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Items: 43

1.

Heterotrimeric Gα12/13 proteins in kidney injury and disease.

Tutunea-Fatan E, Lee JC, Denker BM, Gunaratnam L.

Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F660-F672. doi: 10.1152/ajprenal.00453.2019. Epub 2020 Jan 27.

PMID:
31984793
2.

Growth differentiation factor 15 is decreased by kidney transplantation.

Connelly PW, Yan AT, Nash MM, Lok CE, Gunaratnam L, Prasad GVR.

Clin Biochem. 2019 Nov;73:57-61. doi: 10.1016/j.clinbiochem.2019.07.013. Epub 2019 Jul 27.

PMID:
31361994
3.

Patients with immunological diseases or on peritoneal dialysis are prone to false positive flow cytometry crossmatch.

Xu Q, House AA, Leckie S, Gunaratnam L, Luke PP, Jevnikar AM.

Hum Immunol. 2019 Jul;80(7):487-492. doi: 10.1016/j.humimm.2019.03.015. Epub 2019 Mar 20.

PMID:
30904438
4.

Cardiovascular magnetic resonance left ventricular strain in end-stage renal disease patients after kidney transplantation.

Gong IY, Al-Amro B, Prasad GVR, Connelly PW, Wald RM, Wald R, Deva DP, Leong-Poi H, Nash MM, Yuan W, Gunaratnam L, Kim SJ, Lok CE, Connelly KA, Yan AT.

J Cardiovasc Magn Reson. 2018 Dec 17;20(1):83. doi: 10.1186/s12968-018-0504-5.

5.

Determinants of Left Ventricular Characteristics Assessed by Cardiac Magnetic Resonance Imaging and Cardiovascular Biomarkers Related to Kidney Transplantation.

Prasad GVR, Yan AT, Nash MM, Kim SJ, Wald R, Wald R, Lok C, Gunaratnam L, Karur GR, Kirpalani A, Connelly PW.

Can J Kidney Health Dis. 2018 Nov 9;5:2054358118809974. doi: 10.1177/2054358118809974. eCollection 2018.

6.

Handheld Point-of-Care Lactate Measurement at Admission Predicts Mortality in Ugandan Children Hospitalized with Pneumonia: A Prospective Cohort Study.

Ma C, Gunaratnam LC, Ericson A, Conroy AL, Namasopo S, Opoka RO, Hawkes MT.

Am J Trop Med Hyg. 2019 Jan;100(1):37-42. doi: 10.4269/ajtmh.18-0344.

7.

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury.

Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N, Hébert MJ.

J Am Soc Nephrol. 2018 Jul;29(7):1900-1916. doi: 10.1681/ASN.2017050581. Epub 2018 Jun 20.

8.

Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.

Ismail OZ, Sriranganathan S, Zhang X, Bonventre JV, Zervos AS, Gunaratnam L.

J Cell Physiol. 2018 Oct;233(10):6877-6895. doi: 10.1002/jcp.26578. Epub 2018 Apr 25.

9.

Donor kidney injury molecule-1 promotes graft recovery by regulating systemic necroinflammation.

Lee JY, Ismail OZ, Zhang X, Haig A, Lian D, Gunaratnam L.

Am J Transplant. 2018 Aug;18(8):2021-2028. doi: 10.1111/ajt.14745. Epub 2018 Apr 20.

10.

New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report.

Dieudé M, West LJ, Muruve DA, Gunaratnam L, Mohanakumar T, Zorn E, Cairo CW, Freed DH, Schultz KR, Fairchild RL, Hébert MJ.

Transplantation. 2018 Feb;102(2):209-214. doi: 10.1097/TP.0000000000001872. Review. Erratum in: Transplantation. 2018 Jul;102(7):e360. Gunaratman, Lakshman [corrected to Gunaratnam, Lakshman].

11.

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.

Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, Suzuki Y, Yahagi N, Nishiyama A, Gunaratnam L, Takano T, Miyazaki T.

Nat Med. 2016 Feb;22(2):183-93. doi: 10.1038/nm.4012. Epub 2016 Jan 4.

PMID:
26726878
12.

G protein α12 (Gα12) is a negative regulator of kidney injury molecule-1-mediated efferocytosis.

Ismail OZ, Zhang X, Bonventre JV, Gunaratnam L.

Am J Physiol Renal Physiol. 2016 Apr 1;310(7):F607-F620. doi: 10.1152/ajprenal.00169.2015. Epub 2015 Dec 23.

13.

Hydrogen Sulfide Treatment Mitigates Renal Allograft Ischemia-Reperfusion Injury during Cold Storage and Improves Early Transplant Kidney Function and Survival Following Allogeneic Renal Transplantation.

Lobb I, Davison M, Carter D, Liu W, Haig A, Gunaratnam L, Sener A.

J Urol. 2015 Dec;194(6):1806-15. doi: 10.1016/j.juro.2015.07.096. Epub 2015 Aug 1.

PMID:
26239336
14.

Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury.

Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L.

Am J Pathol. 2015 May;185(5):1207-15. doi: 10.1016/j.ajpath.2015.02.003. Epub 2015 Mar 7.

15.

Cardiac, renal, and central nervous system dysfunction with eosinophilia: eosinophilic granulomatosis with polyangiitis.

Hemmett J, Qirjazi E, Weir MA, Moussa M, Landry YD, Gunaratnam L.

Lancet. 2015 Jan 31;385(9966):480. doi: 10.1016/S0140-6736(14)62352-7. No abstract available.

PMID:
25706976
16.

Dialysis recovery time: more than just another serum albumin.

Suri RS, Gunaratnam L.

Am J Kidney Dis. 2014 Jul;64(1):7-9. doi: 10.1053/j.ajkd.2014.04.008. No abstract available.

PMID:
24954453
17.

Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis.

Gandhi R, Yi J, Ha J, Shi H, Ismail O, Nathoo S, Bonventre JV, Zhang X, Gunaratnam L.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F205-21. doi: 10.1152/ajprenal.00638.2013. Epub 2014 May 14.

18.

Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation.

Lin Q, Chen Y, Lv J, Zhang H, Tang J, Gunaratnam L, Li X, Yang L.

Am J Physiol Renal Physiol. 2014 Apr 15;306(8):F885-95. doi: 10.1152/ajprenal.00331.2013. Epub 2014 Feb 12.

19.

Statistical challenges in the quantification of gunshot residue evidence.

Gauriot R, Gunaratnam L, Moroni R, Reinikainen T, Corander J.

J Forensic Sci. 2013 Sep;58(5):1149-55. doi: 10.1111/1556-4029.12179. Epub 2013 Jul 3.

PMID:
23822522
20.

Transplant renal artery stenosis secondary to mechanical compression from polycystic kidney disease: A case report.

Lee L, Gunaratnam L, Sener A.

Can Urol Assoc J. 2013 Mar-Apr;7(3-4):E251-3. doi: 10.5489/cuaj.548.

21.

Serum susceptibility in clinical isolates of Burkholderia cepacia complex bacteria: development of a growth-based assay for high throughput determination.

Zlosnik JE, Gunaratnam LC, Speert DP.

Front Cell Infect Microbiol. 2012 May 28;2:67. doi: 10.3389/fcimb.2012.00067. eCollection 2012.

22.

Localized mandibular enlargement in end-stage renal disease: two case reports and a review of the literature.

Lerman MA, Do C, Gunaratnam L, Kulkarni C, Tucker K, Woo SB.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Mar;113(3):384-90. doi: 10.1016/j.tripleo.2011.04.039. Epub 2011 Aug 16. Review.

PMID:
22676829
23.

TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors.

Cheong JK, Gunaratnam L, Zang ZJ, Yang CM, Sun X, Nasr SL, Sim KG, Peh BK, Rashid SB, Bonventre JV, Salto-Tellez M, Hsu SI.

J Transl Med. 2009 Jan 20;7:8. doi: 10.1186/1479-5876-7-8.

24.

HIF in kidney disease and development.

Gunaratnam L, Bonventre JV.

J Am Soc Nephrol. 2009 Sep;20(9):1877-87. doi: 10.1681/ASN.2008070804. Epub 2008 Dec 31. Review.

25.

TGF-alpha as a candidate tumor antigen for renal cell carcinomas.

Pelletier S, Tanguay S, Lee S, Gunaratnam L, Arbour N, Lapointe R.

Cancer Immunol Immunother. 2009 Aug;58(8):1207-18. doi: 10.1007/s00262-008-0630-2. Epub 2008 Dec 4.

PMID:
19052740
26.

Identification of PP2A as a novel interactor and regulator of TRIP-Br1.

Zang ZJ, Gunaratnam L, Cheong JK, Lai LY, Hsiao LL, O'Leary E, Sun X, Salto-Tellez M, Bonventre JV, Hsu SI.

Cell Signal. 2009 Jan;21(1):34-42. doi: 10.1016/j.cellsig.2008.09.018. Epub 2008 Oct 7.

PMID:
18940248
27.

Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells.

Ichimura T, Asseldonk EJ, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV.

J Clin Invest. 2008 May;118(5):1657-68. doi: 10.1172/JCI34487.

28.

CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.

Cheong JK, Gunaratnam L, Hsu SI.

J Biol Chem. 2008 Apr 25;283(17):11661-76. doi: 10.1074/jbc.M708365200. Epub 2008 Mar 3.

29.

GSR2005--continuity of the ENFSI proficiency test on identification of GSR by SEM/EDX.

Niewoehner L, Andrasko J, Biegstraaten J, Gunaratnam L, Steffen S, Uhlig S, Antoni S.

J Forensic Sci. 2008 Jan;53(1):162-7. Epub 2007 Nov 13.

PMID:
18005006
30.

Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer.

Franovic A, Gunaratnam L, Smith K, Robert I, Patten D, Lee S.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13092-7. Epub 2007 Aug 1.

31.

Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.

Yanamadala V, Negoro H, Gunaratnam L, Kong T, Denker BM.

J Biol Chem. 2007 Aug 17;282(33):24352-63. Epub 2007 Jun 12.

32.

Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.

Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S.

Cancer Res. 2006 Aug 15;66(16):8083-90.

33.

Regulation of ubiquitin ligase dynamics by the nucleolus.

Mekhail K, Khacho M, Carrigan A, Hache RR, Gunaratnam L, Lee S.

J Cell Biol. 2005 Aug 29;170(5):733-44.

34.

Maintenance of the ENFSI proficiency test program on identification of GSR by SEM/EDX (GSR2003).

Niewoehner L, Andrasko J, Biegstraaten J, Gunaratnam L, Steffen S, Uhlig S.

J Forensic Sci. 2005 Jul;50(4):877-82.

PMID:
16078491
35.

Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.

Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S.

Cancer Res. 2005 Jun 15;65(12):5221-30.

36.

Oxygen sensing by H+: implications for HIF and hypoxic cell memory.

Mekhail K, Khacho M, Gunaratnam L, Lee S.

Cell Cycle. 2004 Aug;3(8):1027-9. Epub 2004 Aug 7. Review.

PMID:
15280664
37.

HIF activation by pH-dependent nucleolar sequestration of VHL.

Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S.

Nat Cell Biol. 2004 Jul;6(7):642-7. Epub 2004 Jun 6.

PMID:
15181450
38.

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.

Gunaratnam L, Morley M, Franovic A, de Paulsen N, Mekhail K, Parolin DA, Nakamura E, Lorimer IA, Lee S.

J Biol Chem. 2003 Nov 7;278(45):44966-74. Epub 2003 Aug 27.

39.

ENFSI proficiency test program on identification of GSR by SEM/EDX.

Niewoehner L, Wenz HW, Andrasko J, Beijer R, Gunaratnam L.

J Forensic Sci. 2003 Jul;48(4):786-93.

PMID:
12877293
40.

Increased myofibrillar protein phosphatase-1 activity impairs rat aortic smooth muscle activation after hypoxia.

Teoh H, Zacour M, Wener AD, Gunaratnam L, Ward ME.

Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1182-9. Epub 2002 Dec 19.

41.

T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice.

Winer S, Astsaturov I, Cheung RK, Schrade K, Gunaratnam L, Wood DD, Moscarello MA, O'Connor P, McKerlie C, Becker DJ, Dosch HM.

J Immunol. 2001 Apr 1;166(7):4751-6.

42.

Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis.

Winer S, Astsaturov I, Cheung R, Gunaratnam L, Kubiak V, Cortez MA, Moscarello M, O'Connor PW, McKerlie C, Becker DJ, Dosch HM.

J Immunol. 2001 Feb 15;166(4):2831-41.

43.

Peptide dose, MHC affinity, and target self-antigen expression are critical for effective immunotherapy of nonobese diabetic mouse prediabetes.

Winer S, Gunaratnam L, Astsatourov I, Cheung RK, Kubiak V, Karges W, Hammond-McKibben D, Gaedigk R, Graziano D, Trucco M, Becker DJ, Dosch HM.

J Immunol. 2000 Oct 1;165(7):4086-94.

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