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Items: 1 to 50 of 103

1.

Microengineered human amniotic ectoderm tissue array for high-content developmental phenotyping.

Nasr Esfahani S, Shao Y, Resto Irizarry AM, Li Z, Xue X, Gumucio DL, Fu J.

Biomaterials. 2019 Sep;216:119244. doi: 10.1016/j.biomaterials.2019.119244. Epub 2019 Jun 7.

PMID:
31207406
2.

Signals and forces shaping organogenesis of the small intestine.

Wang S, Walton KD, Gumucio DL.

Curr Top Dev Biol. 2019;132:31-65. doi: 10.1016/bs.ctdb.2018.12.001. Epub 2019 Jan 2.

PMID:
30797512
3.

Opening the black box: Stem cell-based modeling of human post-implantation development.

Taniguchi K, Heemskerk I, Gumucio DL.

J Cell Biol. 2019 Feb 4;218(2):410-421. doi: 10.1083/jcb.201810084. Epub 2018 Dec 14. Review.

PMID:
30552099
4.

Radial WNT5A-Guided Post-mitotic Filopodial Pathfinding Is Critical for Midgut Tube Elongation.

Wang S, Cebrian C, Schnell S, Gumucio DL.

Dev Cell. 2018 Jul 16;46(2):173-188.e3. doi: 10.1016/j.devcel.2018.06.011.

5.

Blueprint for an intestinal villus: Species-specific assembly required.

Walton KD, Mishkind D, Riddle MR, Tabin CJ, Gumucio DL.

Wiley Interdiscip Rev Dev Biol. 2018 Jul;7(4):e317. doi: 10.1002/wdev.317. Epub 2018 Mar 7. Review.

6.

Indian Hedgehog Suppresses Intestinal Inflammation.

Razumilava N, Gumucio DL, Samuelson LC, Shah YM, Nusrat A, Merchant JL.

Cell Mol Gastroenterol Hepatol. 2017 Oct 31;5(1):63-64. doi: 10.1016/j.jcmgh.2017.10.003. eCollection 2018. No abstract available.

7.

An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.

Taniguchi K, Shao Y, Townshend RF, Cortez CL, Harris CE, Meshinchi S, Kalantry S, Fu J, O'Shea KS, Gumucio DL.

J Cell Biol. 2017 Dec 4;216(12):3981-3990. doi: 10.1083/jcb.201704085. Epub 2017 Oct 11.

8.

A pluripotent stem cell-based model for post-implantation human amniotic sac development.

Shao Y, Taniguchi K, Townshend RF, Miki T, Gumucio DL, Fu J.

Nat Commun. 2017 Aug 8;8(1):208. doi: 10.1038/s41467-017-00236-w.

9.

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche.

Shao Y, Taniguchi K, Gurdziel K, Townshend RF, Xue X, Yong KMA, Sang J, Spence JR, Gumucio DL, Fu J.

Nat Mater. 2017 Apr;16(4):419-425. doi: 10.1038/nmat4829. Epub 2016 Dec 12.

10.

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.

Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP.

Development. 2016 Oct 15;143(20):3711-3722.

11.

Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding.

Freddo AM, Shoffner SK, Shao Y, Taniguchi K, Grosse AS, Guysinger MN, Wang S, Rudraraju S, Margolis B, Garikipati K, Schnell S, Gumucio DL.

Integr Biol (Camb). 2016 Sep 12;8(9):918-28. doi: 10.1039/c6ib00046k. Epub 2016 Aug 1.

12.

Generation of intestinal surface: an absorbing tale.

Walton KD, Freddo AM, Wang S, Gumucio DL.

Development. 2016 Jul 1;143(13):2261-72. doi: 10.1242/dev.135400. Review.

13.

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.

Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL.

Dev Dyn. 2016 May;245(5):614-26. doi: 10.1002/dvdy.24399. Epub 2016 Mar 17.

14.

Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway.

Gurdziel K, Vogt KR, Schneider G, Richards N, Gumucio DL.

BMC Dev Biol. 2016 Feb 24;16:4. doi: 10.1186/s12861-016-0106-0.

15.

Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways.

Syu LJ, Zhao X, Zhang Y, Grachtchouk M, Demitrack E, Ermilov A, Wilbert DM, Zheng X, Kaatz A, Greenson JK, Gumucio DL, Merchant JL, di Magliano MP, Samuelson LC, Dlugosz AA.

Oncotarget. 2016 Mar 1;7(9):10255-70. doi: 10.18632/oncotarget.7182.

16.

Villification in the mouse: Bmp signals control intestinal villus patterning.

Walton KD, Whidden M, Kolterud Å, Shoffner SK, Czerwinski MJ, Kushwaha J, Parmar N, Chandhrasekhar D, Freddo AM, Schnell S, Gumucio DL.

Development. 2016 Feb 1;143(3):427-36. doi: 10.1242/dev.130112. Epub 2015 Dec 31.

17.

Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density.

Gurdziel K, Lorberbaum DS, Udager AM, Song JY, Richards N, Parker DS, Johnson LA, Allen BL, Barolo S, Gumucio DL.

PLoS One. 2015 Dec 28;10(12):e0145225. doi: 10.1371/journal.pone.0145225. eCollection 2015.

18.

Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells.

Taniguchi K, Shao Y, Townshend RF, Tsai YH, DeLong CJ, Lopez SA, Gayen S, Freddo AM, Chue DJ, Thomas DJ, Spence JR, Margolis B, Kalantry S, Fu J, O'Shea KS, Gumucio DL.

Stem Cell Reports. 2015 Dec 8;5(6):954-962. doi: 10.1016/j.stemcr.2015.10.015. Epub 2015 Nov 25.

19.

Roles for Nkx2-5 and Gata3 in the ontogeny of the murine smooth muscle gastric ligaments.

Prakash A, Udager AM, Saenz DA, Gumucio DL.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G430-6. doi: 10.1152/ajpgi.00360.2013. Epub 2014 Jun 26.

20.

Crumbs3 is essential for proper epithelial development and viability.

Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B.

Mol Cell Biol. 2014 Jan;34(1):43-56. doi: 10.1128/MCB.00999-13. Epub 2013 Oct 28.

21.

Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.

Udager AM, Prakash A, Saenz DA, Schinke M, Moriguchi T, Jay PY, Lim KC, Engel JD, Gumucio DL.

Gastroenterology. 2014 Jan;146(1):157-165.e10. doi: 10.1053/j.gastro.2013.10.008. Epub 2013 Oct 9.

22.

Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance.

Liu HX, Ermilov A, Grachtchouk M, Li L, Gumucio DL, Dlugosz AA, Mistretta CM.

Dev Biol. 2013 Oct 1;382(1):82-97. doi: 10.1016/j.ydbio.2013.07.022. Epub 2013 Aug 2.

23.

Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice.

Sun Y, Zhang M, Chen CC, Gillilland M 3rd, Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY.

Gastroenterology. 2013 Jun;144(7):1478-87, 1487.e1-8. doi: 10.1053/j.gastro.2013.02.038. Epub 2013 Mar 5.

24.

Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia.

Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson LC, Dlugosz AA.

Am J Pathol. 2012 Dec;181(6):2114-25. doi: 10.1016/j.ajpath.2012.08.017. Epub 2012 Oct 1.

25.

Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi.

Walton KD, Kolterud A, Czerwinski MJ, Bell MJ, Prakash A, Kushwaha J, Grosse AS, Schnell S, Gumucio DL.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15817-22. Epub 2012 Sep 10.

26.

Villin-marked gastric progenitor cells: conveyors or purveyors of precancerous change?

Gumucio DL, Katz JP.

Gastroenterology. 2012 Mar;142(3):424-8. doi: 10.1053/j.gastro.2012.01.012. Epub 2012 Jan 25. No abstract available.

PMID:
22285359
27.

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud Å, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC.

Development. 2012 Feb;139(3):488-97. doi: 10.1242/dev.070763. Epub 2011 Dec 21.

28.

Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.

Liu HX, Grosse AS, Iwatsuki K, Mishina Y, Gumucio DL, Mistretta CM.

Dev Biol. 2012 Jan 1;361(1):39-56. doi: 10.1016/j.ydbio.2011.10.009. Epub 2011 Oct 15.

29.

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.

Grosse AS, Pressprich MF, Curley LB, Hamilton KL, Margolis B, Hildebrand JD, Gumucio DL.

Development. 2011 Oct;138(20):4423-32. doi: 10.1242/dev.065789. Epub 2011 Aug 31.

30.

Gastric tuft cells express DCLK1 and are expanded in hyperplasia.

Saqui-Salces M, Keeley TM, Grosse AS, Qiao XT, El-Zaatari M, Gumucio DL, Samuelson LC, Merchant JL.

Histochem Cell Biol. 2011 Aug;136(2):191-204. doi: 10.1007/s00418-011-0831-1. Epub 2011 Jun 18.

31.

Current molecular markers for gastric progenitor cells and gastric cancer stem cells.

Qiao XT, Gumucio DL.

J Gastroenterol. 2011 Jul;46(7):855-65. doi: 10.1007/s00535-011-0413-y. Epub 2011 Jun 1. Review.

PMID:
21626457
32.

Hedgehog signaling controls homeostasis of adult intestinal smooth muscle.

Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X, Gumucio DL.

Dev Biol. 2011 Jul 1;355(1):152-62. doi: 10.1016/j.ydbio.2011.04.025. Epub 2011 Apr 28.

33.

Dividing the tubular gut: generation of organ boundaries at the pylorus.

Udager A, Prakash A, Gumucio DL.

Prog Mol Biol Transl Sci. 2010;96:35-62. doi: 10.1016/B978-0-12-381280-3.00002-6. Review.

PMID:
21075339
34.

p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice.

Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ, Reynolds AB.

J Clin Invest. 2010 Jun;120(6):1824-35. doi: 10.1172/JCI41414. Epub 2010 May 17.

35.

Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria.

Zacharias WJ, Li X, Madison BB, Kretovich K, Kao JY, Merchant JL, Gumucio DL.

Gastroenterology. 2010 Jun;138(7):2368-77, 2377.e1-4. doi: 10.1053/j.gastro.2010.02.057. Epub 2010 Mar 3.

36.

Kinetic properties of ASC protein aggregation in epithelial cells.

Cheng J, Waite AL, Tkaczyk ER, Ke K, Richards N, Hunt AJ, Gumucio DL.

J Cell Physiol. 2010 Mar;222(3):738-47. doi: 10.1002/jcp.22005.

37.

Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life.

Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL.

Dev Dyn. 2009 Dec;238(12):3205-17. doi: 10.1002/dvdy.22134.

38.

WNT5a in tongue and fungiform Papilla development.

Liu HX, Grosse AM, Walton KD, Saims DA, Gumucio DL, Mistretta CM.

Ann N Y Acad Sci. 2009 Jul;1170:11-7. doi: 10.1111/j.1749-6632.2009.04369.x.

39.

Pyrin Modulates the Intracellular Distribution of PSTPIP1.

Waite AL, Schaner P, Richards N, Balci-Peynircioglu B, Masters SL, Brydges SD, Fox M, Hong A, Yilmaz E, Kastner DL, Reinherz EL, Gumucio DL.

PLoS One. 2009 Jul 7;4(7):e6147. doi: 10.1371/journal.pone.0006147.

40.

Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin.

Gudjonsson JE, Ding J, Li X, Nair RP, Tejasvi T, Qin ZS, Ghosh D, Aphale A, Gumucio DL, Voorhees JJ, Abecasis GR, Elder JT.

J Invest Dermatol. 2009 Dec;129(12):2795-804. doi: 10.1038/jid.2009.173. Epub 2009 Jul 2.

41.

Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.

Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL.

Gastroenterology. 2009 Aug;137(2):618-28. doi: 10.1053/j.gastro.2009.05.002. Epub 2009 May 13.

42.

Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin.

Waite AL, Schaner P, Hu C, Richards N, Balci-Peynircioglu B, Hong A, Fox M, Gumucio DL.

Exp Biol Med (Maywood). 2009 Jan;234(1):40-52. doi: 10.3181/0806-RM-184.

PMID:
19109554
43.

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

Lees CW, Zacharias WJ, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Torkvist L, Kao J, Farrington S, Drummond HE, Ho GT, Arnott ID, Appelman HD, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SE, Gumucio DL, Satsangi J.

PLoS Med. 2008 Dec 9;5(12):e239. doi: 10.1371/journal.pmed.0050239.

44.
45.

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.

Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL.

Blood. 2008 Sep 1;112(5):1794-803. doi: 10.1182/blood-2008-01-134932. Epub 2008 Jun 24.

46.

Tissue stem cells and cancer stem cells: potential implications for gastric cancer.

Gumucio DL, Fagoonee S, Qiao XT, Liebert M, Merchant JL, Altruda F, Rizzetto M, Pellicano R.

Panminerva Med. 2008 Mar;50(1):65-71. Review.

PMID:
18427389
47.

Specific overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development.

Yang H, Madison B, Gumucio DL, Teitelbaum DH.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1421-30. doi: 10.1152/ajpgi.00060.2008. Epub 2008 Apr 10.

48.

Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva.

Balci-Peynircioglu B, Waite AL, Hu C, Richards N, Staubach-Grosse A, Yilmaz E, Gumucio DL.

J Cell Physiol. 2008 Sep;216(3):595-602. doi: 10.1002/jcp.21435.

49.

Prospective identification of a multilineage progenitor in murine stomach epithelium.

Qiao XT, Ziel JW, McKimpson W, Madison BB, Todisco A, Merchant JL, Samuelson LC, Gumucio DL.

Gastroenterology. 2007 Dec;133(6):1989-98.

50.

Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate.

López-Díaz L, Jain RN, Keeley TM, VanDussen KL, Brunkan CS, Gumucio DL, Samuelson LC.

Dev Biol. 2007 Sep 15;309(2):298-305. Epub 2007 Jul 24.

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