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'Prevalence and determinants for xerosis cutis in the middle-aged and elderly population: a cross-sectional study'.

Mekic S, Jacobs LC, Gunn DA, Mayes AE, Ikram MA, Pardo LM, Nijsten T.

J Am Acad Dermatol. 2018 Dec 23. pii: S0190-9622(18)33112-8. doi: 10.1016/j.jaad.2018.12.038. [Epub ahead of print]


Histone H3 acetylation is a conduit of gene expression perturbations in photodamaged skin.

Gunn DA.

Br J Dermatol. 2018 Jul;179(1):10-11. doi: 10.1111/bjd.16692. No abstract available.


The successful treatment of a multidrug-resistant Achromobacter xylosoxidans corneal ulcer with topical meropenem.

Tavassoli S, Gunn D, Williams OM, Darcy K.

BMJ Case Rep. 2018 Jul 18;2018. pii: bcr-2018-225163. doi: 10.1136/bcr-2018-225163.


Treatment of Metarhizium fungal keratitis in the United Kingdom.

Gunn DJ, Tavassoli S, Darcy K.

Eye (Lond). 2018 Nov;32(11):1790-1796. doi: 10.1038/s41433-018-0134-z. Epub 2018 Jun 11. No abstract available.


A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort.

Mekic S, Jacobs LC, Hamer MA, Ikram MA, Schoufour JD, Gunn DA, Kiefte-de Jong JC, Nijsten T.

J Am Acad Dermatol. 2018 Mar 27. pii: S0190-9622(18)30487-0. doi: 10.1016/j.jaad.2018.03.033. [Epub ahead of print]


Facial Wrinkles in Europeans: A Genome-Wide Association Study.

Hamer MA, Pardo LM, Jacobs LC, Deelen J, Uitterlinden AG, Slagboom E, van Heemst D, Uh HW, Beekman M, Kayser M, Liu F, Gunn DA, Nijsten T.

J Invest Dermatol. 2018 Aug;138(8):1877-1880. doi: 10.1016/j.jid.2017.12.037. Epub 2018 Mar 16. No abstract available.


Do senescence markers correlate in vitro and in situ within individual human donors?

Waaijer MEC, Gunn DA, van Heemst D, Slagboom PE, Sedivy JM, Dirks RW, Tanke HJ, Westendorp RGJ, Maier AB.

Aging (Albany NY). 2018 Feb 28;10(2):278-289. doi: 10.18632/aging.101389.


No Causal Association between 25-Hydroxyvitamin D and Features of Skin Aging: Evidence from a Bidirectional Mendelian Randomization Study.

Noordam R, Hamer MA, Pardo LM, van der Nat T, Kiefte-de Jong JC, Kayser M, Slagboom PE, Uitterlinden A, Zillikens MC, Beekman M, Nijsten T, van Heemst D, Gunn DA.

J Invest Dermatol. 2017 Nov;137(11):2291-2297. doi: 10.1016/j.jid.2017.07.817. Epub 2017 Jul 29. Review.


Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women.

Hamer MA, Pardo LM, Jacobs LC, Ikram MA, Laven JS, Kayser M, Hollestein LM, Gunn DA, Nijsten T.

J Invest Dermatol. 2017 Aug;137(8):1692-1699. doi: 10.1016/j.jid.2017.04.002. Epub 2017 Apr 6.


The MC1R Gene and Youthful Looks.

Liu F, Hamer MA, Deelen J, Lall JS, Jacobs L, van Heemst D, Murray PG, Wollstein A, de Craen AJ, Uh HW, Zeng C, Hofman A, Uitterlinden AG, Houwing-Duistermaat JJ, Pardo LM, Beekman M, Slagboom PE, Nijsten T, Kayser M, Gunn DA.

Curr Biol. 2016 May 9;26(9):1213-20. doi: 10.1016/j.cub.2016.03.008. Epub 2016 Apr 28.


Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

Waaijer ME, Westendorp RG, Goldeck D, Gunn DA, Pawelec G, Stijntjes M, Slagboom PE, Maier AB.

Exp Gerontol. 2017 Jan;87(Pt B):175-181. doi: 10.1016/j.exger.2016.03.020. Epub 2016 Apr 2.


Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women.

Noordam R, Gunn DA, van Drielen K, Westgate G, Slagboom PE, de Craen AJ, van Heemst D.

Br J Dermatol. 2016 Oct;175(4):728-34. doi: 10.1111/bjd.14529. Epub 2016 Jun 23.


Evidence-based approach to unexplained infertility: a systematic review.

Gunn DD, Bates GW.

Fertil Steril. 2016 Jun;105(6):1566-1574.e1. doi: 10.1016/j.fertnstert.2016.02.001. Epub 2016 Feb 19. Review.


P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

Waaijer ME, Gunn DA, Adams PD, Pawlikowski JS, Griffiths CE, van Heemst D, Slagboom PE, Westendorp RG, Maier AB.

J Gerontol A Biol Sci Med Sci. 2016 Aug;71(8):1022-8. doi: 10.1093/gerona/glv114. Epub 2015 Aug 18.


Mortality is Written on the Face.

Gunn DA, Larsen LA, Lall JS, Rexbye H, Christensen K.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):72-7. doi: 10.1093/gerona/glv090. Epub 2015 Aug 11.


Markers of health and disease and pigmented spots in a middle-aged population.

van Drielen K, Gunn DA, Griffiths CE, Griffiths TW, Ogden S, Noordam R, Slagboom PE, van Heemst D, de Craen AJ.

Br J Dermatol. 2015 Dec;173(6):1550-2. doi: 10.1111/bjd.14051. Epub 2015 Nov 3. No abstract available.


Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age.

van Drielen K, Gunn DA, Noordam R, Griffiths CE, Westendorp RG, de Craen AJ, van Heemst D.

Age (Dordr). 2015 Jun;37(3):9771. doi: 10.1007/s11357-015-9771-3. Epub 2015 Apr 16.


A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.

Jacobs LC, Hamer MA, Gunn DA, Deelen J, Lall JS, van Heemst D, Uh HW, Hofman A, Uitterlinden AG, Griffiths CEM, Beekman M, Slagboom PE, Kayser M, Liu F, Nijsten T.

J Invest Dermatol. 2015 Jul;135(7):1735-1742. doi: 10.1038/jid.2015.62. Epub 2015 Feb 23.


Lifestyle and youthful looks.

Gunn DA, Dick JL, van Heemst D, Griffiths CE, Tomlin CC, Murray PG, Griffiths TW, Ogden S, Mayes AE, Westendorp RG, Slagboom PE, de Craen AJ.

Br J Dermatol. 2015;172(5):1338-45. doi: 10.1111/bjd.13646. Epub 2015 Apr 15.


Validation of image analysis techniques to measure skin aging features from facial photographs.

Hamer MA, Jacobs LC, Lall JS, Wollstein A, Hollestein LM, Rae AR, Gossage KW, Hofman A, Liu F, Kayser M, Nijsten T, Gunn DA.

Skin Res Technol. 2015 Nov;21(4):392-402. doi: 10.1111/srt.12205. Epub 2015 Jan 20.


Age-related mitochondrial DNA depletion and the impact on pancreatic Beta cell function.

Nile DL, Brown AE, Kumaheri MA, Blair HR, Heggie A, Miwa S, Cree LM, Payne B, Chinnery PF, Brown L, Gunn DA, Walker M.

PLoS One. 2014 Dec 22;9(12):e115433. doi: 10.1371/journal.pone.0115433. eCollection 2014.


Order parameter and connectivity topology analysis of crystalline ceramics for nuclear waste immobilization.

Archer A, Foxhall HR, Allan NL, Gunn DS, Harding JH, Todorov IT, Travis KP, Purton JA.

J Phys Condens Matter. 2014 Dec 3;26(48):485011. doi: 10.1088/0953-8984/26/48/485011. Epub 2014 Nov 7.


p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients.

Brown AE, Palsgaard J, Borup R, Avery P, Gunn DA, De Meyts P, Yeaman SJ, Walker M.

Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E63-70. doi: 10.1152/ajpendo.00115.2014. Epub 2014 Nov 4.


Intrinsic and extrinsic risk factors for sagging eyelids.

Jacobs LC, Liu F, Bleyen I, Gunn DA, Hofman A, Klaver CC, Uitterlinden AG, Neumann HA, Bataille V, Spector TD, Kayser M, Nijsten T.

JAMA Dermatol. 2014 Aug;150(8):836-43. doi: 10.1001/jamadermatol.2014.27.


Actigraphically-defined sleep disturbance in Parkinson's disease is associated with differential aspects of cognitive functioning.

Gunn DG, Naismith SL, Bolitho SJ, Lewis SJ.

J Clin Neurosci. 2014 Jul;21(7):1112-5. doi: 10.1016/j.jocn.2013.09.017. Epub 2013 Nov 26.


Prevalence and outcomes of laser treatment of aggressive posterior retinopathy of prematurity.

Gunn DJ, Cartwright DW, Gole GA.

Clin Exp Ophthalmol. 2014 Jul;42(5):459-65. doi: 10.1111/ceo.12280. Epub 2014 Jan 23.


The Relationships Between Poor Sleep Efficiency and Mild Cognitive Impairment in Parkinson Disease.

Gunn DG, Naismith SL, Terpening Z, Lewis SJ.

J Geriatr Psychiatry Neurol. 2014 Jun;27(2):77-84. doi: 10.1177/0891988713509135. Epub 2013 Nov 5.


Unawareness of motor phenoconversion in Huntington disease.

McCusker EA, Gunn DG, Epping EA, Loy CT, Radford K, Griffith J, Mills JA, Long JD, Paulsen JS; PREDICT-HD Investigators of the Huntington Study Group.

Neurology. 2013 Sep 24;81(13):1141-7. doi: 10.1212/WNL.0b013e3182a55f05. Epub 2013 Aug 21.


Single-crystal adsorption calorimetry and density functional theory of CO chemisorption on fcc Co{110}.

Liao K, Fiorin V, Gunn DS, Jenkins SJ, King DA.

Phys Chem Chem Phys. 2013 Mar 21;15(11):4059-65. doi: 10.1039/c3cp43836h.


Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study.

Noordam R, Gunn DA, Tomlin CC, Maier AB, Griffiths T, Catt SD, Ogden S, Slagboom PE, Westendorp RG, Griffiths CE, van Heemst D, de Craen AJ; Leiden Longevity Study group.

Br J Dermatol. 2013 Mar;168(3):533-8. doi: 10.1111/bjd.12131. Epub 2013 Jan 31.


The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding.

Sawicka M, Pawlikowski J, Wilson S, Ferdinando D, Wu H, Adams PD, Gunn DA, Parish W.

PLoS One. 2013;8(1):e53313. doi: 10.1371/journal.pone.0053313. Epub 2013 Jan 8.


NCKX5, a natural regulator of human skin colour variation, regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes.

Wilson S, Ginger RS, Dadd T, Gunn D, Lim FL, Sawicka M, Sandel M, Schnetkamp PP, Green MR.

Adv Exp Med Biol. 2013;961:95-107. doi: 10.1007/978-1-4614-4756-6_9. Review.


Gene expression analysis of mTOR pathway: association with human longevity.

Passtoors WM, Beekman M, Deelen J, van der Breggen R, Maier AB, Guigas B, Derhovanessian E, van Heemst D, de Craen AJ, Gunn DA, Pawelec G, Slagboom PE.

Aging Cell. 2013 Feb;12(1):24-31. doi: 10.1111/acel.12015. Epub 2012 Nov 23.


Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

Gunn DA, de Craen AJ, Dick JL, Tomlin CC, van Heemst D, Catt SD, Griffiths T, Ogden S, Maier AB, Murray PG, Griffiths CE, Slagboom PE, Westendorp RG.

J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):145-52. doi: 10.1093/gerona/gls154. Epub 2012 Aug 9.


Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts.

Dekker P, Gunn D, McBryan T, Dirks RW, van Heemst D, Lim FL, Jochemsen AG, Verlaan-de Vries M, Nagel J, Adams PD, Tanke HJ, Westendorp RG, Maier AB.

Mech Ageing Dev. 2012 Jul;133(7):498-507. doi: 10.1016/j.mad.2012.06.002. Epub 2012 Jun 18.


Treatment of retinopathy of prematurity in extremely premature infants over an 18-year period.

Gunn DJ, Cartwright DW, Yuen SA, Gole GA.

Clin Exp Ophthalmol. 2013 Mar;41(2):159-66. doi: 10.1111/j.1442-9071.2012.02839.x.


The number of p16INK4a positive cells in human skin reflects biological age.

Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB.

Aging Cell. 2012 Aug;11(4):722-5. doi: 10.1111/j.1474-9726.2012.00837.x. Epub 2012 Jun 11.


Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

Noordam R, Gunn DA, Tomlin CC, Rozing MP, Maier AB, Slagboom PE, Westendorp RG, van Heemst D, de Craen AJ; Leiden Longevity Study group.

Psychoneuroendocrinology. 2012 Oct;37(10):1669-75. Epub 2012 Mar 18.


Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.

Passtoors WM, Boer JM, Goeman JJ, Akker EB, Deelen J, Zwaan BJ, Scarborough A, Breggen Rv, Vossen RH, Houwing-Duistermaat JJ, Ommen GJ, Westendorp RG, van Heemst D, de Craen AJ, White AJ, Gunn DA, Beekman M, Slagboom PE.

PLoS One. 2012;7(1):e27759. doi: 10.1371/journal.pone.0027759. Epub 2012 Jan 11. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/d4d3b1fb-35e0-4c4d-89bc-e6a839504e54.


Glycaemic control and weight 7 years after Dose Adjustment For Normal Eating (DAFNE) structured education in Type 1 diabetes.

Gunn D, Mansell P.

Diabet Med. 2012 Jun;29(6):807-12. doi: 10.1111/j.1464-5491.2011.03525.x.


High serum glucose levels are associated with a higher perceived age.

Noordam R, Gunn DA, Tomlin CC, Maier AB, Mooijaart SP, Slagboom PE, Westendorp RG, de Craen AJ, van Heemst D; Leiden Longevity Study Group.

Age (Dordr). 2013 Feb;35(1):189-95. doi: 10.1007/s11357-011-9339-9. Epub 2011 Nov 20.


Incidence of retinopathy of prematurity in extremely premature infants over an 18-year period.

Gunn DJ, Cartwright DW, Gole GA.

Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):93-9. doi: 10.1111/j.1442-9071.2011.02724.x. Epub 2011 Dec 23.


Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

Waaijer ME, Gunn DA, Catt SD, van Ginkel M, de Craen AJ, Hudson NM, van Heemst D, Slagboom PE, Westendorp RG, Maier AB.

Age (Dordr). 2012 Dec;34(6):1543-52. doi: 10.1007/s11357-011-9314-5. Epub 2011 Sep 10.


Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population.

Ling CH, de Craen AJ, Slagboom PE, Gunn DA, Stokkel MP, Westendorp RG, Maier AB.

Clin Nutr. 2011 Oct;30(5):610-5. doi: 10.1016/j.clnu.2011.04.001. Epub 2011 May 8.


Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE.

Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6.


Environmental and lifestyle factors associated with perceived facial age in Chinese women.

Mayes AE, Murray PG, Gunn DA, Tomlin CC, Catt SD, Wen YB, Zhou LP, Wang HQ, Catt M, Granger SP.

PLoS One. 2010 Dec 13;5(12):e15270. doi: 10.1371/journal.pone.0015270.


Specific amacrine cell changes in an induced mouse model of glaucoma.

Gunn DJ, Gole GA, Barnett NL.

Clin Exp Ophthalmol. 2011 Aug;39(6):555-63. doi: 10.1111/j.1442-9071.2010.02488.x. Epub 2011 Feb 23.


Detection of simulated memory impairment in 6- to 11-year-old children.

Gunn D, Batchelor J, Jones M.

Child Neuropsychol. 2010;16(2):105-18. doi: 10.1080/09297040903352564.


Sleep disturbances in Parkinson disease and their potential role in heterogeneity.

Gunn DG, Naismith SL, Lewis SJ.

J Geriatr Psychiatry Neurol. 2010 Jun;23(2):131-7. doi: 10.1177/0891988709358591. Epub 2010 Jan 25. Review.


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