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Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications.

Arrigoni P, Ruprecht JC, Chasse DAD, Glass KA, Andress B, Guilak F, Weinberg JB, McNulty AL.

Cartilage. 2019 Oct 14:1947603519880321. doi: 10.1177/1947603519880321. [Epub ahead of print]


Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity.

Guang Y, McGrath TM, Klug N, Nims R, Shih CC, Bayguinov PO, Guilak F, Pham CTN, Fitzpatrick JAJ, Setton LA.

J Biomech Eng. 2019 Sep 1. doi: 10.1115/1.4044892. [Epub ahead of print]


Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury.

Brophy RH, Cai L, Duan X, Zhang Q, Townsend RR, Nunley RM, Guilak F, Rai MF.

Osteoarthritis Cartilage. 2019 Aug 17. pii: S1063-4584(19)31172-0. doi: 10.1016/j.joca.2019.08.002. [Epub ahead of print]


Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs.

Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F.

Tissue Eng Regen Med. 2019 Jan 5;16(4):335-343. doi: 10.1007/s13770-018-0172-4. eCollection 2019 Aug. Review.


Stem cell-derived extracellular vesicles attenuate the early inflammatory response after tendon injury and repair.

Shen H, Yoneda S, Abu-Amer Y, Guilak F, Gelberman RH.

J Orthop Res. 2019 Jul 9. doi: 10.1002/jor.24406. [Epub ahead of print]


miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells.

Lee JM, Ko JY, Kim HY, Park JW, Guilak F, Im GI.

Mol Ther Nucleic Acids. 2019 Sep 6;17:310-322. doi: 10.1016/j.omtn.2019.05.029. Epub 2019 Jun 13.


Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.

Ruprecht JC, Waanders TD, Rowland CR, Nishimuta JF, Glass KA, Stencel J, DeFrate LE, Guilak F, Weinberg JB, McNulty AL.

Sci Rep. 2019 Jun 18;9(1):8719. doi: 10.1038/s41598-019-44855-3.


Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds.

Larson BL, Yu SN, Park H, Estes BT, Moutos FT, Bloomquist CJ, Wu PB, Welter JF, Langer R, Guilak F, Freed LE.

J Tissue Eng Regen Med. 2019 Aug;13(8):1453-1465. doi: 10.1002/term.2899. Epub 2019 Jul 18.


Journal of Orthopaedic Research: Special Issue on Stem Cells.

Guilak F, Sandell LJ, Huard J.

J Orthop Res. 2019 Jun;37(6):1209-1211. doi: 10.1002/jor.24338. Epub 2019 May 17. No abstract available.


Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies.

Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN.

J Orthop Res. 2019 Jun;37(6):1287-1293. doi: 10.1002/jor.24304. Epub 2019 May 2.


A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues.

Pferdehirt L, Ross AK, Brunger JM, Guilak F.

Tissue Eng Part A. 2019 May;25(9-10):809-820. doi: 10.1089/ten.TEA.2019.0027.


Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease.

Thompson MD, Derse A, Ferey J, Reid M, Xie Y, Christ M, Chatterjee D, Nguyen C, Harasymowicz N, Guilak F, Moley KH, Davidson NO.

Am J Physiol Endocrinol Metab. 2019 Apr 1;316(4):E674-E686. doi: 10.1152/ajpendo.00474.2018. Epub 2019 Mar 12.


TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.

Gilchrist CL, Leddy HA, Kaye L, Case ND, Rothenberg KE, Little D, Liedtke W, Hoffman BD, Guilak F.

Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):1992-1997. doi: 10.1073/pnas.1811095116. Epub 2019 Jan 23.


Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.

Harasymowicz NS, Dicks A, Wu CL, Guilak F.

Ann N Y Acad Sci. 2019 Mar;1440(1):36-53. doi: 10.1111/nyas.13999. Epub 2019 Jan 15. Review.


Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity.

Votava L, Schwartz AG, Harasymowicz NS, Wu CL, Guilak F.

J Orthop Res. 2019 Mar;37(3):779-788. doi: 10.1002/jor.24219. Epub 2019 Feb 12.


Cell migration: implications for repair and regeneration in joint disease.

Qu F, Guilak F, Mauck RL.

Nat Rev Rheumatol. 2019 Mar;15(3):167-179. doi: 10.1038/s41584-018-0151-0. Review.


Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.

Adkar SS, Wu CL, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F.

Stem Cells. 2019 Jan;37(1):65-76. doi: 10.1002/stem.2931. Epub 2018 Oct 31.


Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.

Collins AT, Kulvaranon ML, Cutcliffe HC, Utturkar GM, Smith WAR, Spritzer CE, Guilak F, DeFrate LE.

Arthritis Res Ther. 2018 Oct 17;20(1):232. doi: 10.1186/s13075-018-1727-4.


Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times.

Collins AT, Hatcher CC, Kim SY, Ziemian SN, Spritzer CE, Guilak F, DeFrate LE, McNulty AL.

Ann Biomed Eng. 2019 Jan;47(1):190-201. doi: 10.1007/s10439-018-02143-7. Epub 2018 Oct 4.


Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold.

Moffat KL, Goon K, Moutos FT, Estes BT, Oswald SJ, Zhao X, Guilak F.

Macromol Biosci. 2018 Oct;18(10):e1800140. doi: 10.1002/mabi.201800140. Epub 2018 Jul 24.


High-depth transcriptomic profiling reveals the temporal gene signature of human mesenchymal stem cells during chondrogenesis.

Huynh NPT, Zhang B, Guilak F.

FASEB J. 2019 Jan;33(1):358-372. doi: 10.1096/fj.201800534R. Epub 2018 Jul 9.


Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs.

Rowland CR, Glass KA, Ettyreddy AR, Gloss CC, Matthews JRL, Huynh NPT, Guilak F.

Biomaterials. 2018 Sep;177:161-175. doi: 10.1016/j.biomaterials.2018.04.049. Epub 2018 May 30.


Osteoarthritis as a disease of the cartilage pericellular matrix.

Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I.

Matrix Biol. 2018 Oct;71-72:40-50. doi: 10.1016/j.matbio.2018.05.008. Epub 2018 May 22. Review.


Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine.

Martin JT, Gullbrand SE, Fields AJ, Purmessur D, Diwan AD, Oxland TR, Chiba K, Guilak F, Hoyland JA, Iatridis JC.

JOR Spine. 2018 Mar;1(1):e1006. doi: 10.1002/jsp2.1006. Epub 2018 Mar 23.


Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds.

Huynh NPT, Brunger JM, Gloss CC, Moutos FT, Gersbach CA, Guilak F.

Tissue Eng Part A. 2018 Oct;24(19-20):1531-1544. doi: 10.1089/ten.TEA.2017.0510. Epub 2018 Jul 13.


Chondrogenic Differentiation Processes in Human Bone-Marrow Aspirates Seeded in Three-Dimensional-Woven Poly(ɛ-Caprolactone) Scaffolds Enhanced by Recombinant Adeno-Associated Virus-Mediated SOX9 Gene Transfer.

Venkatesan JK, Moutos FT, Rey-Rico A, Estes BT, Frisch J, Schmitt G, Madry H, Guilak F, Cucchiarini M.

Hum Gene Ther. 2018 Nov;29(11):1277-1286. doi: 10.1089/hum.2017.165. Epub 2018 Jun 11.


Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.

Tang R, Jing L, Willard VP, Wu CL, Guilak F, Chen J, Setton LA.

Stem Cell Res Ther. 2018 Mar 9;9(1):61. doi: 10.1186/s13287-018-0797-1.


Dynamics and mechanisms of intracellular calcium waves elicited by tandem bubble-induced jetting flow.

Li F, Yang C, Yuan F, Liao D, Li T, Guilak F, Zhong P.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E353-E362. doi: 10.1073/pnas.1713905115. Epub 2017 Dec 27.


Perspectives on Sharing Models and Related Resources in Computational Biomechanics Research.

Erdemir A, Hunter PJ, Holzapfel GA, Loew LM, Middleton J, Jacobs CR, Nithiarasu P, Löhner R, Wei G, Winkelstein BA, Barocas VH, Guilak F, Ku JP, Hicks JL, Delp SL, Sacks M, Weiss JA, Ateshian GA, Maas SA, McCulloch AD, Peng GCY.

J Biomech Eng. 2018 Feb 1;140(2). doi: 10.1115/1.4038768.


Canine hip dysplasia: A natural animal model for human developmental dysplasia of the hip.

Pascual-Garrido C, Guilak F, Rai MF, Harris MD, Lopez MJ, Todhunter RJ, Clohisy JC.

J Orthop Res. 2018 Jul;36(7):1807-1817. doi: 10.1002/jor.23828. Epub 2018 Feb 27. Review.


Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss.

Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS.

JCI Insight. 2017 Nov 16;2(22). pii: 95512. doi: 10.1172/jci.insight.95512. eCollection 2017 Nov 16.


CXCL10 is upregulated in synovium and cartilage following articular fracture.

Furman BD, Kent CL, Huebner JL, Kraus VB, McNulty AL, Guilak F, Olson SA.

J Orthop Res. 2018 Apr;36(4):1220-1227. doi: 10.1002/jor.23735. Epub 2017 Nov 20.


Genome Engineering for Personalized Arthritis Therapeutics.

Adkar SS, Brunger JM, Willard VP, Wu CL, Gersbach CA, Guilak F.

Trends Mol Med. 2017 Oct;23(10):917-931. doi: 10.1016/j.molmed.2017.08.002. Epub 2017 Sep 5. Review.


Role of Piezo Channels in Joint Health and Injury.

Lee W, Guilak F, Liedtke W.

Curr Top Membr. 2017;79:263-273. doi: 10.1016/bs.ctm.2016.10.003. Epub 2017 Jan 11. Review.


Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.

Wu CL, McNeill J, Goon K, Little D, Kimmerling K, Huebner J, Kraus V, Guilak F.

Arthritis Rheumatol. 2017 Sep;69(9):1772-1783. doi: 10.1002/art.40161. Epub 2017 Aug 8.


Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs.

Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F.

Stem Cell Reports. 2017 May 9;8(5):1202-1213. doi: 10.1016/j.stemcr.2017.03.022. Epub 2017 Apr 27.


Regulation of human nucleus pulposus cells by peptide-coupled substrates.

Bridgen DT, Fearing BV, Jing L, Sanchez-Adams J, Cohan MC, Guilak F, Chen J, Setton LA.

Acta Biomater. 2017 Jun;55:100-108. doi: 10.1016/j.actbio.2017.04.019. Epub 2017 Apr 20.


Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model.

Friedman JM, Sennett ML, Bonadio MB, Orji KO, Neuwirth AL, Keah N, Carey JL, Moutos FT, Estes BT, Guilak F, Madry H, Mauck RL, Dodge GR.

Cartilage. 2018 Oct;9(4):428-437. doi: 10.1177/1947603517700953. Epub 2017 Apr 11.


Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair.

Wu CL, Kimmerling KA, Little D, Guilak F.

Sci Rep. 2017 Mar 20;7:44315. doi: 10.1038/srep44315.


Mechanical Signals as Regulators of Cartilage Degeneration and Regeneration.

Rai MF, Stoddart MJ, Guilak F.

J Am Acad Orthop Surg. 2017 Apr;25(4):e87-e89. doi: 10.5435/JAAOS-D-16-00938. No abstract available.


New tools for Content Innovation and data sharing: Enhancing reproducibility and rigor in biomechanics research.

Guilak F.

J Biomech. 2017 Mar 21;54:1-3. doi: 10.1016/j.jbiomech.2017.01.044. Epub 2017 Feb 10.


Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage.

Hatcher CC, Collins AT, Kim SY, Michel LC, Mostertz WC 3rd, Ziemian SN, Spritzer CE, Guilak F, DeFrate LE, McNulty AL.

J Biomech. 2017 Apr 11;55:18-26. doi: 10.1016/j.jbiomech.2017.02.001. Epub 2017 Feb 6.


* CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory Environments.

Farhang N, Brunger JM, Stover JD, Thakore PI, Lawrence B, Guilak F, Gersbach CA, Setton LA, Bowles RD.

Tissue Eng Part A. 2017 Aug;23(15-16):738-749. doi: 10.1089/ten.TEA.2016.0441. Epub 2017 Feb 28.


On the Functional Role of Valve Interstitial Cell Stress Fibers: A Continuum Modeling Approach.

Sakamoto Y, Buchanan RM, Sanchez-Adams J, Guilak F, Sacks MS.

J Biomech Eng. 2017 Feb 1;139(2). doi: 10.1115/1.4035557. Review.


Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.

Liu B, Goode AP, Carter TE, Utturkar GM, Huebner JL, Taylor DC, Moorman CT 3rd, Garrett WE, Kraus VB, Guilak F, DeFrate LE, McNulty AL.

Connect Tissue Res. 2017 May - Jul;58(3-4):305-316. doi: 10.1080/03008207.2016.1256391. Epub 2016 Nov 4.


CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues.

Brunger JM, Zutshi A, Willard VP, Gersbach CA, Guilak F.

Arthritis Rheumatol. 2017 May;69(5):1111-1121. doi: 10.1002/art.39982. Epub 2017 Mar 31.


Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Jayes FL, Liu B, Moutos FT, Kuchibhatla M, Guilak F, Leppert PC.

Am J Obstet Gynecol. 2016 Nov;215(5):596.e1-596.e8. doi: 10.1016/j.ajog.2016.05.006. Epub 2016 May 10.


Functional outcome measures in a surgical model of hip osteoarthritis in dogs.

Little D, Johnson S, Hash J, Olson SA, Estes BT, Moutos FT, Lascelles BD, Guilak F.

J Exp Orthop. 2016 Dec;3(1):17. doi: 10.1186/s40634-016-0053-5. Epub 2016 Aug 15.


Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing.

Moutos FT, Glass KA, Compton SA, Ross AK, Gersbach CA, Guilak F, Estes BT.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4513-22. doi: 10.1073/pnas.1601639113. Epub 2016 Jul 18.


Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.

O'Conor CJ, Ramalingam S, Zelenski NA, Benefield HC, Rigo I, Little D, Wu CL, Chen D, Liedtke W, McNulty AL, Guilak F.

Sci Rep. 2016 Jul 8;6:29053. doi: 10.1038/srep29053.

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