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Salmonella-induced Diarrhea Occurs in the Absence of IL-8 Receptor (CXCR2)-Dependent Neutrophilic Inflammation.

Marchelletta RR, Gareau MG, Okamoto S, Guiney DG, Barrett KE, Fierer J.

J Infect Dis. 2015 Jul 1;212(1):128-36. doi: 10.1093/infdis/jiu829. Epub 2014 Dec 23.


Innate immune protection against infectious diseases by pulmonary administration of a phospholipid-conjugated TLR7 ligand.

Wu CC, Crain B, Yao S, Sabet M, Lao FS, Tawatao RI, Chan M, Smee DF, Julander JG, Cottam HB, Guiney DG, Corr M, Carson DA, Hayashi T.

J Innate Immun. 2014;6(3):315-24. doi: 10.1159/000355217. Epub 2013 Nov 1.


Altered expression and localization of ion transporters contribute to diarrhea in mice with Salmonella-induced enteritis.

Marchelletta RR, Gareau MG, McCole DF, Okamoto S, Roel E, Klinkenberg R, Guiney DG, Fierer J, Barrett KE.

Gastroenterology. 2013 Dec;145(6):1358-1368.e1-4. doi: 10.1053/j.gastro.2013.08.054. Epub 2013 Aug 31.


Activated charcoal enhanced the antigen-expression and dendritic cell maturation of the vaccine using Listeria-platform.

Wanram S, Guiney D, Panomket P, Jearanaikoon P.

Kobe J Med Sci. 2012 Sep 13;58(3):E63-71.


Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes of bacteremia or enteritis in HIV/AIDS patients in San Diego, California.

Preziosi MJ, Kandel SM, Guiney DG, Browne SH.

J Clin Microbiol. 2012 Nov;50(11):3598-603. doi: 10.1128/JCM.00795-12. Epub 2012 Aug 29.


Diarrhea and colitis in mice require the Salmonella pathogenicity island 2-encoded secretion function but not SifA or Spv effectors.

Fierer J, Okamoto S, Banerjee A, Guiney DG.

Infect Immun. 2012 Oct;80(10):3360-70. doi: 10.1128/IAI.00404-12. Epub 2012 Jul 9.


Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen.

Steininger C, Widhopf GF 2nd, Ghia EM, Morello CS, Vanura K, Sanders R, Spector D, Guiney D, J├Ąger U, Kipps TJ.

Blood. 2012 Mar 8;119(10):2293-301. doi: 10.1182/blood-2011-08-374058. Epub 2012 Jan 10.


Improving reverse vaccinology with a machine learning approach.

Bowman BN, McAdam PR, Vivona S, Zhang JX, Luong T, Belew RK, Sahota H, Guiney D, Valafar F, Fierer J, Woelk CH.

Vaccine. 2011 Oct 19;29(45):8156-64. doi: 10.1016/j.vaccine.2011.07.142. Epub 2011 Aug 22.


Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.

Obonyo M, Rickman B, Guiney DG.

Helicobacter. 2011 Oct;16(5):398-404. doi: 10.1111/j.1523-5378.2011.00861.x.


The Role of the spv Genes in Salmonella Pathogenesis.

Guiney DG, Fierer J.

Front Microbiol. 2011 Jun 14;2:129. doi: 10.3389/fmicb.2011.00129. eCollection 2011.


Inhibitors of Protein Folding: DnaK.

Cellitti J, Zhang Z, Wang S, Wu B, Guiney D, Pellecchia M.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Jan 15 [updated 2010 Sep 2].


Penetration and activation of brain endothelium by Salmonella enterica serovar Typhimurium.

van Sorge NM, Zialcita PA, Browne SH, Quach D, Guiney DG, Doran KS.

J Infect Dis. 2011 Feb 1;203(3):401-5. doi: 10.1093/infdis/jiq048. Epub 2010 Dec 24.


Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax.

Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10638-43. doi: 10.1073/pnas.1002348107. Epub 2010 May 17.


NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH.

Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M.

Chem Biol Drug Des. 2010 Jul;76(1):10-6. doi: 10.1111/j.1747-0285.2010.00982.x. Epub 2010 Apr 28.


Small molecule DnaK modulators targeting the beta-domain.

Cellitti J, Zhang Z, Wang S, Wu B, Yuan H, Hasegawa P, Guiney DG, Pellecchia M.

Chem Biol Drug Des. 2009 Oct;74(4):349-57. doi: 10.1111/j.1747-0285.2009.00869.x. Epub 2009 Aug 20.


The use of viral load as a surrogate marker in predicting disease progression for patients with early invasive cervical cancer with integrated human papillomavirus type 16.

Wanram S, Limpaiboon T, Leelayuwat C, Yuenyao P, Guiney DG, Lulitanond V, Jearanaikoon P.

Am J Obstet Gynecol. 2009 Jul;201(1):79.e1-7. doi: 10.1016/j.ajog.2009.03.013. Epub 2009 May 14.


Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.

Johnson SL, Chen LH, Barile E, Emdadi A, Sabet M, Yuan H, Wei J, Guiney D, Pellecchia M.

Bioorg Med Chem. 2009 May 1;17(9):3352-68. doi: 10.1016/j.bmc.2009.03.040. Epub 2009 Mar 26.


ClpX contributes to innate defense peptide resistance and virulence phenotypes of Bacillus anthracis.

McGillivray SM, Ebrahimi CM, Fisher N, Sabet M, Zhang DX, Chen Y, Haste NM, Aroian RV, Gallo RL, Guiney DG, Friedlander AM, Koehler TM, Nizet V.

J Innate Immun. 2009;1(5):494-506. doi: 10.1159/000225955. Epub 2009 Jun 18.


Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.

Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI.

J Infect Dis. 2008 Dec 15;198(12):1862-9. doi: 10.1086/593213.


Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis.

van Sorge NM, Ebrahimi CM, McGillivray SM, Quach D, Sabet M, Guiney DG, Doran KS.

PLoS One. 2008 Aug 13;3(8):e2964. doi: 10.1371/journal.pone.0002964.


Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds.

Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E.

Immunity. 2008 May;28(5):724. No abstract available.


In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.

Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M.

Cell Immunol. 2008 Feb;251(2):78-85. doi: 10.1016/j.cellimm.2008.04.001. Epub 2008 May 20.


Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses.

Le Negrate G, Faustin B, Welsh K, Loeffler M, Krajewska M, Hasegawa P, Mukherjee S, Orth K, Krajewski S, Godzik A, Guiney DG, Reed JC.

J Immunol. 2008 Apr 1;180(7):5045-56.


A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice.

Woo H, Okamoto S, Guiney D, Gunn JS, Fierer J.

PLoS One. 2008 Feb 13;3(2):e1603. doi: 10.1371/journal.pone.0001603.


Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice.

Browne SH, Hasegawa P, Okamoto S, Fierer J, Guiney DG.

FEMS Immunol Med Microbiol. 2008 Mar;52(2):194-201. doi: 10.1111/j.1574-695X.2007.00364.x. Epub 2008 Jan 31.


Rhodanine derivatives as selective protease inhibitors against bacterial toxins.

Johnson SL, Chen LH, Harbach R, Sabet M, Savinov A, Cotton NJ, Strongin A, Guiney D, Pellecchia M.

Chem Biol Drug Des. 2008 Feb;71(2):131-9. doi: 10.1111/j.1747-0285.2007.00617.x. Epub 2008 Jan 19.


Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response.

Kolla RV, Chintalapati S, Sabet M, Santelli E, Liddington RC, David M, Fierer J, Guiney D, Rickert RC.

PLoS One. 2007 Oct 17;2(10):e1044.


Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.


Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand.

Wu CC, Hayashi T, Takabayashi K, Sabet M, Smee DF, Guiney DD, Cottam HB, Carson DA.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3990-5. Epub 2007 Feb 21.


Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.

Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG.

Infect Immun. 2007 May;75(5):2408-14. Epub 2007 Mar 12.


Vaccination with irradiated Listeria induces protective T cell immunity.

Datta SK, Okamoto S, Hayashi T, Shin SS, Mihajlov I, Fermin A, Guiney DG, Fierer J, Raz E.

Immunity. 2006 Jul;25(1):143-52.


Induction of a homeostatic circuit in lung tissue by microbial compounds.

Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E.

Immunity. 2006 Apr;24(4):475-87. Retraction in: Takabayshi K, Corr M, Hayashi T, Redecke V, Beck L, Guiney D, Sheppard D, Raz E. Immunity. 2008 May;28(5):724.


CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages.

Wang JP, Hayashi T, Datta SK, Kornbluth RS, Raz E, Guiney DG.

FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):303-10.


The role of host cell death in Salmonella infections.

Guiney DG.

Curr Top Microbiol Immunol. 2005;289:131-50. Review.


Targeting of the actin cytoskeleton during infection by Salmonella strains.

Guiney DG, Lesnick M.

Clin Immunol. 2005 Mar;114(3):248-55. Review.


Induction and antimicrobial activity of platelet basic protein derivatives in human monocytes.

Schaffner A, King CC, Schaer D, Guiney DG.

J Leukoc Biol. 2004 Nov;76(5):1010-8. Epub 2004 Aug 17.


Characterization of monospecies biofilm formation by Helicobacter pylori.

Cole SP, Harwood J, Lee R, She R, Guiney DG.

J Bacteriol. 2004 May;186(10):3124-32.


The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M.

Nature. 2004 Mar 18;428(6980):341-5.


Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection.

Wang JP, Rought SE, Corbeil J, Guiney DG.

FEMS Immunol Med Microbiol. 2003 Nov 28;39(2):163-72.


Interactions between inducible nitric oxide and other inflammatory mediators during Helicobacter pylori infection.

Obonyo M, Guiney DG, Fierer J, Cole SP.

Helicobacter. 2003;8(5):495-502.


Syntheses of highly functionalised 6-substituted pteridines.

Guiney D, Gibson CL, Suckling CJ.

Org Biomol Chem. 2003 Feb 21;1(4):664-75.


Genetic requirements for salmonella-induced cytopathology in human monocyte-derived macrophages.

Browne SH, Lesnick ML, Guiney DG.

Infect Immun. 2002 Dec;70(12):7126-35.


Role of gamma interferon in Helicobacter pylori induction of inflammatory mediators during murine infection.

Obonyo M, Guiney DG, Harwood J, Fierer J, Cole SP.

Infect Immun. 2002 Jun;70(6):3295-9.


Characterization of the spv locus in Salmonella enterica serovar Arizona.

Libby SJ, Lesnick M, Hasegawa P, Kurth M, Belcher C, Fierer J, Guiney DG.

Infect Immun. 2002 Jun;70(6):3290-4.

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