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Items: 38

1.

3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis.

Paczia N, Becker-Kettern J, Conrotte JF, Cifuente JO, Guerin ME, Linster CL.

Biochemistry. 2019 Jan 29;58(4):259-275. doi: 10.1021/acs.biochem.8b00990. Epub 2019 Jan 22.

PMID:
30668112
2.

Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain.

Cabrera Y, Dublang L, Fernández-Higuero JA, Albesa-Jové D, Lucas M, Viguera AR, Guerin ME, Vilar JMG, Muga A, Moro F.

J Mol Biol. 2019 Jan 18;431(2):444-461. doi: 10.1016/j.jmb.2018.11.026. Epub 2018 Dec 4.

PMID:
30521813
3.

Conformational entropy of a single peptide controlled under force governs protease recognition and catalysis.

Guerin ME, Stirnemann G, Giganti D.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11525-11530. doi: 10.1073/pnas.1803872115. Epub 2018 Oct 19.

PMID:
30341218
4.

Structural basis for the recognition of complex-type N-glycans by Endoglycosidase S.

Trastoy B, Klontz E, Orwenyo J, Marina A, Wang LX, Sundberg EJ, Guerin ME.

Nat Commun. 2018 May 14;9(1):1874. doi: 10.1038/s41467-018-04300-x.

5.

The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria.

Tersa M, Raich L, Albesa-Jové D, Trastoy B, Prandi J, Gilleron M, Rovira C, Guerin ME.

ACS Chem Biol. 2018 Jan 19;13(1):131-140. doi: 10.1021/acschembio.7b00578. Epub 2017 Dec 11.

PMID:
29185694
6.

Structural Snapshots of α-1,3-Galactosyltransferase with Native Substrates: Insight into the Catalytic Mechanism of Retaining Glycosyltransferases.

Albesa-Jové D, Sainz-Polo MÁ, Marina A, Guerin ME.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14853-14857. doi: 10.1002/anie.201707922. Epub 2017 Oct 20.

PMID:
28960760
7.

Structural Snapshots and Loop Dynamics along the Catalytic Cycle of Glycosyltransferase GpgS.

Albesa-Jové D, Romero-García J, Sancho-Vaello E, Contreras FX, Rodrigo-Unzueta A, Comino N, Carreras-González A, Arrasate P, Urresti S, Biarnés X, Planas A, Guerin ME.

Structure. 2017 Jul 5;25(7):1034-1044.e3. doi: 10.1016/j.str.2017.05.009. Epub 2017 Jun 15.

8.

The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis.

Rosado LA, Wahni K, Degiacomi G, Pedre B, Young D, de la Rubia AG, Boldrin F, Martens E, Marcos-Pascual L, Sancho-Vaello E, Albesa-Jové D, Provvedi R, Martin C, Makarov V, Versées W, Verniest G, Guerin ME, Mateos LM, Manganelli R, Messens J.

J Biol Chem. 2017 Aug 11;292(32):13097-13110. doi: 10.1074/jbc.M117.797837. Epub 2017 Jun 15.

9.

Mechanistic insights into the allosteric regulation of bacterial ADP-glucose pyrophosphorylases.

Comino N, Cifuente JO, Marina A, Orrantia A, Eguskiza A, Guerin ME.

J Biol Chem. 2017 Apr 14;292(15):6255-6268. doi: 10.1074/jbc.M116.773408. Epub 2017 Feb 21.

10.

Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria.

Sancho-Vaello E, Albesa-Jové D, Rodrigo-Unzueta A, Guerin ME.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1355-1367. doi: 10.1016/j.bbalip.2016.11.002. Epub 2016 Nov 5. Review.

PMID:
27826050
11.

Structural Basis of Glycogen Biosynthesis Regulation in Bacteria.

Cifuente JO, Comino N, Madariaga-Marcos J, López-Fernández S, García-Alija M, Agirre J, Albesa-Jové D, Guerin ME.

Structure. 2016 Sep 6;24(9):1613-22. doi: 10.1016/j.str.2016.06.023. Epub 2016 Aug 18.

12.

The conformational plasticity of glycosyltransferases.

Albesa-Jové D, Guerin ME.

Curr Opin Struct Biol. 2016 Oct;40:23-32. doi: 10.1016/j.sbi.2016.07.007. Epub 2016 Jul 21. Review.

PMID:
27450114
13.

Molecular Basis of Membrane Association by the Phosphatidylinositol Mannosyltransferase PimA Enzyme from Mycobacteria.

Rodrigo-Unzueta A, Martínez MA, Comino N, Alzari PM, Chenal A, Guerin ME.

J Biol Chem. 2016 Jul 1;291(27):13955-63. doi: 10.1074/jbc.M116.723676. Epub 2016 May 9.

14.

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.

Albesa-Jové D, Svetlíková Z, Tersa M, Sancho-Vaello E, Carreras-González A, Bonnet P, Arrasate P, Eguskiza A, Angala SK, Cifuente JO, Korduláková J, Jackson M, Mikušová K, Guerin ME.

Nat Commun. 2016 Mar 11;7:10906. doi: 10.1038/ncomms10906.

15.

The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.

Albesa-Jové D, Comino N, Tersa M, Mohorko E, Urresti S, Dainese E, Chiarelli LR, Pasca MR, Manganelli R, Makarov V, Riccardi G, Svergun DI, Glockshuber R, Guerin ME.

J Biol Chem. 2015 Dec 25;290(52):31077-89. doi: 10.1074/jbc.M115.677039. Epub 2015 Nov 6.

16.

A Native Ternary Complex Trapped in a Crystal Reveals the Catalytic Mechanism of a Retaining Glycosyltransferase.

Albesa-Jové D, Mendoza F, Rodrigo-Unzueta A, Gomollón-Bel F, Cifuente JO, Urresti S, Comino N, Gómez H, Romero-García J, Lluch JM, Sancho-Vaello E, Biarnés X, Planas A, Merino P, Masgrau L, Guerin ME.

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9898-902. doi: 10.1002/anie.201504617. Epub 2015 Jul 1.

PMID:
26136334
17.

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

Giganti D, Albesa-Jové D, Urresti S, Rodrigo-Unzueta A, Martínez MA, Comino N, Barilone N, Bellinzoni M, Chenal A, Guerin ME, Alzari PM.

Nat Chem Biol. 2015 Jan;11(1):16-8. doi: 10.1038/nchembio.1694. Epub 2014 Nov 17.

PMID:
25402770
18.

The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.

Boldrin F, Ventura M, Degiacomi G, Ravishankar S, Sala C, Svetlikova Z, Ambady A, Dhar N, Kordulakova J, Zhang M, Serafini A, Vishwas KG, Kolly GS, Kumar N, Palù G, Guerin ME, Mikusova K, Cole ST, Manganelli R.

J Bacteriol. 2014 Oct;196(19):3441-51. doi: 10.1128/JB.01346-13. Epub 2014 Jul 21. Erratum in: J Bacteriol. 2014 Dec;196(23):4197. Vishwas, V G [Corrected to Vishwas, K G].

19.

Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.

Albesa-Jové D, Chiarelli LR, Makarov V, Pasca MR, Urresti S, Mori G, Salina E, Vocat A, Comino N, Mohorko E, Ryabova S, Pfieiffer B, Lopes Ribeiro AL, Rodrigo-Unzueta A, Tersa M, Zanoni G, Buroni S, Altmann KH, Hartkoorn RC, Glockshuber R, Cole ST, Riccardi G, Guerin ME.

ACS Chem Biol. 2014 Jul 18;9(7):1567-75. doi: 10.1021/cb500149m. Epub 2014 Jun 13.

20.

Structural basis of chitin oligosaccharide deacetylation.

Andrés E, Albesa-Jové D, Biarnés X, Moerschbacher BM, Guerin ME, Planas A.

Angew Chem Int Ed Engl. 2014 Jul 1;53(27):6882-7. doi: 10.1002/anie.201400220. Epub 2014 May 8.

PMID:
24810719
21.

Structure-function relationships of membrane-associated GT-B glycosyltransferases.

Albesa-Jové D, Giganti D, Jackson M, Alzari PM, Guerin ME.

Glycobiology. 2014 Feb;24(2):108-24. doi: 10.1093/glycob/cwt101. Epub 2013 Nov 18. Review.

22.

Conformational plasticity of the essential membrane-associated mannosyltransferase PimA from mycobacteria.

Giganti D, Alegre-Cebollada J, Urresti S, Albesa-Jové D, Rodrigo-Unzueta A, Comino N, Kachala M, López-Fernández S, Svergun DI, Fernández JM, Guerin ME.

J Biol Chem. 2013 Oct 11;288(41):29797-808. doi: 10.1074/jbc.M113.462705. Epub 2013 Aug 20.

23.

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.

Albanesi D, Reh G, Guerin ME, Schaeffer F, Debarbouille M, Buschiazzo A, Schujman GE, de Mendoza D, Alzari PM.

PLoS Pathog. 2013 Jan;9(1):e1003108. doi: 10.1371/journal.ppat.1003108. Epub 2013 Jan 3.

24.

Mechanistic insights into the retaining glucosyl-3-phosphoglycerate synthase from mycobacteria.

Urresti S, Albesa-Jové D, Schaeffer F, Pham HT, Kaur D, Gest P, van der Woerd MJ, Carreras-González A, López-Fernández S, Alzari PM, Brennan PJ, Jackson M, Guerin ME.

J Biol Chem. 2012 Jul 13;287(29):24649-61. doi: 10.1074/jbc.M112.368191. Epub 2012 May 25.

25.

Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.

de la Paz Santangelo M, Gest PM, Guerin ME, Coinçon M, Pham H, Ryan G, Puckett SE, Spencer JS, Gonzalez-Juarrero M, Daher R, Lenaerts AJ, Schnappinger D, Therisod M, Ehrt S, Sygusch J, Jackson M.

J Biol Chem. 2011 Nov 18;286(46):40219-31. doi: 10.1074/jbc.M111.259440. Epub 2011 Sep 23.

26.

Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.

Daher R, Coinçon M, Fonvielle M, Gest PM, Guerin ME, Jackson M, Sygusch J, Therisod M.

J Med Chem. 2010 Nov 11;53(21):7836-42. doi: 10.1021/jm1009814.

27.

Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria.

Guerin ME, Korduláková J, Alzari PM, Brennan PJ, Jackson M.

J Biol Chem. 2010 Oct 29;285(44):33577-83. doi: 10.1074/jbc.R110.168328. Epub 2010 Aug 27. Review.

28.

Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

Kaur D, Guerin ME, Skovierová H, Brennan PJ, Jackson M.

Adv Appl Microbiol. 2009;69:23-78. doi: 10.1016/S0065-2164(09)69002-X. Review.

29.

New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB' is an essential enzyme of Mycobacterium smegmatis.

Guerin ME, Kaur D, Somashekar BS, Gibbs S, Gest P, Chatterjee D, Brennan PJ, Jackson M.

J Biol Chem. 2009 Sep 18;284(38):25687-96. doi: 10.1074/jbc.M109.030593. Epub 2009 Jul 28.

30.

Substrate-induced conformational changes in the essential peripheral membrane-associated mannosyltransferase PimA from mycobacteria: implications for catalysis.

Guerin ME, Schaeffer F, Chaffotte A, Gest P, Giganti D, Korduláková J, van der Woerd M, Jackson M, Alzari PM.

J Biol Chem. 2009 Aug 7;284(32):21613-25. doi: 10.1074/jbc.M109.003947. Epub 2009 Jun 11.

31.

Initiation of methylglucose lipopolysaccharide biosynthesis in mycobacteria.

Kaur D, Pham H, Larrouy-Maumus G, Rivière M, Vissa V, Guerin ME, Puzo G, Brennan PJ, Jackson M.

PLoS One. 2009;4(5):e5447. doi: 10.1371/journal.pone.0005447. Epub 2009 May 7.

32.

Preliminary crystallographic analysis of GpgS, a key glucosyltransferase involved in methylglucose lipopolysaccharide biosynthesis in Mycobacterium tuberculosis.

Gest P, Kaur D, Pham HT, van der Woerd M, Hansen E, Brennan PJ, Jackson M, Guerin ME.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Dec 1;64(Pt 12):1121-4. doi: 10.1107/S1744309108032892. Epub 2008 Nov 28.

33.

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.

Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM.

J Biol Chem. 2007 Jul 13;282(28):20705-14. Epub 2007 May 16.

34.

Crystallization and preliminary crystallographic analysis of PimA, an essential mannosyltransferase from Mycobacterium smegmatis.

Guerin ME, Buschiazzo A, Korduláková J, Jackson M, Alzari PM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt 5):518-20. Epub 2005 Apr 22.

35.

Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation.

Buschiazzo A, Ugalde JE, Guerin ME, Shepard W, Ugalde RA, Alzari PM.

EMBO J. 2004 Aug 18;23(16):3196-205. Epub 2004 Jul 22.

36.

Preliminary crystallographic studies of glycogen synthase from Agrobacterium tumefaciens.

Guerin ME, Buschiazzo A, Ugalde JE, Ugalde RA, Alzari PM.

Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):526-8. Epub 2003 Feb 21.

PMID:
12595715
37.

Immunoassay with recombinant Trypanosoma cruzi antigens potentially useful for screening donated blood and diagnosing Chagas disease.

Pastini AC, Iglesias SR, Carricarte VC, Guerin ME, Sánchez DO, Frasch AC.

Clin Chem. 1994 Oct;40(10):1893-7.

38.

Come sing along with me.

Guerin ME.

Geriatr Nurs. 1982 May-Jun;3(3):170-1. No abstract available.

PMID:
6917816

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