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Items: 31

1.

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A.

Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003.

2.

Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators associated with HIV acquisition.

Hearps AC, Tyssen D, Srbinovski D, Bayigga L, Diaz DJD, Aldunate M, Cone RA, Gugasyan R, Anderson DJ, Tachedjian G.

Mucosal Immunol. 2017 Nov;10(6):1480-1490. doi: 10.1038/mi.2017.27. Epub 2017 Apr 12.

PMID:
28401934
3.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Sep 12;30(3):499-500. doi: 10.1016/j.ccell.2016.08.009. Epub 2016 Sep 12. No abstract available.

4.

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.

Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Erratum in: Sci Transl Med. 2017 May 31;9(392):.

PMID:
27194727
5.

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

Messina N, Fulford T, O'Reilly L, Loh WX, Motyer JM, Ellis D, McLean C, Naeem H, Lin A, Gugasyan R, Slattery RM, Grumont RJ, Gerondakis S.

J Autoimmun. 2016 Jun;70:52-62. doi: 10.1016/j.jaut.2016.03.017. Epub 2016 Apr 7.

PMID:
27068879
6.

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R.

J Exp Med. 2016 Apr 4;213(4):621-41. doi: 10.1084/jem.20151182. Epub 2016 Mar 28.

7.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Feb 8;29(2):145-58. doi: 10.1016/j.ccell.2016.01.006. Erratum in: Cancer Cell. 2016 Sep 12;30(3):499-500.

8.

Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis.

Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, Cone RA, Tachedjian G.

Front Physiol. 2015 Jun 2;6:164. doi: 10.3389/fphys.2015.00164. eCollection 2015. Review.

9.

NF-κB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ.

Immunol Rev. 2012 Mar;246(1):272-85. doi: 10.1111/j.1600-065X.2011.01090.x. Review.

PMID:
22435561
10.

The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.

Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S.

EMBO J. 2012 Feb 1;31(3):692-706. doi: 10.1038/emboj.2011.435. Epub 2011 Nov 29.

11.

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway.

Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI.

Immunol Cell Biol. 2011 Feb;89(2):294-303. doi: 10.1038/icb.2010.93. Epub 2010 Aug 10.

PMID:
20697425
12.

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S.

J Exp Med. 2009 Dec 21;206(13):3001-14. doi: 10.1084/jem.20091411. Epub 2009 Dec 7. Erratum in: J Exp Med.2010 Apr 12;207(4):899. Li, Wu [corrected to Wu, Li].

13.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A.

Immunity. 2009 Jan 16;30(1):56-66. doi: 10.1016/j.immuni.2008.10.017.

14.

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.

Banerjee A, Grumont R, Gugasyan R, White C, Strasser A, Gerondakis S.

Blood. 2008 Dec 15;112(13):5063-73. doi: 10.1182/blood-2007-10-120832. Epub 2008 Sep 19.

15.

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction.

Kaufmann T, Gugasyan R, Gerondakis S, Dixit VM, Strasser A.

Cell Death Differ. 2007 Mar;14(3):637-9. Epub 2006 Nov 10. No abstract available.

16.

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, Banerjee A.

Oncogene. 2006 Oct 30;25(51):6781-99. Review.

PMID:
17072328
17.

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells.

Thomas T, Corcoran LM, Gugasyan R, Dixon MP, Brodnicki T, Nutt SL, Metcalf D, Voss AK.

Genes Dev. 2006 May 1;20(9):1175-86.

18.

Bcl-2 transgene expression fails to prevent fatal hepatocyte apoptosis induced by endogenous TNFalpha in mice lacking RelA.

Gugasyan R, Christou A, O'Reilly LA, Strasser A, Gerondakis S.

Cell Death Differ. 2006 Jul;13(7):1235-7. Epub 2006 Feb 17. No abstract available.

19.

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells.

Banerjee A, Gugasyan R, McMahon M, Gerondakis S.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3274-9. Epub 2006 Feb 16.

20.

Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals.

O'Keeffe M, Grumont RJ, Hochrein H, Fuchsberger M, Gugasyan R, Vremec D, Shortman K, Gerondakis S.

Blood. 2005 Nov 15;106(10):3457-64. Epub 2005 Jul 21.

21.

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.

Gugasyan R, Voss A, Varigos G, Thomas T, Grumont RJ, Kaur P, Grigoriadis G, Gerondakis S.

Mol Cell Biol. 2004 Jul;24(13):5733-45.

22.

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites.

Gugasyan R, Quilici C, I ST, Grail D, Verhagen AM, Roberts A, Kitamura T, Dunn AR, Lock P.

J Cell Biol. 2002 Jul 8;158(1):115-25. Epub 2002 Jul 1.

23.

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells.

Pohl T, Gugasyan R, Grumont RJ, Strasser A, Metcalf D, Tarlinton D, Sha W, Baltimore D, Gerondakis S.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4514-9.

24.

c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription.

Grumont R, Hochrein H, O'Keeffe M, Gugasyan R, White C, Caminschi I, Cook W, Gerondakis S.

J Exp Med. 2001 Oct 15;194(8):1021-32.

25.

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression.

Grossmann M, O'Reilly LA, Gugasyan R, Strasser A, Adams JM, Gerondakis S.

EMBO J. 2000 Dec 1;19(23):6351-60.

26.

Rel/NF-kappaB transcription factors: key mediators of B-cell activation.

Gugasyan R, Grumont R, Grossmann M, Nakamura Y, Pohl T, Nesic D, Gerondakis S.

Immunol Rev. 2000 Aug;176:134-40. Review.

PMID:
11043773
27.

Independent selection by I-Ak molecules of two epitopes found in tandem in an extended polypeptide antigen.

Gugasyan R, Velazquez C, Vidavsky I, Deck BM, van der Drift K, Gross ML, Unanue ER.

J Immunol. 2000 Sep 15;165(6):3206-13.

28.

Isolation and quantitation of a minor determinant of hen egg white lysozyme bound to I-Ak by using peptide-specific immunoaffinity.

Gugasyan R, Vidavsky I, Nelson CA, Gross ML, Unanue ER.

J Immunol. 1998 Dec 1;161(11):6074-83.

29.
30.

Prevention of splenic granuloma formation in adjuvant arthritis by 2-acetyl-4-tetrahydroxybutylimidazole (THI).

Gugasyan R, Clouston D, Mandel T, Wicks I.

Immunol Lett. 1997 Aug;58(3):133-8.

PMID:
9293393
31.

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