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Mutations in TP53, ZNF750, and RB1 typify ocular sebaceous carcinoma.

Bao Y, Selfridge JE, Wang J, Zhao Y, Cui J, Guda K, Wang Z, Zhu Y.

J Genet Genomics. 2019 Jun 20;46(6):315-318. doi: 10.1016/j.jgg.2019.06.001. Epub 2019 Jun 21. No abstract available.


Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.

Blum AE, Venkitachalam S, Ravillah D, Chelluboyina AK, Kieber-Emmons AM, Ravi L, Kresak A, Chandar AK, Markowitz SD, Canto MI, Wang JS, Shaheen NJ, Guo Y, Shyr Y, Willis JE, Chak A, Varadan V, Guda K.

Gastroenterology. 2019 May;156(6):1761-1774. doi: 10.1053/j.gastro.2019.01.263. Epub 2019 Feb 12.


Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer.

Evans DR, Venkitachalam S, Revoredo L, Dohey AT, Clarke E, Pennell JJ, Powell AE, Quinn E, Ravi L, Gerken TA, Green JS, Woods MO, Guda K.

Hum Mutat. 2018 Aug;39(8):1092-1101. doi: 10.1002/humu.23549. Epub 2018 May 28.


Association of sporadic and familial Barrett's esophagus with breast cancer.

Chan MQ, Blum AE, Chandar AK, Emmons AMLK, Shindo Y, Brock W, Falk GW, Canto MI, Wang JS, Iyer PG, Shaheen NJ, Grady WM, Abrams JA, Thota PN, Guda KK, Chak A.

Dis Esophagus. 2018 Apr 1;31(4). doi: 10.1093/dote/doy007.


Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.

Moinova HR, LaFramboise T, Lutterbaugh JD, Chandar AK, Dumot J, Faulx A, Brock W, De la Cruz Cabrera O, Guda K, Barnholtz-Sloan JS, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Thota PN, Willis JE, Chak A, Markowitz SD.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaao5848. doi: 10.1126/scitranslmed.aao5848.


Genomic regions associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma in African Americans: The cross BETRNet admixture study.

Sun X, Chandar AK, Canto MI, Thota PN, Brock M, Shaheen NJ, Beer DG, Wang JS, Falk GW, Iyer PG, Abrams JA, Venkat-Ramani M, Veigl M, Miron A, Willis J, Patil DT, Nalbantoglu I, Guda K, Markowitz SD, Zhu X, Elston R, Chak A.

PLoS One. 2017 Oct 26;12(10):e0184962. doi: 10.1371/journal.pone.0184962. eCollection 2017.


Altered glycosyltransferases in colorectal cancer.

Venkitachalam S, Guda K.

Expert Rev Gastroenterol Hepatol. 2017 Jan;11(1):5-7. Epub 2016 Nov 4. No abstract available.


Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.

Wang Z, Li L, Guda K, Chen Z, Barnholtz-Sloan J, Park YS, Markowitz SD, Willis J.

J Natl Cancer Inst. 2016 Aug 31;108(12). pii: djw164. doi: 10.1093/jnci/djw164. Print 2016 Dec.


RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas.

Blum AE, Venkitachalam S, Guo Y, Kieber-Emmons AM, Ravi L, Chandar AK, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Shyr Y, Chak A, Varadan V, Guda K.

Cancer Res. 2016 Oct 1;76(19):5628-5633. Epub 2016 Aug 8.


Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas.

Sun X, Elston R, Falk GW, Grady WM, Faulx A, Mittal SK, Canto MI, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Willis JE, Guda K, Markowitz S, Barnholtz-Sloan JS, Chandar A, Brock W, Chak A.

Mol Genet Genomic Med. 2016 Mar 14;4(4):407-19. doi: 10.1002/mgg3.211. eCollection 2016 Jul.


Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

Fecteau RE, Kong J, Kresak A, Brock W, Song Y, Fujioka H, Elston R, Willis JE, Lynch JP, Markowitz SD, Guda K, Chak A.

JAMA Oncol. 2016 Oct 1;2(10):1333-1339. doi: 10.1001/jamaoncol.2016.2054.


Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Venkitachalam S, Revoredo L, Varadan V, Fecteau RE, Ravi L, Lutterbaugh J, Markowitz SD, Willis JE, Gerken TA, Guda K.

Sci Rep. 2016 Mar 23;6:23642. doi: 10.1038/srep23642.


Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Sun X, Elston RC, Barnholtz-Sloan JS, Falk GW, Grady WM, Faulx A, Mittal SK, Canto M, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Tian YD, Willis JE, Guda K, Markowitz SD, Chandar A, Warfe JM, Brock W, Chak A.

Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):727-35. doi: 10.1158/1055-9965.EPI-15-0832. Epub 2016 Feb 29.


ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.

Varadan V, Singh S, Nosrati A, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Guda K.

Genome Med. 2015 Jul 20;7:69. doi: 10.1186/s13073-015-0192-9. eCollection 2015.


Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2853. doi: 10.1073/pnas.1505059112. Epub 2015 May 4. No abstract available.


Novel recurrently mutated genes in African American colon cancers.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1149-54. doi: 10.1073/pnas.1417064112. Epub 2015 Jan 12.


Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.

Guda K, Fink SP, Milne GL, Molyneaux N, Ravi L, Lewis SM, Dannenberg AJ, Montgomery CG, Zhang S, Willis J, Wiesner GL, Markowitz SD.

Cancer Prev Res (Phila). 2014 Aug;7(8):805-12. doi: 10.1158/1940-6207.CAPR-14-0108. Epub 2014 May 16.


GNAS mutations identify a set of right-sided, RAS mutant, villous colon cancers.

Fecteau RE, Lutterbaugh J, Markowitz SD, Willis J, Guda K.

PLoS One. 2014 Jan 30;9(1):e87966. doi: 10.1371/journal.pone.0087966. eCollection 2014.


Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.

Adams MD, Veigl ML, Wang Z, Molyneux N, Sun S, Guda K, Yu X, Markowitz SD, Willis J.

Mod Pathol. 2012 Dec;25(12):1599-608. doi: 10.1038/modpathol.2012.121. Epub 2012 Aug 10.


How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?

Yu X, Guda K, Willis J, Veigl M, Wang Z, Markowitz S, Adams MD, Sun S.

BioData Min. 2012 Jun 18;5(1):6. doi: 10.1186/1756-0381-5-6.


H3K4me3 inversely correlates with DNA methylation at a large class of non-CpG-island-containing start sites.

Balasubramanian D, Akhtar-Zaidi B, Song L, Bartels CF, Veigl M, Beard L, Myeroff L, Guda K, Lutterbaugh J, Willis J, Crawford GE, Markowitz SD, Scacheri PC.

Genome Med. 2012 May 28;4(5):47. doi: 10.1186/gm346.


Characterizing mutational heterogeneity in a glioblastoma patient with double recurrence.

Nickel GC, Barnholtz-Sloan J, Gould MP, McMahon S, Cohen A, Adams MD, Guda K, Cohen M, Sloan AE, LaFramboise T.

PLoS One. 2012;7(4):e35262. doi: 10.1371/journal.pone.0035262. Epub 2012 Apr 20.


The microRNAs, MiR-31 and MiR-375, as candidate markers in Barrett's esophageal carcinogenesis.

Leidner RS, Ravi L, Leahy P, Chen Y, Bednarchik B, Streppel M, Canto M, Wang JS, Maitra A, Willis J, Markowitz SD, Barnholtz-Sloan J, Adams MD, Chak A, Guda K.

Genes Chromosomes Cancer. 2012 May;51(5):473-9. doi: 10.1002/gcc.21934. Epub 2012 Feb 3.


Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus.

Chak A, Chen Y, Vengoechea J, Canto MI, Elston R, Falk GW, Grady WM, Guda K, Kinnard M, Markowitz S, Mittal S, Prasad G, Shaheen N, Willis JE, Barnholtz-Sloan JS.

Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):376-83. doi: 10.1158/1055-9965.EPI-11-0927. Epub 2011 Dec 16.


Polarization bistability and resultant spin rings in semiconductor microcavities.

Sarkar D, Gavrilov SS, Sich M, Quilter JH, Bradley RA, Gippius NA, Guda K, Kulakovskii VD, Skolnick MS, Krizhanovskii DN.

Phys Rev Lett. 2010 Nov 19;105(21):216402. Epub 2010 Nov 15.


DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

Du Z, Song J, Wang Y, Zhao Y, Guda K, Yang S, Kao HY, Xu Y, Willis J, Markowitz SD, Sedwick D, Ewing RM, Wang Z.

Sci Signal. 2010 Nov 2;3(146):ra80. doi: 10.1126/scisignal.2001462.


Polariton condensation in dynamic acoustic lattices.

Cerda-Méndez EA, Krizhanovskii DN, Wouters M, Bradley R, Biermann K, Guda K, Hey R, Santos PV, Sarkar D, Skolnick MS.

Phys Rev Lett. 2010 Sep 10;105(11):116402. Epub 2010 Sep 9.


Allele-specific expression of TGFBR1 in colon cancer patients.

Tomsic J, Guda K, Liyanarachchi S, Hampel H, Natale L, Markowitz SD, Tanner SM, de la Chapelle A.

Carcinogenesis. 2010 Oct;31(10):1800-4. doi: 10.1093/carcin/bgq165. Epub 2010 Aug 12.


Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22.

Gray-McGuire C, Guda K, Adrianto I, Lin CP, Natale L, Potter JD, Newcomb P, Poole EM, Ulrich CM, Lindor N, Goode EL, Fridley BL, Jenkins R, Le Marchand L, Casey G, Haile R, Hopper J, Jenkins M, Young J, Buchanan D, Gallinger S, Adams M, Lewis S, Willis J, Elston R, Markowitz SD, Wiesner GL.

Cancer Res. 2010 Jul 1;70(13):5409-18. doi: 10.1158/0008-5472.CAN-10-0188. Epub 2010 Jun 15.


Effect of interactions on vortices in a nonequilibrium polariton condensate.

Krizhanovskii DN, Whittaker DM, Bradley RA, Guda K, Sarkar D, Sanvitto D, Vina L, Cerda E, Santos P, Biermann K, Hey R, Skolnick MS.

Phys Rev Lett. 2010 Mar 26;104(12):126402. Epub 2010 Mar 26.


Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.

Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, Iwakura Y, Asano M, Wei L, Yang Z, Zheng W, Dawson D, Willis J, Markowitz SD, Satake M, Wang Z.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2592-7. doi: 10.1073/pnas.0914884107. Epub 2010 Jan 21.


Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.

Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JK, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, Velculescu VE, Kinzler KW, Papadopoulos N, Vogelstein B, Willis J, Gerken TA, Markowitz SD.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12921-5. doi: 10.1073/pnas.0901454106. Epub 2009 Jul 17.


Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.

Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner SM, Tomsic J, Valle L, de la Chapelle A, Elston RC, Willis J, Markowitz SD.

Cancer Res. 2009 Jun 15;69(12):4959-61. doi: 10.1158/0008-5472.CAN-09-0225. Epub 2009 Jun 9.


An improved method for staining cell colonies in clonogenic assays.

Guda K, Natale L, Markowitz SD.

Cytotechnology. 2007 Jun;54(2):85-8. doi: 10.1007/s10616-007-9083-2. Epub 2007 Jun 12.


The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers.

Guo C, Sah JF, Beard L, Willson JK, Markowitz SD, Guda K.

Genes Chromosomes Cancer. 2008 Nov;47(11):939-46. doi: 10.1002/gcc.20596.


Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice.

Guda K, Marino JN, Jung Y, Crary K, Dong M, Rosenberg DW.

Int J Oncol. 2007 Oct;31(4):837-42.


15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.

Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. Epub 2006 Jul 31.


Dietary iron promotes azoxymethane-induced colon tumors in mice.

Ilsley JN, Belinsky GS, Guda K, Zhang Q, Huang X, Blumberg JB, Milbury PE, Roberts LJ 2nd, Stevens RG, Rosenberg DW.

Nutr Cancer. 2004;49(2):162-9.


Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer.

Nambiar PR, Nakanishi M, Gupta R, Cheung E, Firouzi A, Ma XJ, Flynn C, Dong M, Guda K, Levine J, Raja R, Achenie L, Rosenberg DW.

Cancer Res. 2004 Sep 15;64(18):6394-401.


Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells.

Dong M, Guda K, Nambiar PR, Nakanishi M, Lichtler AC, Nishikawa M, Giardina C, Rosenberg DW.

Carcinogenesis. 2004 Nov;25(11):2239-46. Epub 2004 Aug 5.


Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.

Guda K, Upender MB, Belinsky G, Flynn C, Nakanishi M, Marino JN, Ried T, Rosenberg DW.

Oncogene. 2004 May 6;23(21):3813-21.


p53 and its co-activator p300 are inversely regulated in the mouse colon in response to carcinogen.

Aizu W, Guda K, Nambiar P, Xin T, Thibodeau M, Rosenberg DW, Giardina C.

Toxicol Lett. 2003 Sep 30;144(2):213-24.


Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.

Guda K, Claffey KP, Dong M, Nambiar PR, Rosenberg DW.

Mol Carcinog. 2003 May;37(1):51-9.


Multistage gene expression profiling in a differentially susceptible mouse colon cancer model.

Guda K, Cui H, Garg S, Dong M, Nambiar PR, Achenie LE, Rosenberg DW.

Cancer Lett. 2003 Feb 28;191(1):17-25.


Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis.

Dong M, Guda K, Nambiar PR, Rezaie A, Belinsky GS, Lambeau G, Giardina C, Rosenberg DW.

Carcinogenesis. 2003 Feb;24(2):307-15.


Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors.

Nambiar PR, Girnun G, Lillo NA, Guda K, Whiteley HE, Rosenberg DW.

Int J Oncol. 2003 Jan;22(1):145-50.


Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model.

Nambiar PR, Giardina C, Guda K, Aizu W, Raja R, Rosenberg DW.

Cancer Res. 2002 Jul 1;62(13):3667-74.


Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.

Guda K, Giardina C, Nambiar P, Cui H, Rosenberg DW.

Mol Carcinog. 2001 Aug;31(4):204-13.


Actions and interactions of thyroid hormone and zinc status in growing rats.

Freake HC, Govoni KE, Guda K, Huang C, Zinn SA.

J Nutr. 2001 Apr;131(4):1135-41.


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