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Items: 1 to 50 of 105

1.

Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.

Aitken L, Benek O, McKelvie BE, Hughes RE, Hroch L, Schmidt M, Major LL, Vinklarova L, Kuca K, Smith TK, Musilek K, Gunn-Moore FJ.

Molecules. 2019 Jul 29;24(15). pii: E2757. doi: 10.3390/molecules24152757.

2.

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis.

Abdul Razzak R, Florence GJ, Gunn-Moore FJ.

Int J Mol Sci. 2019 Jun 25;20(12). pii: E3108. doi: 10.3390/ijms20123108. Review.

3.

Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer's disease.

Yu Q, Wang Y, Du F, Yan S, Hu G, Origlia N, Rutigliano G, Sun Q, Yu H, Ainge J, Yan SF, Gunn-Moore F, Yan SS.

Nat Commun. 2018 Jul 30;9(1):2968. doi: 10.1038/s41467-018-04389-0.

4.

Light sheet fluorescence microscopy for neuroscience.

Corsetti S, Gunn-Moore F, Dholakia K.

J Neurosci Methods. 2019 May 1;319:16-27. doi: 10.1016/j.jneumeth.2018.07.011. Epub 2018 Jul 23. Review.

PMID:
30048674
5.

All-Optical Assay to Study Biological Neural Networks.

Afshar Saber W, Gasparoli FM, Dirks MG, Gunn-Moore FJ, Antkowiak M.

Front Neurosci. 2018 Jul 5;12:451. doi: 10.3389/fnins.2018.00451. eCollection 2018.

6.

Light-sheet microscopy with attenuation-compensated propagation-invariant beams.

Nylk J, McCluskey K, Preciado MA, Mazilu M, Yang Z, Gunn-Moore FJ, Aggarwal S, Tello JA, Ferrier DEK, Dholakia K.

Sci Adv. 2018 Apr 6;4(4):eaar4817. doi: 10.1126/sciadv.aar4817. eCollection 2018 Apr.

7.

1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.

Benek O, Hroch L, Aitken L, Gunn-Moore F, Vinklarova L, Kuca K, Perez DI, Perez C, Martinez A, Fisar Z, Musilek K.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):665-670. doi: 10.1080/14756366.2018.1445736.

8.

Alzheimer's disease in humans and other animals: A consequence of postreproductive life span and longevity rather than aging.

Gunn-Moore D, Kaidanovich-Beilin O, Gallego Iradi MC, Gunn-Moore F, Lovestone S.

Alzheimers Dement. 2018 Feb;14(2):195-204. doi: 10.1016/j.jalz.2017.08.014. Epub 2017 Sep 30. Review.

PMID:
28972881
9.

In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17β-HSD10 Inhibitors as Therapeutics in Alzheimer's Disease.

Aitken L, Baillie G, Pannifer A, Morrison A, Jones PS, Smith TK, McElroy SP, Gunn-Moore FJ.

SLAS Discov. 2017 Jul;22(6):676-685. doi: 10.1177/2472555217697964. Epub 2017 Mar 17.

PMID:
28314118
10.

Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.

Hroch L, Guest P, Benek O, Soukup O, Janockova J, Dolezal R, Kuca K, Aitken L, Smith TK, Gunn-Moore F, Zala D, Ramsay RR, Musilek K.

Bioorg Med Chem. 2017 Feb 1;25(3):1143-1152. doi: 10.1016/j.bmc.2016.12.029. Epub 2016 Dec 27.

PMID:
28082069
11.

6-benzothiazolyl ureas, thioureas and guanidines are potent inhibitors of ABAD/17β-HSD10 and potential drugs for Alzheimer's disease treatment: Design, synthesis and in vitro evaluation.

Benek O, Hroch L, Aitken L, Dolezal R, Guest P, Benkova M, Soukup O, Musil K, Kuca K, Smith TK, Gunn-Moore F, Musilek K.

Med Chem. 2017 Jan 9. [Epub ahead of print]

PMID:
28067167
12.

Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system.

Mielenz D, Gunn-Moore F.

Biochem J. 2016 Aug 15;473(16):2429-37. doi: 10.1042/BCJ20160168. Review.

13.

Willing to Be Involved in Cancer.

Gunn-Moore FJ, Tilston-Lünel AM, Reynolds PA.

Genes (Basel). 2016 Jul 18;7(7). pii: E37. doi: 10.3390/genes7070037. Review.

14.

Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment.

Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, Musil K, Dohnal V, Dolezal R, Kuca K, Smith TK, Gunn-Moore F, Musilek K.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3675-8. doi: 10.1016/j.bmcl.2016.05.087. Epub 2016 May 30.

PMID:
27287370
15.

Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells.

Tilston-Lünel AM, Haley KE, Schlecht NF, Wang Y, Chatterton AL, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA.

J Mol Cell Biol. 2016 Apr 18. [Epub ahead of print]

16.

Morphology-Specific Inhibition of β-Amyloid Aggregates by 17β-Hydroxysteroid Dehydrogenase Type 10.

Aitken L, Quinn SD, Perez-Gonzalez C, Samuel ID, Penedo JC, Gunn-Moore FJ.

Chembiochem. 2016 Jun 2;17(11):1029-37. doi: 10.1002/cbic.201600081. Epub 2016 Apr 25.

17.

Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach to nephrotic disease.

Pullman JM, Nylk J, Campbell EC, Gunn-Moore FJ, Prystowsky MB, Dholakia K.

Biomed Opt Express. 2016 Jan 6;7(2):302-11. doi: 10.1364/BOE.7.000302. eCollection 2016 Feb 1.

18.

Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF).

Kailainathan S, Piers TM, Yi JH, Choi S, Fahey MS, Borger E, Gunn-Moore FJ, O'Neill L, Lever M, Whitcomb DJ, Cho K, Allen SJ.

Pharmacol Res. 2016 Feb;104:97-107. doi: 10.1016/j.phrs.2015.12.008. Epub 2015 Dec 11.

19.

Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression.

Wang Y, Gersten A, Moleirinho S, Gunn-Moore FJ, Reynolds PA, Prystowsky MB.

Acad Pathol. 2015 Nov 26;2(4):2374289515616972. doi: 10.1177/2374289515616972. eCollection 2015 Oct-Dec.

20.

Macro-optical trapping for sample confinement in light sheet microscopy.

Yang Z, Piksarv P, Ferrier DE, Gunn-Moore FJ, Dholakia K.

Biomed Opt Express. 2015 Jul 8;6(8):2778-85. doi: 10.1364/BOE.6.002778. eCollection 2015 Aug 1.

21.

Development of a graded index microlens based fiber optical trap and its characterization using principal component analysis.

Nylk J, Kristensen MV, Mazilu M, Thayil AK, Mitchell CA, Campbell EC, Powis SJ, Gunn-Moore FJ, Dholakia K.

Biomed Opt Express. 2015 Mar 27;6(4):1512-9. doi: 10.1364/BOE.6.001512. eCollection 2015 Apr 1.

22.

A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease

Benek O, Aitken L, Hroch L, Kuca K, Gunn-Moore F, Musilek K.

Curr Med Chem. 2015 Feb 26;22(9):1056 - 1085.

PMID:
25620098
23.

Benzothiazoles - scaffold of interest for CNS targeted drugs.

Hroch L, Aitken L, Benek O, Dolezal M, Kuca K, Gunn-Moore F, Musilek K.

Curr Med Chem. 2015;22(6):730-47. Review.

PMID:
25515509
24.

The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.

Borger E, Herrmann A, Mann DA, Spires-Jones T, Gunn-Moore F.

J Neuropathol Exp Neurol. 2014 Dec;73(12):1166-82. doi: 10.1097/NEN.0000000000000138.

25.

A compact Airy beam light sheet microscope with a tilted cylindrical lens.

Yang Z, Prokopas M, Nylk J, Coll-Lladó C, Gunn-Moore FJ, Ferrier DE, Vettenburg T, Dholakia K.

Biomed Opt Express. 2014 Sep 5;5(10):3434-42. doi: 10.1364/BOE.5.003434. eCollection 2014 Oct 1.

26.

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.

Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D.

PLoS One. 2014 Aug 18;9(8):e103976. doi: 10.1371/journal.pone.0103976. eCollection 2014.

27.

Light-sheet microscopy using an Airy beam.

Vettenburg T, Dalgarno HI, Nylk J, Coll-Lladó C, Ferrier DE, Čižmár T, Gunn-Moore FJ, Dholakia K.

Nat Methods. 2014 May;11(5):541-4. doi: 10.1038/nmeth.2922. Epub 2014 Apr 6.

PMID:
24705473
28.

Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation.

Antkowiak M, Torres-Mapa ML, Witts EC, Miles GB, Dholakia K, Gunn-Moore FJ.

Sci Rep. 2013 Nov 21;3:3281. doi: 10.1038/srep03281.

29.

Femtosecond optoinjection of intact tobacco BY-2 cells using a reconfigurable photoporation platform.

Mitchell CA, Kalies S, Cizmár T, Heisterkamp A, Torrance L, Roberts AG, Gunn-Moore FJ, Dholakia K.

PLoS One. 2013 Nov 14;8(11):e79235. doi: 10.1371/journal.pone.0079235. eCollection 2013.

30.

Laser-induced breakdown of an optically trapped gold nanoparticle for single cell transfection.

Arita Y, Ploschner M, Antkowiak M, Gunn-Moore F, Dholakia K.

Opt Lett. 2013 Sep 1;38(17):3402-5. doi: 10.1364/OL.38.003402.

PMID:
23988969
31.

Femtosecond optical transfection of individual mammalian cells.

Antkowiak M, Torres-Mapa ML, Stevenson DJ, Dholakia K, Gunn-Moore FJ.

Nat Protoc. 2013 Jun;8(6):1216-33. doi: 10.1038/nprot.2013.071. Epub 2013 May 30.

PMID:
23722260
32.

The expanding family of FERM proteins.

Moleirinho S, Tilston-Lunel A, Angus L, Gunn-Moore F, Reynolds PA.

Biochem J. 2013 Jun 1;452(2):183-93. doi: 10.1042/BJ20121642. Review.

PMID:
23662806
33.

Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts.

Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ.

PLoS One. 2013 Apr 8;8(4):e60028. doi: 10.1371/journal.pone.0060028. Print 2013.

34.

Exploring the ultrashort pulse laser parameter space for membrane permeabilisation in mammalian cells.

Rudhall AP, Antkowiak M, Tsampoula X, Mazilu M, Metzger NK, Gunn-Moore F, Dholakia K.

Sci Rep. 2012;2:858. doi: 10.1038/srep00858. Epub 2012 Nov 14.

35.

High-throughput optical injection of mammalian cells using a Bessel light beam.

Rendall HA, Marchington RF, Praveen BB, Bergmann G, Arita Y, Heisterkamp A, Gunn-Moore FJ, Dholakia K.

Lab Chip. 2012 Nov 21;12(22):4816-20. doi: 10.1039/c2lc40708f.

PMID:
23007197
36.

Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.

Doherty GH, Beccano-Kelly D, Yan SD, Gunn-Moore FJ, Harvey J.

Neurobiol Aging. 2013 Jan;34(1):226-37. doi: 10.1016/j.neurobiolaging.2012.08.003. Epub 2012 Aug 22.

PMID:
22921154
37.

Is amyloid binding alcohol dehydrogenase a drug target for treating Alzheimer's disease?

Borger E, Aitken L, Du H, Zhang W, Gunn-Moore FJ, Yan SS.

Curr Alzheimer Res. 2013 Jan;10(1):21-9. Review.

38.

KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals.

Moleirinho S, Chang N, Sims AH, Tilston-Lünel AM, Angus L, Steele A, Boswell V, Barnett SC, Ormandy C, Faratian D, Gunn-Moore FJ, Reynolds PA.

Oncogene. 2013 Apr 4;32(14):1821-30. doi: 10.1038/onc.2012.196. Epub 2012 May 21.

PMID:
22614006
39.

Dynamics of primary and secondary microbubbles created by laser-induced breakdown of an optically trapped nanoparticle.

Arita Y, Antkowiak M, Venugopalan V, Gunn-Moore FJ, Dholakia K.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jan;85(1 Pt 2):016319. Epub 2012 Jan 25.

40.

Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells.

Soo CY, Song Y, Zheng Y, Campbell EC, Riches AC, Gunn-Moore F, Powis SJ.

Immunology. 2012 Jun;136(2):192-7. doi: 10.1111/j.1365-2567.2012.03569.x.

41.

Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma.

Schlecht NF, Brandwein-Gensler M, Smith RV, Kawachi N, Broughel D, Lin J, Keller CE, Reynolds PA, Gunn-Moore FJ, Harris T, Childs G, Belbin TJ, Prystowsky MB.

Head Neck Pathol. 2012 Jun;6(2):232-43. doi: 10.1007/s12105-011-0328-1. Epub 2012 Jan 7.

42.

Imaging the cellular response to transient shear stress using stroboscopic digital holography.

Antkowiak M, Arita Y, Dholakia K, Gunn-Moore F.

J Biomed Opt. 2011 Dec;16(12):120508. doi: 10.1117/1.3665441.

43.

Mitochondrial β-amyloid in Alzheimer's disease.

Borger E, Aitken L, Muirhead KE, Allen ZE, Ainge JA, Conway SJ, Gunn-Moore FJ.

Biochem Soc Trans. 2011 Aug;39(4):868-73. doi: 10.1042/BST0390868.

PMID:
21787315
44.

Integrated holographic system for all-optical manipulation of developing embryos.

Torres-Mapa ML, Antkowiak M, Cizmarova H, Ferrier DE, Dholakia K, Gunn-Moore FJ.

Biomed Opt Express. 2011 Jun 1;2(6):1564-75. doi: 10.1364/BOE.2.001564. Epub 2011 May 16.

45.

Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.

Angus L, Moleirinho S, Herron L, Sinha A, Zhang X, Niestrata M, Dholakia K, Prystowsky MB, Harvey KF, Reynolds PA, Gunn-Moore FJ.

Oncogene. 2012 Jan 12;31(2):238-50. doi: 10.1038/onc.2011.224. Epub 2011 Jun 13.

PMID:
21666719
46.

Enhancement and optimization of plasmid expression in femtosecond optical transfection.

Praveen BB, Stevenson DJ, Antkowiak M, Dholakia K, Gunn-Moore FJ.

J Biophotonics. 2011 Apr;4(4):229-35. doi: 10.1002/jbio.201000105. Epub 2011 Jan 13.

PMID:
21446012
47.

The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage.

Musilek K, Pavlikova R, Marek J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Dolezal M, Gunn-Moore F, Kuca K.

J Enzyme Inhib Med Chem. 2011 Apr;26(2):245-53. doi: 10.3109/14756366.2010.496362.

PMID:
21406034
48.

Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.

Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2505-9. doi: 10.1016/j.bmcl.2011.02.047. Epub 2011 Feb 21.

PMID:
21397501
49.

Optical transfection using an endoscope-like system.

Ma N, Gunn-Moore F, Dholakia K.

J Biomed Opt. 2011 Feb;16(2):028002. doi: 10.1117/1.3541781.

50.

Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.

Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS.

J Neurosci. 2011 Feb 9;31(6):2313-20. doi: 10.1523/JNEUROSCI.4717-10.2011.

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