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Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice.

Guillaume M, Riant E, Fabre A, Raymond-Letron I, Buscato M, Davezac M, Tramunt B, Montagner A, Smati S, Zahreddine R, Palierne G, Valera MC, Guillou H, Lenfant F, Unsicker K, Metivier R, Fontaine C, Arnal JF, Gourdy P.

Hepatol Commun. 2019 Apr 29;3(7):908-924. doi: 10.1002/hep4.1363. eCollection 2019 Jul.

Free PMC Article

Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes.

Smati S, Régnier M, Fougeray T, Polizzi A, Fougerat A, Lasserre F, Lukowicz C, Tramunt B, Guillaume M, Burnol AF, Postic C, Wahli W, Montagner A, Gourdy P, Guillou H.

Diabetes Metab. 2019 Jun 1. pii: S1262-3636(19)30088-6. doi: 10.1016/j.diabet.2019.05.005. [Epub ahead of print]


PGC-1α induced browning promotes involution and inhibits lactation in mammary glands.

Piccinin E, Morgano A, Peres C, Contursi A, Bertrand-Michel J, Arconzo M, Guillou H, Villani G, Moschetta A.

Cell Mol Life Sci. 2019 Jun 1. doi: 10.1007/s00018-019-03160-y. [Epub ahead of print]


Early life stress induces type 2 diabetes-like features in ageing mice.

Ilchmann-Diounou H, Olier M, Lencina C, Riba A, Barretto S, Nankap M, Sommer C, Guillou H, Ellero-Simatos S, Guzylack-Piriou L, Théodorou V, Ménard S.

Brain Behav Immun. 2019 Apr 11. pii: S0889-1591(18)30787-6. doi: 10.1016/j.bbi.2019.04.025. [Epub ahead of print]


The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.

Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G.

Nat Commun. 2019 Apr 5;10(1):1566. doi: 10.1038/s41467-019-09598-9.


Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

Oh HYP, Ellero-Simatos S, Manickam R, Tan NS, Guillou H, Wahli W.

Int J Mol Sci. 2019 Feb 14;20(4). pii: E812. doi: 10.3390/ijms20040812.


Hepatic PPARα is critical in the metabolic adaptation to sepsis.

Paumelle R, Haas JT, Hennuyer N, Baugé E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B.

J Hepatol. 2019 May;70(5):963-973. doi: 10.1016/j.jhep.2018.12.037. Epub 2019 Jan 21.


A new unspiked K-Ar dating approach using laser fusion on microsamples.

Wang F, Shi W, Guillou H, Zhang W, Yang L, Wu L, Wang Y, Zhu R.

Rapid Commun Mass Spectrom. 2019 Mar 30;33(6):587-599. doi: 10.1002/rcm.8385.


The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity.

Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N.

Arch Toxicol. 2019 Feb;93(2):505-517. doi: 10.1007/s00204-018-2345-2. Epub 2018 Nov 17.


Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.

Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lettéron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, Guillou H, Cravatt BF, Moreau R, Trauner M, Lotersztajn S.

Gut. 2018 Oct 9. pii: gutjnl-2018-316137. doi: 10.1136/gutjnl-2018-316137. [Epub ahead of print]


Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context.

Monteillet L, Gjorgjieva M, Silva M, Verzieux V, Imikirene L, Duchampt A, Guillou H, Mithieux G, Rajas F.

Mol Metab. 2018 Oct;16:100-115. doi: 10.1016/j.molmet.2018.07.006. Epub 2018 Aug 1.


β-catenin oncogenic activation rewires fatty acid catabolism to fuel hepatocellular carcinoma.

Montagner A, Le Cam L, Guillou H.

Gut. 2019 Feb;68(2):183-185. doi: 10.1136/gutjnl-2018-316557. Epub 2018 Aug 4. No abstract available.


Sphingolipid metabolism in non-alcoholic fatty liver diseases.

Régnier M, Polizzi A, Guillou H, Loiseau N.

Biochimie. 2019 Apr;159:9-22. doi: 10.1016/j.biochi.2018.07.021. Epub 2018 Jul 31. Review.


Complementary intestinal mucosa and microbiota responses to caloric restriction.

Duszka K, Ellero-Simatos S, Ow GS, Defernez M, Paramalingam E, Tett A, Ying S, König J, Narbad A, Kuznetsov VA, Guillou H, Wahli W.

Sci Rep. 2018 Jul 27;8(1):11338. doi: 10.1038/s41598-018-29815-7.


Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells.

Lacunza E, Montanaro MA, Salvati A, Memoli D, Rizzo F, Henning MF, Quiroga IY, Guillou H, Abba MC, Gonzalez-Baro MDR, Weisz A, Pellon-Maison M.

Oncotarget. 2018 Jun 15;9(46):28141-28154. doi: 10.18632/oncotarget.25582. eCollection 2018 Jun 15.


Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor.

Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A, Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L.

Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877. eCollection 2018 Jun.


The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.

Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R.

Nat Commun. 2018 May 29;9(1):2092. doi: 10.1038/s41467-018-04361-y.


Dual extraction of mRNA and lipids from a single biological sample.

Podechard N, Ducheix S, Polizzi A, Lasserre F, Montagner A, Legagneux V, Fouché E, Saez F, Lobaccaro JM, Lakhal L, Ellero-Simatos S, Martin PG, Loiseau N, Bertrand-Michel J, Guillou H.

Sci Rep. 2018 May 4;8(1):7019. doi: 10.1038/s41598-018-25332-9.


Glycerol-3-phosphate acyltransferase 2 expression modulates cell roughness and membrane permeability: An atomic force microscopy study.

Cattaneo ER, Prieto ED, Garcia-Fabiani MB, Montanaro MA, Guillou H, Gonzalez-Baro MR.

PLoS One. 2017 Dec 6;12(12):e0189031. doi: 10.1371/journal.pone.0189031. eCollection 2017.


A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response.

Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier M, Fouché E, Lukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C.

Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065.


Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.

Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP.

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700433. Epub 2017 Oct 17.


Insights into the role of hepatocyte PPARα activity in response to fasting.

Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, Smati S, Marrot A, Lasserre F, Naylies C, Batut A, Viars F, Bertrand-Michel J, Postic C, Loiseau N, Wahli W, Guillou H, Montagner A.

Mol Cell Endocrinol. 2018 Aug 15;471:75-88. doi: 10.1016/j.mce.2017.07.035. Epub 2017 Jul 31.


Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling.

Ducheix S, Montagner A, Polizzi A, Lasserre F, Régnier M, Marmugi A, Benhamed F, Bertrand-Michel J, Mselli-Lakhal L, Loiseau N, Martin PG, Lobaccaro JM, Ferrier L, Postic C, Guillou H.

PLoS One. 2017 Jul 21;12(7):e0181393. doi: 10.1371/journal.pone.0181393. eCollection 2017.


Erratum: The gut microbiota: a major player in the toxicity of environmental pollutants?

Claus SP, Guillou H, Ellero-Simatos S.

NPJ Biofilms Microbiomes. 2017 Jun 22;3:17001. doi: 10.1038/npjbiofilms.2017.1. eCollection 2017.


Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse.

Guillaume M, Handgraaf S, Fabre A, Raymond-Letron I, Riant E, Montagner A, Vinel A, Buscato M, Smirnova N, Fontaine C, Guillou H, Arnal JF, Gourdy P.

Am J Pathol. 2017 Jun;187(6):1273-1287. doi: 10.1016/j.ajpath.2017.02.013. Epub 2017 May 11.


Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle.

Laurens C, Bourlier V, Mairal A, Louche K, Badin PM, Mouisel E, Montagner A, Marette A, Tremblay A, Weisnagel JS, Guillou H, Langin D, Joanisse DR, Moro C.

Sci Rep. 2016 Dec 6;6:38310. doi: 10.1038/srep38310.


Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.

Duszka K, Picard A, Ellero-Simatos S, Chen J, Defernez M, Paramalingam E, Pigram A, Vanoaica L, Canlet C, Parini P, Narbad A, Guillou H, Thorens B, Wahli W.

Sci Rep. 2016 Nov 17;6:36937. doi: 10.1038/srep36937.


Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ.

Tan NS, Vázquez-Carrera M, Montagner A, Sng MK, Guillou H, Wahli W.

Prog Lipid Res. 2016 Oct;64:98-122. doi: 10.1016/j.plipres.2016.09.001. Epub 2016 Sep 22. Review. No abstract available.


Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids.

Polizzi A, Fouché E, Ducheix S, Lasserre F, Marmugi AP, Mselli-Lakhal L, Loiseau N, Wahli W, Guillou H, Montagner A.

Int J Mol Sci. 2016 Sep 24;17(10). pii: E1624. doi: 10.3390/ijms17101624.


The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice.

Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G, Gautier-Stein A.

Diabetologia. 2016 Dec;59(12):2645-2653. Epub 2016 Sep 9.


Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism.

Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W.

Elife. 2016 Jul 1;5. pii: e11853. doi: 10.7554/eLife.11853.


Effects of pesticide mixtures in human and animal models: An update of the recent literature.

Rizzati V, Briand O, Guillou H, Gamet-Payrastre L.

Chem Biol Interact. 2016 Jul 25;254:231-46. doi: 10.1016/j.cbi.2016.06.003. Epub 2016 Jun 14. Review.


Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance.

Popineau L, Morzyglod L, Carré N, Caüzac M, Bossard P, Prip-Buus C, Lenoir V, Ragazzon B, Fauveau V, Robert L, Guilmeau S, Postic C, Komatsu M, Canonne-Hergaux F, Guillou H, Burnol AF.

Mol Cell Biol. 2016 Jul 29;36(16):2168-81. doi: 10.1128/MCB.00170-16. Print 2016 Aug 15.


Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L.

Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11.


The gut microbiota: a major player in the toxicity of environmental pollutants?

Claus SP, Guillou H, Ellero-Simatos S.

NPJ Biofilms Microbiomes. 2016 May 4;2:16003. doi: 10.1038/npjbiofilms.2016.3. eCollection 2016. Review. Erratum in: NPJ Biofilms Microbiomes. 2017 Jun 22;3:17001.


White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways.

Barquissau V, Beuzelin D, Pisani DF, Beranger GE, Mairal A, Montagner A, Roussel B, Tavernier G, Marques MA, Moro C, Guillou H, Amri EZ, Langin D.

Mol Metab. 2016 Mar 18;5(5):352-365. doi: 10.1016/j.molmet.2016.03.002. eCollection 2016 May.


Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Apr 20;6:23951. doi: 10.1038/srep23951. No abstract available.


Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Feb 16;6:20127. doi: 10.1038/srep20127. Erratum in: Sci Rep. 2016;6:23951. Maha, Al-Asmakh [corrected to Al-Asmakh, Maha].


Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H.

Gut. 2016 Jul;65(7):1202-14. doi: 10.1136/gutjnl-2015-310798. Epub 2016 Feb 1.


A 36,000-Year-Old Volcanic Eruption Depicted in the Chauvet-Pont d'Arc Cave (Ardèche, France)?

Nomade S, Genty D, Sasco R, Scao V, Féruglio V, Baffier D, Guillou H, Bourdier C, Valladas H, Reigner E, Debard E, Pastre JF, Geneste JM.

PLoS One. 2016 Jan 8;11(1):e0146621. doi: 10.1371/journal.pone.0146621. eCollection 2016.


Localizing the lipid products of PI3Kγ in neutrophils.

Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L.

Adv Biol Regul. 2016 Jan;60:36-45. doi: 10.1016/j.jbior.2015.10.005. Epub 2015 Nov 10.


Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human.

Tremblay-Franco M, Zerbinati C, Pacelli A, Palmaccio G, Lubrano C, Ducheix S, Guillou H, Iuliano L.

Steroids. 2015 Jul;99(Pt B):287-92. doi: 10.1016/j.steroids.2015.03.019. Epub 2015 Apr 18.


Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.

Marmier S, Dentin R, Daujat-Chavanieu M, Guillou H, Bertrand-Michel J, Gerbal-Chaloin S, Girard J, Lotersztajn S, Postic C.

Hepatology. 2015 Oct;62(4):1086-100. doi: 10.1002/hep.27778. Epub 2015 May 6.


Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation.

Roux PF, Boitard S, Blum Y, Parks B, Montagner A, Mouisel E, Djari A, Esquerré D, Désert C, Boutin M, Leroux S, Lecerf F, Le Bihan-Duval E, Klopp C, Servin B, Pitel F, Duclos MJ, Guillou H, Lusis AJ, Demeure O, Lagarrigue S.

G3 (Bethesda). 2015 Feb 3;5(4):517-29. doi: 10.1534/g3.115.016865.


Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N.

Br J Pharmacol. 2015 Feb;172(3):910-23. doi: 10.1111/bph.12957. Epub 2014 Dec 15.


Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.

Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L.

Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.


New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver.

Loiseau N, Polizzi A, Dupuy A, Therville N, Rakotonirainy M, Loy J, Viadere JL, Cossalter AM, Bailly JD, Puel O, Kolf-Clauw M, Bertrand-Michel J, Levade T, Guillou H, Oswald IP.

Arch Toxicol. 2015 Sep;89(9):1619-29. doi: 10.1007/s00204-014-1323-6. Epub 2014 Aug 26.


A link between hepatic glucose production and peripheral energy metabolism via hepatokines.

Abdul-Wahed A, Gautier-Stein A, Casteras S, Soty M, Roussel D, Romestaing C, Guillou H, Tourette JA, Pleche N, Zitoun C, Gri B, Sardella A, Rajas F, Mithieux G.

Mol Metab. 2014 May 28;3(5):531-43. doi: 10.1016/j.molmet.2014.05.005. eCollection 2014 Aug.


Silicon Nanotweezers with a microfluidic cavity for the real time characterization of DNA damage under therapeutic radiation beams.

Perret G, Chiang PT, Lacornerie T, Kumemura M, Lafitte N, Guillou H, Jalabert L, Lartigau E, Fujii T, Cleri F, Fujita H, Collard D.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6820. doi: 10.1109/EMBC.2013.6611123.


Integrated MEMS platform with silicon nanotweezers and open microfluidic device for real-time and routine biomechanical probing on molecules and cells.

Lafitte N, Guillou H, Kumemura M, Jalabert L, Fujii T, Fujita H, Collard D.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:148-51. doi: 10.1109/EMBC.2013.6609459.


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