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Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.

de Groot NG, Otting N, Maccari G, Robinson J, Hammond JA, Blancher A, Lafont BAP, Guethlein LA, Wroblewski EE, Marsh SGE, Shiina T, Walter L, Vigilant L, Parham P, O'Connor DH, Bontrop RE.

Immunogenetics. 2019 Oct 17. doi: 10.1007/s00251-019-01132-x. [Epub ahead of print] Review.


Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans.

Nemat-Gorgani N, Guethlein LA, Henn BM, Norberg SJ, Chiaroni J, Sikora M, Quintana-Murci L, Mountain JL, Norman PJ, Parham P.

J Immunol. 2019 May 1;202(9):2636-2647. doi: 10.4049/jimmunol.1801586. Epub 2019 Mar 27.


Two to Tango: Co-evolution of Hominid Natural Killer Cell Receptors and MHC.

Wroblewski EE, Parham P, Guethlein LA.

Front Immunol. 2019 Feb 19;10:177. doi: 10.3389/fimmu.2019.00177. eCollection 2019. Review.


Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.

Leaton LA, Shortt J, Kichula KM, Tao S, Nemat-Gorgani N, Mentzer AJ, Oppenheimer SJ, Deng Z, Hollenbach JA, Gignoux CR, Guethlein LA, Parham P, Carrington M, Norman PJ.

Front Immunol. 2019 Jan 28;10:24. doi: 10.3389/fimmu.2019.00024. eCollection 2019.


Donor Killer Cell Immunoglobulin-Like Receptor Genotype Does Not Improve Graft-versus-Leukemia Responses in Chronic Lymphocytic Leukemia after Unrelated Donor Transplant: A Center for International Blood and Marrow Transplant Research Analysis.

Bachanova V, Weisdorf DJ, Wang T, Marsh SGE, Cereb N, Haagenson MD, Spellman SR, Lee SJ, Guethlein LA, Parham P, Miller JS, Cooley SA.

Biol Blood Marrow Transplant. 2019 May;25(5):949-954. doi: 10.1016/j.bbmt.2018.12.763. Epub 2018 Dec 27.


KIR Donor Selection: Feasibility in Identifying better Donors.

Weisdorf D, Cooley S, Wang T, Trachtenberg E, Haagenson MD, Vierra-Green C, Spellman S, Spahn A, Vogel J, Kobusingye H, Fehninger T, Woolfrey A, Devine S, Ross M, Waller EK, Sobecks R, Parham P, Guethlein LA, Marsh SGE, Miller J; participating center writing committee.

Biol Blood Marrow Transplant. 2019 Jan;25(1):e28-e32. doi: 10.1016/j.bbmt.2018.08.022. Epub 2018 Aug 24.


Nomenclature for the KIR of non-human species.

Robinson J, Guethlein LA, Maccari G, Blokhuis J, Bimber BN, de Groot NG, Sanderson ND, Abi-Rached L, Walter L, Bontrop RE, Hammond JA, Marsh SGE, Parham P.

Immunogenetics. 2018 Sep;70(9):571-583. doi: 10.1007/s00251-018-1064-4. Epub 2018 Jun 4.


Genetics of Natural Killer Cells in Human Health, Disease, and Survival.

Parham P, Guethlein LA.

Annu Rev Immunol. 2018 Apr 26;36:519-548. doi: 10.1146/annurev-immunol-042617-053149. Epub 2018 Feb 2. Review.


Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage.

Pugh JL, Nemat-Gorgani N, Norman PJ, Guethlein LA, Parham P.

J Immunol. 2018 Feb 1;200(3):1146-1158. doi: 10.4049/jimmunol.1700542. Epub 2017 Dec 20.


Transient receptor potential TRPM3 channels: Pharmacology, signaling, and biological functions.

Thiel G, Rubil S, Lesch A, Guethlein LA, Rössler OG.

Pharmacol Res. 2017 Oct;124:92-99. doi: 10.1016/j.phrs.2017.07.014. Epub 2017 Jul 16. Review.


KIR2DS5 allotypes that recognize the C2 epitope of HLA-C are common among Africans and absent from Europeans.

Blokhuis JH, Hilton HG, Guethlein LA, Norman PJ, Nemat-Gorgani N, Nakimuli A, Chazara O, Moffett A, Parham P.

Immun Inflamm Dis. 2017 Dec;5(4):461-468. doi: 10.1002/iid3.178. Epub 2017 Jul 6.


Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

Robinson J, Guethlein LA, Cereb N, Yang SY, Norman PJ, Marsh SGE, Parham P.

PLoS Genet. 2017 Jun 26;13(6):e1006862. doi: 10.1371/journal.pgen.1006862. eCollection 2017 Jun.


The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.

Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P.

Cell Rep. 2017 May 16;19(7):1394-1405. doi: 10.1016/j.celrep.2017.04.059.


Two alternate strategies for innate immunity to Epstein-Barr virus: One using NK cells and the other NK cells and γδ T cells.

Djaoud Z, Guethlein LA, Horowitz A, Azzi T, Nemat-Gorgani N, Olive D, Nadal D, Norman PJ, Münz C, Parham P.

J Exp Med. 2017 Jun 5;214(6):1827-1841. doi: 10.1084/jem.20161017. Epub 2017 May 3.


Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.

Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, Hollenbach JA, Chang W, Shults Won M, Gunderson KL, Abi-Rached L, Ronaghi M, Parham P.

Genome Res. 2017 May;27(5):813-823. doi: 10.1101/gr.213538.116. Epub 2017 Mar 30.


Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B.

Wroblewski EE, Guethlein LA, Norman PJ, Li Y, Shaw CM, Han AS, Ndjango JN, Ahuka-Mundeke S, Georgiev AV, Peeters M, Hahn BH, Parham P.

J Immunol. 2017 May 1;198(9):3480-3493. doi: 10.4049/jimmunol.1601955. Epub 2017 Mar 27.


Two Orangutan Species Have Evolved Different KIR Alleles and Haplotypes.

Guethlein LA, Norman PJ, Heijmans CM, de Groot NG, Hilton HG, Babrzadeh F, Abi-Rached L, Bontrop RE, Parham P.

J Immunol. 2017 Apr 15;198(8):3157-3169. doi: 10.4049/jimmunol.1602163. Epub 2017 Mar 6.


Resurrecting KIR2DP1: A Key Intermediate in the Evolution of Human Inhibitory NK Cell Receptors That Recognize HLA-C.

Hilton HG, Blokhuis JH, Guethlein LA, Norman PJ, Parham P.

J Immunol. 2017 Mar 1;198(5):1961-1973. doi: 10.4049/jimmunol.1601835. Epub 2017 Jan 25.


IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex.

Maccari G, Robinson J, Ballingall K, Guethlein LA, Grimholt U, Kaufman J, Ho CS, de Groot NG, Flicek P, Bontrop RE, Hammond JA, Marsh SG.

Nucleic Acids Res. 2017 Jan 4;45(D1):D860-D864. doi: 10.1093/nar/gkw1050. Epub 2016 Nov 28.


Class I HLA haplotypes form two schools that educate NK cells in different ways.

Horowitz A, Djaoud Z, Nemat-Gorgani N, Blokhuis J, Hilton HG, Béziat V, Malmberg KJ, Norman PJ, Guethlein LA, Parham P.

Sci Immunol. 2016 Sep;1(3). pii: eaag1672. doi: 10.1126/sciimmunol.aag1672. Epub 2016 Sep 9.


HLA class I variation in Iranian Lur and Kurd populations: high haplotype and allotype diversity with an abundance of KIR ligands.

Ashouri E, Norman PJ, Guethlein LA, Han AS, Nemat-Gorgani N, Norberg SJ, Ghaderi A, Parham P.

HLA. 2016 Sep;88(3):87-99. doi: 10.1111/tan.12852. Epub 2016 Aug 24.


Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P.

Am J Hum Genet. 2016 Aug 4;99(2):375-91. doi: 10.1016/j.ajhg.2016.06.023.


Donor KIR B Genotype Improves Progression-Free Survival of Non-Hodgkin Lymphoma Patients Receiving Unrelated Donor Transplantation.

Bachanova V, Weisdorf DJ, Wang T, Marsh SGE, Trachtenberg E, Haagenson MD, Spellman SR, Ladner M, Guethlein LA, Parham P, Miller JS, Cooley SA.

Biol Blood Marrow Transplant. 2016 Sep;22(9):1602-1607. doi: 10.1016/j.bbmt.2016.05.016. Epub 2016 May 21.


Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1.

Alicata C, Pende D, Meazza R, Canevali P, Loiacono F, Bertaina A, Locatelli F, Nemat-Gorgani N, Guethlein LA, Parham P, Moretta L, Moretta A, Bottino C, Norman PJ, Falco M.

Eur J Immunol. 2016 Jun;46(6):1511-7. doi: 10.1002/eji.201546236.


Description of the novel KIR2DL4*035 allele identified using high-throughput sequencing.

Alicata C, Bottino C, Guethlein LA, Parham P, Norman PJ.

HLA. 2016 Mar;87(3):191-3. doi: 10.1111/tan.12761. Epub 2016 Feb 24.


Complex MHC Class I Gene Transcription Profiles and Their Functional Impact in Orangutans.

de Groot NG, Heijmans CM, van der Wiel MK, Blokhuis JH, Mulder A, Guethlein LA, Doxiadis GG, Claas FH, Parham P, Bontrop RE.

J Immunol. 2016 Jan 15;196(2):750-8. doi: 10.4049/jimmunol.1500820. Epub 2015 Dec 18.


Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation.

Horowitz A, Guethlein LA, Nemat-Gorgani N, Norman PJ, Cooley S, Miller JS, Parham P.

J Immunol. 2015 Nov 1;195(9):4524-36. doi: 10.4049/jimmunol.1401990. Epub 2015 Sep 28.


A Distinctive Cytoplasmic Tail Contributes to Low Surface Expression and Intracellular Retention of the Patr-AL MHC Class I Molecule.

Goyos A, Guethlein LA, Horowitz A, Hilton HG, Gleimer M, Brodsky FM, Parham P.

J Immunol. 2015 Oct 15;195(8):3725-36. doi: 10.4049/jimmunol.1500397. Epub 2015 Sep 14.


Polymorphic HLA-C Receptors Balance the Functional Characteristics of KIR Haplotypes.

Hilton HG, Guethlein LA, Goyos A, Nemat-Gorgani N, Bushnell DA, Norman PJ, Parham P.

J Immunol. 2015 Oct 1;195(7):3160-70. doi: 10.4049/jimmunol.1501358. Epub 2015 Aug 26.


Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.

Hilton HG, Norman PJ, Nemat-Gorgani N, Goyos A, Hollenbach JA, Henn BM, Gignoux CR, Guethlein LA, Parham P.

PLoS Genet. 2015 Aug 20;11(8):e1005439. doi: 10.1371/journal.pgen.1005439. eCollection 2015 Aug.


Co-evolution of MHC class I and variable NK cell receptors in placental mammals.

Guethlein LA, Norman PJ, Hilton HG, Parham P.

Immunol Rev. 2015 Sep;267(1):259-82. doi: 10.1111/imr.12326. Review.


Chimpanzee susceptibility to hepatitis C virus infection correlates with presence of Pt-KIR3DS2 and Pt-KIR2DL9: paired activating and inhibitory natural killer cell receptors.

Abi-Rached L, Guethlein LA, Norman PJ, Parham P.

Immunogenetics. 2015 Oct;67(10):625-8. doi: 10.1007/s00251-015-0863-0. Epub 2015 Aug 12.


Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.

Norman PJ, Norberg SJ, Nemat-Gorgani N, Royce T, Hollenbach JA, Shults Won M, Guethlein LA, Gunderson KL, Ronaghi M, Parham P.

Immunogenetics. 2015 Sep;67(9):479-85. doi: 10.1007/s00251-015-0857-y. Epub 2015 Jul 22.


The production of KIR-Fc fusion proteins and their use in a multiplex HLA class I binding assay.

Hilton HG, Moesta AK, Guethlein LA, Blokhuis J, Parham P, Norman PJ.

J Immunol Methods. 2015 Oct;425:79-87. doi: 10.1016/j.jim.2015.06.012. Epub 2015 Jun 19.


Adaptive Natural Killer Cell and Killer Cell Immunoglobulin-Like Receptor-Expressing T Cell Responses are Induced by Cytomegalovirus and Are Associated with Protection against Cytomegalovirus Reactivation after Allogeneic Donor Hematopoietic Cell Transplantation.

Davis ZB, Cooley SA, Cichocki F, Felices M, Wangen R, Luo X, DeFor TE, Bryceson YT, Diamond DJ, Brunstein C, Blazar BR, Wagner JE, Weisdorf DJ, Horowitz A, Guethlein LA, Parham P, Verneris MR, Miller JS.

Biol Blood Marrow Transplant. 2015 Sep;21(9):1653-62. doi: 10.1016/j.bbmt.2015.05.025. Epub 2015 Jun 6.


Signature Patterns of MHC Diversity in Three Gombe Communities of Wild Chimpanzees Reflect Fitness in Reproduction and Immune Defense against SIVcpz.

Wroblewski EE, Norman PJ, Guethlein LA, Rudicell RS, Ramirez MA, Li Y, Hahn BH, Pusey AE, Parham P.

PLoS Biol. 2015 May 28;13(5):e1002144. doi: 10.1371/journal.pbio.1002144. eCollection 2015 May.


Definition of the cattle killer cell Ig-like receptor gene family: comparison with aurochs and human counterparts.

Sanderson ND, Norman PJ, Guethlein LA, Ellis SA, Williams C, Breen M, Park SD, Magee DA, Babrzadeh F, Warry A, Watson M, Bradley DG, MacHugh DE, Parham P, Hammond JA.

J Immunol. 2014 Dec 15;193(12):6016-30. doi: 10.4049/jimmunol.1401980. Epub 2014 Nov 14.


Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia.

Cooley S, Weisdorf DJ, Guethlein LA, Klein JP, Wang T, Marsh SG, Spellman S, Haagenson MD, Saeturn K, Ladner M, Trachtenberg E, Parham P, Miller JS.

J Immunol. 2014 May 15;192(10):4592-600. doi: 10.4049/jimmunol.1302517. Epub 2014 Apr 18.


Co-evolution of human leukocyte antigen (HLA) class I ligands with killer-cell immunoglobulin-like receptors (KIR) in a genetically diverse population of sub-Saharan Africans.

Norman PJ, Hollenbach JA, Nemat-Gorgani N, Guethlein LA, Hilton HG, Pando MJ, Koram KA, Riley EM, Abi-Rached L, Parham P.

PLoS Genet. 2013 Oct;9(10):e1003938. doi: 10.1371/journal.pgen.1003938. Epub 2013 Oct 31.


Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.

Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, Dekker CL, Mackey S, Maecker H, Swan GE, Davis MM, Norman PJ, Guethlein LA, Desai M, Parham P, Blish CA.

Sci Transl Med. 2013 Oct 23;5(208):208ra145. doi: 10.1126/scitranslmed.3006702.


Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string.

Milius RP, Mack SJ, Hollenbach JA, Pollack J, Heuer ML, Gragert L, Spellman S, Guethlein LA, Trachtenberg EA, Cooley S, Bochtler W, Mueller CR, Robinson J, Marsh SG, Maiers M.

Tissue Antigens. 2013 Aug;82(2):106-12. doi: 10.1111/tan.12150.


Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.

Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M.

PLoS One. 2012;7(11):e47491. doi: 10.1371/journal.pone.0047491. Epub 2012 Nov 5.


Natural selection on marine carnivores elaborated a diverse family of classical MHC class I genes exhibiting haplotypic gene content variation and allelic polymorphism.

Hammond JA, Guethlein LA, Norman PJ, Parham P.

Immunogenetics. 2012 Dec;64(12):915-33. doi: 10.1007/s00251-012-0651-z. Epub 2012 Sep 22.


Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.

Hilton HG, Vago L, Older Aguilar AM, Moesta AK, Graef T, Abi-Rached L, Norman PJ, Guethlein LA, Fleischhauer K, Parham P.

J Immunol. 2012 Aug 1;189(3):1418-30. doi: 10.4049/jimmunol.1100431. Epub 2012 Jul 6.


Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA.

Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):800-11. doi: 10.1098/rstb.2011.0266. Review.


Review: Immunogenetics of human placentation.

Parham P, Norman PJ, Abi-Rached L, Hilton HG, Guethlein LA.

Placenta. 2012 Feb;33 Suppl:S71-80. doi: 10.1016/j.placenta.2011.11.020. Epub 2011 Dec 15. Review.


The shaping of modern human immune systems by multiregional admixture with archaic humans.

Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P.

Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202. Epub 2011 Aug 25.


Variable NK cell receptors exemplified by human KIR3DL1/S1.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA.

J Immunol. 2011 Jul 1;187(1):11-9. doi: 10.4049/jimmunol.0902332. Review.


Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.

Moreland AJ, Guethlein LA, Reeves RK, Broman KW, Johnson RP, Parham P, O'Connor DH, Bimber BN.

BMC Genomics. 2011 Jun 7;12:295. doi: 10.1186/1471-2164-12-295.


Rhesus macaque KIR bind human MHC class I with broad specificity and recognize HLA-C more effectively than HLA-A and HLA-B.

Older Aguilar AM, Guethlein LA, Hermes M, Walter L, Parham P.

Immunogenetics. 2011 Sep;63(9):577-85. doi: 10.1007/s00251-011-0535-7. Epub 2011 May 26.

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