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Items: 1 to 50 of 95

1.

Elevated pre-surgical CA15-3: does it predict the short-term disease-free survival of breast cancer patients without distant metastasis?

Mudduwa LK, Wijayaratne GB, Peiris HH, Gunasekera SN, Abeysiriwardhana D, Liyanage N.

Int J Womens Health. 2018 Jun 26;10:329-335. doi: 10.2147/IJWH.S162867. eCollection 2018.

2.

Kinetics and Degradation Mechanism of Adrenaline Derivative CpQ in Diluted Aqueous Solutions.

Blasko A, Tam J, Gunasekera S, Eboreime A.

Biochemistry. 2018 Jul 19. doi: 10.1021/acs.biochem.8b00462. [Epub ahead of print]

PMID:
29975046
3.

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis.

Gunasekera S, Fernandes-Cerqueira C, Wennmalm S, Wähämaa H, Sommarin Y, Catrina AI, Jakobsson PJ, Göransson U.

ACS Chem Biol. 2018 Jun 15;13(6):1525-1535. doi: 10.1021/acschembio.8b00118. Epub 2018 May 24.

PMID:
29630823
4.

MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia.

Brown FC, Still E, Koche RP, Yim CY, Takao S, Cifani P, Reed C, Gunasekera S, Ficarro SB, Romanienko P, Mark W, McCarthy C, de Stanchina E, Gonen M, Seshan V, Bhola P, O'Donnell C, Spitzer B, Stutzke C, Lavallée VP, Hébert J, Krivtsov AV, Melnick A, Paietta EM, Tallman MS, Letai A, Sauvageau G, Pouliot G, Levine R, Marto JA, Armstrong SA, Kentsis A.

Cancer Discov. 2018 Apr;8(4):478-497. doi: 10.1158/2159-8290.CD-17-1271. Epub 2018 Feb 5.

PMID:
29431698
5.

Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity.

Gunasekera S, Muhammad T, Strömstedt AA, Rosengren KJ, Göransson U.

Chembiochem. 2018 May 4;19(9):931-939. doi: 10.1002/cbic.201700599. Epub 2018 Mar 30.

PMID:
29430821
6.

Production of the Plant Hormone Auxin by Salmonella and Its Role in the Interactions with Plants and Animals.

Cox CE, Brandl MT, de Moraes MH, Gunasekera S, Teplitski M.

Front Microbiol. 2018 Jan 12;8:2668. doi: 10.3389/fmicb.2017.02668. eCollection 2017.

7.

Bloom dynamics and chemical defenses of benthic cyanobacteria in the Indian River Lagoon, Florida.

Sneed JM, Meickle T, Engene N, Reed S, Gunasekera S, Paul VJ.

Harmful Algae. 2017 Nov;69:75-82. doi: 10.1016/j.hal.2017.10.002. Epub 2017 Oct 23.

PMID:
29122244
8.

Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins.

Hellinger R, Thell K, Vasileva M, Muhammad T, Gunasekera S, Kümmel D, Göransson U, Becker CW, Gruber CW.

Front Chem. 2017 Oct 11;5:73. doi: 10.3389/fchem.2017.00073. eCollection 2017.

9.

Single dose Rasburicase is a clinically effective pharmacoeconomic approach for preventing tumour lysis syndrome in children with high tumour burden.

Syrimi E, Gunasekera S, Norton A, Velangi M, Motwani J, Hiwarkar P.

Br J Haematol. 2018 Jun;181(5):696-698. doi: 10.1111/bjh.14689. Epub 2017 May 8. No abstract available.

PMID:
28480955
10.

The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured.

Daly NL, Gunasekera S, Clark RJ, Lin F, Wade JD, Anderson MA, Craik DJ.

Biopolymers. 2016 Nov;106(6):825-833. doi: 10.1002/bip.22977.

PMID:
27564841
11.

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata.

Gunasekera SP, Imperial L, Garst C, Ratnayake R, Dang LH, Paul VJ, Luesch H.

J Nat Prod. 2016 Jul 22;79(7):1867-71. doi: 10.1021/acs.jnatprod.6b00203. Epub 2016 Jul 5.

12.

Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria.

Gunasekera SP, Li Y, Ratnayake R, Luo D, Lo J, Reibenspies JH, Xu Z, Clare-Salzler MJ, Ye T, Paul VJ, Luesch H.

Chemistry. 2016 Jun 6;22(24):8158-66. doi: 10.1002/chem.201600674. Epub 2016 May 3.

13.

Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket.

Strömstedt AA, Kristiansen PE, Gunasekera S, Grob N, Skjeldal L, Göransson U.

Biochim Biophys Acta. 2016 Jun;1858(6):1317-27. doi: 10.1016/j.bbamem.2016.02.013. Epub 2016 Feb 12.

14.

Synthesis, Structural Characterization, and Bioactivity of the Stable Peptide RCB-1 from Ricinus communis.

Boldbaatar D, Gunasekera S, El-Seedi HR, Göransson U.

J Nat Prod. 2015 Nov 25;78(11):2545-51. doi: 10.1021/acs.jnatprod.5b00463. Epub 2015 Oct 28.

PMID:
26509914
15.

Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria.

Meyer JL, Gunasekera SP, Scott RM, Paul VJ, Teplitski M.

ISME J. 2016 May;10(5):1204-16. doi: 10.1038/ismej.2015.184. Epub 2015 Oct 23.

16.

Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.

Carstens BB, Rosengren KJ, Gunasekera S, Schempp S, Bohlin L, Dahlström M, Clark RJ, Göransson U.

J Nat Prod. 2015 Aug 28;78(8):1886-93. doi: 10.1021/acs.jnatprod.5b00210. Epub 2015 Jul 29.

PMID:
26222779
17.

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens.

Fernandes-Cerqueira C, Ossipova E, Gunasekera S, Hansson M, Mathsson L, Catrina AI, Sommarin Y, Klareskog L, Lundberg K, Rönnelid J, Göransson U, Jakobsson PJ.

Arthritis Res Ther. 2015 Jun 10;17:155. doi: 10.1186/s13075-015-0666-6.

18.

A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: a case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18.

Gunasekera SK, Perera KA, Fernando C, Udagama PV.

Infect Agent Cancer. 2015 Apr 16;10:12. doi: 10.1186/s13027-015-0007-z. eCollection 2015.

19.

A cactus-derived toxin-like cystine knot Peptide with selective antimicrobial activity.

Aboye TL, Strömstedt AA, Gunasekera S, Bruhn JG, El-Seedi H, Rosengren KJ, Göransson U.

Chembiochem. 2015 May 4;16(7):1068-77. doi: 10.1002/cbic.201402704. Epub 2015 Mar 27.

PMID:
25821084
20.

Effects of toxic compounds in Montipora capitata on exogenous and endogenous zooxanthellae performance and fertilization success.

Hagedorn M, Farrell A, Carter V, Zuchowicz N, Johnston E, Padilla-Gamiño J, Gunasekera S, Paul V.

PLoS One. 2015 Feb 25;10(2):e0118364. doi: 10.1371/journal.pone.0118364. eCollection 2015.

21.

Carriebowlinol, an antimicrobial tetrahydroquinolinol from an assemblage of marine cyanobacteria containing a novel taxon.

Soares AR, Engene N, Gunasekera SP, Sneed JM, Paul VJ.

J Nat Prod. 2015 Mar 27;78(3):534-8. doi: 10.1021/np500598x. Epub 2014 Dec 23.

PMID:
25536090
22.

Chemistry and biology of cyclotides: circular plant peptides outside the box.

Burman R, Gunasekera S, Strömstedt AA, Göransson U.

J Nat Prod. 2014 Mar 28;77(3):724-36. doi: 10.1021/np401055j. Epub 2014 Feb 14. Review.

PMID:
24527877
23.

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.

Koehbach J, O'Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21183-8. doi: 10.1073/pnas.1311183110. Epub 2013 Nov 18.

24.

Quorum-sensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat.

Abed RM, Dobretsov S, Al-Fori M, Gunasekera SP, Sudesh K, Paul VJ.

J Ind Microbiol Biotechnol. 2013 Jul;40(7):759-72. doi: 10.1007/s10295-013-1276-4. Epub 2013 May 5.

PMID:
23645384
25.

Making Ends Meet: Microwave-Accelerated Synthesis of Cyclic and Disulfide Rich Proteins Via In Situ Thioesterification and Native Chemical Ligation.

Gunasekera S, Aboye TL, Madian WA, El-Seedi HR, Göransson U.

Int J Pept Res Ther. 2013 Mar;19(1):43-54. Epub 2012 Oct 14.

26.

Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria.

Engene N, Gunasekera SP, Gerwick WH, Paul VJ.

Appl Environ Microbiol. 2013 Mar;79(6):1882-8. doi: 10.1128/AEM.03793-12. Epub 2013 Jan 11.

27.

Brain targeted transcranial administration of diazepam and shortening of sleep latency in healthy human volunteers.

Pathirana W, Gunasekera SM, Constantine GR, Perera S, Perera BM, Kamaladiwela R.

Indian J Pharm Sci. 2011 Sep;73(5):497-503. doi: 10.4103/0250-474X.98985.

28.

Circular proteins from plants and fungi.

Göransson U, Burman R, Gunasekera S, Strömstedt AA, Rosengren KJ.

J Biol Chem. 2012 Aug 3;287(32):27001-6. doi: 10.1074/jbc.R111.300129. Epub 2012 Jun 14. Review.

29.

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds.

Chan LY, Gunasekera S, Henriques ST, Worth NF, Le SJ, Clark RJ, Campbell JH, Craik DJ, Daly NL.

Blood. 2011 Dec 15;118(25):6709-17. doi: 10.1182/blood-2011-06-359141. Epub 2011 Oct 28.

30.

Inhibition of marine biofouling by bacterial quorum sensing inhibitors.

Dobretsov S, Teplitski M, Bayer M, Gunasekera S, Proksch P, Paul VJ.

Biofouling. 2011 Sep;27(8):893-905. doi: 10.1080/08927014.2011.609616.

31.

Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp.

Meickle T, Gunasekera SP, Liu Y, Luesch H, Paul VJ.

Bioorg Med Chem. 2011 Nov 15;19(22):6576-80. doi: 10.1016/j.bmc.2011.05.051. Epub 2011 Jun 6.

32.

Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam.

Gunasekera SP, Owle CS, Montaser R, Luesch H, Paul VJ.

J Nat Prod. 2011 Apr 25;74(4):871-6. doi: 10.1021/np1008015. Epub 2011 Feb 22.

33.

Proximal axonal changes after peripheral nerve injury in man.

Gunasekera SM, Wijeskara RL, Sesath HG.

Muscle Nerve. 2011 Mar;43(3):425-31. doi: 10.1002/mus.21879.

PMID:
21321957
34.

Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry.

Dobretsov S, Teplitski M, Alagely A, Gunasekera SP, Paul VJ.

Environ Microbiol Rep. 2010 Dec;2(6):739-44. doi: 10.1111/j.1758-2229.2010.00169.x.

PMID:
23766278
35.

Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization.

Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL.

Antioxid Redox Signal. 2011 Jan 1;14(1):87-95. doi: 10.1089/ars.2009.3068. Epub 2010 Aug 20.

PMID:
20486767
36.

A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.

Guzmán EA, Johnson JD, Linley PA, Gunasekera SE, Wright AE.

Invest New Drugs. 2011 Oct;29(5):777-85. doi: 10.1007/s10637-010-9422-6. Epub 2010 Mar 30.

37.

Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula.

Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H.

J Nat Prod. 2010 Mar 26;73(3):463-6. doi: 10.1021/np900614n.

38.

Neurophysiological findings in patients 1 year after snake bite induced neurotoxicity in Sri Lanka.

Bell DJ, Wijegunasinghe D, Samarakoon S, Palipana H, Gunasekera S, de Silva HA, Lalloo DG, Ranawaka UK, de Silva HJ.

Trans R Soc Trop Med Hyg. 2010 May;104(5):351-6. doi: 10.1016/j.trstmh.2009.12.003. Epub 2010 Jan 22.

PMID:
20096908
39.

Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis.

Gunasekera SP, Miller MW, Kwan JC, Luesch H, Paul VJ.

J Nat Prod. 2010 Mar 26;73(3):459-62. doi: 10.1021/np900603f.

PMID:
20020755
40.

Cardiovascular risk factors in elderly normolipidemic acute myocardial infarct patients--a case controlled study from India.

Kumar A, Nagtilak S, Sivakanesan R, Gunasekera S.

Southeast Asian J Trop Med Public Health. 2009 May;40(3):581-92.

PMID:
19842447
41.

Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida.

Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ.

Appl Environ Microbiol. 2009 May;75(9):2879-88. doi: 10.1128/AEM.02656-08. Epub 2009 Mar 6.

42.

Selective cytotoxic activity of the marine-derived batzelline compounds against pancreatic cancer cell lines.

Guzmán EA, Johnson JD, Carrier MK, Meyer CI, Pitts TP, Gunasekera SP, Wright AE.

Anticancer Drugs. 2009 Feb;20(2):149-55. doi: 10.1097/CAD.0b013e32831fa39e.

43.

Engineering stabilized vascular endothelial growth factor-A antagonists: synthesis, structural characterization, and bioactivity of grafted analogues of cyclotides.

Gunasekera S, Foley FM, Clark RJ, Sando L, Fabri LJ, Craik DJ, Daly NL.

J Med Chem. 2008 Dec 25;51(24):7697-704. doi: 10.1021/jm800704e.

PMID:
19053834
44.

Dissecting the oxidative folding of circular cystine knot miniproteins.

Gunasekera S, Daly NL, Clark RJ, Craik DJ.

Antioxid Redox Signal. 2009 May;11(5):971-80. doi: 10.1089/ARS.2008.2295.

PMID:
19025420
45.

Carriebowmide, a new cyclodepsipeptide from the marine cyanobacterium Lyngbya polychroa.

Gunasekera SP, Ritson-Williams R, Paul VJ.

J Nat Prod. 2008 Dec;71(12):2060-3. doi: 10.1021/np800453t.

PMID:
19007282
46.

Production of successive force impulses by the left and right hands.

Hammond G, Gunasekera S.

J Mot Behav. 2008 Sep;40(5):409-16. doi: 10.3200/JMBR.40.5.409-416.

PMID:
18782716
47.

Quality of life in Hepatitis C virus infection: assessment of rural patients living in north-western New South Wales.

Gunasekera S, Fraser J, Alexander C.

Aust J Rural Health. 2008 Jul;16(4):213-20. doi: 10.1111/j.1440-1584.2008.00983.x.

PMID:
18652609
48.

Oxidative stress and antioxidant status in normolipidemic AMI patients.

Kumar A, Sivakanesan R, Gunasekera S.

Indian J Clin Biochem. 2008 Jul;23(3):296-8. doi: 10.1007/s12291-008-0067-6. Epub 2008 Oct 1.

50.

Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa.

Gunasekera SP, Ross C, Paul VJ, Matthew S, Luesch H.

J Nat Prod. 2008 May;71(5):887-90. doi: 10.1021/np0706769. Epub 2008 Apr 5.

PMID:
18393465

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