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Items: 1 to 50 of 51

1.

Direct and Indirect Inhibition of the Circadian Clock Protein PER1: Effects on ENaC and Blood Pressure.

Alli AA, Yu L, Holzworth MR, Richards J, Cheng KY, Lynch IJ, Wingo CS, Gumz ML.

Am J Physiol Renal Physiol. 2019 Feb 13. doi: 10.1152/ajprenal.00408.2018. [Epub ahead of print]

PMID:
30759025
2.

RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.

Crislip GR, Masten SH, Gumz ML.

Curr Opin Physiol. 2018 Oct;5:38-44. doi: 10.1016/j.cophys.2018.06.002. Epub 2018 Jun 20.

PMID:
30714020
3.

Clock Gene Expression is Altered in Veterans with Sleep Apnea.

Canales MT, Holzworth MR, Bozorgmehri S, Ishani A, Weiner ID, Berry RB, Beyth RJ, Gumz ML.

Physiol Genomics. 2019 Jan 18. doi: 10.1152/physiolgenomics.00091.2018. [Epub ahead of print]

PMID:
30657733
4.

Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.

Douma LG, Solocinski K, Holzworth MR, Crislip GR, Masten SH, Miller AH, Cheng KY, Lynch IJ, Cain BD, Wingo CS, Gumz ML.

Am J Physiol Regul Integr Comp Physiol. 2019 Jan 1;316(1):R50-R58. doi: 10.1152/ajpregu.00381.2017. Epub 2018 Nov 14.

PMID:
30427705
5.

Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.

Wei N, Gumz ML, Layton AT.

Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F665-F676. doi: 10.1152/ajprenal.00008.2018. Epub 2018 Mar 14.

PMID:
29537313
6.

Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.

Douma LG, Holzworth MR, Solocinski K, Masten SH, Miller AH, Cheng KY, Lynch IJ, Cain BD, Wingo CS, Gumz ML.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1138-F1144. doi: 10.1152/ajprenal.00546.2017. Epub 2018 Jan 10.

PMID:
29357420
7.

Clocking skin sodium.

Gumz ML.

Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R542-R543. doi: 10.1152/ajpregu.00453.2017. Epub 2018 Jan 3. No abstract available.

PMID:
29351424
8.

Circadian clock-mediated regulation of blood pressure.

Douma LG, Gumz ML.

Free Radic Biol Med. 2018 May 1;119:108-114. doi: 10.1016/j.freeradbiomed.2017.11.024. Epub 2017 Dec 2. Review.

PMID:
29198725
9.

Renal and colonic potassium transporters in the pregnant rat.

West CA, Welling PA, West DA Jr, Coleman RA, Cheng KY, Chen C, DuBose TD Jr, Verlander JW, Baylis C, Gumz ML.

Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F251-F259. doi: 10.1152/ajprenal.00288.2017. Epub 2017 Oct 18.

10.

ENaC activity in the cortical collecting duct of HKα1 H+,K+-ATPase knockout mice is uncoupled from Na+ intake.

Mironova E, Lynch IJ, Berman JM, Gumz ML, Stockand JD, Wingo CS.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1073-F1080. doi: 10.1152/ajprenal.00401.2016. Epub 2017 Feb 8.

11.

Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.

Solocinski K, Holzworth M, Wen X, Cheng KY, Lynch IJ, Cain BD, Wingo CS, Gumz ML.

Acta Physiol (Oxf). 2017 May;220(1):72-82. doi: 10.1111/apha.12804. Epub 2016 Oct 3.

12.

Molecular basis of circadian rhythmicity in renal physiology and pathophysiology.

Gumz ML.

Exp Physiol. 2016 Aug 1;101(8):1025-9. doi: 10.1113/EP085781. Review.

13.

How to Find More Hours in the Day.

Gumz ML.

Physiologist. 2016 May;59(3):127-9. No abstract available.

PMID:
27266014
14.

Aldosterone alters the chromatin structure of the murine endothelin-1 gene.

Welch AK, Jeanette Lynch I, Gumz ML, Cain BD, Wingo CS.

Life Sci. 2016 Aug 15;159:121-126. doi: 10.1016/j.lfs.2016.01.019. Epub 2016 Jan 14.

15.

Taking into account circadian rhythm when conducting experiments on animals.

Gumz ML.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F454-5. doi: 10.1152/ajprenal.00549.2015. Epub 2015 Dec 30.

16.

The Circadian Clock in the Regulation of Renal Rhythms.

Solocinski K, Gumz ML.

J Biol Rhythms. 2015 Dec;30(6):470-86. doi: 10.1177/0748730415610879. Epub 2015 Nov 2. Review.

17.

An Integrated View of Potassium Homeostasis.

Gumz ML, Rabinowitz L, Wingo CS.

N Engl J Med. 2015 Oct 29;373(18):1787-8. doi: 10.1056/NEJMc1509656. No abstract available.

PMID:
26510039
18.

Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.

Lynch IJ, Welch AK, Gumz ML, Kohan DE, Cain BD, Wingo CS.

Am J Physiol Renal Physiol. 2015 Dec 15;309(12):F1026-34. doi: 10.1152/ajprenal.00220.2015. Epub 2015 Sep 23.

19.

Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.

Solocinski K, Richards J, All S, Cheng KY, Khundmiri SJ, Gumz ML.

Am J Physiol Renal Physiol. 2015 Dec 1;309(11):F933-42. doi: 10.1152/ajprenal.00197.2014. Epub 2015 Sep 16.

20.

An Integrated View of Potassium Homeostasis.

Gumz ML, Rabinowitz L, Wingo CS.

N Engl J Med. 2015 Jul 2;373(1):60-72. doi: 10.1056/NEJMra1313341. Review. No abstract available. Erratum in: N Engl J Med. 2015 Sep 24;373(13):1281.

21.

Molecular origin of the kidney clock.

Gumz ML.

Kidney Int. 2014 Nov;86(5):873-4. doi: 10.1038/ki.2014.239.

22.

Clock genes in hypertension: novel insights from rodent models.

Richards J, Diaz AN, Gumz ML.

Blood Press Monit. 2014 Oct;19(5):249-54. doi: 10.1097/MBP.0000000000000060. Review.

23.

Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.

Richards J, Welch AK, Barilovits SJ, All S, Cheng KY, Wingo CS, Cain BD, Gumz ML.

Life Sci. 2014 Nov 24;118(2):255-62. doi: 10.1016/j.lfs.2014.03.028. Epub 2014 Apr 8.

24.

Tick tock: time to recognize the kidney clock.

Gumz ML.

J Am Soc Nephrol. 2014 Jul;25(7):1369-71. doi: 10.1681/ASN.2014020199. Epub 2014 Mar 20. No abstract available.

25.

A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.

Richards J, Ko B, All S, Cheng KY, Hoover RS, Gumz ML.

J Biol Chem. 2014 Apr 25;289(17):11791-806. doi: 10.1074/jbc.M113.531095. Epub 2014 Mar 7.

26.

A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.

Richards J, Cheng KY, All S, Skopis G, Jeffers L, Lynch IJ, Wingo CS, Gumz ML.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704. doi: 10.1152/ajprenal.00472.2013. Epub 2013 Oct 23.

27.

Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.

Richards J, Jeffers LA, All SC, Cheng KY, Gumz ML.

Front Physiol. 2013 Sep 17;4:253. doi: 10.3389/fphys.2013.00253. eCollection 2013.

28.

Role of circadian rhythms in potassium homeostasis.

Gumz ML, Rabinowitz L.

Semin Nephrol. 2013 May;33(3):229-36. doi: 10.1016/j.semnephrol.2013.04.003. Review.

29.

Molecular bases of circadian rhythmicity in renal physiology and pathology.

Bonny O, Vinciguerra M, Gumz ML, Mazzoccoli G.

Nephrol Dial Transplant. 2013 Oct;28(10):2421-31. doi: 10.1093/ndt/gft319. Epub 2013 Jul 30. Review.

30.

Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.

Richards J, All S, Skopis G, Cheng KY, Compton B, Srialluri N, Stow L, Jeffers LA, Gumz ML.

Am J Physiol Regul Integr Comp Physiol. 2013 Oct 1;305(7):R735-47. doi: 10.1152/ajpregu.00195.2013. Epub 2013 Jul 3.

31.

Mechanism of the circadian clock in physiology.

Richards J, Gumz ML.

Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15;304(12):R1053-64. doi: 10.1152/ajpregu.00066.2013. Epub 2013 Apr 10. Review.

32.

Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.

Richards J, Greenlee MM, Jeffers LA, Cheng KY, Guo L, Eaton DC, Gumz ML.

Am J Physiol Renal Physiol. 2012 Oct;303(7):F918-27. doi: 10.1152/ajprenal.00678.2011. Epub 2012 Jul 25.

33.

Advances in understanding the peripheral circadian clocks.

Richards J, Gumz ML.

FASEB J. 2012 Sep;26(9):3602-13. doi: 10.1096/fj.12-203554. Epub 2012 Jun 1. Review.

34.

The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes.

Stow LR, Richards J, Cheng KY, Lynch IJ, Jeffers LA, Greenlee MM, Cain BD, Wingo CS, Gumz ML.

Hypertension. 2012 Jun;59(6):1151-6. doi: 10.1161/HYPERTENSIONAHA.112.190892. Epub 2012 Apr 23.

35.

Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.

Stow LR, Voren GE, Gumz ML, Wingo CS, Cain BD.

Steroids. 2012 Apr;77(5):360-6. doi: 10.1016/j.steroids.2011.12.011. Epub 2011 Dec 19.

36.

The circadian clock in the kidney.

Stow LR, Gumz ML.

J Am Soc Nephrol. 2011 Apr;22(4):598-604. doi: 10.1681/ASN.2010080803. Epub 2011 Mar 24. Review.

37.

Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.

Greenlee MM, Lynch IJ, Gumz ML, Cain BD, Wingo CS.

J Am Soc Nephrol. 2011 Jan;22(1):49-58. doi: 10.1681/ASN.2010030311. Epub 2010 Dec 16.

38.

Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCD(c14) cells.

Gumz ML, Cheng KY, Lynch IJ, Stow LR, Greenlee MM, Cain BD, Wingo CS.

Biochim Biophys Acta. 2010 Sep;1799(9):622-9. doi: 10.1016/j.bbagrm.2010.09.003. Epub 2010 Sep 22.

39.

The renal H,K-ATPases.

Greenlee MM, Lynch IJ, Gumz ML, Cain BD, Wingo CS.

Curr Opin Nephrol Hypertens. 2010 Sep;19(5):478-82. doi: 10.1097/MNH.0b013e32833ce65f. Review.

PMID:
20616716
40.

Pharmacological profiles of the murine gastric and colonic H,K-ATPases.

Shao J, Gumz ML, Cain BD, Xia SL, Shull GE, van Driel IR, Wingo CS.

Biochim Biophys Acta. 2010 Sep;1800(9):906-11. doi: 10.1016/j.bbagen.2010.05.002. Epub 2010 May 25.

41.

Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.

Lynch IJ, Greenlee MM, Gumz ML, Rudin A, Xia SL, Wingo CS.

Am J Physiol Renal Physiol. 2010 Feb;298(2):F408-15. doi: 10.1152/ajprenal.00333.2009. Epub 2009 Nov 18.

42.

The renal H+-K+-ATPases: physiology, regulation, and structure.

Gumz ML, Lynch IJ, Greenlee MM, Cain BD, Wingo CS.

Am J Physiol Renal Physiol. 2010 Jan;298(1):F12-21. doi: 10.1152/ajprenal.90723.2008. Epub 2009 Jul 29. Review.

43.

Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).

Stow LR, Gumz ML, Lynch IJ, Greenlee MM, Rudin A, Cain BD, Wingo CS.

J Biol Chem. 2009 Oct 30;284(44):30087-96. doi: 10.1074/jbc.M109.030718. Epub 2009 Jul 28.

44.

The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.

Gumz ML, Stow LR, Lynch IJ, Greenlee MM, Rudin A, Cain BD, Weaver DR, Wingo CS.

J Clin Invest. 2009 Aug;119(8):2423-34. doi: 10.1172/JCI36908. Epub 2009 Jul 1.

45.

Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth.

Marlow LA, Reynolds LA, Cleland AS, Cooper SJ, Gumz ML, Kurakata S, Fujiwara K, Zhang Y, Sebo T, Grant C, McIver B, Wadsworth JT, Radisky DC, Smallridge RC, Copland JA.

Cancer Res. 2009 Feb 15;69(4):1536-44. doi: 10.1158/0008-5472.CAN-08-3718. Epub 2009 Feb 10.

46.

Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.

Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA.

Clin Cancer Res. 2007 Aug 15;13(16):4740-9.

47.

The renal H+, K+-ATPases as therapeutic targets.

Zies DL, Gumz ML, Wingo CS, Cain BD.

Expert Opin Ther Targets. 2007 Jul;11(7):881-90. Review.

PMID:
17614757
48.

Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.

Copland JA, Marlow LA, Williams SF, Grebe SK, Gumz ML, Maples WJ, Silverman VE, Smallridge RC.

Thyroid. 2006 Dec;16(12):1293-302.

PMID:
17199440
49.

Characterization of the rabbit HKalpha2 gene promoter.

Zies DL, Gumz ML, Wingo CS, Cain BD.

Biochim Biophys Acta. 2006 Oct;1759(10):443-50. Epub 2006 Sep 12.

50.

Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.

Gumz ML, Duda D, McKenna R, Wingo CS, Cain BD.

J Mol Model. 2003 Oct;9(5):283-9. Epub 2003 Jul 22.

PMID:
12884085

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