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Serum sex steroids as prognostic biomarkers in patients receiving androgen deprivation therapy for recurrent prostate cancer: a post-hoc analysis of the PR.7 trial.

Toren P, Hoffman A, Ding K, Joncas FH, Turcotte V, Caron P, Pouliot F, Fradet Y, Levesque E, Guillemette C, Klotz LH.

Clin Cancer Res. 2018 Jul 18. pii: clincanres.1187.2018. doi: 10.1158/1078-0432.CCR-18-1187. [Epub ahead of print]


Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.

Petrick JL, Hyland PL, Caron P, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Weinstein SJ, Albanes D, Freedman ND, Gapstur SM, Bradwin G, Guillemette C, Campbell PT, Cook MB.

J Natl Cancer Inst. 2018 May 17. doi: 10.1093/jnci/djy082. [Epub ahead of print]


Sex-dependent association of circulating sex steroids and pituitary hormones with treatment-free survival in chronic lymphocytic leukemia patients.

Allain EP, Venzl K, Caron P, Turcotte V, Simonyan D, Gruber M, Le T, Lévesque E, Guillemette C, Vanura K.

Ann Hematol. 2018 May 21. doi: 10.1007/s00277-018-3356-z. [Epub ahead of print]


Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients.

De Mattia E, Cecchin E, Montico M, Labriet A, Guillemette C, Dreussi E, Roncato R, Bignucolo A, Buonadonna A, D'Andrea M, Coppola L, Lonardi S, Lévesque E, Jonker D, Couture F, Toffoli G.

Front Pharmacol. 2018 Apr 13;9:367. doi: 10.3389/fphar.2018.00367. eCollection 2018.


Testosterone suppression in the treatment of recurrent or metastatic prostate cancer - A Canadian consensus statement.

Klotz L, Shayegan B, Guillemette C, Collins LL, Gotto G, Guérette D, Jammal MP, Pickles T, Richard PO, Saad F.

Can Urol Assoc J. 2018 Feb;12(2):30-37. doi: 10.5489/cuaj.5116. Epub 2017 Dec 19.


Identification of Metabolomic Biomarkers for Endometrial Cancer and Its Recurrence after Surgery in Postmenopausal Women.

Audet-Delage Y, Villeneuve L, Grégoire J, Plante M, Guillemette C.

Front Endocrinol (Lausanne). 2018 Mar 12;9:87. doi: 10.3389/fendo.2018.00087. eCollection 2018.


PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics.

Alvarellos M, Guillemette C, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 May;28(5):127-137. doi: 10.1097/FPC.0000000000000331. No abstract available.


Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing.

Labriet A, Allain EP, Rouleau M, Audet-Delage Y, Villeneuve L, Guillemette C.

Drug Metab Dispos. 2018 May;46(5):514-524. doi: 10.1124/dmd.117.079921. Epub 2018 Feb 9.


Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study.

Petrick JL, Falk RT, Hyland PL, Caron P, Pfeiffer RM, Wood SN, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA, Cook MB.

PLoS One. 2018 Jan 17;13(1):e0190325. doi: 10.1371/journal.pone.0190325. eCollection 2018.


Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery.

Audet-Delage Y, Grégoire J, Caron P, Turcotte V, Plante M, Ayotte P, Simonyan D, Villeneuve L, Guillemette C.

J Steroid Biochem Mol Biol. 2018 Apr;178:45-54. doi: 10.1016/j.jsbmb.2017.10.021. Epub 2017 Oct 29.


Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L.

Labriet A, De Mattia E, Cecchin E, Lévesque É, Jonker D, Couture F, Buonadonna A, D'Andrea M, Villeneuve L, Toffoli G, Guillemette C.

Front Pharmacol. 2017 Oct 10;8:712. doi: 10.3389/fphar.2017.00712. eCollection 2017.


The R148.3 Gene Modulates Caenorhabditis elegans Lifespan and Fat Metabolism.

Roy-Bellavance C, Grants JM, Miard S, Lee K, Rondeau É, Guillemette C, Simard MJ, Taubert S, Picard F.

G3 (Bethesda). 2017 Aug 7;7(8):2739-2747. doi: 10.1534/g3.117.041681.


Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues.

Tourancheau A, Rouleau M, Guauque-Olarte S, Villeneuve L, Gilbert I, Droit A, Guillemette C.

Pharmacogenomics J. 2018 Apr;18(2):251-261. doi: 10.1038/tpj.2017.5. Epub 2017 Apr 25.


Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study.

Cook MB, Wood S, Hyland PL, Caron P, Drahos J, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA.

Andrology. 2017 Mar;5(2):240-247. doi: 10.1111/andr.12314. Epub 2017 Feb 27.


Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics.

Rouleau M, Audet-Delage Y, Desjardins S, Rouleau M, Girard-Bock C, Guillemette C.

Front Pharmacol. 2017 Feb 3;8:23. doi: 10.3389/fphar.2017.00023. eCollection 2017.


Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism.

Audet-Delage Y, Rouleau M, Rouleau M, Roberge J, Miard S, Picard F, Têtu B, Guillemette C.

Mol Pharmacol. 2017 Mar;91(3):167-177. doi: 10.1124/mol.116.106161. Epub 2017 Jan 3.


Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit.

Hudon Thibeault AA, Laurent L, Vo Duy S, Sauvé S, Caron P, Guillemette C, Sanderson JT, Vaillancourt C.

Mol Cell Endocrinol. 2017 Feb 15;442:32-39. doi: 10.1016/j.mce.2016.11.021. Epub 2016 Nov 24.


Papaverine-sensitive phosphodiesterase activity is measured in bovine spermatozoa.

Bergeron A, Hébert A, Guillemette C, Laroche A, Poulin MP, Aragon JP, Leclerc P, Sullivan R, Blondin P, Vigneault C, Richard FJ.

Andrology. 2017 Jan;5(1):169-179. doi: 10.1111/andr.12290. Epub 2016 Nov 16.


Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa.

Maréchal L, Guillemette C, Goupil S, Blondin P, Leclerc P, Richard FJ.

Biochim Biophys Acta. 2017 Feb;1861(2):147-156. doi: 10.1016/j.bbagen.2016.11.006. Epub 2016 Nov 9.


A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.

Girard-Bock C, Benoit-Biancamano MO, Villeneuve L, Desjardins S, Guillemette C.

Drug Metab Dispos. 2016 Dec;44(12):1867-1871. Epub 2016 Sep 9.


Prediagnostic circulating inflammation markers and endometrial cancer risk in the prostate, lung, colorectal and ovarian cancer (PLCO) screening trial.

Trabert B, Eldridge RC, Pfeiffer RM, Shiels MS, Kemp TJ, Guillemette C, Hartge P, Sherman ME, Brinton LA, Black A, Chaturvedi AK, Hildesheim A, Berndt SI, Safaeian M, Pinto L, Wentzensen N.

Int J Cancer. 2017 Feb 1;140(3):600-610. doi: 10.1002/ijc.30478. Epub 2016 Nov 7.


Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing.

Rouleau M, Tourancheau A, Girard-Bock C, Villeneuve L, Vaucher J, Duperré AM, Audet-Delage Y, Gilbert I, Popa I, Droit A, Guillemette C.

Cell Rep. 2016 Sep 27;17(1):114-124. doi: 10.1016/j.celrep.2016.08.077.


Characterization of cAMP-phosphodiesterase activity in bovine seminal plasma.

Bergeron A, Aragon JP, Guillemette C, Hébert A, Sullivan R, Blondin P, Richard FJ.

Andrology. 2016 Nov;4(6):1123-1130. doi: 10.1111/andr.12267. Epub 2016 Aug 27.


Correlation between prostate volume and single nucleotide polymorphisms implicated in the steroid pathway.

Cornu JN, Audet-Walsh E, Drouin S, Bigot P, Valeri A, Fournier G, Azzouzi AR, Roupret M, Cormier L, Chanock S, Guillemette C, Cussenot O, Lévesque E, Cancel-Tassin G.

World J Urol. 2017 Feb;35(2):293-298. doi: 10.1007/s00345-016-1869-4. Epub 2016 Jun 8.


Active 3'-5' cyclic nucleotide phosphodiesterases are present in detergent-resistant membranes of mural granulosa cells.

Bergeron A, Guillemette C, Sirard MA, Richard FJ.

Reprod Fertil Dev. 2017 Apr;29(4):778-790. doi: 10.1071/RD15243.


Phase II Drug-Metabolizing Polymorphisms and Smoking Predict Recurrence of Non-Muscle-Invasive Bladder Cancer: A Gene-Smoking Interaction.

Lacombe L, Fradet V, Lévesque É, Pouliot F, Larue H, Bergeron A, Hovington H, Caron A, Nguile-Makao M, Harvey M, Fradet Y, Guillemette C.

Cancer Prev Res (Phila). 2016 Feb;9(2):189-95. doi: 10.1158/1940-6207.CAPR-15-0069. Epub 2015 Dec 8.


Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.

Gammal RS, Court MH, Haidar CE, Iwuchukwu OF, Gaur AH, Alvarellos M, Guillemette C, Lennox JL, Whirl-Carrillo M, Brummel SS, Ratain MJ, Klein TE, Schackman BR, Caudle KE, Haas DW; Clinical Pharmacogenetics Implementation Consortium.

Clin Pharmacol Ther. 2016 Apr;99(4):363-9. doi: 10.1002/cpt.269. Epub 2015 Nov 9. Review.


Assay reproducibility of serum androgen measurements using liquid chromatography-tandem mass spectrometry.

Trabert B, Xu X, Falk RT, Guillemette C, Stanczyk FZ, McGlynn KA.

J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):56-62. doi: 10.1016/j.jsbmb.2015.09.032. Epub 2015 Sep 28.


Evidences of Biological Functions of Biliverdin Reductase A in the Bovine Epididymis.

D'Amours O, Frenette G, Caron P, Belleannée C, Guillemette C, Sullivan R.

J Cell Physiol. 2016 May;231(5):1077-89. doi: 10.1002/jcp.25200. Epub 2015 Sep 30.


Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.

Margaillan G, Lévesque É, Guillemette C.

J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):85-93. doi: 10.1016/j.jsbmb.2015.09.021. Epub 2015 Sep 15.


BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.

Wang ZQ, Faddaoui A, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Guillemette C, Gobeil S, Macdonald E, Vanderhyden B, Bachvarov D.

Oncotarget. 2015 Oct 13;6(31):31522-43. doi: 10.18632/oncotarget.5159.


ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

Chen S, Villeneuve L, Jonker D, Couture F, Laverdière I, Cecchin E, Innocenti F, Toffoli G, Lévesque E, Guillemette C.

Pharmacogenet Genomics. 2015 Dec;25(12):573-83. doi: 10.1097/FPC.0000000000000168.


The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.

Belledant A, Hovington H, Garcia L, Caron P, Brisson H, Villeneuve L, Simonyan D, Têtu B, Fradet Y, Lacombe L, Guillemette C, Lévesque E.

Eur Urol. 2016 Apr;69(4):601-609. doi: 10.1016/j.eururo.2015.06.054. Epub 2015 Jul 26.


Characterization of FSH signalling networks in bovine cumulus cells: a perspective on oocyte competence acquisition.

Khan DR, Guillemette C, Sirard MA, Richard FJ.

Mol Hum Reprod. 2015 Sep;21(9):688-701. doi: 10.1093/molehr/gav032. Epub 2015 Jun 24.


Transcriptomic analysis of cyclic AMP response in bovine cumulus cells.

Khan DR, Guillemette C, Sirard MA, Richard FJ.

Physiol Genomics. 2015 Sep;47(9):432-42. doi: 10.1152/physiolgenomics.00043.2015. Epub 2015 Jun 16.


Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.

Margaillan G, Rouleau M, Klein K, Fallon JK, Caron P, Villeneuve L, Smith PC, Zanger UM, Guillemette C.

Drug Metab Dispos. 2015 Sep;43(9):1331-5. doi: 10.1124/dmd.115.065391. Epub 2015 Jun 15.


Prediagnostic Sex Steroid Hormones in Relation to Male Breast Cancer Risk.

Brinton LA, Key TJ, Kolonel LN, Michels KB, Sesso HD, Ursin G, Van Den Eeden SK, Wood SN, Falk RT, Parisi D, Guillemette C, Caron P, Turcotte V, Habel LA, Isaacs CJ, Riboli E, Weiderpass E, Cook MB.

J Clin Oncol. 2015 Jun 20;33(18):2041-50. doi: 10.1200/JCO.2014.59.1602. Epub 2015 May 11.


Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing.

Tourancheau A, Margaillan G, Rouleau M, Gilbert I, Villeneuve L, Lévesque E, Droit A, Guillemette C.

Pharmacogenomics J. 2016 Feb;16(1):60-70. doi: 10.1038/tpj.2015.20. Epub 2015 Apr 14.


A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients.

Chen S, Laverdiere I, Tourancheau A, Jonker D, Couture F, Cecchin E, Villeneuve L, Harvey M, Court MH, Innocenti F, Toffoli G, Lévesque E, Guillemette C.

Pharmacogenomics J. 2015 Dec;15(6):513-20. doi: 10.1038/tpj.2015.12. Epub 2015 Mar 17.


Quantitative profiling of human renal UDP-glucuronosyltransferases and glucuronidation activity: a comparison of normal and tumoral kidney tissues.

Margaillan G, Rouleau M, Fallon JK, Caron P, Villeneuve L, Turcotte V, Smith PC, Joy MS, Guillemette C.

Drug Metab Dispos. 2015 Apr;43(4):611-9. doi: 10.1124/dmd.114.062877. Epub 2015 Feb 3.


The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy.

Laverdière I, Flageole C, Audet-Walsh É, Caron P, Fradet Y, Lacombe L, Lévesque É, Guillemette C.

Endocr Relat Cancer. 2015 Feb;22(1):77-85. doi: 10.1530/ERC-14-0423. Epub 2014 Dec 1.


Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease.

Laverdière I, Guillemette C, Tamouza R, Loiseau P, Peffault de Latour R, Robin M, Couture F, Filion A, Lalancette M, Tourancheau A, Charron D, Socié G, Lévesque É.

Haematologica. 2015 Feb;100(2):275-83. doi: 10.3324/haematol.2014.109884. Epub 2014 Nov 25.


Association between circulating levels of sex steroid hormones and Barrett's esophagus in men: a case-control analysis.

Cook MB, Wood SN, Cash BD, Young P, Acosta RD, Falk RT, Pfeiffer RM, Hu N, Su H, Wang L, Wang C, Gherman B, Giffen C, Dykes C, Turcotte V, Caron P, Guillemette C, Dawsey SM, Abnet CC, Hyland PL, Taylor PR.

Clin Gastroenterol Hepatol. 2015 Apr;13(4):673-82. doi: 10.1016/j.cgh.2014.08.027. Epub 2014 Aug 24.


Activation of 5' adenosine monophosphate-activated protein kinase blocks cumulus cell expansion through inhibition of protein synthesis during in vitro maturation in Swine.

Santiquet N, Sasseville M, Laforest M, Guillemette C, Gilchrist RB, Richard FJ.

Biol Reprod. 2014 Aug;91(2):51. doi: 10.1095/biolreprod.113.116764. Epub 2014 Jul 16.


Pharmacogenomics of human uridine diphospho-glucuronosyltransferases and clinical implications.

Guillemette C, Lévesque É, Rouleau M.

Clin Pharmacol Ther. 2014 Sep;96(3):324-39. doi: 10.1038/clpt.2014.126. Epub 2014 Jun 12.


New elements in the C-type natriuretic peptide signaling pathway inhibiting swine in vitro oocyte meiotic resumption.

Santiquet N, Papillon-Dion E, Djender N, Guillemette C, Richard FJ.

Biol Reprod. 2014 Jul;91(1):16. doi: 10.1095/biolreprod.113.114132. Epub 2014 Jun 4.


Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer.

Huang SP, Lévesque E, Guillemette C, Yu CC, Huang CY, Lin VC, Chung IC, Chen LC, Laverdière I, Lacombe L, Fradet Y, Chang TY, Lee HZ, Juang SH, Bao BY.

Int J Cancer. 2014 Dec 1;135(11):2661-7. doi: 10.1002/ijc.28904. Epub 2014 Apr 22.


Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.

Lévesque E, Laverdière I, Audet-Walsh E, Caron P, Rouleau M, Fradet Y, Lacombe L, Guillemette C.

Clin Cancer Res. 2014 Jun 1;20(11):2971-83. doi: 10.1158/1078-0432.CCR-13-2567. Epub 2014 Mar 28.


Importance of 5α-reductase gene polymorphisms on circulating and intraprostatic androgens in prostate cancer.

Lévesque É, Laverdière I, Lacombe L, Caron P, Rouleau M, Turcotte V, Têtu B, Fradet Y, Guillemette C.

Clin Cancer Res. 2014 Feb 1;20(3):576-84. doi: 10.1158/1078-0432.CCR-13-1100. Epub 2013 Nov 25.

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