Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 21

1.

Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jiménez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M.

Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013.

2.

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids.

Gonzalez-Exposito R, Semiannikova M, Griffiths B, Khan K, Barber LJ, Woolston A, Spain G, von Loga K, Challoner B, Patel R, Ranes M, Swain A, Thomas J, Bryant A, Saffery C, Fotiadis N, Guettler S, Mansfield D, Melcher A, Powles T, Rao S, Watkins D, Chau I, Matthews N, Wallberg F, Starling N, Cunningham D, Gerlinger M.

J Immunother Cancer. 2019 Apr 15;7(1):101. doi: 10.1186/s40425-019-0575-3.

3.

Solution NMR assignment of the ARC4 domain of human tankyrase 2.

Zaleska M, Pollock K, Collins I, Guettler S, Pfuhl M.

Biomol NMR Assign. 2019 Apr;13(1):255-260. doi: 10.1007/s12104-019-09887-w. Epub 2019 Mar 7.

4.

Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.

Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F.

Structure. 2018 Aug 7;26(8):1101-1115.e6. doi: 10.1016/j.str.2018.05.014. Epub 2018 Jul 5.

5.

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ.

Nat Commun. 2018 May 10;9(1):1849. doi: 10.1038/s41467-018-03917-2.

6.

Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.

Mariotti L, Pollock K, Guettler S.

Br J Pharmacol. 2017 Dec;174(24):4611-4636. doi: 10.1111/bph.14038. Epub 2017 Nov 5. Review.

7.

Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.

Pollock K, Ranes M, Collins I, Guettler S.

Methods Mol Biol. 2017;1608:445-473. doi: 10.1007/978-1-4939-6993-7_28.

8.

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.

Couzens AL, Xiong S, Knight JDR, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC.

Mol Cell Proteomics. 2017 Jun;16(6):1098-1110. doi: 10.1074/mcp.M116.065490. Epub 2017 Apr 3.

9.

Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation.

Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F.

Mol Cell Proteomics. 2017 Jun;16(6):1111-1125. doi: 10.1074/mcp.M117.068130. Epub 2017 Apr 3.

10.

AXIN Shapes Tankyrase ARChitecture.

Guettler S.

Structure. 2016 Oct 4;24(10):1625-1627. doi: 10.1016/j.str.2016.09.003.

11.

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.

Mariotti L, Templeton CM, Ranes M, Paracuellos P, Cronin N, Beuron F, Morris E, Guettler S.

Mol Cell. 2016 Aug 4;63(3):498-513. doi: 10.1016/j.molcel.2016.06.019.

12.

The genomic landscape of oesophagogastric junctional adenocarcinoma.

Chong IY, Cunningham D, Barber LJ, Campbell J, Chen L, Kozarewa I, Fenwick K, Assiotis I, Guettler S, Garcia-Murillas I, Awan S, Lambros M, Starling N, Wotherspoon A, Stamp G, Gonzalez-de-Castro D, Benson M, Chau I, Hulkki S, Nohadani M, Eltahir Z, Lemnrau A, Orr N, Rao S, Lord CJ, Ashworth A.

J Pathol. 2013 Nov;231(3):301-10.

PMID:
24308032
13.

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.

Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F.

Cell. 2011 Dec 9;147(6):1340-54. doi: 10.1016/j.cell.2011.10.046. Erratum in: Cell. 2012 Jan 20;148(1-2):376.

14.

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.

Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D.

EMBO J. 2011 Jul 15;30(16):3259-73. doi: 10.1038/emboj.2011.234.

15.

Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.

Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R.

Sci Signal. 2011 Jun 14;4(177):ra40. doi: 10.1126/scisignal.2001750.

16.

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

Mouilleron S, Guettler S, Langer CA, Treisman R, McDonald NQ.

EMBO J. 2008 Dec 3;27(23):3198-208. doi: 10.1038/emboj.2008.235. Epub 2008 Nov 13.

17.

RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.

Guettler S, Vartiainen MK, Miralles F, Larijani B, Treisman R.

Mol Cell Biol. 2008 Jan;28(2):732-42. Epub 2007 Nov 19.

18.

Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

Vartiainen MK, Guettler S, Larijani B, Treisman R.

Science. 2007 Jun 22;316(5832):1749-52.

19.

Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL.

Posern G, Miralles F, Guettler S, Treisman R.

EMBO J. 2004 Oct 13;23(20):3973-83. Epub 2004 Sep 23.

20.

ESTs from the basidiomycete Schizophyllum commune grown on nitrogen-replete and nitrogen-limited media.

Guettler S, Jackson EN, Lucchese SA, Honaas L, Green A, Hittinger CT, Tian Y, Lilly WW, Gathman AC.

Fungal Genet Biol. 2003 Jul;39(2):191-8.

PMID:
12781677
21.

A myristoyl/phosphotyrosine switch regulates c-Abl.

Hantschel O, Nagar B, Guettler S, Kretzschmar J, Dorey K, Kuriyan J, Superti-Furga G.

Cell. 2003 Mar 21;112(6):845-57.

Supplemental Content

Loading ...
Support Center