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Items: 1 to 50 of 112

1.

Pim1 Maintains Telomere Length in Mouse Cardiomyocytes by Inhibiting TGFβ Signaling.

Ebeid DE, Khalafalla FG, Broughton KM, Monsanto MM, Esquer CY, Sacchi V, Hariharan N, Korski KI, Moshref M, Emathinger J, Cottage CT, Quijada PJ, Nguyen JH, Alvarez R, Völkers M, Konstandin MH, Wang BJ, Firouzi F, Navarrete JM, Gude NA, Goumans MJ, Sussman MA.

Cardiovasc Res. 2020 Mar 16. pii: cvaa066. doi: 10.1093/cvr/cvaa066. [Epub ahead of print]

PMID:
32176281
2.

Cardiac regenerative therapy: Many paths to repair.

Gude NA, Sussman MA.

Trends Cardiovasc Med. 2019 Sep 2. pii: S1050-1738(19)30127-6. doi: 10.1016/j.tcm.2019.08.009. [Epub ahead of print] Review.

PMID:
31515053
3.

Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity.

Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC.

ACS Appl Mater Interfaces. 2019 Jul 31;11(30):26637-26647. doi: 10.1021/acsami.9b08295. Epub 2019 Jul 22.

PMID:
31276378
4.

Cardiac interstitial tetraploid cells can escape replicative senescence in rodents but not large mammals.

Broughton KM, Khieu T, Nguyen N, Rosa M, Mohsin S, Quijada P, Wang BJ, Echeagaray OH, Kubli DA, Kim T, Firouzi F, Monsanto MM, Gude NA, Adamson RM, Dembitsky WP, Davis ME, Sussman MA.

Commun Biol. 2019 Jun 13;2:205. doi: 10.1038/s42003-019-0453-z. eCollection 2019.

5.

Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).

Alvarez R Jr, Wang BJ, Quijada PJ, Avitabile D, Ho T, Shaitrit M, Chavarria M, Firouzi F, Ebeid D, Monsanto MM, Navarrete N, Moshref M, Siddiqi S, Broughton KM, Bailey BA, Gude NA, Sussman MA.

J Mol Cell Cardiol. 2019 Feb;127:154-164. doi: 10.1016/j.yjmcc.2018.12.007. Epub 2018 Dec 18.

6.

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence.

Gude NA, Broughton KM, Firouzi F, Sussman MA.

Nat Rev Cardiol. 2018 Sep;15(9):523-542. doi: 10.1038/s41569-018-0061-5. Review.

PMID:
30054574
7.

Cardiac c-Kit Biology Revealed by Inducible Transgenesis.

Gude NA, Firouzi F, Broughton KM, Ilves K, Nguyen KP, Payne CR, Sacchi V, Monsanto MM, Casillas AR, Khalafalla FG, Wang BJ, Ebeid DE, Alvarez R, Dembitsky WP, Bailey BA, van Berlo J, Sussman MA.

Circ Res. 2018 Jun 22;123(1):57-72. doi: 10.1161/CIRCRESAHA.117.311828. Epub 2018 Apr 10.

8.

Extended Lifetime In Vivo Pulse Stimulated Ultrasound Imaging.

Wang J, Barback CV, Ta CN, Weeks J, Gude N, Mattrey RF, Blair SL, Trogler WC, Lee H, Kummel AC.

IEEE Trans Med Imaging. 2018 Jan;37(1):222-229. doi: 10.1109/TMI.2017.2740784. Epub 2017 Aug 17.

9.

Chasing c-Kit through the heart: Taking a broader view.

Gude NA, Sussman MA.

Pharmacol Res. 2018 Jan;127:110-115. doi: 10.1016/j.phrs.2017.06.007. Epub 2017 Jun 13. Review.

10.

PIM1-minicircle as a therapeutic treatment for myocardial infarction.

Liu N, Wang BJ, Broughton KM, Alvarez R, Siddiqi S, Loaiza R, Nguyen N, Quijada P, Gude N, Sussman MA.

PLoS One. 2017 Mar 21;12(3):e0173963. doi: 10.1371/journal.pone.0173963. eCollection 2017.

11.

S100A4 protects the myocardium against ischemic stress.

Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M.

J Mol Cell Cardiol. 2016 Nov;100:54-63. doi: 10.1016/j.yjmcc.2016.10.001. Epub 2016 Oct 6.

12.

Cardiac Stem Cell Hybrids Enhance Myocardial Repair.

Quijada P, Salunga HT, Hariharan N, Cubillo JD, El-Sayed FG, Moshref M, Bala KM, Emathinger JM, De La Torre A, Ormachea L, Alvarez R Jr, Gude NA, Sussman MA.

Circ Res. 2015 Sep 25;117(8):695-706. doi: 10.1161/CIRCRESAHA.115.306838. Epub 2015 Jul 30.

13.

Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.

Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC.

Circ Res. 2015 Aug 28;117(6):536-46. doi: 10.1161/CIRCRESAHA.115.306993. Epub 2015 Jul 2.

14.

Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells.

Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, Sacchi V, Truffa S, Joyo A, Voelkers M, Alvarez R, Sussman MA.

Basic Res Cardiol. 2015 May;110(3):29. doi: 10.1007/s00395-015-0488-3. Epub 2015 Apr 19.

15.

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.

Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA.

EMBO Mol Med. 2014 Jan;6(1):57-65. doi: 10.1002/emmm.201303183.

16.

Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells.

Toko H, Hariharan N, Konstandin MH, Ormachea L, McGregor M, Gude NA, Sundararaman B, Joyo E, Joyo AY, Collins B, Din S, Mohsin S, Uchida T, Sussman MA.

J Biol Chem. 2014 Feb 28;289(9):5348-56. doi: 10.1074/jbc.M113.526442. Epub 2013 Dec 27.

17.

A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin.

Gude NM, Stevenson JL, Sheehan PM, Brennecke SP.

J Investig Med High Impact Case Rep. 2013 Oct 23;1(4):2324709613509988. doi: 10.1177/2324709613509988. eCollection 2013 Oct-Dec.

18.

Rejuvenation of human cardiac progenitor cells with Pim-1 kinase.

Mohsin S, Khan M, Nguyen J, Alkatib M, Siddiqi S, Hariharan N, Wallach K, Monsanto M, Gude N, Dembitsky W, Sussman MA.

Circ Res. 2013 Oct 25;113(10):1169-79. doi: 10.1161/CIRCRESAHA.113.302302. Epub 2013 Sep 17.

19.

Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.

Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA.

Circulation. 2013 Nov 5;128(19):2132-44. doi: 10.1161/CIRCULATIONAHA.113.003638. Epub 2013 Sep 5.

20.

Cardiac progenitor cells engineered with βARKct have enhanced β-adrenergic tolerance.

Khan M, Mohsin S, Toko H, Alkatib M, Nguyen J, Truffa S, Gude N, Chuprun K, Tilley DG, Koch WJ, Sussman MA.

Mol Ther. 2014 Jan;22(1):178-85. doi: 10.1038/mt.2013.200. Epub 2013 Sep 3.

21.

No change in calreticulin with fetal growth restriction in human and rat pregnancies.

Crawford KE, Stevenson JL, Wlodek ME, Gude NM.

Placenta. 2013 Nov;34(11):1066-71. doi: 10.1016/j.placenta.2013.07.068. Epub 2013 Aug 20.

PMID:
23972286
22.

Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth.

Konstandin MH, Völkers M, Collins B, Quijada P, Quintana M, De La Torre A, Ormachea L, Din S, Gude N, Toko H, Sussman MA.

Basic Res Cardiol. 2013 Sep;108(5):375. doi: 10.1007/s00395-013-0375-8. Epub 2013 Aug 4.

23.

Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.

Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12661-6. doi: 10.1073/pnas.1301455110. Epub 2013 Jul 10.

24.

Fibronectin is essential for reparative cardiac progenitor cell response after myocardial infarction.

Konstandin MH, Toko H, Gastelum GM, Quijada P, De La Torre A, Quintana M, Collins B, Din S, Avitabile D, Völkers M, Gude N, Fässler R, Sussman MA.

Circ Res. 2013 Jul 5;113(2):115-25. doi: 10.1161/CIRCRESAHA.113.301152. Epub 2013 May 7.

25.

Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.

Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, Uchida T, Sussman MA.

Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13.

26.

β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.

Khan M, Mohsin S, Avitabile D, Siddiqi S, Nguyen J, Wallach K, Quijada P, McGregor M, Gude N, Alvarez R, Tilley DG, Koch WJ, Sussman MA.

Circ Res. 2013 Feb 1;112(3):476-86. doi: 10.1161/CIRCRESAHA.112.280735. Epub 2012 Dec 14.

27.

Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells.

Cottage CT, Neidig L, Sundararaman B, Din S, Joyo AY, Bailey B, Gude N, Hariharan N, Sussman MA.

Stem Cells. 2012 Nov;30(11):2512-22. doi: 10.1002/stem.1211.

28.

Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua.

Castrechini NM, Murthi P, Qin S, Kusuma GD, Wilton L, Abumaree M, Gronthos S, Zannettino A, Gude NM, Brennecke SP, Kalionis B.

Reprod Sci. 2012 Dec;19(12):1302-14. doi: 10.1177/1933719112450334. Epub 2012 Aug 10.

PMID:
22886285
29.

Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.

Mohsin S, Khan M, Toko H, Bailey B, Cottage CT, Wallach K, Nag D, Lee A, Siddiqi S, Lan F, Fischer KM, Gude N, Quijada P, Avitabile D, Truffa S, Collins B, Dembitsky W, Wu JC, Sussman MA.

J Am Coll Cardiol. 2012 Oct 2;60(14):1278-87. doi: 10.1016/j.jacc.2012.04.047. Epub 2012 Jul 26.

30.

Sca-1 knockout impairs myocardial and cardiac progenitor cell function.

Bailey B, Fransioli J, Gude NA, Alvarez R Jr, Zhang X, Gustafsson ÅB, Sussman MA.

Circ Res. 2012 Aug 31;111(6):750-60. doi: 10.1161/CIRCRESAHA.112.274662. Epub 2012 Jul 16. Erratum in: Circ Res. 2013 Feb 1;112(3):e33. Zhan, Xiaosue [corrected to Zhang, Xiaoxue].

31.

Placental CLIC3 is increased in fetal growth restriction and pre-eclampsia affected human pregnancies.

Murthi P, Stevenson JL, Money TT, Borg AJ, Brennecke SP, Gude NM.

Placenta. 2012 Sep;33(9):741-4. doi: 10.1016/j.placenta.2012.06.011. Epub 2012 Jul 11.

PMID:
22795578
32.

Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells.

Quijada P, Toko H, Fischer KM, Bailey B, Reilly P, Hunt KD, Gude NA, Avitabile D, Sussman MA.

Circ Res. 2012 Jun 22;111(1):77-86. doi: 10.1161/CIRCRESAHA.112.265207. Epub 2012 May 22.

33.

Notch signaling and cardiac repair.

Gude N, Sussman M.

J Mol Cell Cardiol. 2012 Jun;52(6):1226-32. doi: 10.1016/j.yjmcc.2012.03.007. Epub 2012 Mar 21. Review.

34.

Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase.

Sundararaman B, Avitabile D, Konstandin MH, Cottage CT, Gude N, Sussman MA.

Circ Res. 2012 Apr 27;110(9):1169-73. doi: 10.1161/CIRCRESAHA.112.267716. Epub 2012 Mar 22.

35.

Calreticulin has opposing effects on the migration of human trophoblast and myometrial endothelial cells.

Crawford KE, Kalionis B, Stevenson JL, Brennecke SP, Gude NM.

Placenta. 2012 May;33(5):416-23. doi: 10.1016/j.placenta.2012.02.003. Epub 2012 Feb 28.

PMID:
22377355
36.

Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish.

Völkers M, Dolatabadi N, Gude N, Most P, Sussman MA, Hassel D.

J Cell Sci. 2012 Jan 15;125(Pt 2):287-94. doi: 10.1242/jcs.090464. Epub 2012 Feb 2.

37.

Neural stem cell depletion and CNS developmental defects after enteroviral infection.

Ruller CM, Tabor-Godwin JM, Van Deren DA Jr, Robinson SM, Maciejewski S, Gluhm S, Gilbert PE, An N, Gude NA, Sussman MA, Whitton JL, Feuer R.

Am J Pathol. 2012 Mar;180(3):1107-20. doi: 10.1016/j.ajpath.2011.11.016. Epub 2011 Dec 31.

38.

Myocardial AKT: the omnipresent nexus.

Sussman MA, Völkers M, Fischer K, Bailey B, Cottage CT, Din S, Gude N, Avitabile D, Alvarez R, Sundararaman B, Quijada P, Mason M, Konstandin MH, Malhowski A, Cheng Z, Khan M, McGregor M.

Physiol Rev. 2011 Jul;91(3):1023-70. doi: 10.1152/physrev.00024.2010. Review.

39.

Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin.

Avitabile D, Bailey B, Cottage CT, Sundararaman B, Joyo A, McGregor M, Gude N, Truffa S, Zarrabi A, Konstandin M, Khan M, Mohsin S, Völkers M, Toko H, Mason M, Cheng Z, Din S, Alvarez R Jr, Fischer K, Sussman MA.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6145-50. doi: 10.1073/pnas.1017935108. Epub 2011 Mar 28.

40.

Cardiac progenitor cell commitment is inhibited by nuclear Akt expression.

Fischer KM, Din S, Gude N, Konstandin MH, Wu W, Quijada P, Sussman MA.

Circ Res. 2011 Apr 15;108(8):960-70. doi: 10.1161/CIRCRESAHA.110.237156. Epub 2011 Feb 24.

41.

Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.

Cheng Z, Völkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA.

Eur Heart J. 2011 Sep;32(17):2179-88. doi: 10.1093/eurheartj/ehq496. Epub 2011 Jan 12.

42.

A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS.

Tabor-Godwin JM, Ruller CM, Bagalso N, An N, Pagarigan RR, Harkins S, Gilbert PE, Kiosses WB, Gude NA, Cornell CT, Doran KS, Sussman MA, Whitton JL, Feuer R.

J Neurosci. 2010 Jun 23;30(25):8676-91. doi: 10.1523/JNEUROSCI.1860-10.2010.

43.

Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA.

Circ Res. 2010 Apr 16;106(7):1265-74. doi: 10.1161/CIRCRESAHA.109.212035. Epub 2010 Mar 4.

44.

Orai1 and Stim1 regulate normal and hypertrophic growth in cardiomyocytes.

Voelkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P.

J Mol Cell Cardiol. 2010 Jun;48(6):1329-34. doi: 10.1016/j.yjmcc.2010.01.020. Epub 2010 Feb 6.

45.

Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice.

Huang C, Zhang X, Ramil JM, Rikka S, Kim L, Lee Y, Gude NA, Thistlethwaite PA, Sussman MA, Gottlieb RA, Gustafsson AB.

Circulation. 2010 Feb 9;121(5):675-83. doi: 10.1161/CIRCULATIONAHA.109.902221. Epub 2010 Jan 25.

46.

Cardiac progenitor cell cycling stimulated by pim-1 kinase.

Cottage CT, Bailey B, Fischer KM, Avitabile D, Collins B, Tuck S, Quijada P, Gude N, Alvarez R, Muraski J, Sussman MA.

Circ Res. 2010 Mar 19;106(5):891-901. doi: 10.1161/CIRCRESAHA.109.208629. Epub 2010 Jan 14. Erratum in: Circ Res. 2015 Nov 6;117(11):e90. Avitable, Daniele [corrected to Avitabile, Daniele]. Endocr Pract. 2015 May;21(5):559.

47.

Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche.

Castrechini NM, Murthi P, Gude NM, Erwich JJ, Gronthos S, Zannettino A, Brennecke SP, Kalionis B.

Placenta. 2010 Mar;31(3):203-12. doi: 10.1016/j.placenta.2009.12.006. Epub 2010 Jan 13.

PMID:
20060164
48.

Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.

Belmont PJ, Chen WJ, San Pedro MN, Thuerauf DJ, Gellings Lowe N, Gude N, Hilton B, Wolkowicz R, Sussman MA, Glembotski CC.

Circ Res. 2010 Feb 5;106(2):307-16. doi: 10.1161/CIRCRESAHA.109.203901. Epub 2009 Nov 25.

49.

Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase.

Fischer KM, Cottage CT, Wu W, Din S, Gude NA, Avitabile D, Quijada P, Collins BL, Fransioli J, Sussman MA.

Circulation. 2009 Nov 24;120(21):2077-87. doi: 10.1161/CIRCULATIONAHA.109.884403. Epub 2009 Nov 9.

50.

Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes.

Rubio M, Avitabile D, Fischer K, Emmanuel G, Gude N, Miyamoto S, Mishra S, Schaefer EM, Brown JH, Sussman MA.

J Mol Cell Cardiol. 2009 Jul;47(1):96-103. doi: 10.1016/j.yjmcc.2009.02.022. Epub 2009 Mar 6.

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