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PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

Díaz Acosta CC, Dias AA, Rosa TLSA, Batista-Silva LR, Rosa PS, Toledo-Pinto TG, Costa FDMR, Lara FA, Rodrigues LS, Mattos KA, Sarno EN, Bozza PT, Guilhot C, de Berrêdo-Pinho M, Pessolani MCV.

PLoS Pathog. 2018 Jul 6;14(7):e1007151. doi: 10.1371/journal.ppat.1007151. eCollection 2018 Jul.


Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages.

Oldenburg R, Mayau V, Prandi J, Arbues A, Astarie-Dequeker C, Guilhot C, Werts C, Winter N, Demangel C.

Front Immunol. 2018 Jan 19;9:2. doi: 10.3389/fimmu.2018.00002. eCollection 2018.


Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response.

Alonso H, Parra J, Malaga W, Payros D, Liu CF, Berrone C, Robert C, Meunier E, Burlet-Schiltz O, Rivière M, Guilhot C.

Sci Rep. 2017 Aug 11;7(1):7913. doi: 10.1038/s41598-017-08489-7.


ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.

Augenstreich J, Arbues A, Simeone R, Haanappel E, Wegener A, Sayes F, Le Chevalier F, Chalut C, Malaga W, Guilhot C, Brosch R, Astarie-Dequeker C.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12726. Epub 2017 Feb 15.


Trisaccharides of Phenolic Glycolipids Confer Advantages to Pathogenic Mycobacteria through Manipulation of Host-Cell Pattern-Recognition Receptors.

Arbués A, Malaga W, Constant P, Guilhot C, Prandi J, Astarie-Dequeker C.

ACS Chem Biol. 2016 Oct 21;11(10):2865-2875. Epub 2016 Sep 2.


pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence.

Boritsch EC, Frigui W, Cascioferro A, Malaga W, Etienne G, Laval F, Pawlik A, Le Chevalier F, Orgeur M, Ma L, Bouchier C, Stinear TP, Supply P, Majlessi L, Daffé M, Guilhot C, Brosch R.

Nat Microbiol. 2016 Jan 27;1:15019. doi: 10.1038/nmicrobiol.2015.19.


Trehalose Polyphleates Are Produced by a Glycolipid Biosynthetic Pathway Conserved across Phylogenetically Distant Mycobacteria.

Burbaud S, Laval F, Lemassu A, Daffé M, Guilhot C, Chalut C.

Cell Chem Biol. 2016 Feb 18;23(2):278-289. doi: 10.1016/j.chembiol.2015.11.013. Epub 2016 Jan 28.


[Bovine tubercle bacilli: evolution associated with loss of transmission capacity in humans].

Brosch R, Guilhot C.

Med Sci (Paris). 2015 Feb;31(2):123-6. doi: 10.1051/medsci/20153102003. Epub 2015 Mar 4. French. No abstract available.


Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids.

Arbues A, Lugo-Villarino G, Neyrolles O, Guilhot C, Astarie-Dequeker C.

Front Cell Infect Microbiol. 2014 Dec 9;4:173. doi: 10.3389/fcimb.2014.00173. eCollection 2014.


The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria.

Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A.

Chem Biol. 2014 Dec 18;21(12):1660-9. doi: 10.1016/j.chembiol.2014.10.011. Epub 2014 Nov 26.


Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.

Gonzalo-Asensio J, Malaga W, Pawlik A, Astarie-Dequeker C, Passemar C, Moreau F, Laval F, Daffé M, Martin C, Brosch R, Guilhot C.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11491-6. doi: 10.1073/pnas.1406693111. Epub 2014 Jul 21.


The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

Solans L, Gonzalo-Asensio J, Sala C, Benjak A, Uplekar S, Rougemont J, Guilhot C, Malaga W, Martín C, Cole ST.

PLoS Pathog. 2014 May 29;10(5):e1004183. doi: 10.1371/journal.ppat.1004183. eCollection 2014 May.


Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions.

Passemar C, Arbués A, Malaga W, Mercier I, Moreau F, Lepourry L, Neyrolles O, Guilhot C, Astarie-Dequeker C.

Cell Microbiol. 2014 Feb;16(2):195-213. doi: 10.1111/cmi.12214. Epub 2013 Oct 16.


Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials.

Arbues A, Aguilo JI, Gonzalo-Asensio J, Marinova D, Uranga S, Puentes E, Fernandez C, Parra A, Cardona PJ, Vilaplana C, Ausina V, Williams A, Clark S, Malaga W, Guilhot C, Gicquel B, Martin C.

Vaccine. 2013 Oct 1;31(42):4867-73. doi: 10.1016/j.vaccine.2013.07.051. Epub 2013 Aug 17.


Detection of soluble co-factor dependent protein expression in vivo: application to the 4'-phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis.

Rottier K, Faille A, Prudhomme T, Leblanc C, Chalut C, Cabantous S, Guilhot C, Mourey L, Pedelacq JD.

J Struct Biol. 2013 Sep;183(3):320-328. doi: 10.1016/j.jsb.2013.07.010. Epub 2013 Jul 31.


Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis.

Liu CF, Tonini L, Malaga W, Beau M, Stella A, Bouyssié D, Jackson MC, Nigou J, Puzo G, Guilhot C, Burlet-Schiltz O, Rivière M.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6560-5. doi: 10.1073/pnas.1219704110. Epub 2013 Apr 2.


Functional characterisation of three o-methyltransferases involved in the biosynthesis of phenolglycolipids in Mycobacterium tuberculosis.

Simeone R, Huet G, Constant P, Malaga W, Lemassu A, Laval F, Daffé M, Guilhot C, Chalut C.

PLoS One. 2013;8(3):e58954. doi: 10.1371/journal.pone.0058954. Epub 2013 Mar 11.


4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo.

Leblanc C, Prudhomme T, Tabouret G, Ray A, Burbaud S, Cabantous S, Mourey L, Guilhot C, Chalut C.

PLoS Pathog. 2012 Dec;8(12):e1003097. doi: 10.1371/journal.ppat.1003097. Epub 2012 Dec 20.


Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13.

Bergeret F, Gavalda S, Chalut C, Malaga W, Quémard A, Pedelacq JD, Daffé M, Guilhot C, Mourey L, Bon C.

J Biol Chem. 2012 Sep 28;287(40):33675-90. Epub 2012 Jul 23.


Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1.

Manca C, Peixoto B, Malaga W, Guilhot C, Kaplan G.

J Interferon Cytokine Res. 2012 Jan;32(1):27-33. doi: 10.1089/jir.2011.0044. Epub 2011 Oct 7.


Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.

Krishnan N, Malaga W, Constant P, Caws M, Tran TH, Salmons J, Nguyen TN, Nguyen DB, Daffé M, Young DB, Robertson BD, Guilhot C, Thwaites GE.

PLoS One. 2011;6(9):e23870. doi: 10.1371/journal.pone.0023870. Epub 2011 Sep 8.


Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity.

Kirksey MA, Tischler AD, Siméone R, Hisert KB, Uplekar S, Guilhot C, McKinney JD.

Infect Immun. 2011 Jul;79(7):2829-38. doi: 10.1128/IAI.00097-11. Epub 2011 May 16.


Recent advances in deciphering the contribution of Mycobacterium tuberculosis lipids to pathogenesis.

Neyrolles O, Guilhot C.

Tuberculosis (Edinb). 2011 May;91(3):187-95. doi: 10.1016/ Epub 2011 Feb 16. Review.


Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes.

Tabouret G, Astarie-Dequeker C, Demangel C, Malaga W, Constant P, Ray A, Honoré N, Bello NF, Perez E, Daffé M, Guilhot C.

PLoS Pathog. 2010 Oct 21;6(10):e1001159. doi: 10.1371/journal.ppat.1001159.


Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.

Siméone R, Léger M, Constant P, Malaga W, Marrakchi H, Daffé M, Guilhot C, Chalut C.

FEBS J. 2010 Jun;277(12):2715-25. doi: 10.1111/j.1742-464X.2010.07688.x.


Identification of a stress-induced factor of Corynebacterineae that is involved in the regulation of the outer membrane lipid composition.

Meniche X, Labarre C, de Sousa-d'Auria C, Huc E, Laval F, Tropis M, Bayan N, Portevin D, Guilhot C, Daffé M, Houssin C.

J Bacteriol. 2009 Dec;191(23):7323-32. doi: 10.1128/JB.01042-09. Epub 2009 Oct 2.


A lipid profile typifies the Beijing strains of Mycobacterium tuberculosis: identification of a mutation responsible for a modification of the structures of phthiocerol dimycocerosates and phenolic glycolipids.

Huet G, Constant P, Malaga W, Lanéelle MA, Kremer K, van Soolingen D, Daffé M, Guilhot C.

J Biol Chem. 2009 Oct 2;284(40):27101-13. doi: 10.1074/jbc.M109.041939. Epub 2009 Aug 2.


Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids.

Astarie-Dequeker C, Le Guyader L, Malaga W, Seaphanh FK, Chalut C, Lopez A, Guilhot C.

PLoS Pathog. 2009 Feb;5(2):e1000289. doi: 10.1371/journal.ppat.1000289. Epub 2009 Feb 6.


Identification of the polyketide synthase involved in the biosynthesis of the surface-exposed lipooligosaccharides in mycobacteria.

Etienne G, Malaga W, Laval F, Lemassu A, Guilhot C, Daffé M.

J Bacteriol. 2009 Apr;191(8):2613-21. doi: 10.1128/JB.01235-08. Epub 2009 Jan 30.


The use of temperature-sensitive plasmids in mycobacteria.

Portevin D, Malaga W, Guilhot C.

Methods Mol Biol. 2009;465:229-42. doi: 10.1007/978-1-59745-207-6_15.


The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence.

Sinsimer D, Huet G, Manca C, Tsenova L, Koo MS, Kurepina N, Kana B, Mathema B, Marras SA, Kreiswirth BN, Guilhot C, Kaplan G.

Infect Immun. 2008 Jul;76(7):3027-36. doi: 10.1128/IAI.01663-07. Epub 2008 Apr 28.


Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex.

Malaga W, Constant P, Euphrasie D, Cataldi A, Daffé M, Reyrat JM, Guilhot C.

J Biol Chem. 2008 May 30;283(22):15177-84. doi: 10.1074/jbc.M710275200. Epub 2008 Apr 4.


Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family.

Sacco E, Legendre V, Laval F, Zerbib D, Montrozier H, Eynard N, Guilhot C, Daffé M, Quémard A.

Biochim Biophys Acta. 2007 Feb;1774(2):303-11. Epub 2006 Dec 6.


The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria.

Chalut C, Botella L, de Sousa-D'Auria C, Houssin C, Guilhot C.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8511-6. Epub 2006 May 18.


Characterization of three glycosyltransferases involved in the biosynthesis of the phenolic glycolipid antigens from the Mycobacterium tuberculosis complex.

Pérez E, Constant P, Lemassu A, Laval F, Daffé M, Guilhot C.

J Biol Chem. 2004 Oct 8;279(41):42574-83. Epub 2004 Aug 3.


Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex.

Pérez E, Constant P, Laval F, Lemassu A, Lanéelle MA, Daffé M, Guilhot C.

J Biol Chem. 2004 Oct 8;279(41):42584-92. Epub 2004 Aug 3.


A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms.

Portevin D, De Sousa-D'Auria C, Houssin C, Grimaldi C, Chami M, Daffé M, Guilhot C.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):314-9. Epub 2003 Dec 26.


Production of unmarked mutations in mycobacteria using site-specific recombination.

Malaga W, Perez E, Guilhot C.

FEMS Microbiol Lett. 2003 Feb 28;219(2):261-8.


Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.

Raynaud C, Guilhot C, Rauzier J, Bordat Y, Pelicic V, Manganelli R, Smith I, Gicquel B, Jackson M.

Mol Microbiol. 2002 Jul;45(1):203-17.


An essential role for phoP in Mycobacterium tuberculosis virulence.

Pérez E, Samper S, Bordas Y, Guilhot C, Gicquel B, Martín C.

Mol Microbiol. 2001 Jul;41(1):179-87.


Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier.

Camacho LR, Constant P, Raynaud C, Laneelle MA, Triccas JA, Gicquel B, Daffe M, Guilhot C.

J Biol Chem. 2001 Jun 8;276(23):19845-54. Epub 2001 Mar 13.


Gene Replacement and Transposon Delivery Using the Negative Selection Marker sacB.

Jackson M, Reinaldo Camacho L, Gicquel B, Guilhot C.

Methods Mol Med. 2001;54:59-75. doi: 10.1385/1-59259-147-7:059.


Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis.

Camacho LR, Ensergueix D, Perez E, Gicquel B, Guilhot C.

Mol Microbiol. 1999 Oct;34(2):257-67.


Persistence and protective efficacy of a Mycobacterium tuberculosis auxotroph vaccine.

Jackson M, Phalen SW, Lagranderie M, Ensergueix D, Chavarot P, Marchal G, McMurray DN, Gicquel B, Guilhot C.

Infect Immun. 1999 Jun;67(6):2867-73.


Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope.

Jackson M, Raynaud C, Lanéelle MA, Guilhot C, Laurent-Winter C, Ensergueix D, Gicquel B, Daffé M.

Mol Microbiol. 1999 Mar;31(5):1573-87.

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