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Items: 1 to 50 of 219

1.

Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression.

Achtyes E, Keaton SA, Smart L, Burmeister AR, Heilman PL, Krzyzanowski S, Nagalla M, Guillemin GJ, Escobar Galvis ML, Lim CK, Muzik M, Postolache T, Leach R, Brundin L.

Brain Behav Immun. 2019 Nov 4. pii: S0889-1591(19)31077-3. doi: 10.1016/j.bbi.2019.10.017. [Epub ahead of print]

PMID:
31698012
2.

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer's disease.

Lei M, Teo JD, Song H, McEwen HP, Yup Lee J, Couttas TA, Duncan T, Chesworth R, Bertz J, Przybyla M, Van Eersel J, Heng B, Guillemin GJ, Ittner LM, Fath T, Garner B, Ittner A, Karl T, Don AS.

J Neurosci. 2019 Oct 21. pii: 0524-19. doi: 10.1523/JNEUROSCI.0524-19.2019. [Epub ahead of print]

PMID:
31641049
3.

Correction to: Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson's Disease.

Essa MM, Subash S, Dhanalakshmi C, Manivasagam T, Al-Adawi S, Guillemin GJ, Thenmozhi AJ.

Neurochem Res. 2019 Oct 18. doi: 10.1007/s11064-019-02887-1. [Epub ahead of print]

PMID:
31628643
4.

Kynurenine Pathway Metabolites as Biomarkers for Amyotrophic Lateral Sclerosis.

Tan VX, Guillemin GJ.

Front Neurosci. 2019 Sep 20;13:1013. doi: 10.3389/fnins.2019.01013. eCollection 2019. Review.

5.

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease.

Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, Hye A, Pedrini S, Sohrabi HR, Shah T, Asih PR, Dave P, Shen K, Taddei K, Lovejoy DB, Guillemin GJ, Blennow K, Martins RN.

J Neuroinflammation. 2019 Oct 10;16(1):186. doi: 10.1186/s12974-019-1567-4.

6.

Microglia are both a source and target of extracellular cyclophilin A.

Flora GK, Anderton RS, Meloni BP, Guillemin GJ, Knuckey NW, MacDougall G, Matthews V, Boulos S.

Heliyon. 2019 Sep 3;5(9):e02390. doi: 10.1016/j.heliyon.2019.e02390. eCollection 2019 Sep.

7.

The Cyanotoxin and Non-protein Amino Acid β-Methylamino-L-Alanine (L-BMAA) in the Food Chain: Incorporation into Proteins and Its Impact on Human Health.

Dunlop RA, Guillemin GJ.

Neurotox Res. 2019 Oct;36(3):602-611. doi: 10.1007/s12640-019-00089-9. Epub 2019 Aug 3. Review.

PMID:
31377995
8.

Epithelial Indoleamine 2,3-Dioxygenase 1 Modulates Aryl Hydrocarbon Receptor and Notch Signaling to Increase Differentiation of Secretory Cells and Alter Mucus-Associated Microbiota.

Alvarado DM, Chen B, Iticovici M, Thaker AI, Dai N, VanDussen KL, Shaikh N, Lim CK, Guillemin GJ, Tarr PI, Ciorba MA.

Gastroenterology. 2019 Oct;157(4):1093-1108.e11. doi: 10.1053/j.gastro.2019.07.013. Epub 2019 Jul 17.

PMID:
31325428
9.

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status.

Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ.

Int J Tryptophan Res. 2019 Jun 19;12:1178646919852996. doi: 10.1177/1178646919852996. eCollection 2019. Review.

10.

Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos.

Aksoy YA, Nguyen DT, Chow S, Chung RS, Guillemin GJ, Cole NJ, Hesselson D.

Commun Biol. 2019 May 23;2:198. doi: 10.1038/s42003-019-0444-0. eCollection 2019.

11.

Microbiota Alterations in Alzheimer's Disease: Involvement of the Kynurenine Pathway and Inflammation.

Garcez ML, Jacobs KR, Guillemin GJ.

Neurotox Res. 2019 Aug;36(2):424-436. doi: 10.1007/s12640-019-00057-3. Epub 2019 May 14. Review.

PMID:
31089885
12.

Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis.

French PW, Ludowyke RI, Guillemin GJ.

Neural Regen Res. 2019 Sep;14(9):1490-1493. doi: 10.4103/1673-5374.255959. Review.

13.

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau.

Jacobs KR, Lim CK, Blennow K, Zetterberg H, Chatterjee P, Martins RN, Brew BJ, Guillemin GJ, Lovejoy DB.

Neurobiol Aging. 2019 Aug;80:11-20. doi: 10.1016/j.neurobiolaging.2019.03.015. Epub 2019 Apr 1.

PMID:
31055163
14.

Memantine Is Protective against Cytotoxicity Caused by Lead and Quinolinic Acid in Cultured Rat Embryonic Hippocampal Cells.

Rahman A, Al-Qenaie S, Rao MS, Khan KM, Guillemin GJ.

Chem Res Toxicol. 2019 Jun 17;32(6):1134-1143. doi: 10.1021/acs.chemrestox.8b00421. Epub 2019 Apr 15.

PMID:
30950269
15.

Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia.

Kindler J, Lim CK, Weickert CS, Boerrigter D, Galletly C, Liu D, Jacobs KR, Balzan R, Bruggemann J, O'Donnell M, Lenroot R, Guillemin GJ, Weickert TW.

Mol Psychiatry. 2019 Apr 3. doi: 10.1038/s41380-019-0401-9. [Epub ahead of print]

PMID:
30940904
16.

Human Tick-Borne Diseases in Australia.

Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ.

Front Cell Infect Microbiol. 2019 Jan 28;9:3. doi: 10.3389/fcimb.2019.00003. eCollection 2019. Review.

17.

Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats.

Ahmad Rather M, Justin-Thenmozhi A, Manivasagam T, Saravanababu C, Guillemin GJ, Essa MM.

Neurotox Res. 2019 May;35(4):955-968. doi: 10.1007/s12640-019-9999-2. Epub 2019 Jan 22.

PMID:
30671870
18.

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.

Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ.

Neurotox Res. 2019 Apr;35(3):530-541. doi: 10.1007/s12640-019-9997-4. Epub 2019 Jan 21.

PMID:
30666558
19.

Dendritic spines: Revisiting the physiological role.

Chidambaram SB, Rathipriya AG, Bolla SR, Bhat A, Ray B, Mahalakshmi AM, Manivasagam T, Thenmozhi AJ, Essa MM, Guillemin GJ, Chandra R, Sakharkar MK.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:161-193. doi: 10.1016/j.pnpbp.2019.01.005. Epub 2019 Jan 15. Review.

PMID:
30654089
20.

Protective Effects of Antioxidants in Huntington's Disease: an Extensive Review.

Essa MM, Moghadas M, Ba-Omar T, Walid Qoronfleh M, Guillemin GJ, Manivasagam T, Justin-Thenmozhi A, Ray B, Bhat A, Chidambaram SB, Fernandes AJ, Song BJ, Akbar M.

Neurotox Res. 2019 Apr;35(3):739-774. doi: 10.1007/s12640-018-9989-9. Epub 2019 Jan 11. Review.

PMID:
30632085
21.

Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.

Engel M, Gee YS, Cross D, Maccarone A, Heng B, Hulme A, Smith G, Guillemin GJ, Stringer BW, Hyland CJT, Ooi L.

J Neurochem. 2019 May;149(4):535-550. doi: 10.1111/jnc.14655. Epub 2019 Feb 3.

22.

Microorganisms' Footprint in Neurodegenerative Diseases.

Dehhaghi M, Kazemi Shariat Panahi H, Guillemin GJ.

Front Cell Neurosci. 2018 Dec 4;12:466. doi: 10.3389/fncel.2018.00466. eCollection 2018. Review.

23.

Fungal Neurotoxins and Sporadic Amyotrophic Lateral Sclerosis.

French PW, Ludowyke R, Guillemin GJ.

Neurotox Res. 2019 May;35(4):969-980. doi: 10.1007/s12640-018-9980-5. Epub 2018 Dec 5. Review.

PMID:
30515715
24.

Protective Effects of Myxobacterial Extracts on Hydrogen Peroxide-induced Toxicity on Human Primary Astrocytes.

Dehhaghi M, Tan V, Heng B, Mohammadipanah F, Guillemin GJ.

Neuroscience. 2019 Feb 10;399:1-11. doi: 10.1016/j.neuroscience.2018.11.033. Epub 2018 Nov 26.

PMID:
30496822
25.

Antioxidant therapies in attention deficit hyperactivity disorder.

Moghadas M, Essa MM, Ba-Omar T, Al-Shehi A, Qoronfleh MW, Eltayeb EA, Guillemin GJ, Manivasagam T, Justin-Thenmozhi A, Al-Bulushi BS, Al-Adawi S, Edalatmanesh MA.

Front Biosci (Landmark Ed). 2019 Jan 1;24:313-333. Review.

PMID:
30468658
26.

Time-dependent effect of oligomeric amyloid-β (1-42)-induced hippocampal neurodegeneration in rat model of Alzheimer's disease.

Karthick C, Nithiyanandan S, Essa MM, Guillemin GJ, Jayachandran SK, Anusuyadevi M.

Neurol Res. 2019 Feb;41(2):139-150. doi: 10.1080/01616412.2018.1544745. Epub 2018 Nov 19.

PMID:
30453864
27.

Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.

Haslinger D, Waltes R, Yousaf A, Lindlar S, Schneider I, Lim CK, Tsai MM, Garvalov BK, Acker-Palmer A, Krezdorn N, Rotter B, Acker T, Guillemin GJ, Fulda S, Freitag CM, Chiocchetti AG.

Mol Autism. 2018 Nov 6;9:56. doi: 10.1186/s13229-018-0239-z. eCollection 2018.

28.

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma.

Corre S, Tardif N, Mouchet N, Leclair HM, Boussemart L, Gautron A, Bachelot L, Perrot A, Soshilov A, Rogiers A, Rambow F, Dumontet E, Tarte K, Bessede A, Guillemin GJ, Marine JC, Denison MS, Gilot D, Galibert MD.

Nat Commun. 2018 Nov 14;9(1):4775. doi: 10.1038/s41467-018-06951-2.

29.

Low Molecular Weight Sulfated Chitosan: Neuroprotective Effect on Rotenone-Induced In Vitro Parkinson's Disease.

Manigandan V, Nataraj J, Karthik R, Manivasagam T, Saravanan R, Thenmozhi AJ, Essa MM, Guillemin GJ.

Neurotox Res. 2019 Apr;35(3):505-515. doi: 10.1007/s12640-018-9978-z. Epub 2018 Nov 13.

PMID:
30426393
30.

Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways.

Hallal S, Mallawaaratchy DM, Wei H, Ebrahimkhani S, Stringer BW, Day BW, Boyd AW, Guillemin GJ, Buckland ME, Kaufman KL.

Mol Neurobiol. 2019 Jun;56(6):4566-4581. doi: 10.1007/s12035-018-1385-1. Epub 2018 Oct 23.

31.

Neuroprotective Effect of Myxobacterial Extracts on Quinolinic Acid-Induced Toxicity in Primary Human Neurons.

Dehhaghi M, Tan V, Heng B, Braidy N, Mohammadipanah F, Guillemin GJ.

Neurotox Res. 2019 Feb;35(2):281-290. doi: 10.1007/s12640-018-9945-8. Epub 2018 Sep 28.

PMID:
30267267
32.

Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model.

Dhivya Bharathi M, Justin-Thenmozhi A, Manivasagam T, Ahmad Rather M, Saravana Babu C, Mohamed Essa M, Guillemin GJ.

Neurotox Res. 2019 Feb;35(2):318-330. doi: 10.1007/s12640-018-9956-5. Epub 2018 Sep 21.

PMID:
30242626
33.

Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SH-SY5Y).

Chidambaram SB, Bhat A, Ray B, Sugumar M, Muthukumar SP, Manivasagam T, Justin Thenmozhi A, Essa MM, Guillemin GJ, Sakharkar MK.

Nutr Neurosci. 2018 Sep 12:1-10. doi: 10.1080/1028415X.2018.1521088. [Epub ahead of print]

PMID:
30207204
34.

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.

Ma L, Chin YKY, Dekan Z, Herzig V, Chow CY, Heighway J, Lam SW, Guillemin GJ, Alewood PF, King GF.

Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25.

PMID:
30149017
35.

Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism.

Sekar S, Mani S, Rajamani B, Manivasagam T, Thenmozhi AJ, Bhat A, Ray B, Essa MM, Guillemin GJ, Chidambaram SB.

Neurotox Res. 2018 Oct;34(3):597-612. doi: 10.1007/s12640-018-9921-3. Epub 2018 Jul 13.

PMID:
30006683
36.

Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.

Sofia MA, Ciorba MA, Meckel K, Lim CK, Guillemin GJ, Weber CR, Bissonnette M, Pekow JR.

Inflamm Bowel Dis. 2018 Jun 8;24(7):1471-1480. doi: 10.1093/ibd/izy103.

37.

Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.

Chatterjee P, Goozee K, Lim CK, James I, Shen K, Jacobs KR, Sohrabi HR, Shah T, Asih PR, Dave P, ManYan C, Taddei K, Lovejoy DB, Chung R, Guillemin GJ, Martins RN.

Sci Rep. 2018 May 22;8(1):8008. doi: 10.1038/s41598-018-25968-7.

38.

Detection of the suspected neurotoxin β-methylamino-l-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia.

Main BJ, Bowling LC, Padula MP, Bishop DP, Mitrovic SM, Guillemin GJ, Rodgers KJ.

Harmful Algae. 2018 Apr;74:10-18. doi: 10.1016/j.hal.2018.03.004. Epub 2018 Mar 27.

PMID:
29724339
39.

HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau.

Anderson AM, Croteau D, Ellis RJ, Rosario D, Potter M, Guillemin GJ, Brew BJ, Woods SP, Letendre SL.

J Neuroimmunol. 2018 Jun 15;319:13-18. doi: 10.1016/j.jneuroim.2018.03.007. Epub 2018 Mar 18.

40.

Demethoxycurcumin, a Natural Derivative of Curcumin Abrogates Rotenone-induced Dopamine Depletion and Motor Deficits by Its Antioxidative and Anti-inflammatory Properties in Parkinsonian Rats.

Ramkumar M, Rajasankar S, Gobi VV, Janakiraman U, Manivasagam T, Thenmozhi AJ, Essa MM, Chidambaram R, Chidambaram SB, Guillemin GJ.

Pharmacogn Mag. 2018 Jan-Mar;14(53):9-16. doi: 10.4103/pm.pm_113_17. Epub 2018 Feb 20.

41.

Myxobacterial natural products: An under-valued source of products for drug discovery for neurological disorders.

Dehhaghi M, Mohammadipanah F, Guillemin GJ.

Neurotoxicology. 2018 May;66:195-203. doi: 10.1016/j.neuro.2018.02.017. Epub 2018 Mar 2. Review.

PMID:
29499217
42.

Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice.

Mani S, Sekar S, Barathidasan R, Manivasagam T, Thenmozhi AJ, Sevanan M, Chidambaram SB, Essa MM, Guillemin GJ, Sakharkar MK.

Neurotox Res. 2018 Apr;33(3):656-670. doi: 10.1007/s12640-018-9869-3. Epub 2018 Feb 9.

PMID:
29427283
43.

Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.

Jacobs KR, Guillemin GJ, Lovejoy DB.

SLAS Discov. 2018 Jul;23(6):554-560. doi: 10.1177/2472555218757180. Epub 2018 Feb 8.

PMID:
29420107
44.

Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes.

de Paula Martins R, Ghisoni K, Lim CK, Aguiar AS Jr, Guillemin GJ, Latini A.

Free Radic Biol Med. 2018 Feb 1;115:371-382. doi: 10.1016/j.freeradbiomed.2017.11.022. Epub 2017 Dec 2.

45.

Mechanisms of L-Serine Neuroprotection in vitro Include ER Proteostasis Regulation.

Dunlop RA, Powell J, Guillemin GJ, Cox PA.

Neurotox Res. 2018 Jan;33(1):123-132. doi: 10.1007/s12640-017-9829-3. Epub 2017 Nov 2.

PMID:
29098664
46.

L-Serine-Mediated Neuroprotection Includes the Upregulation of the ER Stress Chaperone Protein Disulfide Isomerase (PDI).

Dunlop RA, Powell JT, Metcalf JS, Guillemin GJ, Cox PA.

Neurotox Res. 2018 Jan;33(1):113-122. doi: 10.1007/s12640-017-9817-7. Epub 2017 Oct 3.

PMID:
28975502
47.

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease.

Ahmad Rather M, Justin Thenmozhi A, Manivasagam T, Dhivya Bharathi M, Essa MM, Guillemin GJ.

Front Biosci (Schol Ed). 2018 Jan 1;10:262-275.

PMID:
28930532
48.

Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-L-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring-Potential Involvement of DNA Damage and Oxidative Stress.

Laugeray A, Oummadi A, Jourdain C, Feat J, Meyer-Dilhet G, Menuet A, Plé K, Gay M, Routier S, Mortaud S, Guillemin GJ.

Neurotox Res. 2018 Jan;33(1):87-112. doi: 10.1007/s12640-017-9802-1. Epub 2017 Sep 6.

PMID:
28879461
49.

Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis.

Sundaramoorthy V, Walker AK, Tan V, Fifita JA, Mccann EP, Williams KL, Blair IP, Guillemin GJ, Farg MA, Atkin JD.

Hum Mol Genet. 2017 Sep 1;26(17):3452. doi: 10.1093/hmg/ddx268. No abstract available.

PMID:
28854706
50.

Detection of the Cyanotoxins L-BMAA Uptake and Accumulation in Primary Neurons and Astrocytes.

Tan VX, Mazzocco C, Varney B, Bodet D, Guillemin TA, Bessede A, Guillemin GJ.

Neurotox Res. 2018 Jan;33(1):55-61. doi: 10.1007/s12640-017-9787-9. Epub 2017 Aug 30.

PMID:
28852990

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