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Items: 1 to 50 of 112

1.

Development of Novel and Efficient Processes for the Synthesis of 5-Amino and 5-Iminoimidazo[1,2-a]imidazoles via Three-Component Reaction Catalyzed by Zirconium(IV) Chloride.

Driowya M, Guillot R, Bonnet P, Guillaumet G.

Front Chem. 2019 Jul 8;7:457. doi: 10.3389/fchem.2019.00457. eCollection 2019.

2.

An original class of small sized molecules as versatile fluorescent probes for cellular imaging.

Sirbu D, Diharce J, Martinić I, Chopin N, Eliseeva SV, Guillaumet G, Petoud S, Bonnet P, Suzenet F.

Chem Commun (Camb). 2019 Jul 2;55(54):7776-7779. doi: 10.1039/c9cc03765a.

PMID:
31210218
3.

S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization.

Boutin JA, Bouillaud F, Janda E, Gacsalyi I, Guillaumet G, Hirsch EC, Kane DA, Nepveu F, Reybier K, Dupuis P, Bertrand M, Chhour M, Le Diguarher T, Antoine M, Brebner K, Da Costa H, Ducrot P, Giganti A, Goswami V, Guedouari H, Michel PP, Patel A, Paysant J, Stojko J, Viaud-Massuard MC, Ferry G.

Mol Pharmacol. 2019 Mar;95(3):269-285. doi: 10.1124/mol.118.114231. Epub 2018 Dec 19.

4.

Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions.

Ejjoummany A, Belaroussi R, El Hakmaoui A, Akssira M, Guillaumet G, Buron F, Routier S.

Molecules. 2018 Oct 23;23(11). pii: E2740. doi: 10.3390/molecules23112740.

5.

Palladium-Catalyzed C3-Arylations of 1 H- and 2 H-Pyrazolo[4,3- b]pyridines on Water.

Faarasse S, El Kazzouli S, Suzenet F, Guillaumet G.

J Org Chem. 2018 Oct 19;83(20):12847-12854. doi: 10.1021/acs.joc.8b01728. Epub 2018 Oct 4.

PMID:
30240222
6.

Access to 1H-indazoles, 1H-benzoindazoles and 1H-azaindazoles from (het)aryl azides: a one-pot Staudinger-aza-Wittig reaction leading to N-N bond formation?

Alaime T, Daniel M, Hiebel MA, Pasquinet E, Suzenet F, Guillaumet G.

Chem Commun (Camb). 2018 Jul 24;54(60):8411-8414. doi: 10.1039/c8cc03612h.

PMID:
29999074
7.

Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress.

Loubidi M, Jouha J, Tber Z, Khouili M, Suzenet F, Akssira M, Erdogan MA, Köse FA, Dagcı T, Armagan G, Saso L, Guillaumet G.

Eur J Med Chem. 2018 Feb 10;145:113-123. doi: 10.1016/j.ejmech.2017.12.081. Epub 2017 Dec 27.

PMID:
29324335
8.

"On Water" Direct C-3 Arylation of 2H-Pyrazolo[3,4-b]pyridines.

Faarasse S, El Kazzouli S, Naas M, Jouha J, Suzenet F, Guillaumet G.

J Org Chem. 2017 Dec 1;82(23):12300-12306. doi: 10.1021/acs.joc.7b02136. Epub 2017 Nov 13.

PMID:
29090922
9.

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5.

10.

Domino Aza-Michael-ih-Diels-Alder Reaction to Various 3-Vinyl-1,2,4-triazines: Access to Polysubstituted Tetrahydro-1,6-naphthyridines.

Jouha J, Buttard F, Lorion M, Berthonneau C, Khouili M, Hiebel MA, Guillaumet G, Brière JF, Suzenet F.

Org Lett. 2017 Sep 15;19(18):4770-4773. doi: 10.1021/acs.orglett.7b02132. Epub 2017 Aug 31.

PMID:
28857570
11.

Design and validation of the first cell-impermeant melatonin receptor agonist.

Gbahou F, Cecon E, Viault G, Gerbier R, Jean-Alphonse F, Karamitri A, Guillaumet G, Delagrange P, Friedlander RM, Vilardaga JP, Suzenet F, Jockers R.

Br J Pharmacol. 2017 Jul;174(14):2409-2421. doi: 10.1111/bph.13856. Epub 2017 Jun 11.

12.

Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP+-induced neurodegeneration.

Jouha J, Loubidi M, Bouali J, Hamri S, Hafid A, Suzenet F, Guillaumet G, Dagcı T, Khouili M, Aydın F, Saso L, Armagan G.

Eur J Med Chem. 2017 Mar 31;129:41-52. doi: 10.1016/j.ejmech.2017.02.019. Epub 2017 Feb 11.

PMID:
28214632
13.

Synthetic Modification of 9α- and 9β-Hydroxyparthenolide by Heck or Acylation Reactions and Evaluation of Cytotoxic Activities.

El Bouakher A, Jismy B, Allouchi H, Duverger E, Barkaoui L, El Hakmaoui A, Daniellou R, Guillaumet G, Akssira M.

Planta Med. 2017 May;83(7):661-671. doi: 10.1055/s-0042-119864. Epub 2016 Dec 5.

PMID:
27919107
14.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2016 Jun 10;115:311-25. doi: 10.1016/j.ejmech.2016.02.072. Epub 2016 Mar 2.

PMID:
27019296
15.

Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.

Couhert A, Delagrange P, Caignard DH, Chartier A, Suzenet F, Guillaumet G.

Eur J Med Chem. 2016 Feb 15;109:268-75. doi: 10.1016/j.ejmech.2016.01.008. Epub 2016 Jan 12.

PMID:
26785296
16.

Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain.

Deau E, Robin E, Voinea R, Percina N, Satała G, Finaru AL, Chartier A, Tamagnan G, Alagille D, Bojarski AJ, Morisset-Lopez S, Suzenet F, Guillaumet G.

J Med Chem. 2015 Oct 22;58(20):8066-96. doi: 10.1021/acs.jmedchem.5b00874. Epub 2015 Oct 5.

PMID:
26348247
17.

Palladium-Catalyzed Oxidative Direct C3- and C7-Alkenylations of Indazoles: Application to the Synthesis of Gamendazole.

Naas M, El Kazzouli S, Essassi el M, Bousmina M, Guillaumet G.

Org Lett. 2015 Sep 4;17(17):4320-3. doi: 10.1021/acs.orglett.5b02136. Epub 2015 Aug 26.

PMID:
26308587
18.

Ligandless Palladium-Catalyzed Regioselective Direct C-H Arylation of Imidazo[1,2-a]imidazole Derivatives.

Grosse S, Pillard C, Massip S, Marchivie M, Jarry C, Bernard P, Guillaumet G.

J Org Chem. 2015 Sep 4;80(17):8539-51. doi: 10.1021/acs.joc.5b00534. Epub 2015 Aug 20.

PMID:
26243437
19.

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.

Boulahjar R, Ouach A, Bourg S, Bonnet P, Lozach O, Meijer L, Guguen-Guillouzo C, Le Guevel R, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S.

Eur J Med Chem. 2015 Aug 28;101:274-87. doi: 10.1016/j.ejmech.2015.06.046. Epub 2015 Jun 27.

20.

Metal Free Formation of Various 3-Iodo-1H-pyrrolo[3',2':4,5]imidazo-[1,2-a]pyridines and [1,2-b]Pyridazines and Their Further Functionalization.

Tber Z, Hiebel MA, El Hakmaoui A, Akssira M, Guillaumet G, Berteina-Raboin S.

J Org Chem. 2015 Jul 2;80(13):6564-73. doi: 10.1021/acs.joc.5b00555. Epub 2015 Jun 17.

PMID:
26083102
21.

Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels-Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms.

Lorion M, Guillaumet G, Brière JF, Suzenet F.

Org Lett. 2015 Jun 19;17(12):3154-7. doi: 10.1021/acs.orglett.5b01487. Epub 2015 Jun 11.

PMID:
26066589
22.

Recent advances in the chemistry and biology of pyridopyrimidines.

Buron F, Mérour JY, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2015 May 5;95:76-95. doi: 10.1016/j.ejmech.2015.03.029. Epub 2015 Mar 14. Review.

PMID:
25794791
23.

New imidazo[1,2-b]pyrazoles as anticancer agents: synthesis, biological evaluation and structure activity relationship analysis.

Grosse S, Mathieu V, Pillard C, Massip S, Marchivie M, Jarry C, Bernard P, Kiss R, Guillaumet G.

Eur J Med Chem. 2014 Sep 12;84:718-30. doi: 10.1016/j.ejmech.2014.07.057. Epub 2014 Jul 18.

PMID:
25064349
24.

Palladium-catalyzed direct C7-arylation of substituted indazoles.

Naas M, El Kazzouli S, Essassi el M, Bousmina M, Guillaumet G.

J Org Chem. 2014 Aug 15;79(16):7286-93. doi: 10.1021/jo500876q. Epub 2014 Jul 25.

PMID:
25046583
25.

Synthesis and biological evaluation of 9α- and 9β-hydroxyamino-parthenolides as novel anticancer agents.

Moumou M, El Bouakher A, Allouchi H, El Hakmaoui A, Benharref A, Mathieu V, Guillaumet G, Akssira M.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):4014-8. doi: 10.1016/j.bmcl.2014.06.019. Epub 2014 Jun 14.

PMID:
24998377
26.

Original Design of Fluorescent Ligands by Fusing BODIPY and Melatonin Neurohormone.

Thireau J, Marteaux J, Delagrange P, Lefoulon F, Dufourny L, Guillaumet G, Suzenet F.

ACS Med Chem Lett. 2013 Nov 20;5(2):158-61. doi: 10.1021/ml4004155. eCollection 2014 Feb 13.

27.

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors.

Dehbi O, Tikad A, Bourg S, Bonnet P, Lozach O, Meijer L, Aadil M, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2014 Jun 10;80:352-63. doi: 10.1016/j.ejmech.2014.04.055. Epub 2014 Apr 22.

PMID:
24793883
28.

Synthesis of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones via microwave-activated inverse electron-demand Diels-Alder reactions.

Fadel S, Hajbi Y, Khouili M, Lazar S, Suzenet F, Guillaumet G.

Beilstein J Org Chem. 2014 Jan 28;10:282-6. doi: 10.3762/bjoc.10.24. eCollection 2014.

29.

Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors.

Saurat T, Buron F, Rodrigues N, de Tauzia ML, Colliandre L, Bourg S, Bonnet P, Guillaumet G, Akssira M, Corlu A, Guillouzo C, Berthier P, Rio P, Jourdan ML, Bénédetti H, Routier S.

J Med Chem. 2014 Feb 13;57(3):613-31. doi: 10.1021/jm401138v. Epub 2014 Jan 21.

PMID:
24345273
30.

Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors.

Gomez C, Berteina-Raboin S, De Nanteuil G, Guillaumet G.

Bioorg Med Chem. 2013 Nov 15;21(22):7216-21. doi: 10.1016/j.bmc.2013.08.032. Epub 2013 Sep 11.

PMID:
24095015
31.

Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Arnould M, Hiebel MA, Massip S, Léger JM, Jarry C, Berteina-Raboin S, Guillaumet G.

Chemistry. 2013 Sep 9;19(37):12249-53. doi: 10.1002/chem.201300961. Epub 2013 Aug 16.

PMID:
23955568
32.

N-(2-Bromo-4-methyl-phen-yl)-2-(5-methyl-2-phenyl-pyrazolo-[1,5-a]pyrimidin-7-yl)acetamide.

Bassoude I, Berteina-Raboin S, Essassi el M, Guillaumet G, El Ammari L.

Acta Crystallogr Sect E Struct Rep Online. 2013 May 4;69(Pt 6):o829. doi: 10.1107/S1600536813011811. Print 2013 Jun 1.

33.

7-Chloro-5-methyl-2-phenyl-pyrazolo-[1,5-a]pyrimidine.

Bassoude I, Berteina-Raboin S, Essassi el M, Guillaumet G, El Ammari L.

Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 17;69(Pt 5):o749. doi: 10.1107/S1600536813009896. Print 2013 May 1.

34.

Ethyl 7-methyl-2-phenyl-pyrazolo-[1,5-a]pyrimidine-5-carboxyl-ate.

Bassoude I, Berteina-Raboin S, Essassi el M, Guillaumet G, El Ammari L.

Acta Crystallogr Sect E Struct Rep Online. 2013 Apr 17;69(Pt 5):o740. doi: 10.1107/S1600536813009902. Print 2013 May 1.

35.

New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors.

Legros C, Matthey U, Grelak T, Pedragona-Moreau S, Hassler W, Yous S, Thomas E, Suzenet F, Folleas B, Lefoulon F, Berthelot P, Caignard DH, Guillaumet G, Delagrange P, Brayer JL, Nosjean O, Boutin JA.

Int J Mol Sci. 2013 Apr 25;14(5):8948-62. doi: 10.3390/ijms14058948.

36.

Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.

Grosse S, Pillard C, Massip S, Léger JM, Jarry C, Bourg S, Bernard P, Guillaumet G.

Chemistry. 2012 Nov 19;18(47):14943-7. doi: 10.1002/chem.201202593. Epub 2012 Oct 19.

PMID:
23086664
37.

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.

Boulahjar R, Ouach A, Matteo C, Bourg S, Ravache M, le Guével R, Marionneau S, Oullier T, Lozach O, Meijer L, Guguen-Guillouzo C, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S.

J Med Chem. 2012 Nov 26;55(22):9589-606. doi: 10.1021/jm3008536. Epub 2012 Nov 1.

PMID:
23083119
38.

New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts.

Riadi Y, Abrouki Y, Mamouni R, El Haddad M, Routier S, Guillaumet G, Lazar S.

Chem Cent J. 2012 Jun 21;6(1):60. doi: 10.1186/1752-153X-6-60.

39.

Design and synthesis of 2-phenylimidazo[1,2-a]pyridines as a novel class of melatonin receptor ligands.

El Kazzouli S, Griffon du Bellay A, Berteina-Raboin S, Delagrange P, Caignard DH, Guillaumet G.

Eur J Med Chem. 2011 Sep;46(9):4252-7. doi: 10.1016/j.ejmech.2011.06.030. Epub 2011 Jul 1.

PMID:
21764185
40.

Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.

Jeanty M, Suzenet F, Delagrange P, Nosjean O, Boutin JA, Caignard DH, Guillaumet G.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2316-9. doi: 10.1016/j.bmcl.2011.02.097. Epub 2011 Feb 26.

PMID:
21420861
41.

Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist.

Picard M, Morisset S, Cloix JF, Bizot JC, Guerin M, Beneteau V, Guillaumet G, Hevor TK.

Neuroscience. 2010 Sep 1;169(3):1337-46. doi: 10.1016/j.neuroscience.2010.05.040. Epub 2010 May 24.

PMID:
20580787
42.

Old and new inhibitors of quinone reductase 2.

Ferry G, Hecht S, Berger S, Moulharat N, Coge F, Guillaumet G, Leclerc V, Yous S, Delagrange P, Boutin JA.

Chem Biol Interact. 2010 Jul 30;186(2):103-9. doi: 10.1016/j.cbi.2010.04.006. Epub 2010 May 4.

PMID:
20399199
43.

Synthesis and grafting of a BTP derivative onto a quartz crystal microbalance for lanthanide detection.

Mercier D, Leconte N, Méthivier C, Suzenet F, Guillaumet G, Wuillaume A, Pradier CM.

Phys Chem Chem Phys. 2010 Jun 21;12(23):6099-106. doi: 10.1039/b921389a. Epub 2010 Apr 13.

PMID:
20390153
44.

Desulfitative cross-coupling of protecting group-free 2-thiouracil derivatives with organostannanes.

Sun Q, Suzenet F, Guillaumet G.

J Org Chem. 2010 May 21;75(10):3473-6. doi: 10.1021/jo1003482.

PMID:
20359202
45.

SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling.

Badarau E, Bugno R, Suzenet F, Bojarski AJ, Finaru AL, Guillaumet G.

Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. doi: 10.1016/j.bmc.2010.01.035. Epub 2010 Jan 18.

PMID:
20138771
46.

Hydrophobic chromophore cargo in micellar structures: a different strategy to sensitize lanthanide cations.

Bonnet CS, Pellegatti L, Buron F, Shade CM, Villette S, Kubícek V, Guillaumet G, Suzenet F, Petoud S, Tóth E.

Chem Commun (Camb). 2010 Jan 7;46(1):124-6. doi: 10.1039/b918881a. Epub 2009 Nov 20.

PMID:
20024314
47.

Efficient one-pot synthesis of 2,4-di(het)aryl and 2,4-diamino pyrido[3,2-d]pyrimidines involving regioselective S(N)Ar and palladium-catalyzed reactions.

Tikad A, Routier S, Akssira M, Guillaumet G.

Org Biomol Chem. 2009 Dec 21;7(24):5113-8. doi: 10.1039/b913657f. Epub 2009 Oct 15.

PMID:
20024106
48.

Smiles rearrangement as a tool for the preparation of dihydrodipyridopyrazines.

Patriciu OI, Fînaru AL, Massip S, Leger JM, Jarry C, Guillaumet G.

Org Lett. 2009 Dec 3;11(23):5502-5. doi: 10.1021/ol902369v.

PMID:
19877627
49.

New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.

Badarau E, Putey A, Suzenet F, Joseph B, Bojarski A, Finaru A, Guillaumet G.

J Enzyme Inhib Med Chem. 2010 Jun;25(3):301-5. doi: 10.3109/14756360903179393.

PMID:
19874209
50.

Synthesis of 4- and 6-azaindoles via the Fischer reaction.

Jeanty M, Blu J, Suzenet F, Guillaumet G.

Org Lett. 2009 Nov 19;11(22):5142-5. doi: 10.1021/ol902139r.

PMID:
19839585

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