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Items: 1 to 50 of 437

1.

Bisphenol-A in the European Prospective Investigation into Cancer and Nutrition cohort in Spain: Levels at recruitment and associated dietary factors.

Salamanca-Fernández E, Rodríguez-Barranco M, Arrebola JP, Vela F, Díaz C, Chirlaque MD, Colorado-Yohar S, Jiménez-Zabala A, Irizar A, Guevara M, Ardanaz E, Iribarne-Durán LM, Pérez Del Palacio J, Olea N, Agudo A, Sánchez MJ.

Environ Res. 2019 Dec 7;182:109012. doi: 10.1016/j.envres.2019.109012. [Epub ahead of print]

PMID:
31837551
2.

Long-term culturing of porcine nodose ganglia.

Kuan SP, Atanasova KR, Guevara MV, Collins EN, Reznikov LR.

J Neurosci Methods. 2019 Dec 7:108546. doi: 10.1016/j.jneumeth.2019.108546. [Epub ahead of print]

PMID:
31821820
3.

Morphological alterations caused by manual venom extraction on the main venom gland of Bothrops asper and Crotalus simus snakes (Serpentes: Viperidae): Long-term implications for antivenom production.

Rodríguez-Abarca S, Corrales G, Chacón D, Guevara M, Esquivel C, Arroyo C, Gómez A.

Toxicon. 2019 Oct 25;172:23-32. doi: 10.1016/j.toxicon.2019.10.242. Epub 2019 Nov 2.

PMID:
31689424
4.

Impact of wind speed and direction and key meteorological parameters on potential pesticide drift mass loadings from sequential aerial applications.

Desmarteau DA, Ritter AM, Hendley P, Guevara MW.

Integr Environ Assess Manag. 2019 Oct 7. doi: 10.1002/ieam.4221. [Epub ahead of print]

PMID:
31589364
5.

"Plis de passage" Deserve a Role in Models of the Cortical Folding Process.

Mangin JF, Le Guen Y, Labra N, Grigis A, Frouin V, Guevara M, Fischer C, Rivière D, Hopkins WD, Régis J, Sun ZY.

Brain Topogr. 2019 Nov;32(6):1035-1048. doi: 10.1007/s10548-019-00734-8. Epub 2019 Oct 3. Review.

PMID:
31583493
6.

Downscaling satellite soil moisture using geomorphometry and machine learning.

Guevara M, Vargas R.

PLoS One. 2019 Sep 24;14(9):e0219639. doi: 10.1371/journal.pone.0219639. eCollection 2019.

7.

Chemical Composition and Antioxidant Activity of the Main Fruits Consumed in the Western Coastal Region of Ecuador as a Source of Health-Promoting Compounds.

Guevara M, Tejera E, Granda-Albuja MG, Iturralde G, Chisaguano-Tonato M, Granda-Albuja S, Jaramillo-Vivanco T, Giampieri F, Battino M, Alvarez-Suarez JM.

Antioxidants (Basel). 2019 Sep 10;8(9). pii: E387. doi: 10.3390/antiox8090387.

8.

Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration.

Guevara ML, Jilesen Z, Stojdl D, Persano S.

ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

9.

Observing Erotic Videos with Heterosexual Content Induces Different Cerebral Responses in Homosexual and Heterosexual Men.

Amezcua-Gutiérrez C, Hernández-González M, Guasti AF, Aguilar MAC, Guevara MA.

J Homosex. 2019 Aug 20:1-19. doi: 10.1080/00918369.2019.1648079. [Epub ahead of print]

PMID:
31430230
10.

Detecting clustered independent rare variant associations using genetic algorithms.

Guevara M, Vallejo EE, Estrada K.

IEEE/ACM Trans Comput Biol Bioinform. 2019 Aug 12. doi: 10.1109/TCBB.2019.2930505. [Epub ahead of print]

PMID:
31403438
11.

Estimated Substitution of Tea or Coffee for Sugar-Sweetened Beverages Was Associated with Lower Type 2 Diabetes Incidence in Case-Cohort Analysis across 8 European Countries in the EPIC-InterAct Study.

Imamura F, Schulze MB, Sharp SJ, Guevara M, Romaguera D, Bendinelli B, Salamanca-Fernández E, Ardanaz E, Arriola L, Aune D, Boeing H, Dow C, Fagherazzi G, Franks PW, Freisling H, Jakszyn P, Kaaks R, Khaw KT, Kühn T, Mancini FR, Masala G, Chirlaque MD, Nilsson PM, Overvad K, Pala VM, Panico S, Perez-Cornago A, Quirós JR, Ricceri F, Rodríguez-Barranco M, Rolandsson O, Sluijs I, Stepien M, Spijkerman AMW, Tjønneland A, Tong TYN, Tumino R, Vissers LET, Ward HA, Langenberg C, Riboli E, Forouhi NG, Wareham NJ.

J Nutr. 2019 Nov 1;149(11):1985-1993. doi: 10.1093/jn/nxz156.

12.

Medium-term outcomes after robotic-assisted lateral suspension with mesh for advanced multi-compartmental prolapse.

Russo E, Giannini A, Guevara MM, Mannella P, Misasi G, Falcone M, Simoncini T.

Int Urogynecol J. 2019 Aug 6. doi: 10.1007/s00192-019-04069-7. [Epub ahead of print]

PMID:
31388718
13.

Domain-specific patterns of physical activity and risk of breast cancer sub-types in the MCC-Spain study.

Huerta JM, Molina AJ, Chirlaque MD, Yepes P, Moratalla-Navarro F, Moreno V, Amiano P, Guevara M, Moreno-Iribas C, Llorca J, Fernández-Tardón G, Molina-Barceló A, Alguacil J, Marcos-Gragera R, Castaño-Vinyals G, Pérez-Gómez B, Kogevinas M, Pollán M, Martín V.

Breast Cancer Res Treat. 2019 Oct;177(3):749-760. doi: 10.1007/s10549-019-05358-x. Epub 2019 Jul 17.

PMID:
31317349
14.

Lipid-Based Vectors for Therapeutic mRNA-Based Anti-Cancer Vaccines.

Guevara ML, Persano S, Persano F.

Curr Pharm Des. 2019;25(13):1443-1454. doi: 10.2174/1381612825666190619150221.

PMID:
31258071
15.

Effects of inactivation of the ventral tegmental area on prefronto-accumbens activity and sexual motivation in male rats.

Cortes PM, Hernández-Arteaga E, Sotelo-Tapia C, Guevara MA, Medina AC, Hernández-González M.

Physiol Behav. 2019 Oct 1;209:112593. doi: 10.1016/j.physbeh.2019.112593. Epub 2019 Jun 27.

PMID:
31255646
16.

Anti-inflammatory effect of the medicinal herbal mixture infusion, Horchata, from southern Ecuador against LPS-induced cytotoxic damage in RAW 264.7 macrophages.

Guevara M, Tejera E, Iturralde GA, Jaramillo-Vivanco T, Granda-Albuja MG, Granja-Albuja S, Santos-Buelga C, González-Paramás AM, Álvarez-Suarez JM.

Food Chem Toxicol. 2019 Sep;131:110594. doi: 10.1016/j.fct.2019.110594. Epub 2019 Jun 18.

PMID:
31226431
17.

Supporting the improvement of air quality management practices: The "FAIRMODE pilot" activity.

Pisoni E, Guerreiro C, Lopez-Aparicio S, Guevara M, Tarrason L, Janssen S, Thunis P, Pfäfflin F, Piersanti A, Briganti G, Cappelletti A, D'Elia I, Mircea M, Villani MG, Vitali L, Matavž L, Rus M, Žabkar R, Kauhaniemi M, Karppinen A, Kousa A, Väkevä O, Eneroth K, Stortini M, Delaney K, Struzewska J, Durka P, Kaminski JW, Krmpotic S, Vidic S, Belavic M, Brzoja D, Milic V, Assimakopoulos VD, Fameli KM, Polimerova T, Stoyneva E, Hristova Y, Sokolovski E, Cuvelier C.

J Environ Manage. 2019 Sep 1;245:122-130. doi: 10.1016/j.jenvman.2019.04.118. Epub 2019 May 28.

18.

[Spanish rare disease registries research network: first results of Spain-RDR's project in Navarre].

Vicente E, Guevara M, Lasanta MJ, Ramos-Arroyo MA, Ardanaz E.

An Sist Sanit Navar. 2019 Aug 23;42(2):179-186. doi: 10.23938/ASSN.0636. Spanish.

19.

Fatty acid intake and breast cancer in the Spanish multicase-control study on cancer (MCC-Spain).

Dierssen-Sotos T, Gómez-Acebo I, Palazuelos C, Gracia-Lavedan E, Pérez-Gómez B, Oribe M, Martín V, Guevara M, Rodríguez-Cundín P, Fernández-Tardón G, Marcos-Gragera R, Molina-Barceló A, Díaz-Santos M, Castaño-Vinyals G, Aragonés N, López-Gonzalez A, Amiano P, Castilla J, Alonso-Molero J, Kogevinas M, Pollán M, Llorca J.

Eur J Nutr. 2019 May 8. doi: 10.1007/s00394-019-01977-8. [Epub ahead of print]

PMID:
31069457
20.

Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study.

Vitelli Storelli F, Molina AJ, Zamora-Ros R, Fernández-Villa T, Roussou V, Romaguera D, Aragonés N, Obón-Santacana M, Guevara M, Gómez-Acebo I, Fernández-Tardón G, Molina-Barceló A, Olmedo-Requena R, Capelo R, Chirlaque MD, Pérez-Gómez B, Moreno V, Castilla J, Rubín-García M, Pollán M, Kogevinas M, Lera JPB, Martín V.

Nutrients. 2019 Apr 27;11(5). pii: E967. doi: 10.3390/nu11050967.

21.

Rate of Fentanyl Positivity Among Urine Drug Test Results Positive for Cocaine or Methamphetamine.

LaRue L, Twillman RK, Dawson E, Whitley P, Frasco MA, Huskey A, Guevara MG.

JAMA Netw Open. 2019 Apr 5;2(4):e192851. doi: 10.1001/jamanetworkopen.2019.2851. Erratum in: JAMA Netw Open. 2019 Oct 2;2(10):e1916040.

22.

Optimization of fibrinogenolytic activity of Solanum tuberosum subtilisin-like protease (StSBTc-3) by response surface methodology.

Pepe A, Tito FR, Daleo GR, Guevara MG.

Biotechnol Rep (Amst). 2019 Apr 1;22:e00330. doi: 10.1016/j.btre.2019.e00330. eCollection 2019 Jun.

23.

Disparities in the management of cutaneous malignant melanoma. A population-based high-resolution study.

Guevara M, Rodríguez-Barranco M, Puigdemont M, Minicozzi P, Yanguas-Bayona I, Porras-Povedano M, Rubió-Casadevall J, Sánchez Pérez MJ, Marcos-Gragera R, Ardanaz E.

Eur J Cancer Care (Engl). 2019 Jul;28(4):e13043. doi: 10.1111/ecc.13043. Epub 2019 Apr 16.

PMID:
30993764
24.

Improvement of hyponatremia in cirrhosis is associated with improved complex information processing.

Watson H, Guevara M, Vilstrup H, Ginès P.

J Gastroenterol Hepatol. 2019 Nov;34(11):1999-2003. doi: 10.1111/jgh.14683. Epub 2019 May 27.

PMID:
30965392
25.

Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder.

Ji E, Guevara P, Guevara M, Grigis A, Labra N, Sarrazin S, Hamdani N, Bellivier F, Delavest M, Leboyer M, Tamouza R, Poupon C, Mangin JF, Houenou J.

Schizophr Bull. 2019 Oct 24;45(6):1367-1378. doi: 10.1093/schbul/sbz015.

PMID:
30953566
26.

Agreement among Mediterranean Diet Pattern Adherence Indexes: MCC-Spain Study.

Olmedo-Requena R, González-Donquiles C, Dávila-Batista V, Romaguera D, Castelló A, Molina de la Torre AJ, Amiano P, Dierssen-Sotos T, Guevara M, Fernández-Tardón G, Lozano-Lorca M, Alguacil J, Peiró R, Huerta JM, Gracia-Lavedan E, Aragonés N, Fernández-Villa T, Solans M, Gómez-Acebo I, Castaño-Vinyals G, Kogevinas M, Pollán M, Martín V.

Nutrients. 2019 Feb 26;11(3). pii: E488. doi: 10.3390/nu11030488.

27.

EEG correlation during the solving of simple and complex logical-mathematical problems.

Molina Del Río J, Guevara MA, Hernández González M, Hidalgo Aguirre RM, Cruz Aguilar MA.

Cogn Affect Behav Neurosci. 2019 Aug;19(4):1036-1046. doi: 10.3758/s13415-019-00703-5.

PMID:
30790182
28.

Evaluation of microvascular invasion as a prognostic factor in the progression of non-metastatic renal cancer.

Bengió RG, Arribillaga LC, Epelde J, Orellana S, Montedoro A, Bengió V, Cordero E, Guevara M.

Cent European J Urol. 2018;71(4):386-390. doi: 10.5173/ceju.2018.1746. Epub 2018 Oct 23.

29.

Bioactive compounds and antioxidant capacity of Chuquiraga jussieui J.F.Gmel from the highlands of Ecuador.

Guerrero Bonilla DA, Granda-Albuja MG, Guevara M, Iturralde GA, Jaramillo-Vivanco T, Giampieri F, Alvarez-Suarez JM.

Nat Prod Res. 2019 Jan 19:1-4. doi: 10.1080/14786419.2018.1548450. [Epub ahead of print]

PMID:
30663345
30.

Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study.

Peremiquel-Trillas P, Benavente Y, Martín-Bustamante M, Casabonne D, Pérez-Gómez B, Gómez-Acebo I, Oliete-Canela A, Diéguez-Rodríguez M, Tusquets I, Amiano P, Mengual L, Ardanaz E, Capelo R, Molina de la Torre AJ, Salas Trejo D, Fernández-Tardón G, Lope V, Jimenez-Moleon JJ, Marcos-Gragera R, Dierssen-Sotos T, Azpiri M, Muñoz M, Guevara M, Fernández-Villa T, Molina-Barceló A, Aragonés N, Pollán M, Castaño-Vinyals G, Alguacil J, Kogevinas M, de Sanjosé S, Costas L.

Environ Int. 2019 Jan;122:389-399. doi: 10.1016/j.envint.2018.12.007. Epub 2018 Dec 13.

31.

Observing Erotic Videos With Heterosexual Content Induces Different Cerebral Responses in Homosexual and Heterosexual Men.

Amezcua-Gutiérrez C, Marisela HG, Fernández Guasti A, Aguilar MAC, Guevara MA.

J Homosex. 2018 Dec 10:1-19. doi: 10.1080/00918369.2018.1550331. [Epub ahead of print]

PMID:
30526443
32.

Melatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer's Disease: A Pilot Study.

Cruz-Aguilar MA, Ramírez-Salado I, Guevara MA, Hernández-González M, Benitez-King G.

J Alzheimers Dis Rep. 2018 Mar 6;2(1):55-65. doi: 10.3233/ADR-170019.

33.

[Implementing a population-based rare diseases registry in Spain: the Navarre´s experience].

Vicente E, Guevara M, Lasanta MJ, Ramos-Arroyo MA, Ardanaz E.

Rev Esp Salud Publica. 2018 Nov 19;92. pii: e201811082. Spanish.

34.

A stringent fiber distance measure for dMRI tractography clustering and segmentation.

Pinto D, Roman C, Guevara M, Poupon C, Mangin JF, Guevara P.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8512333.

PMID:
30440248
35.

Local structural connectivity is associated with social cognition in autism spectrum disorder.

d'Albis MA, Guevara P, Guevara M, Laidi C, Boisgontier J, Sarrazin S, Duclap D, Delorme R, Bolognani F, Czech C, Bouquet C, Ly-Le Moal M, Holiga S, Amestoy A, Scheid I, Gaman A, Leboyer M, Poupon C, Mangin JF, Houenou J.

Brain. 2018 Dec 1;141(12):3472-3481. doi: 10.1093/brain/awy275.

PMID:
30423029
36.

Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.

Minicozzi P, Van Eycken L, Molinie F, Innos K, Guevara M, Marcos-Gragera R, Castro C, Rapiti E, Katalinic A, Torrella A, Žagar T, Bielska-Lasota M, Giorgi Rossi P, Larrañaga N, Bastos J, Sánchez MJ, Sant M; European HR Working Group on breast cancer.

Int J Cancer. 2019 May 1;144(9):2118-2127. doi: 10.1002/ijc.31974. Epub 2018 Dec 27.

PMID:
30411340
37.

Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid.

Reznikov LR, Liao YSJ, Gu T, Davis KM, Kuan SP, Atanasova KR, Dadural JS, Collins EN, Guevara MV, Vogt K.

Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L131-L143. doi: 10.1152/ajplung.00417.2018. Epub 2018 Nov 8.

PMID:
30407862
38.

Positivity rates of drugs in patients treated for opioid dependence with buprenorphine: A comparison of oral fluid and urine using paired collections and LC-MS/MS.

West R, Mikel C, Hofilena D, Guevara M.

Drug Alcohol Depend. 2018 Dec 1;193:183-191. doi: 10.1016/j.drugalcdep.2018.07.023. Epub 2018 Sep 1.

PMID:
30391868
39.

Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination.

Hanquet G, Krizova P, Valentiner-Branth P, Ladhani SN, Nuorti JP, Lepoutre A, Mereckiene J, Knol M, Winje BA, Ciruela P, Ordobas M, Guevara M, McDonald E, Morfeldt E, Kozakova J, Slotved HC, Fry NK, Rinta-Kokko H, Varon E, Corcoran M, van der Ende A, Vestrheim DF, Munoz-Almagro C, Latasa P, Castilla J, Smith A, Henriques-Normark B, Whittaker R, Pastore Celentano L, Savulescu C; SpIDnet/I-MOVE+ Pneumo Group.

Thorax. 2019 May;74(5):473-482. doi: 10.1136/thoraxjnl-2018-211767. Epub 2018 Oct 24.

40.

Simulated climate change affects how biocrusts modulate water gains and desiccation dynamics after rainfall events.

Lafuente A, Berdugo M, de Guevara ML, Gozalo B, Maestre FT.

Ecohydrology. 2018 Sep;11(6). pii: e1935. doi: 10.1002/eco.1935. Epub 2017 Dec 22.

41.

Graphics and Media Technologies for Operators in Industry 4.0.

Posada J, Zorrilla M, Dominguez A, Simoes B, Eisert P, Stricker D, Rambach J, Dollner J, Guevara M.

IEEE Comput Graph Appl. 2018 Sep/Oct;38(5):119-132. doi: 10.1109/MCG.2018.053491736.

PMID:
30273132
42.

Complement your knowledge with a rare cause of pauci-immune glomerulonephritis.

Lomzenski H, Thibodaux R, Guevara M.

Clin Rheumatol. 2018 Nov;37(11):3151-3155. doi: 10.1007/s10067-018-4275-z. Epub 2018 Sep 10.

PMID:
30203317
43.

Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial.

Solà E, Solé C, Simón-Talero M, Martín-Llahí M, Castellote J, Garcia-Martínez R, Moreira R, Torrens M, Márquez F, Fabrellas N, de Prada G, Huelin P, Lopez Benaiges E, Ventura M, Manríquez M, Nazar A, Ariza X, Suñé P, Graupera I, Pose E, Colmenero J, Pavesi M, Guevara M, Navasa M, Xiol X, Córdoba J, Vargas V, Ginès P.

J Hepatol. 2018 Dec;69(6):1250-1259. doi: 10.1016/j.jhep.2018.08.006. Epub 2018 Aug 21.

PMID:
30138685
44.

Alpha electroencephalographic activity during rapid eye movement sleep in the spider monkey (Ateles geoffroyi): An index of arousal during sleep?

Cruz-Aguilar MA, Hernández-González M, Guevara MA, Hernández-Arteaga E, Hidalgo Aguirre RM, Amezcua Gutiérrez CDC, Ramírez-Salado I.

J Exp Zool A Ecol Integr Physiol. 2018 Dec;329(10):557-569. doi: 10.1002/jez.2220. Epub 2018 Aug 21.

PMID:
30129115
45.

Is the cancer survival improvement in European and American adolescent and young adults still lagging behind that in children?

Trama A, Bernasconi A, McCabe MG, Guevara M, Gatta G, Botta L; RARECAREnet Working Group, Ries L, Bleyer A.

Pediatr Blood Cancer. 2019 Jan;66(1):e27407. doi: 10.1002/pbc.27407. Epub 2018 Aug 19. Review.

PMID:
30124231
46.

Xylariales: First results of mycological exploration in the Sangay and Llanganates National Parks, Ecuador.

Guevara MF, Mátyás B, Ordoñez ME.

Version 2. F1000Res. 2018 Feb 23 [revised 2018 Jan 1];7:222. doi: 10.12688/f1000research.13623.2. eCollection 2018.

47.

Night-shift work and breast and prostate cancer risk: updating the evidence from epidemiological studies.

Salamanca-Fernández E, Rodríguez-Barranco M, Guevara M, Ardanaz E, Olry de Labry Lima A, Sánchez MJ.

An Sist Sanit Navar. 2018 Aug 29;41(2):211-226. doi: 10.23938/ASSN.0307.

48.

Compositional analysis of dietary patterns.

Solans M, Coenders G, Marcos-Gragera R, Castelló A, Gràcia-Lavedan E, Benavente Y, Moreno V, Pérez-Gómez B, Amiano P, Fernández-Villa T, Guevara M, Gómez-Acebo I, Fernández-Tardón G, Vanaclocha-Espi M, Chirlaque MD, Capelo R, Barrios R, Aragonés N, Molinuevo A, Vitelli-Storelli F, Castilla J, Dierssen-Sotos T, Castaño-Vinyals G, Kogevinas M, Pollán M, Saez M.

Stat Methods Med Res. 2019 Sep;28(9):2834-2847. doi: 10.1177/0962280218790110. Epub 2018 Jul 26.

PMID:
30045678
49.

Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study).

Kogevinas M, Espinosa A, Castelló A, Gómez-Acebo I, Guevara M, Martin V, Amiano P, Alguacil J, Peiro R, Moreno V, Costas L, Fernández-Tardón G, Jimenez JJ, Marcos-Gragera R, Perez-Gomez B, Llorca J, Moreno-Iribas C, Fernández-Villa T, Oribe M, Aragones N, Papantoniou K, Pollán M, Castano-Vinyals G, Romaguera D.

Int J Cancer. 2018 Nov 15;143(10):2380-2389. doi: 10.1002/ijc.31649. Epub 2018 Jul 17.

50.

Association study of dietary non-enzymatic antioxidant capacity (NEAC) and colorectal cancer risk in the Spanish Multicase-Control Cancer (MCC-Spain) study.

Amiano P, Molina-Montes E, Molinuevo A, Huerta JM, Romaguera D, Gracia E, Martín V, Castaño-Vinyals G, Pérez-Gómez B, Moreno V, Castilla J, Gómez-Acebo I, Jiménez-Moleón JJ, Fernández-Tardón G, Chirlaque MD, Capelo R, Salas L, Azpiri M, Fernández-Villa T, Bessa X, Aragonés N, Obón-Santacana M, Guevara M, Dierssen-Sotos T, Barrios-Rodríguez R, de la Torre AJM, Vega AB, Pollán M, Kogevinas M, Sánchez MJ.

Eur J Nutr. 2019 Sep;58(6):2229-2242. doi: 10.1007/s00394-018-1773-3. Epub 2018 Jul 11.

PMID:
29995245

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