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Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids.

Zemdegs J, Martin H, Pintana H, Bullich S, Manta S, Marqués MA, Moro C, Layé S, Ducrocq F, Chattipakorn N, Chattipakorn SC, Rampon C, Pénicaud L, Fioramonti X, Guiard BP.

J Neurosci. 2019 Jul 24;39(30):5935-5948. doi: 10.1523/JNEUROSCI.2904-18.2019. Epub 2019 Jun 3.


Lack of correlation between the activity of the mesolimbic dopaminergic system and the rewarding properties of pregabalin in mouse.

Coutens B, Mouledous L, Stella M, Rampon C, Lapeyre-Mestre M, Roussin A, Guiard BP, Jouanjus E.

Psychopharmacology (Berl). 2019 Jul;236(7):2069-2082. doi: 10.1007/s00213-019-05198-z. Epub 2019 Mar 16.


Viral vector-mediated Cre recombinase expression in substantia nigra induces lesions of the nigrostriatal pathway associated with perturbations of dopamine-related behaviors and hallmarks of programmed cell death.

Rezai Amin S, Gruszczynski C, Guiard BP, Callebert J, Launay JM, Louis F, Betancur C, Vialou V, Gautron S.

J Neurochem. 2019 Aug;150(3):330-340. doi: 10.1111/jnc.14684. Epub 2019 Mar 27.


Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice.

Zemdegs J, Rainer Q, Grossmann CP, Rousseau-Ralliard D, Grynberg A, Ribeiro E, Guiard BP.

Front Neurosci. 2018 Dec 21;12:974. doi: 10.3389/fnins.2018.00974. eCollection 2018.


Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane.

Schendzielorz AB, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, Chacinska A, Rehling P.

Nat Commun. 2018 Oct 2;9(1):4028. doi: 10.1038/s41467-018-06492-8.


Positive regulation of raphe serotonin neurons by serotonin 2B receptors.

Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L.

Neuropsychopharmacology. 2018 Jun;43(7):1623-1632. doi: 10.1038/s41386-018-0013-0. Epub 2018 Feb 5.


Membrane protein insertion through a mitochondrial β-barrel gate.

Höhr AIC, Lindau C, Wirth C, Qiu J, Stroud DA, Kutik S, Guiard B, Hunte C, Becker T, Pfanner N, Wiedemann N.

Science. 2018 Jan 19;359(6373). pii: eaah6834. doi: 10.1126/science.aah6834.


Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease.

Richetin K, Petsophonsakul P, Roybon L, Guiard BP, Rampon C.

Neurobiol Aging. 2017 Sep;57:220-231. doi: 10.1016/j.neurobiolaging.2017.05.025. Epub 2017 Jun 6.


Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.

Moutkine I, Quentin E, Guiard BP, Maroteaux L, Doly S.

J Biol Chem. 2017 Apr 14;292(15):6352-6368. doi: 10.1074/jbc.M117.779041. Epub 2017 Mar 3.


Serotonin Signaling through Prefrontal Cortex 5-HT1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors.

Garcia-Garcia AL, Meng Q, Canetta S, Gardier AM, Guiard BP, Kellendonk C, Dranovsky A, Leonardo ED.

Cell Rep. 2017 Jan 31;18(5):1144-1156. doi: 10.1016/j.celrep.2017.01.021.


Two distinct membrane potential-dependent steps drive mitochondrial matrix protein translocation.

Schendzielorz AB, Schulz C, Lytovchenko O, Clancy A, Guiard B, Ieva R, van der Laan M, Rehling P.

J Cell Biol. 2017 Jan 2;216(1):83-92. doi: 10.1083/jcb.201607066. Epub 2016 Dec 23.


Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice.

Pham TH, Mendez-David I, Defaix C, Guiard BP, Tritschler L, David DJ, Gardier AM.

Neuropharmacology. 2017 Jan;112(Pt A):198-209. doi: 10.1016/j.neuropharm.2016.05.010. Epub 2016 May 17.


Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10.

Ellenrieder L, Opaliński Ł, Becker L, Krüger V, Mirus O, Straub SP, Ebell K, Flinner N, Stiller SB, Guiard B, Meisinger C, Wiedemann N, Schleiff E, Wagner R, Pfanner N, Becker T.

Nat Commun. 2016 Oct 10;7:13021. doi: 10.1038/ncomms13021.


Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.

Besson M, Guiducci S, Granon S, Guilloux JP, Guiard B, Repérant C, Faure P, Pons S, Cannazza G, Zoli M, Gardier AM, Maskos U.

Psychopharmacology (Berl). 2016 Sep;233(18):3297-314. doi: 10.1007/s00213-016-4362-2. Epub 2016 Jul 6.


Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential.

Turakhiya U, von der Malsburg K, Gold VAM, Guiard B, Chacinska A, van der Laan M, Ieva R.

J Mol Biol. 2016 Mar 27;428(6):1041-1052. doi: 10.1016/j.jmb.2016.01.020. Epub 2016 Jan 29.


Genetic dysfunction of serotonin 2A receptor hampers response to antidepressant drugs: A translational approach.

Qesseveur G, Petit AC, Nguyen HT, Dahan L, Colle R, Rotenberg S, Seif I, Robert P, David D, Guilloux JP, Gardier AM, Verstuyft C, Becquemont L, Corruble E, Guiard BP.

Neuropharmacology. 2016 Jun;105:142-153. doi: 10.1016/j.neuropharm.2015.12.022. Epub 2016 Jan 4.


Attenuated Levels of Hippocampal Connexin 43 and its Phosphorylation Correlate with Antidepressant- and Anxiolytic-Like Activities in Mice.

Quesseveur G, Portal B, Basile JA, Ezan P, Mathou A, Halley H, Leloup C, Fioramonti X, Déglon N, Giaume C, Rampon C, Guiard BP.

Front Cell Neurosci. 2015 Dec 22;9:490. doi: 10.3389/fncel.2015.00490. eCollection 2015.


High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice.

Zemdegs J, Quesseveur G, Jarriault D, Pénicaud L, Fioramonti X, Guiard BP.

Br J Pharmacol. 2016 Jul;173(13):2095-110. doi: 10.1111/bph.13343. Epub 2015 Dec 9.


Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: the missing link?

Guiard BP, Di Giovanni G.

Front Pharmacol. 2015 Mar 17;6:46. doi: 10.3389/fphar.2015.00046. eCollection 2015. Review.


Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.

Böttinger L, Oeljeklaus S, Guiard B, Rospert S, Warscheid B, Becker T.

J Biol Chem. 2015 May 1;290(18):11611-22. doi: 10.1074/jbc.M115.642017. Epub 2015 Mar 18.


Functional study of the Hap4-like genes suggests that the key regulators of carbon metabolism HAP4 and oxidative stress response YAP1 in yeast diverged from a common ancestor.

Petryk N, Zhou YF, Sybirna K, Mucchielli MH, Guiard B, Bao WG, Stasyk OV, Stasyk OG, Krasovska OS, Budin K, Reymond N, Imbeaud S, Coudouel S, Delacroix H, Sibirny A, Bolotin-Fukuhara M.

PLoS One. 2014 Dec 5;9(12):e112263. doi: 10.1371/journal.pone.0112263. eCollection 2014.


Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.

Ieva R, Schrempp SG, Opaliński L, Wollweber F, Höß P, Heißwolf AK, Gebert M, Zhang Y, Guiard B, Rospert S, Becker T, Chacinska A, Pfanner N, van der Laan M.

Mol Cell. 2014 Dec 4;56(5):641-52. doi: 10.1016/j.molcel.2014.10.010. Epub 2014 Nov 13.


Mitochondria. Cell cycle-dependent regulation of mitochondrial preprotein translocase.

Harbauer AB, Opalińska M, Gerbeth C, Herman JS, Rao S, Schönfisch B, Guiard B, Schmidt O, Pfanner N, Meisinger C.

Science. 2014 Nov 28;346(6213):1109-13. doi: 10.1126/science.1261253. Epub 2014 Nov 6.


The mitochondrial ADP/ATP carrier associates with the inner membrane presequence translocase in a stoichiometric manner.

Mehnert CS, Rampelt H, Gebert M, Oeljeklaus S, Schrempp SG, Kochbeck L, Guiard B, Warscheid B, van der Laan M.

J Biol Chem. 2014 Sep 26;289(39):27352-62. doi: 10.1074/jbc.M114.556498. Epub 2014 Aug 14.


Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling.

Couroussé T, Bacq A, Belzung C, Guiard B, Balasse L, Louis F, Le Guisquet AM, Gardier AM, Schinkel AH, Giros B, Gautron S.

Mol Psychiatry. 2015 Jul;20(7):889-900. doi: 10.1038/mp.2014.86. Epub 2014 Aug 5.


Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy-induced neuropathic pain.

Hache G, Guiard BP, Nguyen TH, Quesseveur G, Gardier AM, Peters D, Munro G, Coudoré F.

Eur J Pain. 2015 Mar;19(3):322-33. doi: 10.1002/ejp.550.


NREM sleep hypersomnia and reduced sleep/wake continuity in a neuroendocrine mouse model of anxiety/depression based on chronic corticosterone administration.

Le Dantec Y, Hache G, Guilloux JP, Guiard BP, David DJ, Adrien J, Escourrou P.

Neuroscience. 2014 Aug 22;274:357-68. doi: 10.1016/j.neuroscience.2014.05.050. Epub 2014 Jun 6.


Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.

Petit AC, Quesseveur G, Gressier F, Colle R, David DJ, Gardier AM, Ferreri F, Lépine JP, Falissard B, Verstuyft C, Guiard BP, Corruble E.

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3;54:76-82. doi: 10.1016/j.pnpbp.2014.04.013. Epub 2014 May 5.


The presequence pathway is involved in protein sorting to the mitochondrial outer membrane.

Wenz LS, Opaliński L, Schuler MH, Ellenrieder L, Ieva R, Böttinger L, Qiu J, van der Laan M, Wiedemann N, Guiard B, Pfanner N, Becker T.

EMBO Rep. 2014 Jun;15(6):678-85. doi: 10.1002/embr.201338144. Epub 2014 Apr 29.


Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases.

Gerbeth C, Schmidt O, Rao S, Harbauer AB, Mikropoulou D, Opalińska M, Guiard B, Pfanner N, Meisinger C.

Cell Metab. 2013 Oct 1;18(4):578-87. doi: 10.1016/j.cmet.2013.09.006.


The functional interaction of mitochondrial Hsp70s with the escort protein Zim17 is critical for Fe/S biogenesis and substrate interaction at the inner membrane preprotein translocase.

Lewrenz I, Rietzschel N, Guiard B, Lill R, van der Laan M, Voos W.

J Biol Chem. 2013 Oct 25;288(43):30931-43. doi: 10.1074/jbc.M113.465997. Epub 2013 Sep 12.


The monoaminergic tripartite synapse: a putative target for currently available antidepressant drugs.

Quesseveur G, Gardier AM, Guiard BP.

Curr Drug Targets. 2013 Oct;14(11):1277-94. Review.


Glia: a new cellular target in the treatment of major depression.

Guiard B.

Curr Drug Targets. 2013 Oct;14(11):1219. No abstract available.


Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation.

Qiu J, Wenz LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T.

Cell. 2013 Aug 1;154(3):596-608. doi: 10.1016/j.cell.2013.06.033.


A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase.

Böttinger L, Guiard B, Oeljeklaus S, Kulawiak B, Zufall N, Wiedemann N, Warscheid B, van der Laan M, Becker T.

Mol Biol Cell. 2013 Sep;24(17):2609-19. doi: 10.1091/mbc.E13-02-0106. Epub 2013 Jul 17.


Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice.

Guilloux JP, Mendez-David I, Pehrson A, Guiard BP, Repérant C, Orvoën S, Gardier AM, Hen R, Ebert B, Miller S, Sanchez C, David DJ.

Neuropharmacology. 2013 Oct;73:147-59. doi: 10.1016/j.neuropharm.2013.05.014. Epub 2013 May 28.


BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.

Quesseveur G, David DJ, Gaillard MC, Pla P, Wu MV, Nguyen HT, Nicolas V, Auregan G, David I, Dranovsky A, Hantraye P, Hen R, Gardier AM, Déglon N, Guiard BP.

Transl Psychiatry. 2013 Apr 30;3:e253. doi: 10.1038/tp.2013.30.


5-HT₂A receptor inactivation potentiates the acute antidepressant-like activity of escitalopram: involvement of the noradrenergic system.

Quesseveur G, Repérant C, David DJ, Gardier AM, Sanchez C, Guiard BP.

Exp Brain Res. 2013 Apr;226(2):285-95. doi: 10.1007/s00221-013-3434-3. Epub 2013 Feb 15.


The mitochondrial protein import machinery has multiple connections to the respiratory chain.

Kulawiak B, Höpker J, Gebert M, Guiard B, Wiedemann N, Gebert N.

Biochim Biophys Acta. 2013 May;1827(5):612-26. doi: 10.1016/j.bbabio.2012.12.004. Epub 2012 Dec 26. Review.


Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

Sztolsztener ME, Brewinska A, Guiard B, Chacinska A.

Traffic. 2013 Mar;14(3):309-20. doi: 10.1111/tra.12030. Epub 2012 Dec 16.


The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.

Reinhold R, Krüger V, Meinecke M, Schulz C, Schmidt B, Grunau SD, Guiard B, Wiedemann N, van der Laan M, Wagner R, Rehling P, Dudek J.

Mol Cell Biol. 2012 Dec;32(24):5009-21. doi: 10.1128/MCB.00843-12. Epub 2012 Oct 8.


Impaired folding of the mitochondrial small TIM chaperones induces clearance by the i-AAA protease.

Baker MJ, Mooga VP, Guiard B, Langer T, Ryan MT, Stojanovski D.

J Mol Biol. 2012 Dec 14;424(5):227-39. doi: 10.1016/j.jmb.2012.09.019. Epub 2012 Oct 2.


In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

Böttinger L, Gornicka A, Czerwik T, Bragoszewski P, Loniewska-Lwowska A, Schulze-Specking A, Truscott KN, Guiard B, Milenkovic D, Chacinska A.

Mol Biol Cell. 2012 Oct;23(20):3957-69. doi: 10.1091/mbc.E12-05-0358. Epub 2012 Aug 23.


5-HT2 ligands in the treatment of anxiety and depression.

Quesseveur G, Nguyen HT, Gardier AM, Guiard BP.

Expert Opin Investig Drugs. 2012 Nov;21(11):1701-25. doi: 10.1517/13543784.2012.719872. Epub 2012 Aug 24. Review.


Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes.

Gebert M, Schrempp SG, Mehnert CS, Heißwolf AK, Oeljeklaus S, Ieva R, Bohnert M, von der Malsburg K, Wiese S, Kleinschroth T, Hunte C, Meyer HE, Haferkamp I, Guiard B, Warscheid B, Pfanner N, van der Laan M.

J Cell Biol. 2012 May 28;197(5):595-604. doi: 10.1083/jcb.201110047. Epub 2012 May 21.


Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression.

Hache G, Guiard BP, Le Dantec Y, Orvoën S, David DJ, Gardier AM, Coudoré F.

Neuroreport. 2012 Jun 20;23(9):525-9. doi: 10.1097/WNR.0b013e328353d70a.


Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import.

Rao S, Schmidt O, Harbauer AB, Schönfisch B, Guiard B, Pfanner N, Meisinger C.

Mol Biol Cell. 2012 May;23(9):1618-27. doi: 10.1091/mbc.E11-11-0933. Epub 2012 Mar 14.


The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase.

Corvest V, Murrey DA, Hirasawa M, Knaff DB, Guiard B, Hamel PP.

Mol Microbiol. 2012 Mar;83(5):968-80. doi: 10.1111/j.1365-2958.2012.07981.x. Epub 2012 Feb 8.


Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice.

Nguyen HT, Guiard BP, Bacq A, David DJ, David I, Quesseveur G, Gautron S, Sanchez C, Gardier AM.

Br J Pharmacol. 2013 Jan;168(1):103-16. doi: 10.1111/j.1476-5381.2012.01850.x.


Dual function of Sdh3 in the respiratory chain and TIM22 protein translocase of the mitochondrial inner membrane.

Gebert N, Gebert M, Oeljeklaus S, von der Malsburg K, Stroud DA, Kulawiak B, Wirth C, Zahedi RP, Dolezal P, Wiese S, Simon O, Schulze-Specking A, Truscott KN, Sickmann A, Rehling P, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N.

Mol Cell. 2011 Dec 9;44(5):811-8. doi: 10.1016/j.molcel.2011.09.025.

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