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Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation.

Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J.

J Infect Dis. 2015 Jul 1;212(1):128-36. doi: 10.1093/infdis/jiu829. Epub 2014 Dec 23.


Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.

Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T.

J Innate Immun. 2014;6(3):315-24. doi: 10.1159/000355217. Epub 2013 Nov 1.


Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis.

Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE.

Gastroenterology. 2013 Dec;145(6):1358-1368.e1-4. doi: 10.1053/j.gastro.2013.08.054. Epub 2013 Aug 31.


Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California.

Preziosi MJ, Kandel SM, Guiney DG, Browne SH.

J Clin Microbiol. 2012 Nov;50(11):3598-603. doi: 10.1128/JCM.00795-12. Epub 2012 Aug 29.


Diarrhea and colitis in mice require the Salmonella pathogenicity island 2-encoded secretion function but not SifA or Spv effectors.

Fierer J, Okamoto S, Banerjee A, Guiney DG.

Infect Immun. 2012 Oct;80(10):3360-70. doi: 10.1128/IAI.00404-12. Epub 2012 Jul 9.


Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.

Obonyo M, Rickman B, Guiney DG.

Helicobacter. 2011 Oct;16(5):398-404. doi: 10.1111/j.1523-5378.2011.00861.x.


The Role of the spv Genes in Salmonella Pathogenesis.

Guiney DG, Fierer J.

Front Microbiol. 2011 Jun 14;2:129. doi: 10.3389/fmicb.2011.00129. eCollection 2011.


Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium.

van Sorge NM, Zialcita PA, Browne SH, Quach D, Guiney DG, Doran KS.

J Infect Dis. 2011 Feb 1;203(3):401-5. doi: 10.1093/infdis/jiq048. Epub 2010 Dec 24.


Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.

Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10638-43. doi: 10.1073/pnas.1002348107. Epub 2010 May 17.


Small molecule DnaK modulators targeting the beta-domain.

Cellitti J, Zhang Z, Wang S, Wu B, Yuan H, Hasegawa P, Guiney DG, Pellecchia M.

Chem Biol Drug Des. 2009 Oct;74(4):349-57. doi: 10.1111/j.1747-0285.2009.00869.x. Epub 2009 Aug 20.


The use of viral load as a surrogate marker in predicting disease progression for patients with early invasive cervical cancer with integrated human papillomavirus type 16.

Wanram S, Limpaiboon T, Leelayuwat C, Yuenyao P, Guiney DG, Lulitanond V, Jearanaikoon P.

Am J Obstet Gynecol. 2009 Jul;201(1):79.e1-7. doi: 10.1016/j.ajog.2009.03.013. Epub 2009 May 14.


ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis.

McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V.

J Innate Immun. 2009;1(5):494-506. doi: 10.1159/000225955. Epub 2009 Jun 18.


Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.

Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI.

J Infect Dis. 2008 Dec 15;198(12):1862-9. doi: 10.1086/593213.


Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.

van Sorge NM, Ebrahimi CM, McGillivray SM, Quach D, Sabet M, Guiney DG, Doran KS.

PLoS One. 2008 Aug 13;3(8):e2964. doi: 10.1371/journal.pone.0002964.


In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.

Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M.

Cell Immunol. 2008 Feb;251(2):78-85. doi: 10.1016/j.cellimm.2008.04.001. Epub 2008 May 20.


Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.

Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC.

J Immunol. 2008 Apr 1;180(7):5045-56.


Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice.

Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney DG.

FEMS Immunol Med Microbiol. 2008 Mar;52(2):194-201. doi: 10.1111/j.1574-695X.2007.00364.x. Epub 2008 Jan 31.


Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.


Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.

Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG.

Infect Immun. 2007 May;75(5):2408-14. Epub 2007 Mar 12.


Vaccination with irradiated Listeria induces protective T cell immunity.

Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E.

Immunity. 2006 Jul;25(1):143-52.


CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages.

Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG.

FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):303-10.


The role of host cell death in Salmonella infections.

Guiney DG.

Curr Top Microbiol Immunol. 2005;289:131-50. Review.


Targeting of the actin cytoskeleton during infection by Salmonella strains.

Guiney DG, Lesnick M.

Clin Immunol. 2005 Mar;114(3):248-55. Review.


Induction and antimicrobial activity of platelet basic protein derivatives in human monocytes.

Schaffner A, King CC, Schaer D, Guiney DG.

J Leukoc Biol. 2004 Nov;76(5):1010-8. Epub 2004 Aug 17.


Characterization of monospecies biofilm formation by Helicobacter pylori.

Cole SP, Harwood J, Lee R, She R, Guiney DG.

J Bacteriol. 2004 May;186(10):3124-32.


The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M.

Nature. 2004 Mar 18;428(6980):341-5.


Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection.

Wang JP, Rought SE, Corbeil J, Guiney DG.

FEMS Immunol Med Microbiol. 2003 Nov 28;39(2):163-72.


Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection.

Obonyo M, Guiney DG, Fierer J, Cole SP.

Helicobacter. 2003;8(5):495-502.


Genetic requirements for salmonella-induced cytopathology in human monocyte-derived macrophages.

Browne SH, Lesnick ML, Guiney DG.

Infect Immun. 2002 Dec;70(12):7126-35.


Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection.

Obonyo M, Guiney DG, Harwood J, Fierer J, Cole SP.

Infect Immun. 2002 Jun;70(6):3295-9.


Characterization of the spv locus in Salmonella enterica serovar Arizona.

Libby SJ, Lesnick M, Hasegawa P, Kurth M, Belcher C, Fierer J, Guiney DG.

Infect Immun. 2002 Jun;70(6):3290-4.


Diverse virulence traits underlying different clinical outcomes of Salmonella infection.

Fierer J, Guiney DG.

J Clin Invest. 2001 Apr;107(7):775-80. Review.


The Salmonella virulence plasmid spv genes are required for cytopathology in human monocyte-derived macrophages.

Libby SJ, Lesnick M, Hasegawa P, Weidenhammer E, Guiney DG.

Cell Microbiol. 2000 Feb;2(1):49-58.


The best defense is a good offense--Salmonella deploys an ADP-ribosylating toxin.

Lesnick ML, Guiney DG.

Trends Microbiol. 2001 Jan;9(1):2-4; discussion 4-5. Review.


Effect of nitric oxide on Helicobacter pylori morphology.

Cole SP, Kharitonov VF, Guiney DG.

J Infect Dis. 1999 Nov;180(5):1713-7.


The spv genes on the Salmonella dublin virulence plasmid are required for severe enteritis and systemic infection in the natural host.

Libby SJ, Adams LG, Ficht TA, Allen C, Whitford HA, Buchmeier NA, Bossie S, Guiney DG.

Infect Immun. 1997 May;65(5):1786-92.


Regulation of bacterial virulence gene expression by the host environment.

Guiney DG.

J Clin Invest. 1997 Feb 15;99(4):565-9. Review. No abstract available.


Host/pathogen interactions: series introduction.

Guiney DG, Kagnoff MF.

J Clin Invest. 1997 Jan 15;99(2):155. No abstract available.


Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells.

Chen CY, Eckmann L, Libby SJ, Fang FC, Okamoto S, Kagnoff MF, Fierer J, Guiney DG.

Infect Immun. 1996 Nov;64(11):4739-43.

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