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Items: 1 to 50 of 68

1.

Usefulness of monitoring antitumor necrosis factor serum levels during the induction phase in patients with Crohn's disease.

Chaparro M, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, García-Sánchez V, Marín-Jiménez I, Barreiro-de Acosta M, Vera I, Martín-Arranz MD, Hernández-Breijo B, Mesonero F, Sempere L, Gomollón F, Hinojosa J, Bermejo F, Beltrán B, Rodríguez Pescador A, Banales JM, Olivares D, Aguilar-Melero P, Menchén L, Ferreiro-Iglesias R, Blazquez Gomez I, Benítez García B, Guijarro LG, Marin A, Bernardo D, Gisbert JP; PREDICROHN Study Group from GETECCU.

Eur J Gastroenterol Hepatol. 2020 May;32(5):588-596. doi: 10.1097/MEG.0000000000001706.

PMID:
32251204
2.

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.

Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, Carrascosa JM, Valverde ÁM.

Mol Metab. 2020 Feb 6;35:100954. doi: 10.1016/j.molmet.2020.01.018. [Epub ahead of print]

3.

Extracellular allograft inflammatory factor-1 (AIF-1) potentiates Th1 cell differentiation and inhibits Treg response in human peripheral blood mononuclear cells from normal subjects.

Cano-Martínez D, Monserrat J, Hernández-Breijo B, Sanmartín Salinas P, Álvarez-Mon M, Val Toledo-Lobo M, Guijarro LG.

Hum Immunol. 2020 Feb - Mar;81(2-3):91-100. doi: 10.1016/j.humimm.2020.01.011. Epub 2020 Feb 11.

PMID:
32057519
4.

Functional rare variants influence the clinical response to anti-TNF therapy in Crohn's disease.

Chaparro M, Aterido A, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, García-Sánchez V, Marín-Jiménez I, Barreiro-de Acosta M, Vera I, Martín-Arranz MD, Hernández-Breijo B, Mesonero F, Sempere L, Gomollón F, Hinojosa J, Bermejo F, Beltrán B, Rodríguez-Pescador A, Banales JM, Olivares D, Aguilar-Melero P, Menchén L, Ferreiro-Iglesias R, Blazquez Gómez I, Benitez García B, Guijarro LG, Marin AC, Bernardo D, Marsal S, Julia A, Gisbert JP.

Therap Adv Gastroenterol. 2019 Sep 25;12:1756284819867848. doi: 10.1177/1756284819867848. eCollection 2019.

5.

Overexpression of IRS-4 Correlates with Procaspase 3 Levels in Tumoural Tissue of Patients with Colorectal Cancer.

Sanmartín-Salinas P, Guijarro LG.

J Oncol. 2018 Oct 16;2018:3812581. doi: 10.1155/2018/3812581. eCollection 2018.

6.

Insulin receptor substrate-4 is overexpressed in colorectal cancer and promotes retinoblastoma-cyclin-dependent kinase activation.

Sanmartín-Salinas P, Lobo MDVT, Noguerales-Fraguas F, Londoño MT, Jiménez-Ruiz A, Guijarro LG.

J Gastroenterol. 2018 Aug;53(8):932-944. doi: 10.1007/s00535-018-1432-8. Epub 2018 Jan 20.

PMID:
29353348
7.

Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients.

Sanmartín-Salinas P, Toledo-Lobo MV, Noguerales-Fraguas F, Fernández-Contreras ME, Guijarro LG.

J Mol Histol. 2018 Feb;49(1):39-49. doi: 10.1007/s10735-017-9745-0. Epub 2017 Nov 28.

PMID:
29185229
8.

Infliximab therapy reverses the increase of allograft inflammatory factor-1 in serum and colonic mucosa of rats with inflammatory bowel disease.

Román ID, Cano-Martínez D, Lobo MV, Fernández-Moreno MD, Hernández-Breijo B, Sacristán S, Sanmartín-Salinas P, Monserrat J, Gisbert JP, Guijarro LG.

Biomarkers. 2017 Mar;22(2):133-144. doi: 10.1080/1354750X.2016.1252950. Epub 2016 Nov 8.

PMID:
27781498
9.

Standardization of the homogeneous mobility shift assay protocol for evaluation of anti-infliximab antibodies. Application of the method to Crohn's disease patients treated with infliximab.

Hernández-Breijo B, Chaparro M, Cano-Martínez D, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, García-Sánchez V, Marín-Jiménez I, Barreiro-de Acosta M, Vera I, Martín-Arranz MD, Mesonero F, Sempere L, Gomollón F, Hinojosa J, Gisbert JP, Guijarro LG; PREDICROHN study group from GETECCU.

Biochem Pharmacol. 2016 Dec 15;122:33-41. doi: 10.1016/j.bcp.2016.09.019. Epub 2016 Sep 21.

PMID:
27664854
10.

Effect of Infliximab in oxidised serum albumin levels during experimental colitis.

Cano-Martínez D, Román ID, T Lobo MV, Pastor O, Moreno-Villena I, Paradela A, Hernández-Breijo B, Fernández-Moreno MD, Monserrat J, Sanmartín-Salinas P, Gisbert JP, Guijarro LG.

Biomarkers. 2014 Dec;19(8):693-701. doi: 10.3109/1354750X.2014.982189. Epub 2014 Nov 10.

PMID:
25382460
11.

Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.

Hernández-Breijo B, Monserrat J, Román ID, González-Rodríguez Á, Fernández-Moreno MD, Lobo MV, Valverde ÁM, Gisbert JP, Guijarro LG.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):568-78. doi: 10.1016/j.taap.2013.07.024. Epub 2013 Aug 16.

PMID:
23958494
12.

In vitro studies of water-stable cationic carbosilane dendrimers as delivery vehicles for gene therapy against HIV and hepatocarcinoma.

de Las Cuevas N, Garcia-Gallego S, Rasines B, de la Mata FJ, Guijarro LG, Muñoz-Fernández MÁ, Gómez R.

Curr Med Chem. 2012;19(29):5052-61.

PMID:
22963627
13.

Is the autophagy induced by thiopurines beneficial or deleterious?

Guijarro LG, Román ID, Fernández-Moreno MD, Gisbert JP, Hernández-Breijo B.

Curr Drug Metab. 2012 Nov;13(9):1267-76. Review.

PMID:
22493985
14.

Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma.

Hernández-Breijo B, Monserrat J, Ramírez-Rubio S, Cuevas EP, Vara D, Díaz-Laviada I, Fernández-Moreno MD, Román ID, Gisbert JP, Guijarro LG.

World J Gastroenterol. 2011 Sep 14;17(34):3899-911. doi: 10.3748/wjg.v17.i34.3899.

15.

RNAi-mediated silencing of insulin receptor substrate-4 enhances actinomycin D- and tumor necrosis factor-alpha-induced cell death in hepatocarcinoma cancer cell lines.

Cuevas EP, Escribano O, Monserrat J, Martínez-Botas J, Sánchez MG, Chiloeches A, Hernández-Breijo B, Sánchez-Alonso V, Román ID, Fernández-Moreno MD, Guijarro LG.

J Cell Biochem. 2009 Dec 15;108(6):1292-301. doi: 10.1002/jcb.22359.

PMID:
19795387
16.

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: randomized, placebo-controlled pilot study.

Guijarro LG, Mate J, Gisbert JP, Perez-Calle JL, Marin-Jimenez I, Arriaza E, Olleros T, Delgado M, Castillejo MS, Prieto-Merino D, Gonzalez Lara V, Pena AS.

World J Gastroenterol. 2008 May 14;14(18):2851-7.

17.

Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.

Cuevas EP, Escribano O, Chiloeches A, Ramirez Rubio S, Román ID, Fernández-Moreno MD, Guijarro LG.

J Hepatol. 2007 Jun;46(6):1089-98. Epub 2007 Feb 27.

PMID:
17408801
18.

Thiopurine methyltransferase activity in Spain: a study of 14,545 patients.

Gisbert JP, Gomollón F, Cara C, Luna M, González-Lama Y, Pajares JM, Maté J, Guijarro LG.

Dig Dis Sci. 2007 May;52(5):1262-9. Epub 2007 Mar 2.

PMID:
17334911
19.

MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease.

Mendoza JL, Urcelay E, Lana R, Martín MC, López N, Guijarro LG, Mayol JA, Taxonera C, de la Concha EG, Peña AS, Díaz-Rubio M.

Inflamm Bowel Dis. 2007 May;13(5):585-90.

PMID:
17262810
20.

Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.

Gisbert JP, Niño P, Rodrigo L, Cara C, Guijarro LG.

Am J Gastroenterol. 2006 Dec;101(12):2769-76. Epub 2006 Oct 6.

PMID:
17026564
21.

[Thiopurine methyltransferase activity in inflammatory bowel disease. A study on 7046 Spanish patients].

Gisbert JP, Gomollón F, Cara C, Luna M, González-Lama Y, Pajares JM, Maté J, Guijarro LG.

Med Clin (Barc). 2005 Sep 10;125(8):281-5. Spanish.

PMID:
16159550
22.

Reviewing the mechanism of action of thiopurine drugs: towards a new paradigm in clinical practice.

Cara CJ, Pena AS, Sans M, Rodrigo L, Guerrero-Esteo M, Hinojosa J, García-Paredes J, Guijarro LG.

Med Sci Monit. 2004 Nov;10(11):RA247-54. Epub 2004 Oct 26. Review.

PMID:
15507865
23.

Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.

Menor C, Fernández-Moreno MD, Fueyo JA, Escribano O, Olleros T, Arriaza E, Cara C, Lorusso M, Di Paola M, Román ID, Guijarro LG.

J Pharmacol Exp Ther. 2004 Nov;311(2):668-76. Epub 2004 Jun 28.

PMID:
15226385
24.

Association of adenylate cyclase with an actin-like protein in the human myometrium.

Bajo AM, Prieto JC, Valenzuela P, Martínez P, Menor C, Marina A, Vázquez J, Guijarro LG.

Gynecol Endocrinol. 2004 Feb;18(2):89-96.

PMID:
15195500
25.

Solubilization of adenylyl cyclase from human myometrium in a alphas-coupled form.

Bajo AM, Prieto JC, Valenzuela P, Martinez P, Guijarro LG.

Biosci Rep. 2003 Aug;23(4):175-86.

PMID:
14748538
26.

Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.

Escribano O, Fernández-Moreno MD, Zueco JA, Menor C, Fueyo J, Ropero RM, Diaz-Laviada I, Román ID, Guijarro LG.

Hepatology. 2003 Jun;37(6):1461-9.

PMID:
12774026
27.

Pretreatment with FK506 up-regulates insulin receptors in regenerating rat liver.

Escribano O, Fernández-Moreno MD, Piña MJ, Fueyo J, Menor C, Román ID, Guijarro LG.

Hepatology. 2002 Sep;36(3):555-61.

PMID:
12198647
28.

Thiopurine methyltransferase activity in a Spanish population sample: decrease of enzymatic activity in multiple sclerosis patients.

Menor C, Fueyo J, Escribano O, Piña MJ, Redondo P, Cara C, Román ID, Fernández-Moreno MD, Guijarro LG.

Mult Scler. 2002 May;8(3):243-8.

PMID:
12120697
29.

Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method.

Menor C, Fueyo JA, Escribano O, Cara C, Fernández-Moreno MD, Román ID, Guijarro LG.

Ther Drug Monit. 2001 Oct;23(5):536-41.

PMID:
11591900
30.

Vasoactive intestinal peptide (VIP) stimulates rat prostatic epithelial cell proliferation.

Juarranz MG, Bodega G, Prieto JC, Guijarro LG.

Prostate. 2001 Jun 1;47(4):285-92.

PMID:
11398176
31.

Impairment of adenylate cyclase activity and G-proteins in human uterine leiomyoma.

Bajo A, Carrero I, Hrïstov RL, Valenzuela P, Martínez P, Cortés J, Prieto JC, Guijarro LG.

Tissue Cell. 2000 Oct;32(5):399-404.

PMID:
11201279
32.

Expression of vasoactive intestinal peptide (VIP) receptors in human uterus.

Bajo AM, Juarranz MG, Valenzuela P, Martínez P, Prieto JC, Guijarro LG.

Peptides. 2000 Sep;21(9):1383-8.

PMID:
11072126
33.

Identification and functional properties of the pituitary adenylate cyclase activating peptide (PAC1) receptor in human benign hyperplastic prostate.

Solano RM, Carmena MJ, Busto R, Sánchez-Chapado M, Guijarro LG, Prieto JC.

Cell Signal. 1999 Nov;11(11):813-9.

PMID:
10617284
34.

Expression, pharmacological, and functional evidence for PACAP/VIP receptors in human lung.

Busto R, Carrero I, Guijarro LG, Solano RM, Zapatero J, Noguerales F, Prieto JC.

Am J Physiol. 1999 Jul;277(1):L42-8. doi: 10.1152/ajplung.1999.277.1.L42.

PMID:
10409229
35.

Effects of chronic ethanol ingestion on the vasoactive intestinal peptide receptor-effector system from rat seminal vesicle membranes.

Juarranz MG, Marinero MJ, Bodega G, Prieto JC, Guijarro LG.

Alcohol Clin Exp Res. 1999 Feb;23(2):318-23.

PMID:
10069562
36.

Cyclosporin A induces apoptosis in rat hepatocytes in culture.

Román ID, Rodríguez-Henche N, Fueyo JA, Zueco JA, Menor C, Prieto JC, Guijarro LG.

Arch Toxicol. 1998 Sep;72(9):559-65.

PMID:
9806427
37.

G-protein regulation of adenylate cyclase activity in rat prostatic membranes after chronic ethanol ingestion.

Juarranz MG, Guijarro LG, Bodega G, Prieto JC.

Prostate. 1998 Sep 1;36(4):226-34.

PMID:
9719022
38.

Inhibitory effect of cyclosporin A peptide on rat hepatocytes proliferation induced by mitogens.

Rodriguez-Henche N, Román ID, Fueyo J, Menor C, Zueco JA, Prieto JC, Guijarro LG.

Peptides. 1998;19(3):427-35.

PMID:
9533630
39.

Ontogenic development of the adenylyl cyclase enzyme and the alpha s, alpha i1 and alpha i2 G-protein regulatory subunits from rat prostate.

Juarranz MG, Carrero I, Busto R, Carmena MJ, Prieto JC, Guijarro LG.

Cell Signal. 1997 Sep;9(6):451-6.

PMID:
9376227
40.

Modulation of cyclic AMP and inositol phosphate production in rat prostatic cultures by VIP/PACAP, ATP, and carbachol: role in prostatic proliferation.

Guijarro LG, Juarranz MG, Marinero MJ, Pajuelo L, Carmena MJ, Prieto JC.

Ann N Y Acad Sci. 1996 Dec 26;805:723-8. No abstract available.

PMID:
8993468
41.

PACAP-preferring receptors in human hyperplastic prostate.

Carmena MJ, Solano RM, Guijarro LG, Prieto JC.

Ann N Y Acad Sci. 1996 Dec 26;805:708-12. No abstract available.

PMID:
8993465
42.

Characterization of adenylyl cyclase stimulated by VIP in rat and mouse peritoneal macrophage membranes.

Pozo D, Segura JJ, Carrero I, Guijarro LG, Prieto JC, Calvo JR.

Biochim Biophys Acta. 1996 Jul 24;1312(3):249-54.

43.

Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate.

Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC.

Endocrinology. 1996 Jul;137(7):2815-22.

PMID:
8770902
44.

Protein kinase C isozymes in prostatic epithelial cells from normal, diabetic and insulin-treated diabetic rats.

Garcia-Paramio PL, Carmena MJ, Guijarro LG, Prieto JC.

Gen Pharmacol. 1995 Dec;26(8):1673-8.

PMID:
8745155
45.

Receptors for pituitary adenylate cyclase-activating peptide in human liver.

Guijarro LG, Rodriguez-Henche N, García-López E, Noguerales F, Dapena MA, Juarranz MG, Prieto JC.

J Clin Endocrinol Metab. 1995 Aug;80(8):2451-7.

PMID:
7629241
46.

Alpha-2 adrenoceptors modulate the somatostatinergic system and G protein levels in the rat hippocampus.

López-Sañudo S, Puebla L, Guijarro LG, Prieto JC, Arilla E.

Neuropsychopharmacology. 1995 Feb;12(1):47-55.

47.

G proteins in rat liver proliferation during cholestasis.

Rodriguez-Henche N, Guijarro LG, Couvineau A, Carrero I, Arilla E, Laburthe M, Prieto JC.

Hepatology. 1994 Oct;20(4 Pt 1):1041-7.

PMID:
7927206
48.

Neuropeptide Y inhibits vasoactive intestinal peptide-stimulated adenylyl cyclase in rat ventral prostate.

Solano RM, Carmena MJ, Guijarro LG, Prieto JC.

Neuropeptides. 1994 Jul;27(1):31-7.

PMID:
7969818
49.

Effect of sulpiride on somatostatin receptors, somatostatin-like immunoreactivity and modulation of adenylyl cyclase activity in the rat brain.

Rodriguez-Sanchez MN, Boyano-Adánez MC, Puebla L, Rodriguez-Henche N, Guijarro LG, Prieto JC, Arilla E.

Neuropharmacology. 1994 Jun;33(6):745-54.

PMID:
7936112
50.

Ontogeny of vasoactive intestinal peptide receptors in rat ventral prostate.

Juarranz MG, Guijarro LG, Bajo AM, Carmena MJ, Prieto JC.

Gen Pharmacol. 1994 May;25(3):509-14.

PMID:
7926599

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