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Items: 1 to 50 of 250

1.

Retraction of "Development of Novel Adenosine Monophosphate-Activated Protein Kinase Activators".

Guh JH, Chang WL, Yang J, Lee SL, Wei S, Wang D, Kulp SK, Chen CS.

J Med Chem. 2018 Jun 14;61(11):5055. doi: 10.1021/acs.jmedchem.8b00707. Epub 2018 May 18. No abstract available.

PMID:
29772897
2.

Addressing Racism in Medical Education An Interactive Training Module.

White-Davis T, Edgoose J, Brown Speights JS, Fraser K, Ring JM, Guh J, Saba GW.

Fam Med. 2018 May;50(5):364-368. doi: 10.22454/FamMed.2018.875510.

3.

An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia.

Chan SH, Liang PH, Guh JH.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Jun;391(6):587-602. doi: 10.1007/s00210-018-1484-6. Epub 2018 Mar 28.

PMID:
29594316
4.

Glomerular Filtration Rates in Asians.

Teo BW, Zhang L, Guh JY, Tang SCW, Jha V, Kang DH, Tanchanco R, Hooi LS, Praditpornsilpa K, Kong X, Zuo L, Chan GC, Lee EJC.

Adv Chronic Kidney Dis. 2018 Jan;25(1):41-48. doi: 10.1053/j.ackd.2017.10.005. Review.

PMID:
29499886
5.

Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathways.

Chan ML, Yu CC, Hsu JL, Leu WJ, Chan SH, Hsu LC, Liu SP, Ivantcova PM, Dogan Ö, Bräse S, Kudryavtsev KV, Guh JH.

Oncotarget. 2017 May 20;8(57):96668-96683. doi: 10.18632/oncotarget.18040. eCollection 2017 Nov 14.

6.

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities.

Chao SW, Chen LC, Yu CC, Liu CY, Lin TE, Guh JH, Wang CY, Chen CY, Hsu KC, Huang WJ.

Eur J Med Chem. 2018 Jan 1;143:792-805. doi: 10.1016/j.ejmech.2017.11.092. Epub 2017 Dec 5.

PMID:
29223096
7.

Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine.

Lin YY, Chan SH, Juang YP, Hsiao HM, Guh JH, Liang PH.

Eur J Med Chem. 2018 Jan 1;143:1942-1958. doi: 10.1016/j.ejmech.2017.11.004. Epub 2017 Nov 6.

PMID:
29133061
8.

KMUP-1 attenuates high glucose and transforming growth factor-β1-induced pro-fibrotic proteins in mesangial cells.

Lin SH, Chen IJ, Chuang CT, Ho WT, Chuang LY, Guh JY.

Mol Med Rep. 2017 Jun;15(6):4199-4206. doi: 10.3892/mmr.2017.6486. Epub 2017 Apr 20.

PMID:
28440482
9.

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5.

Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH, Hung MC, Ghoshal K, Teng CM, Peng Y, Croce CM.

Cancer Cell. 2016 Nov 14;30(5):723-736. doi: 10.1016/j.ccell.2016.10.001.

10.

Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways.

Leu WJ, Swain ShP, Chan SH, Hsu JL, Liu SP, Chan ML, Yu CC, Hsu LC, Chou YL, Chang WL, Hou DR, Guh JH.

Oncotarget. 2016 Nov 22;7(47):76995-77009. doi: 10.18632/oncotarget.12765.

11.

Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin and p21(WAF1) in mesangial cells.

Lin SH, Ho WT, Wang YT, Chuang CT, Chuang LY, Guh JY.

Int J Biochem Cell Biol. 2016 Sep;78:96-105. doi: 10.1016/j.biocel.2016.06.021. Epub 2016 Jun 29.

PMID:
27373678
12.

Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth.

Lai WT, Cheng KL, Baruchello R, Rondanin R, Marchetti P, Simoni D, Lee RM, Guh JH, Hsu LC.

Biochem Pharmacol. 2016 Aug 1;113:12-23. doi: 10.1016/j.bcp.2016.06.010. Epub 2016 Jun 17.

PMID:
27328368
13.

Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase.

Lin SH, Chiou SJ, Ho WT, Chuang CT, Chuang LY, Guh JY.

Toxicology. 2016 Feb 17;344-346:53-60. doi: 10.1016/j.tox.2016.02.004. Epub 2016 Feb 22.

PMID:
26908192
14.

Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers.

Kudryavtsev KV, Ivantcova PM, Muhle-Goll C, Churakov AV, Sokolov MN, Dyuba AV, Arutyunyan AM, Howard JA, Yu CC, Guh JH, Zefirov NS, Bräse S.

Org Lett. 2015 Dec 18;17(24):6178-81. doi: 10.1021/acs.orglett.5b03154. Epub 2015 Dec 1.

PMID:
26624275
15.
16.

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.

Lee YR, Chen TC, Lee CC, Chen CL, Ahmed Ali AA, Tikhomirov A, Guh JH, Yu DS, Huang HS.

Eur J Med Chem. 2015 Sep 18;102:661-76. doi: 10.1016/j.ejmech.2015.07.052. Epub 2015 Aug 7.

PMID:
26344783
17.

Catalytic transfer hydrogenation and anticancer activity of arene-ruthenium compounds incorporating bi-dentate precursors.

Chang YH, Leu WJ, Datta A, Hsiao HC, Lin CH, Guh JH, Huang JH.

Dalton Trans. 2015 Sep 28;44(36):16107-18. doi: 10.1039/c5dt01310k.

PMID:
26287471
18.

Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult.

Chan ML, Liang JW, Hsu LC, Chang WL, Lee SS, Guh JH.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388(11):1223-36. doi: 10.1007/s00210-015-1152-z. Epub 2015 Aug 6.

PMID:
26246051
19.

Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway.

Ho CH, Hsu JL, Liu SP, Hsu LC, Chang WL, Chao CC, Guh JH.

Prostate. 2015 Sep;75(13):1454-66. doi: 10.1002/pros.23033. Epub 2015 Jul 14.

PMID:
26180030
20.

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma.

Hsu JL, Liu FL, Hsu LC, Chang HS, Leu WJ, Yu CC, Chang WL, Chen IS, Kung FL, Guh JH.

Oncotarget. 2015 Sep 15;6(27):24032-46.

21.

Vitamin D-binding protein is required for the protective effects of vitamin D in renal fibroblasts and is phosphorylated in diabetic rats.

Chou CH, Chuang LY, Lu CY, Guh JY.

Mol Cell Endocrinol. 2015 Aug 15;411:67-74. doi: 10.1016/j.mce.2015.04.012. Epub 2015 Apr 21.

PMID:
25911112
22.

Steap4 attenuates high glucose and S100B-induced effects in mesangial cells.

Chuang CT, Guh JY, Lu CY, Wang YT, Chen HC, Chuang LY.

J Cell Mol Med. 2015 Jun;19(6):1234-44. doi: 10.1111/jcmm.12472. Epub 2015 Mar 27.

23.

Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells – a critical role of Cdk1 in mitotic entry.

Chang WL, Yu CC, Chen CS, Guh JH.

Biochem Pharmacol. 2015 Mar 1;94(1):12-21. doi: 10.1016/j.bcp.2015.01.005. Epub 2015 Jan 20.

PMID:
25615907
24.
25.

Cinnamaldehyde and nitric oxide attenuate advanced glycation end products-induced the Jak/STAT signaling in human renal tubular cells.

Huang JS, Lee YH, Chuang LY, Guh JY, Hwang JY.

J Cell Biochem. 2015 Jun;116(6):1028-38. doi: 10.1002/jcb.25058.

PMID:
25561392
26.

S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells.

Chuang CT, Guh JY, Lu CY, Chen HC, Chuang LY.

Int J Mol Med. 2015 Feb;35(2):546-52. doi: 10.3892/ijmm.2014.2024. Epub 2014 Dec 5.

PMID:
25482070
27.

Structural studies and anticancer activity of a novel class of β-peptides.

Kudryavtsev KV, Yu CC, Ivantcova PM, Polshakov VI, Churakov AV, Bräse S, Zefirov NS, Guh JH.

Chem Asian J. 2015 Feb;10(2):383-9. doi: 10.1002/asia.201403171. Epub 2014 Nov 18.

PMID:
25408436
28.

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.

Chen CL, Liu FL, Lee CC, Chen TC, Chang WW, Guh JH, Ahmed Ali AA, Chang DM, Huang HS.

Eur J Med Chem. 2014 Nov 24;87:30-8. doi: 10.1016/j.ejmech.2014.09.016. Epub 2014 Sep 6.

PMID:
25240093
29.

Sagittally malrotated kidney: a case series of two patients.

Tsai HY, Lee MH, Chen HC, Chen HC, Guh JY.

Surg Radiol Anat. 2015 Jul;37(5):551-3. doi: 10.1007/s00276-014-1376-5. Epub 2014 Sep 19.

PMID:
25234317
30.

The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells.

Lin YH, Chen BY, Lai WT, Wu SF, Guh JH, Cheng AL, Hsu LC.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Jan;388(1):19-31. doi: 10.1007/s00210-014-1032-y. Epub 2014 Aug 28.

PMID:
25164962
31.

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway.

Hsu JL, Liu SP, Lee CC, Hsu LC, Ho YF, Huang HS, Guh JH.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):979-90. doi: 10.1007/s00210-014-0998-9. Epub 2014 Jul 9.

PMID:
25005758
32.

Modification of diet in renal disease (MDRD) study and CKD epidemiology collaboration (CKD-EPI) equations for Taiwanese adults.

Chen LI, Guh JY, Wu KD, Chen YM, Kuo MC, Hwang SJ, Chen TH, Chen HC.

PLoS One. 2014 Jun 13;9(6):e99645. doi: 10.1371/journal.pone.0099645. eCollection 2014.

33.

A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I.

Yu CC, Pan SL, Chao SW, Liu SP, Hsu JL, Yang YC, Li TK, Huang WJ, Guh JH.

Biochem Pharmacol. 2014 Aug 1;90(3):320-30. doi: 10.1016/j.bcp.2014.06.001. Epub 2014 Jun 7.

PMID:
24915421
34.

Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts.

Huang JS, Chuang CT, Liu MH, Lin SH, Guh JY, Chuang LY.

Mol Cell Endocrinol. 2014 Jun 5;390(1-2):45-53. doi: 10.1016/j.mce.2014.04.001. Epub 2014 Apr 8.

PMID:
24721634
35.

A general synthetic strategy and the anti-proliferation properties on prostate cancer cell lines for natural phenylethanoid glycosides.

Mulani SK, Guh JH, Mong KK.

Org Biomol Chem. 2014 May 14;12(18):2926-37. doi: 10.1039/c3ob42503g.

PMID:
24691797
36.

Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.

Liu FL, Hsu JL, Lee YJ, Dong YS, Kung FL, Chen CS, Guh JH.

Eur J Pharmacol. 2014 May 5;730:90-101. doi: 10.1016/j.ejphar.2014.02.029. Epub 2014 Mar 6.

37.

Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption.

Hsiao CJ, Hsiao G, Chen WL, Wang SW, Chiang CP, Liu LY, Guh JH, Lee TH, Chung CL.

J Nat Prod. 2014 Apr 25;77(4):758-65. doi: 10.1021/np400517g. Epub 2014 Mar 3.

PMID:
24588135
38.

Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycle.

Leu WJ, Chang HS, Chan SH, Hsu JL, Yu CC, Hsu LC, Chen IS, Guh JH.

PLoS One. 2014 Jan 27;9(1):e87323. doi: 10.1371/journal.pone.0087323. eCollection 2014.

39.

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer.

Hsu JL, Lee YJ, Leu WJ, Dong YS, Pan SL, Uang BJ, Guh JH.

J Urol. 2014 May;191(5):1429-38. doi: 10.1016/j.juro.2013.11.102. Epub 2013 Dec 6.

PMID:
24316097
40.

Synthesis and anti-cancer activity of a glycosyl library of N-acetylglucosamine-bearing oleanolic acid.

Zeng YB, Hsiao HM, Chan SH, Wang YH, Lin YY, Kuo YH, Guh JH, Liang PH.

Mol Divers. 2014 Feb;18(1):13-23. doi: 10.1007/s11030-013-9480-8. Epub 2013 Sep 25.

PMID:
24222528
41.

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.

Chan SH, Leu WJ, Hsu LC, Chang HS, Hwang TL, Chen IS, Chen CS, Guh JH.

Biochem Pharmacol. 2013 Dec 1;86(11):1564-75. doi: 10.1016/j.bcp.2013.09.021. Epub 2013 Oct 4.

42.

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

Lee CC, Chang DM, Huang KF, Chen CL, Chen TC, Lo Y, Guh JH, Huang HS.

Bioorg Med Chem. 2013 Nov 15;21(22):7125-33. doi: 10.1016/j.bmc.2013.09.006. Epub 2013 Sep 13.

PMID:
24094433
43.

Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation.

Wang WT, Chen YH, Hsu JL, Leu WJ, Yu CC, Chan SH, Ho YF, Hsu LC, Guh JH.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):33-45. doi: 10.1007/s00210-013-0912-x. Epub 2013 Sep 19.

PMID:
24048439
44.
45.

Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy.

Wang YH, Yeh HW, Wang HW, Yu CC, Guh JH, Liu DZ, Liang PH.

Carbohydr Res. 2013 Jun 28;375:118-35. doi: 10.1016/j.carres.2013.04.022. Epub 2013 Apr 28.

PMID:
23707361
46.

Urinary neutrophil gelatinase-associated lipocalin levels predict cisplatin-induced acute kidney injury better than albuminuria or urinary cystatin C levels.

Lin HY, Lee SC, Lin SF, Hsiao HH, Liu YC, Yang WC, Hwang DY, Hung CC, Chen HC, Guh JY.

Kaohsiung J Med Sci. 2013 Jun;29(6):304-11. doi: 10.1016/j.kjms.2012.10.004. Epub 2013 Jan 11.

47.

Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.

Ko YM, Chang CY, Chiou SJ, Hsu FJ, Huang JS, Yang YL, Guh JY, Chuang LY.

Arch Biochem Biophys. 2013 Jul 15;535(2):177-86. doi: 10.1016/j.abb.2013.03.003. Epub 2013 Mar 13.

PMID:
23500140
48.

2-(1H-Imidazol-1-yl)-4-[3-(trifluoro-meth-yl)phen-yl]-1,3-thia-zole.

Kudryavtsev KV, Churakov AV, Guh JH.

Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o238. doi: 10.1107/S1600536813000615. Epub 2013 Jan 16.

49.

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

Chen CL, Chang DM, Chen TC, Lee CC, Hsieh HH, Huang FC, Huang KF, Guh JH, Lin JJ, Huang HS.

Eur J Med Chem. 2013 Feb;60:29-41. doi: 10.1016/j.ejmech.2012.11.032. Epub 2012 Nov 29.

PMID:
23279865
50.

Interaction between TGF-β and ACE2-Ang-(1-7)-Mas pathway in high glucose-cultured NRK-52E cells.

Chou CH, Chuang LY, Lu CY, Guh JY.

Mol Cell Endocrinol. 2013 Feb 5;366(1):21-30. doi: 10.1016/j.mce.2012.11.004. Epub 2012 Nov 19.

PMID:
23174757

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