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Items: 1 to 50 of 52

1.

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria.

Liang X, Luo D, Yan JL, Rezaei MA, Salvador-Reyes LA, Gunasekera SP, Li C, Ye T, Paul VJ, Luesch H.

Org Lett. 2019 Mar 15;21(6):1622-1626. doi: 10.1021/acs.orglett.9b00163. Epub 2019 Feb 19.

PMID:
30779584
2.

Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles.

Gunasekera SP, Meyer JL, Ding Y, Abboud KA, Luo D, Campbell JE, Angerhofer A, Goodsell JL, Raymundo LJ, Liu J, Ye T, Luesch H, Teplitski M, Paul VJ.

J Nat Prod. 2019 Jan 25;82(1):111-121. doi: 10.1021/acs.jnatprod.8b00804. Epub 2019 Jan 13.

3.

Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales).

Brumley D, Spencer KA, Gunasekera SP, Sauvage T, Biggs J, Paul VJ, Luesch H.

J Nat Prod. 2018 Dec 28;81(12):2716-2721. doi: 10.1021/acs.jnatprod.8b00650. Epub 2018 Nov 29.

PMID:
30489078
4.

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata.

Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H.

J Nat Prod. 2016 Jul 22;79(7):1867-71. doi: 10.1021/acs.jnatprod.6b00203. Epub 2016 Jul 5.

5.

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria.

Gunasekera SP, Li Y, Ratnayake R, Luo D, Lo J, Reibenspies JH, Xu Z, Clare-Salzler MJ, Ye T, Paul VJ, Luesch H.

Chemistry. 2016 Jun 6;22(24):8158-66. doi: 10.1002/chem.201600674. Epub 2016 May 3.

6.

Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria.

Meyer JL, Gunasekera SP, Scott RM, Paul VJ, Teplitski M.

ISME J. 2016 May;10(5):1204-16. doi: 10.1038/ismej.2015.184. Epub 2015 Oct 23.

7.

Carriebowlinol, an antimicrobial tetrahydroquinolinol from an assemblage of marine cyanobacteria containing a novel taxon.

Soares AR, Engene N, Gunasekera SP, Sneed JM, Paul VJ.

J Nat Prod. 2015 Mar 27;78(3):534-8. doi: 10.1021/np500598x. Epub 2014 Dec 23.

PMID:
25536090
8.

Quorum-sensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat.

Abed RM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ.

J Ind Microbiol Biotechnol. 2013 Jul;40(7):759-72. doi: 10.1007/s10295-013-1276-4. Epub 2013 May 5.

PMID:
23645384
9.

Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria.

Engene N, Gunasekera SP, Gerwick WH, Paul VJ.

Appl Environ Microbiol. 2013 Mar;79(6):1882-8. doi: 10.1128/AEM.03793-12. Epub 2013 Jan 11.

10.

Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp.

Meickle T, Gunasekera SP, Liu Y, Luesch H, Paul VJ.

Bioorg Med Chem. 2011 Nov 15;19(22):6576-80. doi: 10.1016/j.bmc.2011.05.051. Epub 2011 Jun 6.

11.

Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam.

Gunasekera SP, Owle CS, Montaser R, Luesch H, Paul VJ.

J Nat Prod. 2011 Apr 25;74(4):871-6. doi: 10.1021/np1008015. Epub 2011 Feb 22.

12.

Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry.

Dobretsov S, Teplitski M, Alagely A, Gunasekera SP, Paul VJ.

Environ Microbiol Rep. 2010 Dec;2(6):739-44. doi: 10.1111/j.1758-2229.2010.00169.x.

PMID:
23766278
13.

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula.

Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H.

J Nat Prod. 2010 Mar 26;73(3):463-6. doi: 10.1021/np900614n.

14.

Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.

Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ.

J Nat Prod. 2010 Mar 26;73(3):459-62. doi: 10.1021/np900603f.

PMID:
20020755
15.

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida.

Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ.

Appl Environ Microbiol. 2009 May;75(9):2879-88. doi: 10.1128/AEM.02656-08. Epub 2009 Mar 6.

16.

Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines.

Guzmán EA, Johnson JD, Carrier MK, Meyer CI, Pitts TP, Gunasekera SP, Wright AE.

Anticancer Drugs. 2009 Feb;20(2):149-55. doi: 10.1097/CAD.0b013e32831fa39e.

17.

Carriebowmide, a new cyclodepsipeptide from the marine cyanobacterium Lyngbya polychroa.

Gunasekera SP, Ritson-Williams R, Paul VJ.

J Nat Prod. 2008 Dec;71(12):2060-3. doi: 10.1021/np800453t.

PMID:
19007282
19.

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa.

Gunasekera SP, Ross C, Paul VJ, Matthew S, Luesch H.

J Nat Prod. 2008 May;71(5):887-90. doi: 10.1021/np0706769. Epub 2008 Apr 5.

PMID:
18393465
20.

Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico.

Park YC, Gunasekera SP, Lopez JV, McCarthy PJ, Wright AE.

J Nat Prod. 2006 Apr;69(4):580-4.

PMID:
16643030
21.

Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines.

Mayer AM, Hall ML, Lynch SM, Gunasekera SP, Sennett SH, Pomponi SA.

BMC Pharmacol. 2005 Mar 11;5:6.

22.

Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity.

Gunasekera SP, Mickel SJ, Daeffler R, Niederer D, Wright AE, Linley P, Pitts T.

J Nat Prod. 2004 May;67(5):749-56.

PMID:
15165132
23.

Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp.

Gunasekera SP, Isbrucker RA, Longley RE, Wright AE, Pomponi SA, Reed JK.

J Nat Prod. 2004 Jan;67(1):110-1.

PMID:
14738400
24.

Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella.

Gunasekera SP, Zuleta IA, Longley RE, Wright AE, Pomponi SA.

J Nat Prod. 2003 Dec;66(12):1615-7.

PMID:
14695808
25.

Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.

Gunasekera SP, Longley RE, Isbrucker RA.

J Nat Prod. 2002 Dec;65(12):1830-7.

PMID:
12502323
26.

Five new discodermolide analogues from the marine sponge Discodermia species.

Gunasekera SP, Paul GK, Longley RE, Isbrucker RA, Pomponi SA.

J Nat Prod. 2002 Nov;65(11):1643-8.

PMID:
12444691
27.

Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species.

Paul GK, Gunasekera SP, Longley RE, Pomponi SA.

J Nat Prod. 2002 Jan;65(1):59-61.

PMID:
11809067
28.

Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity.

Isbrucker RA, Gunasekera SP, Longley RE.

Cancer Chemother Pharmacol. 2001 Jul;48(1):29-36.

PMID:
11488521
29.

Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity.

Gunasekera SP, Longley RE, Isbrucker RA.

J Nat Prod. 2001 Feb;64(2):171-4.

PMID:
11429994
30.
31.

Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.

Gunasekera SP, McCarthy PJ, Longley RE, Pomponi SA, Wright AE.

J Nat Prod. 1999 Aug;62(8):1208-11.

PMID:
10479344
32.

Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.

Gunasekera SP, McCarthy PJ, Longley RE, Pomponi SA, Wright AE, Lobkovsky E, Clardy J.

J Nat Prod. 1999 Jan;62(1):173-5.

PMID:
9917313
34.

A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi.

Gunasekera SP, Kelly-Borges M, Longley RE.

J Nat Prod. 1996 Feb;59(2):161-2.

PMID:
8991949
35.

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.

ter Haar E, Kowalski RJ, Hamel E, Lin CM, Longley RE, Gunasekera SP, Rosenkranz HS, Day BW.

Biochemistry. 1996 Jan 9;35(1):243-50.

PMID:
8555181
36.

Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.

Gunasekera SP, Sennett SH, Kelly-Borges M, Bryant RW.

J Nat Prod. 1994 Dec;57(12):1751-4.

PMID:
7714543
37.

Hamacanthins A and B, new antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.

Gunasekera SP, McCarthy PJ, Kelly-Borges M.

J Nat Prod. 1994 Oct;57(10):1437-41.

PMID:
7807127
38.

Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp.

Gunasekera SP, Pomponi SA, McCarthy PJ.

J Nat Prod. 1994 Jan;57(1):79-83.

PMID:
8158168
39.

Immunosuppression by discodermolide.

Longley RE, Gunasekera SP, Faherty D, Mclane J, Dumont F.

Ann N Y Acad Sci. 1993 Nov 30;696:94-107. Review.

PMID:
8109858
41.

Discodermolide--a new, marine-derived immunosuppressive compound. II. In vivo studies.

Longley RE, Caddigan D, Harmody D, Gunasekera M, Gunasekera SP.

Transplantation. 1991 Oct;52(4):656-61.

PMID:
1926345
42.

Discodermolide--a new, marine-derived immunosuppressive compound. I. In vitro studies.

Longley RE, Caddigan D, Harmody D, Gunasekera M, Gunasekera SP.

Transplantation. 1991 Oct;52(4):650-6. Erratum in: Transplantation 1993 Jan;55(1):236.

PMID:
1833864
43.

Antitumor activity and biochemical effects of topsentin.

Burres NS, Barber DA, Gunasekera SP, Shen LL, Clement JJ.

Biochem Pharmacol. 1991 Jul 25;42(4):745-51.

PMID:
1867631
44.

Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis.

Gunasekera SP, Cranick S, Longley RE.

J Nat Prod. 1989 Jul-Aug;52(4):757-61.

PMID:
2530314
45.

Marine natural products: pyrrololactams from several sponges.

Schmitz FJ, Gunasekera SP, Lakshmi V, Tillekeratne LM.

J Nat Prod. 1985 Jan-Feb;48(1):47-53.

PMID:
2861253
46.

3 beta-hydroxy-28-P-coumaroyloxy-lup-20(29)-en-27-oic acid from Caraipa densifolia.

Gunasekera SP, Cordell GA, Farnsworth NR.

J Nat Prod. 1983 Jan;46(1):118-22.

PMID:
6854336
47.

Plant anticancer agents XXI. Constituents of Merrilliodendron megacarpum.

Arisawa M, Gunasekera SP, Cordell GA, Farnsworth NR.

Planta Med. 1981 Dec;43(4):404-7. No abstract available.

PMID:
7330109
48.

Plant anticancer agents XX. Constituents of Nicandra physalodes.

Gunasekera SP, Cordell GA, Farnsworth NR.

Planta Med. 1981 Dec;43(4):389-91. No abstract available.

PMID:
7330107
49.

Plant anticancer agents. XIX Constituents of Aquilaria malaccensis.

Gunasekera SP, Kinghorn AD, Cordell GA, Farnsworth NR.

J Nat Prod. 1981 Sep-Oct;44(5):569-72.

PMID:
7320738
50.

Constituents of Nealchornea yapurenis (Euophorbiaceae).

Gunasekera SP, Cordell GA, Farnsworth NR.

J Nat Prod. 1980 Mar-Apr;43(2):285-7.

PMID:
7381509

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