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Items: 12

1.

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

Martínez-Hoyos M, Perez-Herran E, Gulten G, Encinas L, Álvarez-Gómez D, Alvarez E, Ferrer-Bazaga S, García-Pérez A, Ortega F, Angulo-Barturen I, Rullas-Trincado J, Blanco Ruano D, Torres P, Castañeda P, Huss S, Fernández Menéndez R, González Del Valle S, Ballell L, Barros D, Modha S, Dhar N, Signorino-Gelo F, McKinney JD, García-Bustos JF, Lavandera JL, Sacchettini JC, Jimenez MS, Martín-Casabona N, Castro-Pichel J, Mendoza-Losana A.

EBioMedicine. 2016 Jun;8:291-301. doi: 10.1016/j.ebiom.2016.05.006. Epub 2016 May 8.

2.

N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.

Guardia A, Gulten G, Fernandez R, Gómez J, Wang F, Convery M, Blanco D, Martínez M, Pérez-Herrán E, Alonso M, Ortega F, Rullás J, Calvo D, Mata L, Young R, Sacchettini JC, Mendoza-Losana A, Remuiñán M, Ballell Pages L, Castro-Pichel J.

ChemMedChem. 2016 Apr 5;11(7):687-701. doi: 10.1002/cmdc.201600020. Epub 2016 Mar 2.

PMID:
26934341
3.

Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach.

Kanetaka H, Koseki Y, Taira J, Umei T, Komatsu H, Sakamoto H, Gulten G, Sacchettini JC, Kitamura M, Aoki S.

Eur J Med Chem. 2015 Apr 13;94:378-85. doi: 10.1016/j.ejmech.2015.02.062. Epub 2015 Mar 5.

PMID:
25778993
4.

Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD.

Gulten G, Sacchettini JC.

Structure. 2013 Oct 8;21(10):1859-69. doi: 10.1016/j.str.2013.08.014. Epub 2013 Sep 19.

5.

Identification of compounds with potential antibacterial activity against Mycobacterium through structure-based drug screening.

Kinjo T, Koseki Y, Kobayashi M, Yamada A, Morita K, Yamaguchi K, Tsurusawa R, Gulten G, Komatsu H, Sakamoto H, Sacchettini JC, Kitamura M, Aoki S.

J Chem Inf Model. 2013 May 24;53(5):1200-12. doi: 10.1021/ci300571n. Epub 2013 Apr 19.

PMID:
23600706
6.

Breast, cervical, and colorectal cancer screening status of a group of Turkish women.

Gulten G, Memnun S, Ayse K, Aygul A, Gulcin A.

Asian Pac J Cancer Prev. 2012;13(9):4273-9.

7.

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.

Molle V, Gulten G, Vilchèze C, Veyron-Churlet R, Zanella-Cléon I, Sacchettini JC, Jacobs WR Jr, Kremer L.

Mol Microbiol. 2010 Dec;78(6):1591-605. doi: 10.1111/j.1365-2958.2010.07446.x. Epub 2010 Nov 9.

8.

Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

Wang F, Jain P, Gulten G, Liu Z, Feng Y, Ganesula K, Motiwala AS, Ioerger TR, Alland D, Vilchèze C, Jacobs WR Jr, Sacchettini JC.

Antimicrob Agents Chemother. 2010 Sep;54(9):3776-82. doi: 10.1128/AAC.00453-10. Epub 2010 Jun 21.

9.

Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.

Freundlich JS, Wang F, Vilchèze C, Gulten G, Langley R, Schiehser GA, Jacobus DP, Jacobs WR Jr, Sacchettini JC.

ChemMedChem. 2009 Feb;4(2):241-8. doi: 10.1002/cmdc.200800261.

10.

Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.

Wang F, Langley R, Gulten G, Wang L, Sacchettini JC.

Chem Biol. 2007 May;14(5):543-51.

11.

Mechanism of thioamide drug action against tuberculosis and leprosy.

Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR Jr, Sacchettini JC.

J Exp Med. 2007 Jan 22;204(1):73-8. Epub 2007 Jan 16.

12.

Phase separation in liquid crystalline mesophases of [Co(H2O)6]X2:P65 Systems (X = NO3-, Cl-, or ClO4-).

Albayrak C, Gülten G, Dag O.

Langmuir. 2007 Jan 16;23(2):855-60.

PMID:
17209644

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