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Items: 27


Vaccine adjuvant activity of emulsified oils from species of the Pinaceae family.

Fox CB, Van Hoeven N, Granger B, Lin S, Guderian JA, Hartwig A, Marlenee N, Bowen RA, Soultanov V, Carter D.

Phytomedicine. 2019 Apr 12;64:152927. doi: 10.1016/j.phymed.2019.152927. [Epub ahead of print]


Adjuvant composition and delivery route shape immune response quality and protective efficacy of a recombinant vaccine for Entamoeba histolytica.

Abhyankar MM, Orr MT, Lin S, Suraju MO, Simpson A, Blust M, Pham T, Guderian JA, Tomai MA, Elvecrog J, Pedersen K, Petri WA Jr, Fox CB.

NPJ Vaccines. 2018 Jun 5;3:22. doi: 10.1038/s41541-018-0060-x. eCollection 2018.


Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection.

Baldwin SL, Hsu FC, Van Hoeven N, Gage E, Granger B, Guderian JA, Larsen SE, Lorenzo EC, Haynes L, Reed SG, Coler RN.

Front Immunol. 2018 Feb 19;9:295. doi: 10.3389/fimmu.2018.00295. eCollection 2018.


A structure-function approach to optimizing TLR4 ligands for human vaccines.

Carter D, Fox CB, Day TA, Guderian JA, Liang H, Rolf T, Vergara J, Sagawa ZK, Ireton G, Orr MT, Desbien A, Duthie MS, Coler RN, Reed SG.

Clin Transl Immunology. 2016 Nov 2;5(11):e108. eCollection 2016 Nov.


Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii.

El Bissati K, Chentoufi AA, Krishack PA, Zhou Y, Woods S, Dubey JP, Vang L, Lykins J, Broderick KE, Mui E, Suzuki Y, Sa Q, Bi S, Cardona N, Verma SK, Frazeck L, Reardon CA, Sidney J, Alexander J, Sette A, Vedvick T, Fox C, Guderian JA, Reed S, Roberts CW, McLeod R.

JCI Insight. 2016 Sep 22;1(15):e85955. doi: 10.1172/jci.insight.85955.


Multi-epitope proteins for improved serological detection of Trypanosoma cruzi infection and Chagas Disease.

Duthie MS, Guderian JA, Vallur AC, Misquith A, Liang H, Mohamath R, Luquetti AO, Carter D, Tavares SN, Reed SG.

Diagn Microbiol Infect Dis. 2016 Mar;84(3):191-6. doi: 10.1016/j.diagmicrobio.2015.11.006. Epub 2015 Nov 10.


Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications.

Adlington K, El Harfi J, Li J, Carmichael K, Guderian JA, Fox CB, Irvine DJ.

Biomacromolecules. 2016 Jan 11;17(1):165-72. doi: 10.1021/acs.biomac.5b01285. Epub 2015 Dec 29.


A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7.

Fox CB, Sivananthan SJ, Duthie MS, Vergara J, Guderian JA, Moon E, Coblentz D, Reed SG, Carter D.

J Nanobiotechnology. 2014 Apr 26;12:17. doi: 10.1186/1477-3155-12-17.


Modulating potency: Physicochemical characteristics are a determining factor of TLR4-agonist nanosuspension activity.

Dowling QM, Sivananthan SJ, Guderian JA, Moutaftsi M, Chesko JD, Fox CB, Vedvick TS, Kramer RM.

J Pharm Sci. 2014 Mar;103(3):879-89. doi: 10.1002/jps.23868. Epub 2014 Jan 24.


Optimizing manufacturing and composition of a TLR4 nanosuspension: physicochemical stability and vaccine adjuvant activity.

Fung HW, Mikasa TJ, Vergara J, Sivananthan SJ, Guderian JA, Duthie MS, Vedvick TS, Fox CB.

J Nanobiotechnology. 2013 Dec 21;11:43. doi: 10.1186/1477-3155-11-43.


Early experience with a brief, multimodal, multidisciplinary treatment program for fibromyalgia.

Vincent A, Whipple MO, Oh TH, Guderian JA, Barton DL, Luedtke CA.

Pain Manag Nurs. 2013 Dec;14(4):228-235. doi: 10.1016/j.pmn.2011.05.001. Epub 2011 Jul 2.


In vitro evaluation of TLR4 agonist activity: formulation effects.

Misquith A, Fung HW, Dowling QM, Guderian JA, Vedvick TS, Fox CB.

Colloids Surf B Biointerfaces. 2014 Jan 1;113:312-9. doi: 10.1016/j.colsurfb.2013.09.006. Epub 2013 Sep 19.


High levels of soluble CD40 ligand and matrix metalloproteinase-9 in serum are associated with favorable clinical evolution in human visceral leishmaniasis.

de Oliveira FA, Vanessa Oliveira Silva C, Damascena NP, Passos RO, Duthie MS, Guderian JA, Bhatia A, de Moura TR, Reed SG, de Almeida RP, de Jesus AR.

BMC Infect Dis. 2013 Jul 19;13:331. doi: 10.1186/1471-2334-13-331.


MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant.

Orr MT, Duthie MS, Windish HP, Lucas EA, Guderian JA, Hudson TE, Shaverdian N, O'Donnell J, Desbien AL, Reed SG, Coler RN.

Eur J Immunol. 2013 Sep;43(9):2398-408. doi: 10.1002/eji.201243124. Epub 2013 Jul 3.


Transcriptional profiling of TLR-4/7/8-stimulated guinea pig splenocytes and whole blood by bDNA assay.

Ching LK, Mompoint F, Guderian JA, Picone A, Orme IM, Coler RN, Reed SG, Baldwin SL.

J Immunol Methods. 2011 Oct 28;373(1-2):54-62. doi: 10.1016/j.jim.2011.07.021. Epub 2011 Aug 3.


Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.

Coler RN, Bertholet S, Moutaftsi M, Guderian JA, Windish HP, Baldwin SL, Laughlin EM, Duthie MS, Fox CB, Carter D, Friede M, Vedvick TS, Reed SG.

PLoS One. 2011 Jan 26;6(1):e16333. doi: 10.1371/journal.pone.0016333.


Design, development and evaluation of rK28-based point-of-care tests for improving rapid diagnosis of visceral leishmaniasis.

Pattabhi S, Whittle J, Mohamath R, El-Safi S, Moulton GG, Guderian JA, Colombara D, Abdoon AO, Mukhtar MM, Mondal D, Esfandiari J, Kumar S, Chun P, Reed SG, Bhatia A.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e822. doi: 10.1371/journal.pntd.0000822.


Applying TLR synergy in immunotherapy: implications in cutaneous leishmaniasis.

Raman VS, Bhatia A, Picone A, Whittle J, Bailor HR, O'Donnell J, Pattabhi S, Guderian JA, Mohamath R, Duthie MS, Reed SG.

J Immunol. 2010 Aug 1;185(3):1701-10. doi: 10.4049/jimmunol.1000238. Epub 2010 Jul 2.


Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, Mtb72F, delivered as naked DNA or recombinant protein.

Skeiky YA, Alderson MR, Ovendale PJ, Guderian JA, Brandt L, Dillon DC, Campos-Neto A, Lobet Y, Dalemans W, Orme IM, Reed SG.

J Immunol. 2004 Jun 15;172(12):7618-28.


A novel method for increasing the expression level of recombinant proteins.

Wang A, Clapper J, Guderian JA, Foy TM, Fanger GR, Retter MW, Skeiky YA.

Protein Expr Purif. 2003 Jul;30(1):124-33.


Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis.

Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG.

Infect Immun. 1999 Aug;67(8):3998-4007.


LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile.

Skeiky YA, Kennedy M, Kaufman D, Borges MM, Guderian JA, Scholler JK, Ovendale PJ, Picha KS, Morrissey PJ, Grabstein KH, Campos-Neto A, Reed SG.

J Immunol. 1998 Dec 1;161(11):6171-9.


Molecular cloning, expression, and immunogenicity of MTB12, a novel low-molecular-weight antigen secreted by Mycobacterium tuberculosis.

Webb JR, Vedvick TS, Alderson MR, Guderian JA, Jen SS, Ovendale PJ, Johnson SM, Reed SG, Skeiky YA.

Infect Immun. 1998 Sep;66(9):4208-14.


Immune responses of leishmaniasis patients to heat shock proteins of Leishmania species and humans.

Skeiky YA, Benson DR, Guderian JA, Whittle JA, Bacelar O, Carvalho EM, Reed SG.

Infect Immun. 1995 Oct;63(10):4105-14.


A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.

Skeiky YA, Guderian JA, Benson DR, Bacelar O, Carvalho EM, Kubin M, Badaro R, Trinchieri G, Reed SG.

J Exp Med. 1995 Apr 1;181(4):1527-37.


Trypanosoma cruzi acidic ribosomal P protein gene family. Novel P proteins encoding unusual cross-reactive epitopes.

Skeiky YA, Benson DR, Guderian JA, Sleath PR, Parsons M, Reed SG.

J Immunol. 1993 Nov 15;151(10):5504-15.


Trypanosoma brucei minicircles encode multiple guide RNAs which can direct editing of extensively overlapping sequences.

Corell RA, Feagin JE, Riley GR, Strickland T, Guderian JA, Myler PJ, Stuart K.

Nucleic Acids Res. 1993 Sep 11;21(18):4313-20.

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