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Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.

Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS.

Nucleic Acids Res. 2018 Nov 9. doi: 10.1093/nar/gky1104. [Epub ahead of print]


Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.

Chong PSY, Zhou J, Chooi JY, Chan ZL, Toh SHM, Tan TZ, Wee S, Gunaratne J, Zeng Q, Chng WJ.

Oncogene. 2018 Oct 10. doi: 10.1038/s41388-018-0526-3. [Epub ahead of print]


CDK1-mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling.

Chen J, Rajasekaran M, Xia H, Kong SN, Deivasigamani A, Sekar K, Gao H, Swa HL, Gunaratne J, Ooi LL, Xie T, Hong W, Hui KM.

EMBO J. 2018 Oct 15;37(20). pii: e99395. doi: 10.15252/embj.201899395. Epub 2018 Sep 14.


Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence.

Jakhar R, Luijten MNH, Wong AXF, Cheng B, Guo K, Neo SP, Au B, Kulkarni M, Lim KJ, Maimaiti J, Chong HC, Lim EH, Tan TBK, Ong KW, Sim Y, Wong JSL, Khoo JBK, Ho JTS, Chua BT, Sinha I, Wang X, Connolly JE, Gunaratne J, Crasta KC.

Mol Cancer Res. 2018 Nov;16(11):1625-1640. doi: 10.1158/1541-7786.MCR-18-0024. Epub 2018 Jul 23.


Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.

Liao KC, Chuo V, Ng WC, Neo SP, Pompon J, Gunaratne J, Ooi EE, Garcia-Blanco MA.

RNA. 2018 Jun;24(6):803-814. doi: 10.1261/rna.064006.117. Epub 2018 Mar 23.


Phosphoproteomics reveals network rewiring to a pro-adhesion state in annexin-1-deficient mammary epithelial cells.

Alli-Shaik A, Wee S, Lim LHK, Gunaratne J.

Breast Cancer Res. 2017 Dec 12;19(1):132. doi: 10.1186/s13058-017-0924-4.


Phosphorylation of Mig6 negatively regulates the ubiquitination and degradation of EGFR mutants in lung adenocarcinoma cell lines.

Boopathy GTK, Lynn JLS, Wee S, Gunaratne J, Hong W.

Cell Signal. 2018 Mar;43:21-31. doi: 10.1016/j.cellsig.2017.11.006. Epub 2017 Dec 2.


In vitro cytotoxicity of L-amino acid oxidase from the venom of Crotalus mitchellii pyrrhus.

Tan KK, Ler SG, Gunaratne J, Bay BH, Ponnampalam G.

Toxicon. 2017 Dec 1;139:20-30. doi: 10.1016/j.toxicon.2017.09.012. Epub 2017 Sep 22.


Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

Toloczko A, Guo F, Yuen HF, Wen Q, Wood SA, Ong YS, Chan PY, Shaik AA, Gunaratne J, Dunne MJ, Hong W, Chan SW.

Cancer Res. 2017 Sep 15;77(18):4921-4933. doi: 10.1158/0008-5472.CAN-16-3413. Epub 2017 Jul 18.


YBX1 gene silencing inhibits migratory and invasive potential via CORO1C in breast cancer in vitro.

Lim JP, Shyamasundar S, Gunaratne J, Scully OJ, Matsumoto K, Bay BH.

BMC Cancer. 2017 Mar 16;17(1):201. doi: 10.1186/s12885-017-3187-7.


Yersinia effector protein (YopO)-mediated phosphorylation of host gelsolin causes calcium-independent activation leading to disruption of actin dynamics.

Singaravelu P, Lee WL, Wee S, Ghoshdastider U, Ding K, Gunaratne J, Grimes JM, Swaminathan K, Robinson RC.

J Biol Chem. 2017 May 12;292(19):8092-8100. doi: 10.1074/jbc.M116.757971. Epub 2017 Mar 9.


Mechanisms of Yersinia YopO kinase substrate specificity.

Lee WL, Singaravelu P, Wee S, Xue B, Ang KC, Gunaratne J, Grimes JM, Swaminathan K, Robinson RC.

Sci Rep. 2017 Jan 4;7:39998. doi: 10.1038/srep39998.


The Golgi associated ERI3 is a Flavivirus host factor.

Ward AM, Calvert ME, Read LR, Kang S, Levitt BE, Dimopoulos G, Bradrick SS, Gunaratne J, Garcia-Blanco MA.

Sci Rep. 2016 Sep 29;6:34379. doi: 10.1038/srep34379.


Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.

Diril MK, Bisteau X, Kitagawa M, Caldez MJ, Wee S, Gunaratne J, Lee SH, Kaldis P.

PLoS Genet. 2016 Sep 15;12(9):e1006310. doi: 10.1371/journal.pgen.1006310. eCollection 2016 Sep.


Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale.

Dong JM, Tay FP, Swa HL, Gunaratne J, Leung T, Burke B, Manser E.

Sci Signal. 2016 Jun 14;9(432):rs4. doi: 10.1126/scisignal.aaf3572.


Erratum: Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Alli Shaik A, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V.

Sci Rep. 2016 Jun 10;6:27230. doi: 10.1038/srep27230. No abstract available.


Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.

Brichkina A, Nguyen NT, Baskar R, Wee S, Gunaratne J, Robinson RC, Bulavin DV.

Cell Death Differ. 2016 Oct;23(10):1592-601. doi: 10.1038/cdd.2016.45. Epub 2016 May 27.


Phosphoprotein network analysis of white adipose tissues unveils deregulated pathways in response to high-fat diet.

Shaik AA, Qiu B, Wee S, Choi H, Gunaratne J, Tergaonkar V.

Sci Rep. 2016 May 16;6:25844. doi: 10.1038/srep25844. Erratum in: Sci Rep. 2016 Jun 10;6:27230.


Acetylation of C/EBPα inhibits its granulopoietic function.

Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG.

Nat Commun. 2016 Mar 23;7:10968. doi: 10.1038/ncomms10968.


ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Szczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B.

Cell Stem Cell. 2015 Oct 1;17(4):435-47. doi: 10.1016/j.stem.2015.08.010. Epub 2015 Sep 17. Erratum in: Cell Stem Cell. 2015 Nov 5;17(5):635. Sczerbinska, Iwona [corrected to Szczerbinska, Iwona].


Systematic identification of factors for provirus silencing in embryonic stem cells.

Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, Loh YH.

Cell. 2015 Sep 24;163(1):230-45. doi: 10.1016/j.cell.2015.08.037. Epub 2015 Sep 10.


Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling.

Lee J, Wee S, Gunaratne J, Chua RJ, Smith RA, Ling L, Fernig DG, Swaminathan K, Nurcombe V, Cool SM.

Glycobiology. 2015 Dec;25(12):1491-504. doi: 10.1093/glycob/cwv064. Epub 2015 Aug 24.


Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.

Manokaran G, Finol E, Wang C, Gunaratne J, Bahl J, Ong EZ, Tan HC, Sessions OM, Ward AM, Gubler DJ, Harris E, Garcia-Blanco MA, Ooi EE.

Science. 2015 Oct 9;350(6257):217-21. doi: 10.1126/science.aab3369. Epub 2015 Jul 2.


Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.

Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, Børresen-Dale AL, Neilsen PM, Prives C.

Genes Dev. 2015 Jun 15;29(12):1298-315. doi: 10.1101/gad.263202.115. Epub 2015 Jun 16.


Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma.

Kumar P, Nandi S, Tan TZ, Ler SG, Chia KS, Lim WY, Bütow Z, Vordos D, De la Taille A, Al-Haddawi M, Raida M, Beyer B, Ricci E, Colombel M, Chong TW, Chiong E, Soo R, Park MK, Ha HK, Gunaratne J, Thiery JP.

Oncotarget. 2015 May 30;6(15):13539-49.


EBprot: Statistical analysis of labeling-based quantitative proteomics data.

Koh HW, Swa HL, Fermin D, Ler SG, Gunaratne J, Choi H.

Proteomics. 2015 Aug;15(15):2580-91. doi: 10.1002/pmic.201400620. Epub 2015 May 28.


Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy.

Tan CL, Teissier S, Gunaratne J, Quek LS, Bellanger S.

Cell Cycle. 2015;14(9):1459-70. doi: 10.1080/15384101.2015.1021519.


An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma.

Chakraborty S, Lakshmanan M, Swa HL, Chen J, Zhang X, Ong YS, Loo LS, Akıncılar SC, Gunaratne J, Tergaonkar V, Hui KM, Hong W.

Nat Commun. 2015 Jan 29;6:6184. doi: 10.1038/ncomms7184.


Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex.

Zhang W, Neo SP, Gunaratne J, Poulsen A, Boping L, Ong EH, Sangthongpitag K, Pendharkar V, Hill J, Cohen SM.

Cell Signal. 2015 Mar;27(3):436-42. doi: 10.1016/j.cellsig.2014.12.010. Epub 2014 Dec 19.


Altered protein expression profile associated with phenotypic changes in lung fibroblasts co-cultured with gold nanoparticle-treated small airway epithelial cells.

Ng CT, Yung LY, Swa HL, Poh RW, Gunaratne J, Bay BH.

Biomaterials. 2015 Jan;39:31-8. doi: 10.1016/j.biomaterials.2014.10.063. Epub 2014 Nov 13.


Functional mapping of the zebrafish early embryo proteome and transcriptome.

Alli Shaik A, Wee S, Li RH, Li Z, Carney TJ, Mathavan S, Gunaratne J.

J Proteome Res. 2014 Dec 5;13(12):5536-50. doi: 10.1021/pr5005136. Epub 2014 Sep 26.


Mass spectrometry based quantitative proteomics and integrative network analysis accentuates modulating roles of annexin-1 in mammary tumorigenesis.

Swa HL, Shaik AA, Lim LH, Gunaratne J.

Proteomics. 2015 Jan;15(2-3):408-18. doi: 10.1002/pmic.201400175. Epub 2014 Sep 30.


NUCKS is a positive transcriptional regulator of insulin signaling.

Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akıncılar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W, Tergaonkar V.

Cell Rep. 2014 Jun 26;7(6):1876-86. doi: 10.1016/j.celrep.2014.05.030. Epub 2014 Jun 12.


Isg15 controls p53 stability and functions.

Huang YF, Wee S, Gunaratne J, Lane DP, Bulavin DV.

Cell Cycle. 2014;13(14):2200-10. doi: 10.4161/cc.29209. Epub 2014 May 20.


Identification of dengue RNA binding proteins using RNA chromatography and quantitative mass spectrometry.

Ward AM, Gunaratne J, Garcia-Blanco MA.

Methods Mol Biol. 2014;1138:253-70. doi: 10.1007/978-1-4939-0348-1_16.


Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism.

Lai D, Tan CL, Gunaratne J, Quek LS, Nei W, Thierry F, Bellanger S.

PLoS One. 2013 Sep 24;8(9):e75625. doi: 10.1371/journal.pone.0075625. eCollection 2013.


Plasma membrane proteomics identifies biomarkers associated with MMSET overexpression in T(4;14) multiple myeloma.

Xie Z, Gunaratne J, Cheong LL, Liu SC, Koh TL, Huang G, Blackstock WP, Chng WJ.

Oncotarget. 2013 Jul;4(7):1008-18.


EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

Bard-Chapeau EA, Gunaratne J, Kumar P, Chua BQ, Muller J, Bard FA, Blackstock W, Copeland NG, Jenkins NA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2885-94. doi: 10.1073/pnas.1309310110. Epub 2013 Jul 15.


Extensive mass spectrometry-based analysis of the fission yeast proteome: the Schizosaccharomyces pombe PeptideAtlas.

Gunaratne J, Schmidt A, Quandt A, Neo SP, Saraç OS, Gracia T, Loguercio S, Ahrné E, Xia RL, Tan KH, Lössner C, Bähler J, Beyer A, Blackstock W, Aebersold R.

Mol Cell Proteomics. 2013 Jun;12(6):1741-51. doi: 10.1074/mcp.M112.023754. Epub 2013 Mar 5.


ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation.

Zhang W, Hietakangas V, Wee S, Lim SC, Gunaratne J, Cohen SM.

Genes Dev. 2013 Feb 15;27(4):441-9. doi: 10.1101/gad.201731.112.


"Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle.

Khong JH, Zhang T, Gunaratne J, Blackstock W, Surana U.

Cell Cycle. 2012 Aug 1;11(15):2896-910. doi: 10.4161/cc.21303. Epub 2012 Aug 1.


Expanding the zebrafish embryo proteome using multiple fractionation approaches and tandem mass spectrometry.

Lößner C, Wee S, Ler SG, Li RH, Carney T, Blackstock W, Gunaratne J.

Proteomics. 2012 Jun;12(11):1879-82. doi: 10.1002/pmic.201100576.


Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

Coffill CR, Muller PA, Oh HK, Neo SP, Hogue KA, Cheok CF, Vousden KH, Lane DP, Blackstock WP, Gunaratne J.

EMBO Rep. 2012 Jun 29;13(7):638-44. doi: 10.1038/embor.2012.74.


RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors.

Chuang LS, Lai SK, Murata-Hori M, Yamada A, Li HY, Gunaratne J, Ito Y.

Cell Cycle. 2012 May 15;11(10):1938-47. doi: 10.4161/cc.20278. Epub 2012 May 15.


HPV-18 E2^E4 chimera: 2 new spliced transcripts and proteins induced by keratinocyte differentiation.

Tan CL, Gunaratne J, Lai D, Carthagena L, Wang Q, Xue YZ, Quek LS, Doorbar J, Bachelerie F, Thierry F, Bellanger S.

Virology. 2012 Jul 20;429(1):47-56. doi: 10.1016/j.virol.2012.03.023. Epub 2012 Apr 27.


Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration.

Swa HL, Blackstock WP, Lim LH, Gunaratne J.

Mol Cell Proteomics. 2012 Aug;11(8):381-93. doi: 10.1074/mcp.M111.011205. Epub 2012 Apr 16.


Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.

Bard-Chapeau EA, Jeyakani J, Kok CH, Muller J, Chua BQ, Gunaratne J, Batagov A, Jenjaroenpun P, Kuznetsov VA, Wei CL, D'Andrea RJ, Bourque G, Jenkins NA, Copeland NG.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2168-73. doi: 10.1073/pnas.1119229109. Epub 2012 Jan 19.


Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance.

Migliori V, Müller J, Phalke S, Low D, Bezzi M, Mok WC, Sahu SK, Gunaratne J, Capasso P, Bassi C, Cecatiello V, De Marco A, Blackstock W, Kuznetsov V, Amati B, Mapelli M, Guccione E.

Nat Struct Mol Biol. 2012 Jan 8;19(2):136-44. doi: 10.1038/nsmb.2209.


Enhanced performance of pulsed Q collision induced dissociation-based peptide identification on a dual-pressure linear ion trap.

Lössner C, Blackstock W, Gunaratne J.

J Am Soc Mass Spectrom. 2012 Jan;23(1):186-9. doi: 10.1007/s13361-011-0256-z. Epub 2011 Oct 27.


Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures.

Ward AM, Bidet K, Yinglin A, Ler SG, Hogue K, Blackstock W, Gunaratne J, Garcia-Blanco MA.

RNA Biol. 2011 Nov-Dec;8(6):1173-86. doi: 10.4161/rna.8.6.17836. Epub 2011 Nov 1.

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