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Correction: An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency.

Laursen KB, Kashyap V, Scandura J, Gudas LJ.

J Biol Chem. 2020 Jan 17;295(3):898. doi: 10.1074/jbc.AAC119.012410. No abstract available.


NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma.

Molina AM, van der Mijn JC, Christos P, Wright J, Thomas C, Dutcher JP, Nanus DM, Tagawa ST, Gudas LJ.

Invest New Drugs. 2020 Jan 3. doi: 10.1007/s10637-019-00880-7. [Epub ahead of print]


Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma.

van der Mijn JC, Fu L, Khani F, Zhang T, Molina AM, Barbieri CE, Chen Q, Gross SS, Gudas LJ, Nanus DM.

Transl Oncol. 2019 Dec 19;13(2):177-185. doi: 10.1016/j.tranon.2019.10.015. [Epub ahead of print]


Modification of stem cell states by alcohol and acetaldehyde.

Serio RN, Gudas LJ.

Chem Biol Interact. 2019 Dec 14;316:108919. doi: 10.1016/j.cbi.2019.108919. [Epub ahead of print] Review.


Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells.

Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL.

Mol Oncol. 2019 Dec 10. doi: 10.1002/1878-0261.12614. [Epub ahead of print]


Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series.

van der Mijn JC, Al Hussein Al Awamlh B, Islam Khan A, Posada-Calderon L, Oromendia C, Fainberg J, Alshak M, Elahjji R, Pierce H, Taylor B, Gudas LJ, Nanus DM, Molina AM, Del Pizzo J, Scherr DS.

PLoS One. 2019 Dec 9;14(12):e0226285. doi: 10.1371/journal.pone.0226285. eCollection 2019.


All-trans retinoic acid (ATRA)-induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL).

Orfali N, O'Donovan TR, Cahill MR, Benjamin D, Nanus DM, McKenna SL, Gudas LJ, Mongan NP.

Eur J Haematol. 2019 Dec 6. doi: 10.1111/ejh.13367. [Epub ahead of print]


Lentiviral-Mediated shRNA Approaches: Applications in Cellular Differentiation and Autophagy.

Orfali N, Jeyapalan JN, Woodcock CL, O'Donovan TR, Benjamin D, Cahill M, McKenna S, Gudas LJ, Mongan NP.

Methods Mol Biol. 2019;2019:33-49. doi: 10.1007/978-1-4939-9585-1_3.


Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation.

Serio RN, Lu C, Gross SS, Gudas LJ.

Alcohol Clin Exp Res. 2019 Sep;43(9):1859-1871. doi: 10.1111/acer.14146. Epub 2019 Aug 5.


Retinoids induce antagonism between FOXO3A and FOXM1 transcription factors in human oral squamous cell carcinoma (OSCC) cells.

Osei-Sarfo K, Gudas LJ.

PLoS One. 2019 Apr 12;14(4):e0215234. doi: 10.1371/journal.pone.0215234. eCollection 2019.


Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ.

Serio RN, Laursen KB, Urvalek AM, Gross SS, Gudas LJ.

J Biol Chem. 2019 Apr 5;294(14):5536-5548. doi: 10.1074/jbc.RA118.007153. Epub 2019 Feb 8.


Effects of AM80 compared to AC261066 in a high fat diet mouse model of liver disease.

Melis M, Tang XH, Trasino SE, Patel VM, Stummer DJ, Jessurun J, Gudas LJ.

PLoS One. 2019 Jan 24;14(1):e0211071. doi: 10.1371/journal.pone.0211071. eCollection 2019.


CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation.

Quintero CM, Laursen KB, Mongan NP, Luo M, Gudas LJ.

J Mol Biol. 2018 Oct 19;430(21):4168-4182. doi: 10.1016/j.jmb.2018.08.014. Epub 2018 Aug 25.


Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor β2 Agonist.

Trasino SE, Tang XH, Shevchuk MM, Choi ME, Gudas LJ.

J Pharmacol Exp Ther. 2018 Oct;367(1):82-94. doi: 10.1124/jpet.118.249375. Epub 2018 Jul 27.


A Retinoic Acid β2-Receptor Agonist Exerts Cardioprotective Effects.

Marino A, Sakamoto T, Tang XH, Gudas LJ, Levi R.

J Pharmacol Exp Ther. 2018 Aug;366(2):314-321. doi: 10.1124/jpet.118.250605. Epub 2018 Jun 15.


Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.

Laursen KB, Gudas LJ.

J Biol Chem. 2018 Jul 27;293(30):11891-11900. doi: 10.1074/jbc.RA118.001951. Epub 2018 May 30.


Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays.

Lee M, Gudas LJ, Saavedra HI.

Methods Mol Biol. 2018;1726:143-151. doi: 10.1007/978-1-4939-7565-5_13.


OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation.

Simandi Z, Horvath A, Wright LC, Cuaranta-Monroy I, De Luca I, Karolyi K, Sauer S, Deleuze JF, Gudas LJ, Cowley SM, Nagy L.

Mol Cell. 2016 Aug 18;63(4):647-661. doi: 10.1016/j.molcel.2016.06.039. Epub 2016 Aug 4.


A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease.

Trasino SE, Tang XH, Jessurun J, Gudas LJ.

J Mol Med (Berl). 2016 Oct;94(10):1143-1151. Epub 2016 Jun 6.


Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.

Minton DR, Fu L, Mongan NP, Shevchuk MM, Nanus DM, Gudas LJ.

Clin Cancer Res. 2016 Jun 1;22(11):2791-801. doi: 10.1158/1078-0432.CCR-15-1511. Epub 2016 Jan 18.


Vitamin A: a missing link in diabetes?

Trasino SE, Gudas LJ.

Diabetes Manag (Lond). 2015;5(5):359-367.


Obesity Leads to Tissue, but not Serum Vitamin A Deficiency.

Trasino SE, Tang XH, Jessurun J, Gudas LJ.

Sci Rep. 2015 Nov 2;5:15893. doi: 10.1038/srep15893.


Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis.

Trasino SE, Tang XH, Jessurun J, Gudas LJ.

Diabetes Obes Metab. 2016 Feb;18(2):142-51. doi: 10.1111/dom.12590. Epub 2015 Dec 23.


MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.

Nilsson EM, Laursen KB, Whitchurch J, McWilliam A, Ødum N, Persson JL, Heery DM, Gudas LJ, Mongan NP.

Oncotarget. 2015 Nov 3;6(34):35710-25. doi: 10.18632/oncotarget.5958.


The Tale of Two Hypoxia-Inducible Factors in Renal Cell Carcinoma.

Nanus DM, Gudas LJ.

Eur Urol. 2016 Apr;69(4):658-659. doi: 10.1016/j.eururo.2015.09.020. Epub 2015 Oct 1. No abstract available.


Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis.

Urvalek AM, Osei-Sarfo K, Tang XH, Zhang T, Scognamiglio T, Gudas LJ.

Alcohol Clin Exp Res. 2015 Aug;39(8):1360-72. doi: 10.1111/acer.12772.


Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology.

Tang XH, Urvalek AM, Osei-Sarfo K, Zhang T, Scognamiglio T, Gudas LJ.

Oncotarget. 2015 Sep 15;6(27):24424-35.


Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.

Orfali N, O'Donovan TR, Nyhan MJ, Britschgi A, Tschan MP, Cahill MR, Mongan NP, Gudas LJ, McKenna SL.

Exp Hematol. 2015 Sep;43(9):781-93.e2. doi: 10.1016/j.exphem.2015.04.012. Epub 2015 May 16.


Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.

Minton DR, Fu L, Chen Q, Robinson BD, Gross SS, Nanus DM, Gudas LJ.

PLoS One. 2015 Apr 1;10(4):e0120649. doi: 10.1371/journal.pone.0120649. eCollection 2015.


Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.

Williams RM, Shah J, Ng BD, Minton DR, Gudas LJ, Park CY, Heller DA.

Nano Lett. 2015 Apr 8;15(4):2358-64. doi: 10.1021/nl504610d. Epub 2015 Mar 26.


Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome.

Fu L, Minton DR, Zhang T, Nanus DM, Gudas LJ.

Mol Cancer Res. 2015 May;13(5):870-8. doi: 10.1158/1541-7786.MCR-14-0423. Epub 2015 Feb 25.


Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model.

Osei-Sarfo K, Urvalek AM, Tang XH, Scognamiglio T, Gudas LJ.

Oncotarget. 2015 Mar 20;6(8):6040-52.


An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency.

Laursen KB, Kashyap V, Scandura J, Gudas LJ.

J Biol Chem. 2015 Feb 13;290(7):4356-66. doi: 10.1074/jbc.M114.613968. Epub 2014 Dec 28. Erratum in: J Biol Chem. 2020 Jan 17;295(3):898.


Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.

Trasino SE, Benoit YD, Gudas LJ.

J Biol Chem. 2015 Jan 16;290(3):1456-73. doi: 10.1074/jbc.M114.616763. Epub 2014 Dec 1.


The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes.

Urvalek A, Laursen KB, Gudas LJ.

Subcell Biochem. 2014;70:129-49. doi: 10.1007/978-94-017-9050-5_7. Review.


Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.

Tang XH, Osei-Sarfo K, Urvalek AM, Zhang T, Scognamiglio T, Gudas LJ.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12. doi: 10.1073/pnas.1404828111. Epub 2014 Jun 3.


The role of HIF1α in renal cell carcinoma tumorigenesis.

Gudas LJ, Fu L, Minton DR, Mongan NP, Nanus DM.

J Mol Med (Berl). 2014 Aug;92(8):825-36. doi: 10.1007/s00109-014-1180-z. Epub 2014 Jun 12. Review.


Crossing the barrier: STRA6 in epidermal differentiation.

Laursen KB, Gudas LJ.

J Invest Dermatol. 2014 Jun;134(6):1504-1506. doi: 10.1038/jid.2014.49.


Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells.

Urvalek AM, Gudas LJ.

J Biol Chem. 2014 Jul 11;289(28):19519-30. doi: 10.1074/jbc.M114.556555. Epub 2014 May 12.


Retinoid receptor signaling and autophagy in acute promyelocytic leukemia.

Orfali N, McKenna SL, Cahill MR, Gudas LJ, Mongan NP.

Exp Cell Res. 2014 May 15;324(1):1-12. doi: 10.1016/j.yexcr.2014.03.018. Epub 2014 Mar 30. Review.


Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.

Marcinkiewicz KM, Gudas LJ.

J Cell Physiol. 2014 Oct;229(10):1405-16. doi: 10.1002/jcp.24577.


Expression of cyclin d1 and its association with disease characteristics in bladder cancer.

Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.

Anticancer Res. 2013 Dec;33(12):5235-42.


Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.

Marcinkiewicz KM, Gudas LJ.

Exp Cell Res. 2014 Jan 1;320(1):128-43. doi: 10.1016/j.yexcr.2013.09.011. Epub 2013 Sep 25.


Retinoids induce stem cell differentiation via epigenetic changes.

Gudas LJ.

Semin Cell Dev Biol. 2013 Dec;24(10-12):701-5. doi: 10.1016/j.semcdb.2013.08.002. Epub 2013 Aug 21. Review.


Cytochrome p450 cyp26a1 alters spinal motor neuron subtype identity in differentiating embryonic stem cells.

Ricard MJ, Gudas LJ.

J Biol Chem. 2013 Oct 4;288(40):28801-13. doi: 10.1074/jbc.M113.474254. Epub 2013 Aug 13.


The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC.

Osei-Sarfo K, Tang XH, Urvalek AM, Scognamiglio T, Gudas LJ.

Carcinogenesis. 2013 Nov;34(11):2673-81. doi: 10.1093/carcin/bgt223. Epub 2013 Jun 19.


Deletion of retinoic acid receptor β (RARβ) impairs pancreatic endocrine differentiation.

Pérez RJ, Benoit YD, Gudas LJ.

Exp Cell Res. 2013 Aug 15;319(14):2196-204. doi: 10.1016/j.yexcr.2013.05.032. Epub 2013 Jun 10.


Expression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer.

Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, Persson JL.

Anticancer Res. 2013 Jun;33(6):2381-90.


Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.

Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.

Nucleic Acids Res. 2013 Jul;41(13):6430-43. doi: 10.1093/nar/gkt367. Epub 2013 May 10.

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