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Items: 1 to 50 of 81

1.

Prostaglandin E2 Signals Through E Prostanoid Receptor 2 to Inhibit Mitochondrial Superoxide Formation and the Ensuing Downstream Cytotoxic and Genotoxic Effects Induced by Arsenite.

Cerioni L, Guidarelli A, Fiorani M, Cantoni O.

Front Pharmacol. 2019 Jul 12;10:781. doi: 10.3389/fphar.2019.00781. eCollection 2019.

2.
3.

Melatonin protects hippocampal HT22 cells from the effects of serum deprivation specifically targeting mitochondria.

Cesarini E, Cerioni L, Canonico B, Di Sario G, Guidarelli A, Lattanzi D, Savelli D, Guescini M, Nasoni MG, Bigini N, Cuppini R, Stocchi V, Ambrogini P, Papa S, Luchetti F.

PLoS One. 2018 Aug 29;13(8):e0203001. doi: 10.1371/journal.pone.0203001. eCollection 2018.

4.

The In Vitro Activity of Angelica archangelica L. Essential Oil on Inflammation.

Fraternale D, Teodori L, Rudov A, Prattichizzo F, Olivieri F, Guidarelli A, Albertini MC.

J Med Food. 2018 Aug 29. doi: 10.1089/jmf.2018.0017. [Epub ahead of print]

PMID:
30156459
5.

Low Concentrations of Arsenite Target the Intraluminal Inositol 1, 4, 5-Trisphosphate Receptor/Ryanodine Receptor Crosstalk to Significantly Elevate Intracellular Ca2.

Guidarelli A, Fiorani M, Cantoni O.

J Pharmacol Exp Ther. 2018 Oct;367(1):184-193. doi: 10.1124/jpet.118.250480. Epub 2018 Aug 1.

PMID:
30068729
6.

Differentiation of Promonocytic U937 Cells to Monocytes Is Associated with Reduced Mitochondrial Transport of Ascorbic Acid.

Scotti M, Fiorani M, Guidarelli A, Cantoni O.

Oxid Med Cell Longev. 2018 Feb 8;2018:4194502. doi: 10.1155/2018/4194502. eCollection 2018.

7.

The dual role of mitochondrial superoxide in arsenite toxicity: Signaling at the boundary between apoptotic commitment and cytoprotection.

Fiorani M, Guidarelli A, Capellacci V, Cerioni L, Crinelli R, Cantoni O.

Toxicol Appl Pharmacol. 2018 Apr 15;345:26-35. doi: 10.1016/j.taap.2018.03.008. Epub 2018 Mar 8.

PMID:
29526526
8.

Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca2+-Independent Mechanism.

Guidarelli A, Cerioni L, Fiorani M, Cantoni O.

Int J Mol Sci. 2017 Aug 2;18(8). pii: E1686. doi: 10.3390/ijms18081686.

9.

Arsenite induces DNA damage via mitochondrial ROS and induction of mitochondrial permeability transition.

Guidarelli A, Fiorani M, Cerioni L, Scotti M, Cantoni O.

Biofactors. 2017 Sep 10;43(5):673-684. doi: 10.1002/biof.1375. Epub 2017 Jul 13.

PMID:
28703385
10.

Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn from Cell Culture Studies?

Cantoni O, Guidarelli A, Fiorani M.

Antioxid Redox Signal. 2018 Nov 20;29(15):1502-1515. doi: 10.1089/ars.2017.7253. Epub 2017 Aug 9. Review.

PMID:
28699359
11.

The study of the mechanism of arsenite toxicity in respiration-deficient cells reveals that NADPH oxidase-derived superoxide promotes the same downstream events mediated by mitochondrial superoxide in respiration-proficient cells.

Guidarelli A, Fiorani M, Carloni S, Cerioni L, Balduini W, Cantoni O.

Toxicol Appl Pharmacol. 2016 Sep 15;307:35-44. doi: 10.1016/j.taap.2016.07.012. Epub 2016 Jul 20.

PMID:
27450018
12.

Mitochondrial ascorbic acid prevents mitochondrial O₂·⁻ formation, an event critical for U937 cell apoptosis induced by arsenite through both autophagic-dependent and independent mechanisms.

Guidarelli A, Carloni S, Balduini W, Fiorani M, Cantoni O.

Biofactors. 2016 Mar-Apr;42(2):190-200. doi: 10.1002/biof.1263. Epub 2016 Feb 19.

PMID:
26893200
13.

Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria.

Fiorani M, Azzolini C, Guidarelli A, Cerioni L, Scotti M, Cantoni O.

Pharmacol Res. 2015 Sep;99:289-95. doi: 10.1016/j.phrs.2015.07.004. Epub 2015 Jul 15.

PMID:
26188149
14.

U937 cell apoptosis induced by arsenite is prevented by low concentrations of mitochondrial ascorbic acid with hardly any effect mediated by the cytosolic fraction of the vitamin.

Guidarelli A, Fiorani M, Azzolini C, Cerioni L, Scotti M, Cantoni O.

Biofactors. 2015 Mar-Apr;41(2):101-10. doi: 10.1002/biof.1204. Epub 2015 Mar 23.

PMID:
25809564
15.

The mitochondrial transporter of ascorbic acid functions with high affinity in the presence of low millimolar concentrations of sodium and in the absence of calcium and magnesium.

Fiorani M, Azzolini C, Cerioni L, Scotti M, Guidarelli A, Ciacci C, Cantoni O.

Biochim Biophys Acta. 2015 Jun;1848(6):1393-401. doi: 10.1016/j.bbamem.2015.03.009. Epub 2015 Mar 15.

16.

A novel biological role of dehydroascorbic acid: Inhibition of Na(+)-dependent transport of ascorbic acid.

Fiorani M, Azzolini C, Guidarelli A, Cerioni L, Cantoni O.

Pharmacol Res. 2014 Jun;84:12-7. doi: 10.1016/j.phrs.2014.04.006. Epub 2014 Apr 24.

PMID:
24769194
17.

Novel SETX variants in a patient with ataxia, neuropathy, and oculomotor apraxia are associated with normal sensitivity to oxidative DNA damaging agents.

Vantaggiato C, Cantoni O, Guidarelli A, Romaniello R, Citterio A, Arrigoni F, Doneda C, Castelli M, Airoldi G, Bresolin N, Borgatti R, Bassi MT.

Brain Dev. 2014 Sep;36(8):682-9. doi: 10.1016/j.braindev.2013.10.003. Epub 2013 Oct 31.

PMID:
24183476
18.

Mitochondrial ascorbic acid is responsible for enhanced susceptibility of U937 cells to the toxic effects of peroxynitrite.

Guidarelli A, Cerioni L, Fiorani M, Azzolini C, Cantoni O.

Biofactors. 2014 Mar-Apr;40(2):236-46. doi: 10.1002/biof.1139. Epub 2013 Sep 16.

PMID:
24105898
19.

Sodium-dependent transport of ascorbic acid in U937 cell mitochondria.

Azzolini C, Fiorani M, Cerioni L, Guidarelli A, Cantoni O.

IUBMB Life. 2013 Feb;65(2):149-53. doi: 10.1002/iub.1124. Epub 2013 Jan 3.

20.

Superoxide dictates the mode of U937 cell ascorbic acid uptake and prevents the enhancing effects of the vitamin to otherwise nontoxic levels of reactive oxygen/nitrogen species.

Fiorani M, Azzolini C, Cerioni L, Guidarelli A, Cantoni O.

J Nutr Biochem. 2013 Feb;24(2):467-74. doi: 10.1016/j.jnutbio.2012.01.009. Epub 2012 May 26.

PMID:
22633911
21.

Studies with low micromolar levels of ascorbic and dehydroascorbic acid fail to unravel a preferential route for vitamin C uptake and accumulation in U937 cells.

Azzolini C, Fiorani M, Guidarelli A, Cantoni O.

Br J Nutr. 2012 Mar;107(5):691-6. doi: 10.1017/S0007114511003540. Epub 2011 Jul 28.

PMID:
21794197
22.

A novel nonsense mutation in the APTX gene associated with delayed DNA single-strand break removal fails to enhance sensitivity to different genotoxic agents.

Crimella C, Cantoni O, Guidarelli A, Vantaggiato C, Martinuzzi A, Fiorani M, Azzolini C, Orso G, Bresolin N, Bassi MT.

Hum Mutat. 2011 Apr;32(4):E2118-33. doi: 10.1002/humu.21464. Epub 2011 Feb 8.

PMID:
21412945
23.
24.

Differentiation-associated loss of ryanodine receptors: a strategy adopted by monocytes/macrophages to prevent the DNA single-strand breakage induced by peroxynitrite.

Guidarelli A, Cerioni L, Fiorani M, Cantoni O.

J Immunol. 2009 Oct 1;183(7):4449-57. doi: 10.4049/jimmunol.0901260. Epub 2009 Sep 4.

25.

Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin.

Airoldi G, Guidarelli A, Cantoni O, Panzeri C, Vantaggiato C, Bonato S, Grazia D'Angelo M, Falcone S, De Palma C, Tonelli A, Crimella C, Bondioni S, Bresolin N, Clementi E, Bassi MT.

Neurogenetics. 2010 Feb;11(1):91-100. doi: 10.1007/s10048-009-0206-0. Epub 2009 Jul 11.

PMID:
19593598
26.

Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid.

Fiorani M, Guidarelli A, Blasa M, Azzolini C, Candiracci M, Piatti E, Cantoni O.

J Nutr Biochem. 2010 May;21(5):397-404. doi: 10.1016/j.jnutbio.2009.01.014. Epub 2009 Mar 17.

PMID:
19278846
27.

Peroxynitrite damages U937 cell DNA via the intermediate formation of mitochondrial oxidants.

Cantoni O, Guidarelli A.

IUBMB Life. 2008 Nov;60(11):753-6. doi: 10.1002/iub.116. Review.

28.

Susceptibility of rat astrocytes to DNA strand scission induced by activation of NADPH oxidase and collateral resistance to the effects of peroxynitrite.

Guidarelli A, Palomba L, Fiorani M, Cantoni O.

Free Radic Biol Med. 2008 Aug 15;45(4):521-9. doi: 10.1016/j.freeradbiomed.2008.05.005. Epub 2008 May 17.

PMID:
18514075
29.

Indirect mechanisms of DNA strand scission by peroxynitrite.

Cantoni O, Guidarelli A.

Methods Enzymol. 2008;440:111-20. doi: 10.1016/S0076-6879(07)00806-3.

PMID:
18423213
30.
31.

Phenolic-rich juice prevents DNA single-strand breakage and cytotoxicity caused by tert-butylhydroperoxide in U937 cells: the role of iron chelation.

Garcia-Alonso FJ, Guidarelli A, Periago MJ.

J Nutr Biochem. 2007 Jul;18(7):457-66. Epub 2006 Sep 25.

PMID:
16997539
32.

5-Hydroxyeicosatetraenoic acid is a key intermediate of the arachidonate-dependent protective signaling in monocytes/macrophages exposed to peroxynitrite.

Tommasini I, Guidarelli A, Palomba L, Cerioni L, Cantoni O.

J Leukoc Biol. 2006 Oct;80(4):929-38. Epub 2006 Aug 2.

PMID:
16885503
34.

Role of Bcl-2 in the arachidonate-mediated survival signaling preventing mitochondrial permeability transition-dependent U937 cell necrosis induced by peroxynitrite.

Guidarelli A, Cerioni L, Tommasini I, Fiorani M, Brüne B, Cantoni O.

Free Radic Biol Med. 2005 Dec 15;39(12):1638-49. Epub 2005 Sep 7.

PMID:
16298689
35.

Reduced mitochondrial formation of H(2)O(2) is responsible for resistance of dimethyl sulfoxide differentiated U937 cells to peroxynitrite.

Guidarelli A, Fiorani M, Tommasini I, Cerioni L, Cantoni O.

Int J Biochem Cell Biol. 2006 Jan;38(1):56-68. Epub 2005 Aug 1.

PMID:
16103003
36.

Survival pathways triggered by peroxynitrite in cells belonging to the monocyte/macrophage lineage.

Cantoni O, Tommasini I, Cerioni L, Palomba L, Carloni E, Guidarelli A.

Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct;142(2):118-23. Epub 2005 Jun 17. Review.

PMID:
15964776
37.

A downstream role for protein kinase Calpha in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells.

Guidarelli A, Cerioni L, Tommasini I, Brüne B, Cantoni O.

Biochem Pharmacol. 2005 Apr 15;69(8):1275-86.

PMID:
15794949
38.

ERK1/2-dependent regulation of U937 cell survival after exposure to peroxynitrite.

Tommasini I, Cerioni L, Guidarelli A, Cantoni O.

Biochem Biophys Res Commun. 2005 Apr 22;329(4):1282-7.

PMID:
15766565
39.

U937 cell necrosis mediated by peroxynitrite is not caused by depletion of ATP and is prevented by arachidonate via an ATP-dependent mechanism.

Cantoni O, Guidarelli A, Palomba L, Fiorani M.

Mol Pharmacol. 2005 May;67(5):1399-405. Epub 2005 Feb 2.

PMID:
15689569
41.

The arachidonate-dependent cytoprotective signaling evoked by peroxynitrite is a general response of the monocyte/macrophage lineage.

Tommasini I, Guidarelli A, Cerioni L, Cantoni O.

Biochem Biophys Res Commun. 2004 Apr 16;316(4):1191-5.

PMID:
15044111
45.

Cell signaling and cytotoxicity by peroxynitrite.

Cantoni O, Palomba L, Guidarelli A, Tommasini I, Cerioni L, Sestili P.

Environ Health Perspect. 2002 Oct;110 Suppl 5:823-5.

47.

Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells.

Brigotti M, Alfieri R, Sestili P, Bonelli M, Petronini PG, Guidarelli A, Barbieri L, Stirpe F, Sperti S.

FASEB J. 2002 Mar;16(3):365-72.

PMID:
11874985
50.

Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells.

Guidarelli A, De Sanctis R, Cellini B, Fiorani M, Dachà M, Cantoni O.

Biochem J. 2001 Jun 1;356(Pt 2):509-13.

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