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Items: 6


Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells.

Tremblay CS, Saw J, Chiu SK, Wong NC, Tsyganov K, Ghotb S, Graham AN, Yan F, Guirguis AA, Sonderegger SE, Lee N, Kalitsis P, Reynolds J, Ting SB, Powell DR, Jane SM, Curtis DJ.

Nat Commun. 2018 Aug 30;9(1):3535. doi: 10.1038/s41467-018-06021-7.


Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.

Fink EC, McConkey M, Adams DN, Haldar SD, Kennedy JA, Guirguis AA, Udeshi ND, Mani DR, Chen M, Liddicoat B, Svinkina T, Nguyen AT, Carr SA, Ebert BL.

Blood. 2018 Oct 4;132(14):1535-1544. doi: 10.1182/blood-2018-05-852798. Epub 2018 Jul 31.


Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome.

Kraakman MJ, Kammoun HL, Dragoljevic D, Al-Sharea A, Lee MKS, Flynn MC, Stolz CJ, Guirguis AA, Lancaster GI, Chin-Dusting J, Curtis DJ, Murphy AJ.

Haematologica. 2018 Apr;103(4):597-606. doi: 10.3324/haematol.2017.181958. Epub 2018 Jan 25.


PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.

Guirguis AA, Slape CI, Failla LM, Saw J, Tremblay CS, Powell DR, Rossello F, Wei A, Strasser A, Curtis DJ.

Cell Death Differ. 2016 Jun;23(6):1049-59. doi: 10.1038/cdd.2015.159. Epub 2016 Jan 8.


Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond.

Guirguis AA, Ebert BL.

Curr Opin Cell Biol. 2015 Dec;37:61-7. doi: 10.1016/ Epub 2015 Nov 11. Review.


Cholesterol-dependent human complement activation resulting in damage to liposomal model membranes.

Alving CR, Richards RL, Guirguis AA.

J Immunol. 1977 Jan;118(1):342-7.


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