorylated peptides and proteins in aqueous solutions.

Kraskouskaya D, Cabral AD, Fong R, Bancerz M, Toutah K, Rosa D, Gardiner JE, de Araujo ED, Duodu E, Armstrong D, Fekl U, Gunning PT.

Analyst. 2017 Jun 26;142(13):2451-2459. doi: 10.1039/c6an02537d.

PMID:
28574079
43.

Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.

Currier MA, Stehn JR, Swain A, Chen D, Hook J, Eiffe E, Heaton A, Brown D, Nartker BA, Eaves DW, Kloss N, Treutlein H, Zeng J, Alieva IB, Dugina VB, Hardeman EC, Gunning PW, Cripe TP.

Mol Cancer Ther. 2017 Aug;16(8):1555-1565. doi: 10.1158/1535-7163.MCT-16-0873. Epub 2017 May 18.

44.

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia.

Eiring AM, Page BDG, Kraft IL, Mason CC, Vellore NA, Resetca D, Zabriskie MS, Zhang TY, Khorashad JS, Engar AJ, Reynolds KR, Anderson DJ, Senina A, Pomicter AD, Arpin CC, Ahmad S, Heaton WL, Tantravahi SK, Todic A, Colaguori R, Moriggl R, Wilson DJ, Baron R, O'Hare T, Gunning PT, Deininger MW.

Leukemia. 2017 May;31(5):1253-1254. doi: 10.1038/leu.2017.14. No abstract available.

PMID:
28465516
45.

Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling.

Jeong S, Lim S, Schevzov G, Gunning PW, Helfman DM.

Oncotarget. 2017 May 16;8(20):33544-33559. doi: 10.18632/oncotarget.16825.

46.

Sleep to Lower Elevated Blood Pressure: A Randomized Controlled Trial (SLEPT).

McGrath ER, Espie CA, Power A, Murphy AW, Newell J, Kelly C, Duffy N, Gunning P, Gibson I, Bostock S, O'Donnell MJ.

Am J Hypertens. 2017 Mar 1;30(3):319-327. doi: 10.1093/ajh/hpw132.

PMID:
28391289
47.

Tumor suppressor tropomyosin Tpm2.1 regulates sensitivity to apoptosis beyond anoikis characterized by changes in the levels of intrinsic apoptosis proteins.

Desouza-Armstrong M, Gunning PW, Stehn JR.

Cytoskeleton (Hoboken). 2017 Jun;74(6):233-248. doi: 10.1002/cm.21367. Epub 2017 Apr 26.

PMID:
28378936
48.

Letter from the editors.

Gunning P, Shivashankar GV.

Bioarchitecture. 2016 Nov;6(6):105. doi: 10.1080/19490992.2016.1291050. No abstract available.

49.

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro.

Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, Gunning PW, Manstein DJ, Michelot A, Lappalainen P.

Curr Biol. 2017 Mar 6;27(5):705-713. doi: 10.1016/j.cub.2017.01.018. Epub 2017 Feb 16.

50.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.

Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT.

J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.

Supplemental Content

Loading ...
Support Center