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Items: 1 to 50 of 51

1.

Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.

Jung SM, Hung CM, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA.

Mol Cell. 2019 Aug 22;75(4):807-822.e8. doi: 10.1016/j.molcel.2019.07.023.

PMID:
31442424
2.

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.

Martinez N, Cheng CY, Ketheesan N, Cullen A, Tang Y, Lum J, West K, Poidinger M, Guertin DA, Singhal A, Kornfeld H.

EBioMedicine. 2019 Jul;45:314-327. doi: 10.1016/j.ebiom.2019.06.052. Epub 2019 Jul 4.

3.

Spatiotemporal structure of cell fate decisions in murine neural crest.

Soldatov R, Kaucka M, Kastriti ME, Petersen J, Chontorotzea T, Englmaier L, Akkuratova N, Yang Y, Häring M, Dyachuk V, Bock C, Farlik M, Piacentino ML, Boismoreau F, Hilscher MM, Yokota C, Qian X, Nilsson M, Bronner ME, Croci L, Hsiao WY, Guertin DA, Brunet JF, Consalez GG, Ernfors P, Fried K, Kharchenko PV, Adameyko I.

Science. 2019 Jun 7;364(6444). pii: eaas9536. doi: 10.1126/science.aas9536.

PMID:
31171666
4.

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.

Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM, Wellen KE.

Cell Rep. 2019 May 28;27(9):2772-2784.e6. doi: 10.1016/j.celrep.2019.04.112.

5.

Brown fat organogenesis and maintenance requires AKT1 and AKT2.

Sanchez-Gurmaches J, Martinez Calejman C, Jung SM, Li H, Guertin DA.

Mol Metab. 2019 May;23:60-74. doi: 10.1016/j.molmet.2019.02.004. Epub 2019 Feb 20.

6.

Oncogenic AKTivation by methylation.

Luciano AK, Guertin DA.

Nat Cell Biol. 2019 Feb;21(2):114-115. doi: 10.1038/s41556-019-0275-8. No abstract available.

PMID:
30692624
7.

Insulin PACS a Punch in SIRT1 Activity.

Jung SM, Guertin DA.

Mol Cell. 2018 Dec 20;72(6):917-919. doi: 10.1016/j.molcel.2018.12.004.

PMID:
30576653
8.

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.

Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM.

Nat Chem Biol. 2018 Nov;14(11):1021-1031. doi: 10.1038/s41589-018-0132-2. Epub 2018 Oct 16.

9.

Brown Adipose Tissue Development and Metabolism.

Jung SM, Sanchez-Gurmaches J, Guertin DA.

Handb Exp Pharmacol. 2019;251:3-36. doi: 10.1007/164_2018_168. Review.

PMID:
30203328
10.

Unexpected cell population gives fat a brake.

Guertin DA.

Nature. 2018 Jul;559(7712):41-42. doi: 10.1038/d41586-018-05120-1. No abstract available.

PMID:
29959410
11.

River otters (Lontra canadensis) "trapped" in a coastal environment contaminated with persistent organic pollutants: Demographic and physiological consequences.

Huang AC, Nelson C, Elliott JE, Guertin DA, Ritland C, Drouillard K, Cheng KM, Schwantje HM.

Environ Pollut. 2018 Jul;238:306-316. doi: 10.1016/j.envpol.2018.03.035. Epub 2018 Mar 22.

12.

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis.

Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA.

Cell Metab. 2018 Jan 9;27(1):195-209.e6. doi: 10.1016/j.cmet.2017.10.008. Epub 2017 Nov 16.

13.

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.

Lee PL, Jung SM, Guertin DA.

Trends Endocrinol Metab. 2017 May;28(5):319-339. doi: 10.1016/j.tem.2017.01.004. Epub 2017 Feb 22. Review.

14.

Amplification of Adipogenic Commitment by VSTM2A.

Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, Marsolais D, Bossé Y, Birsoy K, Laplante M.

Cell Rep. 2017 Jan 3;18(1):93-106. doi: 10.1016/j.celrep.2016.12.015.

15.

Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease.

Lee PL, Tang Y, Li H, Guertin DA.

Mol Metab. 2016 Apr 11;5(6):422-432. doi: 10.1016/j.molmet.2016.04.001. eCollection 2016 Jun.

16.

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.

Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA.

Nat Commun. 2016 Apr 21;7:11365. doi: 10.1038/ncomms11365.

17.

Emerging Complexities in Adipocyte Origins and Identity.

Sanchez-Gurmaches J, Hung CM, Guertin DA.

Trends Cell Biol. 2016 May;26(5):313-326. doi: 10.1016/j.tcb.2016.01.004. Epub 2016 Feb 11. Review.

18.

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.

Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.

Nucleic Acids Res. 2015 Sep 18;43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27.

19.

Highly selective in vivo labeling of subcutaneous white adipocyte precursors with Prx1-Cre.

Sanchez-Gurmaches J, Hsiao WY, Guertin DA.

Stem Cell Reports. 2015 Apr 14;4(4):541-50. doi: 10.1016/j.stemcr.2015.02.008. Epub 2015 Mar 19.

20.

mTORC1 gRABs the Golgi.

Sanchez-Gurmaches J, Guertin DA.

Cancer Cell. 2014 Nov 10;26(5):601-3. doi: 10.1016/j.ccell.2014.10.011. Epub 2014 Nov 10.

21.

Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease.

Hung CM, Calejman CM, Sanchez-Gurmaches J, Li H, Clish CB, Hettmer S, Wagers AJ, Guertin DA.

Cell Rep. 2014 Jul 10;8(1):256-71. doi: 10.1016/j.celrep.2014.06.007. Epub 2014 Jul 4.

22.

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed.

Sanchez-Gurmaches J, Guertin DA.

Nat Commun. 2014 Jun 19;5:4099. doi: 10.1038/ncomms5099.

23.

T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.

Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H.

Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5.

24.

Adipocyte lineages: tracing back the origins of fat.

Sanchez-Gurmaches J, Guertin DA.

Biochim Biophys Acta. 2014 Mar;1842(3):340-51. doi: 10.1016/j.bbadis.2013.05.027. Epub 2013 Jun 4. Review.

25.

mTOR-dependent cell survival mechanisms.

Hung CM, Garcia-Haro L, Sparks CA, Guertin DA.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a008771. doi: 10.1101/cshperspect.a008771. Review.

26.

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA.

Cell Stem Cell. 2012 Sep 7;11(3):429-39. doi: 10.1016/j.stem.2012.06.009.

27.

PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.

Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA.

Cell Metab. 2012 Sep 5;16(3):348-62.

28.

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135.

29.

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.

Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20002-7. doi: 10.1073/pnas.1111733108. Epub 2011 Nov 30.

30.

Evaluating the therapeutic potential of mTOR inhibitors using mouse genetics.

Li H, Cotton JL, Guertin DA.

Methods Mol Biol. 2012;821:329-47. doi: 10.1007/978-1-61779-430-8_21.

PMID:
22125076
31.

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.

Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ.

Cell Metab. 2011 Oct 5;14(4):516-27. doi: 10.1016/j.cmet.2011.09.001.

32.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.

Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.

33.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE.

Genome Res. 2011 Mar;21(3):433-46. doi: 10.1101/gr.111492.110. Epub 2011 Jan 14.

34.

Fecal genotyping and contaminant analyses reveal variation in individual river otter exposure to localized persistent contaminants.

Guertin DA, Harestad AS, Ben-David M, Drouillard KG, Elliott JE.

Environ Toxicol Chem. 2010 Feb;29(2):275-84. doi: 10.1002/etc.53.

PMID:
20821445
35.

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.

Sparks CA, Guertin DA.

Oncogene. 2010 Jul 1;29(26):3733-44. doi: 10.1038/onc.2010.139. Epub 2010 Apr 26. Review.

36.

The pharmacology of mTOR inhibition.

Guertin DA, Sabatini DM.

Sci Signal. 2009 Apr 21;2(67):pe24. doi: 10.1126/scisignal.267pe24.

PMID:
19383975
37.

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM.

Cancer Cell. 2009 Feb 3;15(2):148-59. doi: 10.1016/j.ccr.2008.12.017.

38.

Chlorinated hydrocarbon contaminants in feces of river otters from the southern Pacific coast of Canada, 1998-2004.

Elliott JE, Guertin DA, Balke JM.

Sci Total Environ. 2008 Jul 1;397(1-3):58-71. doi: 10.1016/j.scitotenv.2008.01.063. Epub 2008 Apr 22.

PMID:
18433835
39.

Defining the role of mTOR in cancer.

Guertin DA, Sabatini DM.

Cancer Cell. 2007 Jul;12(1):9-22. Review.

40.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

41.

CellProfiler: image analysis software for identifying and quantifying cell phenotypes.

Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM.

Genome Biol. 2006;7(10):R100. Epub 2006 Oct 31.

42.

Functional genomics identifies TOR-regulated genes that control growth and division.

Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM.

Curr Biol. 2006 May 23;16(10):958-70.

43.

An expanding role for mTOR in cancer.

Guertin DA, Sabatini DM.

Trends Mol Med. 2005 Aug;11(8):353-61. Review.

PMID:
16002336
44.

RNAi living-cell microarrays for loss-of-function screens in Drosophila melanogaster cells.

Wheeler DB, Bailey SN, Guertin DA, Carpenter AE, Higgins CO, Sabatini DM.

Nat Methods. 2004 Nov;1(2):127-32. Epub 2004 Oct 21.

PMID:
15782175
45.

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.

46.

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Curr Biol. 2004 Jul 27;14(14):1296-302.

47.
48.

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).

Guertin DA, Venkatram S, Gould KL, McCollum D.

Dev Cell. 2002 Dec;3(6):779-90.

49.

Cytokinesis in eukaryotes.

Guertin DA, Trautmann S, McCollum D.

Microbiol Mol Biol Rev. 2002 Jun;66(2):155-78. Review.

50.

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