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Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice.

Macke EL, Henningsen E, Jessen E, Zumwalde NA, Landowski M, Western DE, Lee WH, Liu C, Gruenke NP, Doebley AL, Miller S, Pattnaik B, Ikeda S, Gumperz JE, Ikeda A.

Genetics. 2020 Jan;214(1):121-134. doi: 10.1534/genetics.119.302834. Epub 2019 Nov 21.


Expansion and Adoptive Transfer of Human Vδ2+ T Cells to Assess Antitumor Effects In Vivo.

Sharma A, Zumwalde NA, Gumperz JE.

Methods Mol Biol. 2019;1884:57-72. doi: 10.1007/978-1-4939-8885-3_4.


Mucosal associated invariant T cells from human breast ducts mediate a Th17-skewed response to bacterially exposed breast carcinoma cells.

Zumwalde NA, Haag JD, Gould MN, Gumperz JE.

Breast Cancer Res. 2018 Sep 12;20(1):111. doi: 10.1186/s13058-018-1036-5.


LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes.

Sharma A, Lawry SM, Klein BS, Wang X, Sherer NM, Zumwalde NA, Gumperz JE.

J Immunol. 2018 Oct 15;201(8):2452-2461. doi: 10.4049/jimmunol.1800537. Epub 2018 Aug 31.


Modeling Human Antitumor Responses In Vivo Using Umbilical Cord Blood-Engrafted Mice.

Zumwalde NA, Gumperz JE.

Front Immunol. 2018 Jan 26;9:54. doi: 10.3389/fimmu.2018.00054. eCollection 2018. Review.


Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model.

Zumwalde NA, Sharma A, Xu X, Ma S, Schneider CL, Romero-Masters JC, Hudson AW, Gendron-Fitzpatrick A, Kenney SC, Gumperz JE.

JCI Insight. 2017 Jul 6;2(13). pii: 93179. doi: 10.1172/jci.insight.93179. eCollection 2017 Jul 6.


Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs.

Xu X, Pocock GM, Sharma A, Peery SL, Fites JS, Felley L, Zarnowski R, Stewart D, Berthier E, Klein BS, Sherer NM, Gumperz JE.

Cell Rep. 2016 Sep 20;16(12):3273-3285. doi: 10.1016/j.celrep.2016.08.061.


Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway.

Felley LE, Sharma A, Theisen E, Romero-Masters JC, Sauer JD, Gumperz JE.

J Immunol. 2016 Sep 15;197(6):2455-64. doi: 10.4049/jimmunol.1600790. Epub 2016 Aug 17.


Are human iNKT cells keeping tabs on lipidome perturbations triggered by oxidative stress in the blood?

Felley L, Gumperz JE.

Immunogenetics. 2016 Aug;68(8):611-22. doi: 10.1007/s00251-016-0936-8. Epub 2016 Jul 8. Review.


PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

Ma SD, Xu X, Jones R, Delecluse HJ, Zumwalde NA, Sharma A, Gumperz JE, Kenney SC.

PLoS Pathog. 2016 May 17;12(5):e1005642. doi: 10.1371/journal.ppat.1005642. eCollection 2016 May.


Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate.

Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE.

Cancer Prev Res (Phila). 2016 Apr;9(4):305-16. doi: 10.1158/1940-6207.CAPR-15-0370-T. Epub 2016 Jan 25.


LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.

Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC.

J Clin Invest. 2015 Jan;125(1):304-15. doi: 10.1172/JCI76357. Epub 2014 Dec 8.


Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers.

Bishop KA, Wang X, Coy HM, Meyer MB, Gumperz JE, Pike JW.

J Cell Biochem. 2015 Feb;116(2):320-30. doi: 10.1002/jcb.24974.


Expression of CD1c enhances human invariant NKT cell activation by α-GalCer.

Fox LM, Miksanek J, May NA, Scharf L, Lockridge JL, Veerapen N, Besra GS, Adams EJ, Hudson AW, Gumperz JE.

Cancer Immun. 2013 May 10;13:9. Print 2013.


Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease.

Lockridge JL, Zhou Y, Becker YA, Ma S, Kenney SC, Hematti P, Capitini CM, Burlingham WJ, Gendron-Fitzpatrick A, Gumperz JE.

Biol Blood Marrow Transplant. 2013 Sep;19(9):1310-22. doi: 10.1016/j.bbmt.2013.06.007. Epub 2013 Jun 24.


An Epstein-Barr Virus (EBV) mutant with enhanced BZLF1 expression causes lymphomas with abortive lytic EBV infection in a humanized mouse model.

Ma SD, Yu X, Mertz JE, Gumperz JE, Reinheim E, Zhou Y, Tang W, Burlingham WJ, Gulley ML, Kenney SC.

J Virol. 2012 Aug;86(15):7976-87. doi: 10.1128/JVI.00770-12. Epub 2012 May 23.


Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation.

Wang X, Bishop KA, Hegde S, Rodenkirch LA, Pike JW, Gumperz JE.

J Exp Med. 2012 May 7;209(5):987-1000. doi: 10.1084/jem.20111024. Epub 2012 Apr 16.


A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist.

Wiemer AJ, Hegde S, Gumperz JE, Huttenlocher A.

J Immunol. 2011 Oct 1;187(7):3663-70. doi: 10.4049/jimmunol.1100103. Epub 2011 Sep 7.


Analysis of the CD1 antigen presenting system in humanized SCID mice.

Lockridge JL, Chen X, Zhou Y, Rajesh D, Roenneburg DA, Hegde S, Gerdts S, Cheng TY, Anderson RJ, Painter GF, Moody DB, Burlingham WJ, Gumperz JE.

PLoS One. 2011;6(6):e21701. doi: 10.1371/journal.pone.0021701. Epub 2011 Jun 30.


Human NKT cells direct the differentiation of myeloid APCs that regulate T cell responses via expression of programmed cell death ligands.

Hegde S, Lockridge JL, Becker YA, Ma S, Kenney SC, Gumperz JE.

J Autoimmun. 2011 Aug;37(1):28-38. doi: 10.1016/j.jaut.2011.03.001. Epub 2011 Apr 12.


The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.

Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ.

Immunity. 2010 Dec 14;33(6):853-62. doi: 10.1016/j.immuni.2010.11.026.


A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas.

Ma SD, Hegde S, Young KH, Sullivan R, Rajesh D, Zhou Y, Jankowska-Gan E, Burlingham WJ, Sun X, Gulley ML, Tang W, Gumperz JE, Kenney SC.

J Virol. 2011 Jan;85(1):165-77. doi: 10.1128/JVI.01512-10. Epub 2010 Oct 27.


Natural killer T cells: innate lymphocytes positioned as a bridge between acute and chronic inflammation?

Fox L, Hegde S, Gumperz JE.

Microbes Infect. 2010 Dec;12(14-15):1125-33. doi: 10.1016/j.micinf.2010.08.011. Epub 2010 Sep 17. Review.


Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.

J Clin Invest. 2010 Aug;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1.


Autoreactive natural killer T cells: promoting immune protection and immune tolerance through varied interactions with myeloid antigen-presenting cells.

Hegde S, Fox L, Wang X, Gumperz JE.

Immunology. 2010 Aug;130(4):471-83. doi: 10.1111/j.1365-2567.2010.03293.x. Epub 2010 May 11. Review.


Recognition of lyso-phospholipids by human natural killer T lymphocytes.

Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, Trott DL, Ndonye RM, Veerapen N, Besra GS, Howell AR, Cook ME, Adams EJ, Hildebrand WH, Gumperz JE.

PLoS Biol. 2009 Oct;7(10):e1000228. doi: 10.1371/journal.pbio.1000228. Epub 2009 Oct 27.


Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.

Hegde S, Jankowska-Gan E, Roenneburg DA, Torrealba J, Burlingham WJ, Gumperz JE.

J Leukoc Biol. 2009 Oct;86(4):757-68. doi: 10.1189/jlb.0209059.


Natural killer T-cell autoreactivity leads to a specialized activation state.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE.

Blood. 2008 Nov 15;112(10):4128-38. doi: 10.1182/blood-2008-05-157529. Epub 2008 Sep 8.


Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop.

Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB.

Eur J Immunol. 2008 Jun;38(6):1756-66. doi: 10.1002/eji.200737389.


Serum lipids regulate dendritic cell CD1 expression and function.

Leslie DS, Dascher CC, Cembrola K, Townes MA, Hava DL, Hugendubler LC, Mueller E, Fox L, Roura-Mir C, Moody DB, Vincent MS, Gumperz JE, Illarionov PA, Besra GS, Reynolds CG, Brenner MB.

Immunology. 2008 Nov;125(3):289-301. doi: 10.1111/j.1365-2567.2008.02842.x. Epub 2008 Apr 28.


Modulation of CD1d-restricted NKT cell responses by CD4.

Chen X, Wang X, Besra GS, Gumperz JE.

J Leukoc Biol. 2007 Dec;82(6):1455-65. Epub 2007 Aug 28.


Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules.

Chen X, Wang X, Keaton JM, Reddington F, Illarionov PA, Besra GS, Gumperz JE.

J Immunol. 2007 May 15;178(10):6181-90.


NKT cells direct monocytes into a DC differentiation pathway.

Hegde S, Chen X, Keaton JM, Reddington F, Besra GS, Gumperz JE.

J Leukoc Biol. 2007 May;81(5):1224-35. Epub 2007 Feb 20.


Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors.

Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, Reddington F, Illarianov PA, Besra GS, Brenner MB, Gumperz JE.

J Immunol. 2006 Mar 15;176(6):3625-34.


Apolipoprotein-mediated pathways of lipid antigen presentation.

van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.

Nature. 2005 Oct 6;437(7060):906-10.


Regulation of CD1d expression and function by a herpesvirus infection.

Sanchez DJ, Gumperz JE, Ganem D.

J Clin Invest. 2005 May;115(5):1369-78.


Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds?

Gumperz JE.

Immunol Cell Biol. 2004 Jun;82(3):285-94. Review.


Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.

Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.

Nat Immunol. 2003 Dec;4(12):1230-7. Epub 2003 Oct 26.


Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.

Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB.

J Immunol. 2003 Oct 15;171(8):4149-55.


CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells.

Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB, Luster AD.

J Immunol. 2003 Sep 1;171(5):2571-80.


Understanding the function of CD1-restricted T cells.

Vincent MS, Gumperz JE, Brenner MB.

Nat Immunol. 2003 Jun;4(6):517-23. Review.


Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission.

Araki M, Kondo T, Gumperz JE, Brenner MB, Miyake S, Yamamura T.

Int Immunol. 2003 Feb;15(2):279-88.


CD1-dependent dendritic cell instruction.

Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.

Nat Immunol. 2002 Dec;3(12):1163-8. Epub 2002 Nov 4.


Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining.

Gumperz JE, Miyake S, Yamamura T, Brenner MB.

J Exp Med. 2002 Mar 4;195(5):625-36.


CD1-specific T cells in microbial immunity.

Gumperz JE, Brenner MB.

Curr Opin Immunol. 2001 Aug;13(4):471-8. Review.


Generation of HLA class I transfected target cell lines.

Gumperz JE.

Methods Mol Biol. 2000;121:49-60. Review. No abstract available.


Murine CD1d-restricted T cell recognition of cellular lipids.

Gumperz JE, Roy C, Makowska A, Lum D, Sugita M, Podrebarac T, Koezuka Y, Porcelli SA, Cardell S, Brenner MB, Behar SM.

Immunity. 2000 Feb;12(2):211-21.


Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.

Winter CC, Gumperz JE, Parham P, Long EO, Wagtmann N.

J Immunol. 1998 Jul 15;161(2):571-7.

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