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Items: 30


Des mécanismes moléculaires aux applications cliniques. L’essentiel du Colloque Réplication-Réparation-Recombinaison 2019.

Lambert S, Borde V, Charbonnier JB, Dantzer F, Espéli O, Guirouilh-Barbat J, Llorente B, Legube G, Prioleau MN, Radicella P.

Bull Cancer. 2020 Jan 31. pii: S0007-4551(20)30006-0. doi: 10.1016/j.bulcan.2020.01.003. [Epub ahead of print] French. No abstract available.


Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.

Petitalot A, Dardillac E, Jacquet E, Nhiri N, Guirouilh-Barbat J, Julien P, Bouazzaoui I, Bonte D, Feunteun J, Schnell JA, Lafitte P, Aude JC, Noguès C, Rouleau E, Lidereau R, Lopez BS, Zinn-Justin S, Caputo SM; UNICANCER Genetic Group BRCA network.

Mol Cancer Res. 2019 Jan;17(1):54-69. doi: 10.1158/1541-7786.MCR-17-0357. Epub 2018 Sep 26.


The Cohesion complex maintains genome stability by preventing end joining of distant DNA ends in S phase.

Gelot C, Guirouilh-Barbat J, Lopez BS.

Mol Cell Oncol. 2018 Apr 19;5(3):e1154123. doi: 10.1080/23723556.2016.1154123. eCollection 2018.


Combined therapy of colon carcinomas with an oncolytic adenovirus and valproic acid.

Bressy C, Majhen D, Raddi N, Jdey W, Cornilleau G, Zig L, Guirouilh-Barbat J, Lopez BS, Bawa O, Opolon P, Grellier E, Benihoud K.

Oncotarget. 2017 Oct 26;8(57):97344-97360. doi: 10.18632/oncotarget.22107. eCollection 2017 Nov 14.


PARP2 controls double-strand break repair pathway choice by limiting 53BP1 accumulation at DNA damage sites and promoting end-resection.

Fouquin A, Guirouilh-Barbat J, Lopez B, Hall J, Amor-Guéret M, Pennaneach V.

Nucleic Acids Res. 2017 Dec 1;45(21):12325-12339. doi: 10.1093/nar/gkx881.


Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells.

So A, Le Guen T, Lopez BS, Guirouilh-Barbat J.

FEBS J. 2017 Aug;284(15):2324-2344. doi: 10.1111/febs.14053. Epub 2017 Mar 22. Review.


53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks.

Guirouilh-Barbat J, Gelot C, Xie A, Dardillac E, Scully R, Lopez BS.

PLoS Genet. 2016 Oct 31;12(10):e1006230. doi: 10.1371/journal.pgen.1006230. eCollection 2016 Oct.


The cohesin complex prevents the end-joining of distant DNA double-strand ends in S phase: Consequences on genome stability maintenance.

Gelot C, Guirouilh-Barbat J, Lopez BS.

Nucleus. 2016 Jul 3;7(4):339-45. doi: 10.1080/19491034.2016.1194159. Epub 2016 Jun 21. Review.


The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends.

Gelot C, Guirouilh-Barbat J, Le Guen T, Dardillac E, Chailleux C, Canitrot Y, Lopez BS.

Mol Cell. 2016 Jan 7;61(1):15-26. doi: 10.1016/j.molcel.2015.11.002. Epub 2015 Dec 10.


Control of alternative end joining by the chromatin remodeler p400 ATPase.

Taty-Taty GC, Chailleux C, Quaranta M, So A, Guirouilh-Barbat J, Lopez BS, Bertrand P, Trouche D, Canitrot Y.

Nucleic Acids Res. 2016 Feb 29;44(4):1657-68. doi: 10.1093/nar/gkv1202. Epub 2015 Nov 17.


Role of the double-strand break repair pathway in the maintenance of genomic stability.

Le Guen T, Ragu S, Guirouilh-Barbat J, Lopez BS.

Mol Cell Oncol. 2014 Oct 30;2(1):e968020. doi: 10.4161/23723548.2014.968020. eCollection 2015 Jan-Mar. Review.


Is homologous recombination really an error-free process?

Guirouilh-Barbat J, Lambert S, Bertrand P, Lopez BS.

Front Genet. 2014 Jun 11;5:175. doi: 10.3389/fgene.2014.00175. eCollection 2014. Review.


RhoB promotes γH2AX dephosphorylation and DNA double-strand break repair.

Mamouni K, Cristini A, Guirouilh-Barbat J, Monferran S, Lemarié A, Faye JC, Lopez BS, Favre G, Sordet O.

Mol Cell Biol. 2014 Aug;34(16):3144-55. doi: 10.1128/MCB.01525-13. Epub 2014 Jun 9.


PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.

Beck C, Boehler C, Guirouilh Barbat J, Bonnet ME, Illuzzi G, Ronde P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin FD, Schreiber V, Dantzer F.

Nucleic Acids Res. 2014 May;42(9):5616-32. doi: 10.1093/nar/gku174. Epub 2014 Mar 5.


A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining.

Grabarz A, Guirouilh-Barbat J, Barascu A, Pennarun G, Genet D, Rass E, Germann SM, Bertrand P, Hickson ID, Lopez BS.

Cell Rep. 2013 Oct 17;5(1):21-8. doi: 10.1016/j.celrep.2013.08.034. Epub 2013 Oct 3.


The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response.

Lemaître C, Fischer B, Kalousi A, Hoffbeck AS, Guirouilh-Barbat J, Shahar OD, Genet D, Goldberg M, Betrand P, Lopez B, Brino L, Soutoglou E.

Oncogene. 2012 Nov 8;31(45):4803-9. doi: 10.1038/onc.2011.638. Epub 2012 Jan 16.


Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes.

Laulier C, Barascu A, Guirouilh-Barbat J, Pennarun G, Le Chalony C, Chevalier F, Palierne G, Bertrand P, Verbavatz JM, Lopez BS.

Cancer Res. 2011 May 15;71(10):3590-602. doi: 10.1158/0008-5472.CAN-10-3119. Epub 2011 Mar 28.


Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

Guirouilh-Barbat J, Antony S, Pommier Y.

Mol Cancer Ther. 2009 Jul;8(7):2007-14. doi: 10.1158/1535-7163.MCT-09-0336. Epub 2009 Jul 7.


Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin.

Guirouilh-Barbat J, Zhang YW, Pommier Y.

Mol Cancer Ther. 2009 Jul;8(7):1985-94. doi: 10.1158/1535-7163.MCT-09-0320. Epub 2009 Jul 7.


Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks.

Sordet O, Redon CE, Guirouilh-Barbat J, Smith S, Solier S, Douarre C, Conti C, Nakamura AJ, Das BB, Nicolas E, Kohn KW, Bonner WM, Pommier Y.

EMBO Rep. 2009 Aug;10(8):887-93. doi: 10.1038/embor.2009.97. Epub 2009 Jun 26.


Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin.

Aune GJ, Takagi K, Sordet O, Guirouilh-Barbat J, Antony S, Bohr VA, Pommier Y.

Clin Cancer Res. 2008 Oct 15;14(20):6449-55. doi: 10.1158/1078-0432.CCR-08-0730.


Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.

Guirouilh-Barbat J, Redon C, Pommier Y.

Mol Biol Cell. 2008 Sep;19(9):3969-81. doi: 10.1091/mbc.E08-02-0215. Epub 2008 Jul 16.


Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.

Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20902-7. Epub 2007 Dec 18.


Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.

Liao Z, Robey RW, Guirouilh-Barbat J, To KK, Polgar O, Bates SE, Pommier Y.

Mol Pharmacol. 2008 Feb;73(2):490-7. Epub 2007 Nov 5.


Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.

Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao ZH, Davies SL, Saccá B, Hickson ID, Bensimon A, Pommier Y.

Mol Cancer Res. 2007 Jul;5(7):713-24.


Reconstitution of the yeast RNA polymerase III transcription system with all recombinant factors.

Ducrot C, Lefebvre O, Landrieux E, Guirouilh-Barbat J, Sentenac A, Acker J.

J Biol Chem. 2006 Apr 28;281(17):11685-92. Epub 2006 Mar 3.


Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells.

Guirouilh-Barbat J, Huck S, Bertrand P, Pirzio L, Desmaze C, Sabatier L, Lopez BS.

Mol Cell. 2004 Jun 4;14(5):611-23.

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