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Items: 49


The pattern-recognition molecule mindin binds integrin Mac-1 to promote macrophage phagocytosis via Syk activation and NF-κB p65 translocation.

Liu YS, Wang LF, Cheng XS, Huo YN, Ouyang XM, Liang LY, Lin Y, Wu JF, Ren JL, Guleng B.

J Cell Mol Med. 2019 May;23(5):3402-3416. doi: 10.1111/jcmm.14236. Epub 2019 Mar 14.


miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner.

Shi Y, Huang X, Chen G, Wang Y, Liu Y, Xu W, Tang S, Guleng B, Liu J, Ren J.

BMC Cancer. 2019 Jan 7;19(1):14. doi: 10.1186/s12885-018-5247-z.


Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population.

Guo J, Huang J, Zhou Y, Zhou Y, Yu L, Li H, Hou L, Zhu L, Ge D, Zeng Y, Guleng B, Li Q.

BMC Genomics. 2018 Jul 16;19(1):538. doi: 10.1186/s12864-018-4906-4.


The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation.

Wang LF, Liu YS, Yang B, Li P, Cheng XS, Xiao CX, Liu JJ, Li S, Ren JL, Guleng B.

Oncogene. 2018 Feb 1;37(5):601-615. doi: 10.1038/onc.2017.359. Epub 2017 Oct 9.


Trefoil factor family 2 expression inhibits gastric cancer cell growth and invasion in vitro via interactions with the transcription factor Sp3.

Cai Y, Yi M, Chen D, Liu J, Guleng B, Ren J, Shi H.

Int J Mol Med. 2016 Nov;38(5):1474-1480. doi: 10.3892/ijmm.2016.2739. Epub 2016 Sep 19.


Dragon (RGMb) induces oxaliplatin resistance in colon cancer cells.

Shi Y, Huang XX, Chen GB, Wang Y, Zhi Q, Liu YS, Wu XL, Wang LF, Yang B, Xiao CX, Xing HQ, Ren JL, Xia Y, Guleng B.

Oncotarget. 2016 Jul 26;7(30):48027-48037. doi: 10.18632/oncotarget.10338.


Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma.

Hirotsu Y, Zheng TH, Amemiya K, Mochizuki H, Guleng B, Omata M.

Hepatol Res. 2016 Oct;46(11):1145-1151. doi: 10.1111/hepr.12663. Epub 2016 Mar 15.


Advances in Molecular Biomarkers for Gastric Cancer.

Zheng TH, Zhao JL, Guleng B.

Crit Rev Eukaryot Gene Expr. 2015;25(4):299-305. Review.


Immunopathogenesis of Colitis-Associated Cancer in an Animal Model.

Zhao JL, Xiao CX, Guleng B.

Crit Rev Eukaryot Gene Expr. 2015;25(3):245-51. Review.


Silencing ECHS1 attenuates the proliferation and induces the autophagy of hepatocellular carcinoma via impairing cell metabolism and activating AMPK.

Xu WJ, Chen LG, Chen X, Liu YS, Zheng TH, Song JJ, Xu W, Li P, Zhang MQ, Xiao CX, Guleng B, Ren JL.

Neoplasma. 2015;62(6):872-80. doi: 10.4149/neo_2015_106.


Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells.

Chen YL, Song JJ, Chen XC, Xu W, Zhi Q, Liu YP, Xu HZ, Pan JS, Ren JL, Guleng B.

World J Gastroenterol. 2015 Aug 14;21(30):9093-102. doi: 10.3748/wjg.v21.i30.9093.


Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth.

Shi Y, Chen GB, Huang XX, Xiao CX, Wang HH, Li YS, Zhang JF, Li S, Xia Y, Ren JL, Guleng B.

Oncotarget. 2015 Aug 21;6(24):20540-54.


Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.

Xiao CX, Xiao JJ, Xu HZ, Wang HH, Chen X, Liu YS, Li P, Shi Y, Nie YZ, Li S, Wu KC, Liu ZJ, Ren JL, Guleng B.

Sci Rep. 2015 May 22;5:10514. doi: 10.1038/srep10514.


miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner.

Shi Y, Chen GB, Huang QW, Chen X, Liu JJ, Xu W, Huang XX, Liu YP, Xiao CX, Wu DC, Guleng B, Ren JL.

Biochim Biophys Acta. 2015 May;1852(5):970-9. doi: 10.1016/j.bbadis.2015.01.016. Epub 2015 Jan 31.


Hepatitis B Virus-Related Hepatocellular Carcinoma: Pathogenic Mechanisms and Novel Therapeutic Interventions.

Xu HZ, Liu YP, Guleng B, Ren JL.

Gastrointest Tumors. 2014 Aug;1(3):135-45. doi: 10.1159/000365307. Epub 2014 Jul 18. Review.


ALDOB acts as a novel HBsAg-binding protein and its coexistence inhibits cisplatin-induced HepG2 cell apoptosis.

Wu J, Dan C, Zhao HB, Xiao CX, Liu YP, Si LJ, Ren JL, Guleng B.

Crit Rev Eukaryot Gene Expr. 2014;24(3):181-91.


Serum TFF3 may be a pharamcodynamic marker of responses to chemotherapy in gastrointestinal cancers.

Xiao L, Liu YP, Xiao CX, Ren JL, Guleng B.

BMC Clin Pathol. 2014 Jun 14;14:26. doi: 10.1186/1472-6890-14-26. eCollection 2014.


Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro.

Yang XN, Lu YP, Liu JJ, Huang JK, Liu YP, Xiao CX, Jazag A, Ren JL, Guleng B.

Dig Dis Sci. 2014 Jul;59(7):1428-35. doi: 10.1007/s10620-014-3044-3. Epub 2014 May 6.


miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.

Liu J, Wang X, Yang X, Liu Y, Shi Y, Ren J, Guleng B.

Cancer Lett. 2014 May 28;347(1):98-104. doi: 10.1016/j.canlet.2014.01.024. Epub 2014 Jan 31.


Exome sequencing revealed novel germline mutations in Chinese Peutz-Jeghers syndrome patients.

Wang HH, Xie NN, Li QY, Hu YQ, Ren JL, Guleng B.

Dig Dis Sci. 2014 Jan;59(1):64-71. doi: 10.1007/s10620-013-2875-7. Epub 2013 Oct 24.


Distribution of bone-marrow-derived endothelial and immune cells in a murine colitis-associated colorectal cancer model.

Xiao CX, Wang HH, Shi Y, Li P, Liu YP, Ren JL, Guleng B.

PLoS One. 2013 Sep 10;8(9):e73666. doi: 10.1371/journal.pone.0073666. eCollection 2013.


Silencing of Pokemon enhances caspase-dependent apoptosis via fas- and mitochondria-mediated pathways in hepatocellular carcinoma cells.

Zhang YQ, Xiao CX, Lin BY, Shi Y, Liu YP, Liu JJ, Guleng B, Ren JL.

PLoS One. 2013 Jul 17;8(7):e68981. doi: 10.1371/journal.pone.0068981. Print 2013.


Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells.

Wang LY, Liu YP, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL, Guleng B.

PLoS One. 2013 Jun 28;8(6):e67542. doi: 10.1371/journal.pone.0067542. Print 2013.


The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway.

Lin CC, Zhou JP, Liu YP, Liu JJ, Yang XN, Jazag A, Zhang ZP, Guleng B, Ren JL.

PLoS One. 2012;7(12):e51916. doi: 10.1371/journal.pone.0051916. Epub 2012 Dec 26.


Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation.

Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC.

Immunity. 2013 Jan 24;38(1):153-65. doi: 10.1016/j.immuni.2012.09.018. Epub 2012 Dec 13.


ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells.

Xiao CX, Yang XN, Huang QW, Zhang YQ, Lin BY, Liu JJ, Liu YP, Jazag A, Guleng B, Ren JL.

Cancer Lett. 2013 Mar 1;330(1):67-73. doi: 10.1016/j.canlet.2012.11.030. Epub 2012 Nov 23.


The regulation of trefoil factor 2 expression by the transcription factor Sp3.

Liu J, Wang X, Cai Y, Zhou J, Guleng B, Shi H, Ren J.

Biochem Biophys Res Commun. 2012 Oct 19;427(2):410-4. doi: 10.1016/j.bbrc.2012.09.078. Epub 2012 Sep 21.


HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression.

Liu YP, Yang XN, Jazag A, Pan JS, Hu TH, Liu JJ, Guleng B, Ren JL.

PLoS One. 2012;7(5):e36914. doi: 10.1371/journal.pone.0036914. Epub 2012 May 15.


Aplasia ras homolog member I is downregulated in gastric cancer and silencing its expression promotes cell growth in vitro.

Tang HL, Hu YQ, Qin XP, Jazag A, Yang H, Yang YX, Yang XN, Liu JJ, Chen JM, Guleng B, Ren JL.

J Gastroenterol Hepatol. 2012 Aug;27(8):1395-404. doi: 10.1111/j.1440-1746.2012.07146.x.


Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC.

Inflamm Bowel Dis. 2012 Apr;18(4):603-12. doi: 10.1002/ibd.21851. Epub 2011 Sep 1.


TFF3 mediated induction of VEGF via hypoxia in human gastric cancer SGC-7901 cells.

Guleng B, Han J, Yang JQ, Huang QW, Huang JK, Yang XN, Liu JJ, Ren JL.

Mol Biol Rep. 2012 Apr;39(4):4127-34. doi: 10.1007/s11033-011-1195-2. Epub 2011 Jul 17.


Small molecule tyrosine kinase inhibitors for the treatment of intestinal inflammation.

Sidhu M, Cotoner CA, Guleng B, Arihiro S, Chang S, Duncan KW, Ajami AM, Chau M, Reinecker HC.

Inflamm Bowel Dis. 2011 Dec;17(12):2416-26. doi: 10.1002/ibd.21646. Epub 2011 Mar 21.


Artificial liver support system in treatment of liver failure after acute poisoning.

Chen LG, Guleng B, Ren JL, Chen JM, Wang L.

World J Emerg Med. 2011;2(4):283-6. doi: 10.5847/wjem.j.1920-8642.2011.04.007.


Mindin is upregulated during colitis and may activate NF-kappaB in a TLR-9 mediated manner.

Guleng B, Lian YM, Ren JL.

World J Gastroenterol. 2010 Mar 7;16(9):1070-5.


Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.

Chang JH, Kato N, Muroyama R, Taniguchi H, Guleng B, Dharel N, Shao RX, Tateishi K, Jazag A, Kawabe T, Omata M.

Liver Int. 2010 Feb;30(2):311-8. doi: 10.1111/j.1478-3231.2009.02144.x. Epub 2009 Oct 16.


Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity.

Guleng B, Tateishi K, Ohta M, Asaoka Y, Jazag A, Lin LJ, Tanaka Y, Tada M, Seto M, Kanai F, Kawabe T, Omata M.

J Gastroenterol. 2006 Dec;41(12):1238-9. Epub 2007 Feb 6. No abstract available.


Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract.

Tateishi K, Ohta M, Kanai F, Guleng B, Tanaka Y, Asaoka Y, Tada M, Seto M, Jazag A, Lianjie L, Okamoto M, Isayama H, Tada M, Yoshida H, Kawabe T, Omata M.

Clin Cancer Res. 2006 Dec 1;12(23):6960-6.


Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.

Shao RX, Kato N, Lin LJ, Muroyama R, Moriyama M, Ikenoue T, Watabe H, Otsuka M, Guleng B, Ohta M, Tanaka Y, Kondo S, Dharel N, Chang JH, Yoshida H, Kawabe T, Omata M.

Oncogene. 2007 Mar 29;26(14):2133-5. Epub 2006 Oct 2.


TRAIL-induced cell death cooperates with IFN-gamma activation in the graft-versus-tumor effect against colon tumors.

Tateishi K, Ohta M, Guleng B, Kanai F, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Imamura T, Ijichi H, Ikenoue T, Kawakami T, Fukushima Y, Washida M, Sata M, Miyagishi M, Taira K, Yoshida H, Kawabe T, Omata M.

Int J Cancer. 2006 May 1;118(9):2237-46.


Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients.

Tanaka Y, Kanai F, Tada M, Asaoka Y, Guleng B, Jazag A, Ohta M, Ikenoue T, Tateishi K, Obi S, Kawabe T, Yokosuka O, Omata M.

Oncogene. 2006 May 11;25(20):2950-2.


p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.

Ohta M, Tateishi K, Kanai F, Watabe H, Kondo S, Guleng B, Tanaka Y, Asaoka Y, Jazag A, Imamura J, Ijichi H, Ikenoue T, Sata M, Miyagishi M, Taira K, Tada M, Kawabe T, Omata M.

Cancer Res. 2005 Dec 1;65(23):10822-9.


The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1.

Tanaka Y, Kanai F, Ichimura T, Tateishi K, Asaoka Y, Guleng B, Jazag A, Ohta M, Imamura J, Ikenoue T, Ijichi H, Kawabe T, Isobe T, Omata M.

Oncogene. 2006 Jan 26;25(4):633-42.


Cancer-derived VEGF plays no role in malignant ascites formation in the mouse.

Guleng B, Tateishi K, Kanai F, Jazag A, Ohta M, Asaoka Y, Ijichi H, Tanaka Y, Imamura J, Ikenoue T, Fukushima Y, Morikane K, Miyagishi M, Taira K, Kawabe T, Omata M.

World J Gastroenterol. 2005 Sep 21;11(35):5455-9.


Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components.

Jazag A, Kanai F, Ijichi H, Tateishi K, Ikenoue T, Tanaka Y, Ohta M, Imamura J, Guleng B, Asaoka Y, Kawabe T, Miyagishi M, Taira K, Omata M.

Nucleic Acids Res. 2005 Aug 19;33(15):e131.


Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner.

Guleng B, Tateishi K, Ohta M, Kanai F, Jazag A, Ijichi H, Tanaka Y, Washida M, Morikane K, Fukushima Y, Yamori T, Tsuruo T, Kawabe T, Miyagishi M, Taira K, Sata M, Omata M.

Cancer Res. 2005 Jul 1;65(13):5864-71.


Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice.

Ohta M, Tateishi K, Kanai F, Ueha S, Guleng B, Washida M, Tanaka Y, Ijichi H, Ikenoue T, Sata M, Sudo T, Shiina S, Kawabe T, Matsushima K, Omata M.

Eur J Immunol. 2005 Jul;35(7):2210-21.


Functional analysis of PIK3CA gene mutations in human colorectal cancer.

Ikenoue T, Kanai F, Hikiba Y, Obata T, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Tateishi K, Asaoka Y, Matsumura M, Kawabe T, Omata M.

Cancer Res. 2005 Jun 1;65(11):4562-7.


Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers.

Ikenoue T, Kanai F, Hikiba Y, Tanaka Y, Imamura J, Ohta M, Jazag A, Guleng B, Asaoka Y, Tateishi K, Kawakami T, Matsumura M, Kawabe T, Omata M.

Mol Carcinog. 2005 May;43(1):59-63.


Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta.

Jazag A, Ijichi H, Kanai F, Imamura T, Guleng B, Ohta M, Imamura J, Tanaka Y, Tateishi K, Ikenoue T, Kawakami T, Arakawa Y, Miyagishi M, Taira K, Kawabe T, Omata M.

Oncogene. 2005 Jan 20;24(4):662-71.


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