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Effects of rigosertib on the osteo-hematopoietic niche in myelodysplastic syndromes.

Balaian E, Weidner H, Wobus M, Baschant U, Jacobi A, Mies A, Bornhäuser M, Guck J, Hofbauer LC, Rauner M, Platzbecker U.

Ann Hematol. 2019 Jul 16. doi: 10.1007/s00277-019-03756-1. [Epub ahead of print]


CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability.

Kapplusch F, Schulze F, Rabe-Matschewsky S, Russ S, Herbig M, Heymann MC, Schoepf K, Stein R, Range U, Rösen-Wolff A, Winkler S, Hedrich CM, Guck J, Hofmann SR.

Clin Immunol. 2019 Jun 25. pii: S1521-6616(19)30179-2. doi: 10.1016/j.clim.2019.06.008. [Epub ahead of print]


High-Throughput Microfluidic Characterization of Erythrocyte Shapes and Mechanical Variability.

Reichel F, Mauer J, Nawaz AA, Gompper G, Guck J, Fedosov DA.

Biophys J. 2019 Jul 9;117(1):14-24. doi: 10.1016/j.bpj.2019.05.022. Epub 2019 May 29.


Analysis of Biomechanical Properties of Hematopoietic Stem and Progenitor Cells Using Real-Time Fluorescence and Deformability Cytometry.

Jacobi A, Rosendahl P, Kräter M, Urbanska M, Herbig M, Guck J.

Methods Mol Biol. 2019;2017:135-148. doi: 10.1007/978-1-4939-9574-5_11.


Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery.

Poser SW, Otto O, Arps-Forker C, Ge Y, Herbig M, Andree C, Gruetzmann K, Adasme MF, Stodolak S, Nikolakopoulou P, Park DM, Mcintyre A, Lesche M, Dahl A, Lennig P, Bornstein SR, Schroeck E, Klink B, Leker RR, Bickle M, Chrousos GP, Schroeder M, Cannistraci CV, Guck J, Androutsellis-Theotokis A.

FASEB J. 2019 May 30:fj201802603RR. doi: 10.1096/fj.201802603RR. [Epub ahead of print]


Morpho-Rheological Fingerprinting of Rod Photoreceptors Using Real-Time Deformability Cytometry.

Santos-Ferreira T, Herbig M, Otto O, Carido M, Karl MO, Michalakis S, Guck J, Ader M.

Cytometry A. 2019 May 20. doi: 10.1002/cyto.a.23798. [Epub ahead of print]


Erratum: Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation.

Tietze S, Kräter M, Jacobi A, Taubenberger A, Herbig M, Wehner R, Schmitz M, Otto O, List C, Kaya B, Wobus M, Bornhäuser M, Guck J.

Adv Sci (Weinh). 2019 Apr 17;6(8):1900622. doi: 10.1002/advs.201900622. eCollection 2019 Apr 17.


Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation.

Tietze S, Kräter M, Jacobi A, Taubenberger A, Herbig M, Wehner R, Schmitz M, Otto O, List C, Kaya B, Wobus M, Bornhäuser M, Guck J.

Adv Sci (Weinh). 2019 Feb 19;6(8):1802104. doi: 10.1002/advs.201802104. eCollection 2019 Apr 17. Erratum in: Adv Sci (Weinh). 2019 Apr 17;6(8):1900622.


Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions.

Hauck N, Seixas N, Centeno SP, Schlüßler R, Cojoc G, Müller P, Guck J, Wöll D, Wessjohann LA, Thiele J.

Polymers (Basel). 2018 Sep 21;10(10). pii: E1055. doi: 10.3390/polym10101055.


Real-time deformability cytometry reveals sequential contraction and expansion during neutrophil priming.

Bashant KR, Vassallo A, Herold C, Berner R, Menschner L, Subburayalu J, Kaplan MJ, Summers C, Guck J, Chilvers ER, Toepfner N.

J Leukoc Biol. 2019 Jun;105(6):1143-1153. doi: 10.1002/JLB.MA0718-295RR. Epub 2019 Mar 5.


The relationship between metastatic potential and in vitro mechanical properties of osteosarcoma cells.

Holenstein CN, Horvath A, Schär B, Schoenenberger AD, Bollhalder M, Goedecke N, Bartalena G, Otto O, Herbig M, Guck J, Müller DA, Snedeker JG, Silvan U.

Mol Biol Cell. 2019 Mar 21;30(7):887-898. doi: 10.1091/mbc.E18-08-0545. Epub 2019 Feb 20.


Axonal Transport, Phase-Separated Compartments, and Neuron Mechanics - A New Approach to Investigate Neurodegenerative Diseases.

Nötzel M, Rosso G, Möllmert S, Seifert A, Schlüßler R, Kim K, Hermann A, Guck J.

Front Cell Neurosci. 2018 Oct 9;12:358. doi: 10.3389/fncel.2018.00358. eCollection 2018. Review.


Alterations in Cell Mechanics by Actin Cytoskeletal Changes Correlate with Strain-Specific Rubella Virus Phenotypes for Cell Migration and Induction of Apoptosis.

Kräter M, Sapudom J, Bilz NC, Pompe T, Guck J, Claus C.

Cells. 2018 Sep 13;7(9). pii: E136. doi: 10.3390/cells7090136.


High-throughput single-cell mechanical phenotyping with real-time deformability cytometry.

Urbanska M, Rosendahl P, Kräter M, Guck J.

Methods Cell Biol. 2018;147:175-198. doi: 10.1016/bs.mcb.2018.06.009. Epub 2018 Jul 29.


Mechanical Mapping of Spinal Cord Growth and Repair in Living Zebrafish Larvae by Brillouin Imaging.

Schlüßler R, Möllmert S, Abuhattum S, Cojoc G, Müller P, Kim K, Möckel C, Zimmermann C, Czarske J, Guck J.

Biophys J. 2018 Sep 4;115(5):911-923. doi: 10.1016/j.bpj.2018.07.027. Epub 2018 Aug 4.


Metabolic Profiling of Human Eosinophils.

Porter L, Toepfner N, Bashant KR, Guck J, Ashcroft M, Farahi N, Chilvers ER.

Front Immunol. 2018 Jun 21;9:1404. doi: 10.3389/fimmu.2018.01404. eCollection 2018.


A comparison of methods to assess cell mechanical properties.

Wu PH, Aroush DR, Asnacios A, Chen WC, Dokukin ME, Doss BL, Durand-Smet P, Ekpenyong A, Guck J, Guz NV, Janmey PA, Lee JSH, Moore NM, Ott A, Poh YC, Ros R, Sander M, Sokolov I, Staunton JR, Wang N, Whyte G, Wirtz D.

Nat Methods. 2018 Jul;15(7):491-498. doi: 10.1038/s41592-018-0015-1. Epub 2018 Jun 18.


Accurate evaluation of size and refractive index for spherical objects in quantitative phase imaging.

Müller P, Schürmann M, Girardo S, Cojoc G, Guck J.

Opt Express. 2018 Apr 16;26(8):10729-10743. doi: 10.1364/OE.26.010729.


Real-time fluorescence and deformability cytometry.

Rosendahl P, Plak K, Jacobi A, Kraeter M, Toepfner N, Otto O, Herold C, Winzi M, Herbig M, Ge Y, Girardo S, Wagner K, Baum B, Guck J.

Nat Methods. 2018 May;15(5):355-358. doi: 10.1038/nmeth.4639. Epub 2018 Apr 2.


Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.

Toepfner N, Herold C, Otto O, Rosendahl P, Jacobi A, Kräter M, Stächele J, Menschner L, Herbig M, Ciuffreda L, Ranford-Cartwright L, Grzybek M, Coskun Ü, Reithuber E, Garriss G, Mellroth P, Henriques-Normark B, Tregay N, Suttorp M, Bornhäuser M, Chilvers ER, Berner R, Guck J.

Elife. 2018 Jan 13;7. pii: e29213. doi: 10.7554/eLife.29213.


Single-cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage.

Urbanska M, Winzi M, Neumann K, Abuhattum S, Rosendahl P, Müller P, Taubenberger A, Anastassiadis K, Guck J.

Development. 2017 Dec 1;144(23):4313-4321. doi: 10.1242/dev.155218.


Mechanical mismatch between Ras transformed and untransformed epithelial cells.

Gullekson C, Cojoc G, Schürmann M, Guck J, Pelling A.

Soft Matter. 2017 Nov 22;13(45):8483-8491. doi: 10.1039/c7sm01396e.


Real-Time Deformability Cytometry: Label-Free Functional Characterization of Cells.

Herbig M, Kräter M, Plak K, Müller P, Guck J, Otto O.

Methods Mol Biol. 2018;1678:347-369. doi: 10.1007/978-1-4939-7346-0_15.


Toll-Like Receptor-Mediated Upregulation of CXCL16 in Psoriasis Orchestrates Neutrophil Activation.

Steffen S, Abraham S, Herbig M, Schmidt F, Blau K, Meisterfeld S, Beissert S, Guck J, Günther C.

J Invest Dermatol. 2018 Feb;138(2):344-354. doi: 10.1016/j.jid.2017.08.041. Epub 2017 Sep 20.


Three-dimensional correlative single-cell imaging utilizing fluorescence and refractive index tomography.

Schürmann M, Cojoc G, Girardo S, Ulbricht E, Guck J, Müller P.

J Biophotonics. 2018 Mar;11(3). doi: 10.1002/jbio.201700145. Epub 2017 Sep 25.


Mechanical deformation induces depolarization of neutrophils.

Ekpenyong AE, Toepfner N, Fiddler C, Herbig M, Li W, Cojoc G, Summers C, Guck J, Chilvers ER.

Sci Adv. 2017 Jun 14;3(6):e1602536. doi: 10.1126/sciadv.1602536. eCollection 2017 Jun.


Bone marrow niche-mimetics modulate HSPC function via integrin signaling.

Kräter M, Jacobi A, Otto O, Tietze S, Müller K, Poitz DM, Palm S, Zinna VM, Biehain U, Wobus M, Chavakis T, Werner C, Guck J, Bornhauser M.

Sci Rep. 2017 May 31;7(1):2549. doi: 10.1038/s41598-017-02352-5.


Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells.

Tavares S, Vieira AF, Taubenberger AV, Araújo M, Martins NP, Brás-Pereira C, Polónia A, Herbig M, Barreto C, Otto O, Cardoso J, Pereira-Leal JB, Guck J, Paredes J, Janody F.

Nat Commun. 2017 May 16;8:15237. doi: 10.1038/ncomms15237.


Mechanical Strain Promotes Oligodendrocyte Differentiation by Global Changes of Gene Expression.

Jagielska A, Lowe AL, Makhija E, Wroblewska L, Guck J, Franklin RJM, Shivashankar GV, Van Vliet KJ.

Front Cell Neurosci. 2017 Apr 20;11:93. doi: 10.3389/fncel.2017.00093. eCollection 2017.


High-throughput cell mechanical phenotyping for label-free titration assays of cytoskeletal modifications.

Golfier S, Rosendahl P, Mietke A, Herbig M, Guck J, Otto O.

Cytoskeleton (Hoboken). 2017 Aug;74(8):283-296. doi: 10.1002/cm.21369. Epub 2017 Jul 18.


Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion.

Koch M, Wright KE, Otto O, Herbig M, Salinas ND, Tolia NH, Satchwell TJ, Guck J, Brooks NJ, Baum J.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4225-4230. doi: 10.1073/pnas.1620843114. Epub 2017 Apr 3.


Volume Transitions of Isolated Cell Nuclei Induced by Rapid Temperature Increase.

Chan CJ, Li W, Cojoc G, Guck J.

Biophys J. 2017 Mar 28;112(6):1063-1076. doi: 10.1016/j.bpj.2017.01.022.


Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy.

Newton VL, Guck JD, Cotter MA, Cameron NE, Gardiner NJ.

J Diabetes Res. 2017;2017:4729284. doi: 10.1155/2017/4729284. Epub 2017 Feb 15.


Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies.

Ciucci S, Ge Y, Durán C, Palladini A, Jiménez-Jiménez V, Martínez-Sánchez LM, Wang Y, Sales S, Shevchenko A, Poser SW, Herbig M, Otto O, Androutsellis-Theotokis A, Guck J, Gerl MJ, Cannistraci CV.

Sci Rep. 2017 Mar 13;7:43946. doi: 10.1038/srep43946.


Initiation of acute graft-versus-host disease by angiogenesis.

Riesner K, Shi Y, Jacobi A, Kräter M, Kalupa M, McGearey A, Mertlitz S, Cordes S, Schrezenmeier JF, Mengwasser J, Westphal S, Perez-Hernandez D, Schmitt C, Dittmar G, Guck J, Penack O.

Blood. 2017 Apr 6;129(14):2021-2032. doi: 10.1182/blood-2016-08-736314. Epub 2017 Jan 17.


V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.

Bartel K, Winzi M, Ulrich M, Koeberle A, Menche D, Werz O, Müller R, Guck J, Vollmar AM, von Schwarzenberg K.

Oncotarget. 2017 Feb 7;8(6):9476-9487. doi: 10.18632/oncotarget.14339.


Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells.

Schreck C, Istvánffy R, Ziegenhain C, Sippenauer T, Ruf F, Henkel L, Gärtner F, Vieth B, Florian MC, Mende N, Taubenberger A, Prendergast Á, Wagner A, Pagel C, Grziwok S, Götze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA.

J Exp Med. 2017 Jan;214(1):165-181. doi: 10.1084/jem.20151414. Epub 2016 Dec 20.


Mechanosensing is critical for axon growth in the developing brain.

Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan GK, Svoboda H, Viana M, Costa LD, Guck J, Holt CE, Franze K.

Nat Neurosci. 2016 Dec;19(12):1592-1598. doi: 10.1038/nn.4394. Epub 2016 Sep 19.


Chemotherapy impedes in vitro microcirculation and promotes migration of leukemic cells with impact on metastasis.

Prathivadhi-Bhayankaram SV, Ning J, Mimlitz M, Taylor C, Gross E, Nichols M, Guck J, Ekpenyong AE.

Biochem Biophys Res Commun. 2016 Oct 28;479(4):841-846. doi: 10.1016/j.bbrc.2016.09.121. Epub 2016 Sep 26.


The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512.

Mziaut H, Mulligan B, Hoboth P, Otto O, Ivanova A, Herbig M, Schumann D, Hildebrandt T, Dehghany J, Sönmez A, Münster C, Meyer-Hermann M, Guck J, Kalaidzidis Y, Solimena M.

Mol Metab. 2016 Jun 10;5(8):656-668. doi: 10.1016/j.molmet.2016.05.015. eCollection 2016 Aug.


Brain tissue stiffness is a sensitive marker for acidosis.

Holtzmann K, Gautier HO, Christ AF, Guck J, Káradóttir RT, Franze K.

J Neurosci Methods. 2016 Sep 15;271:50-4. doi: 10.1016/j.jneumeth.2016.07.002. Epub 2016 Jul 1.


A Nanoprinted Model of Interstitial Cancer Migration Reveals a Link between Cell Deformability and Proliferation.

Panagiotakopoulou M, Bergert M, Taubenberger A, Guck J, Poulikakos D, Ferrari A.

ACS Nano. 2016 Jul 26;10(7):6437-48. doi: 10.1021/acsnano.5b07406. Epub 2016 Jun 10.


Cell nuclei have lower refractive index and mass density than cytoplasm.

Schürmann M, Scholze J, Müller P, Guck J, Chan CJ.

J Biophotonics. 2016 Oct;9(10):1068-1076. doi: 10.1002/jbio.201500273. Epub 2016 Mar 24.


A pH-driven transition of the cytoplasm from a fluid- to a solid-like state promotes entry into dormancy.

Munder MC, Midtvedt D, Franzmann T, Nüske E, Otto O, Herbig M, Ulbricht E, Müller P, Taubenberger A, Maharana S, Malinovska L, Richter D, Guck J, Zaburdaev V, Alberti S.

Elife. 2016 Mar 22;5. pii: e09347. doi: 10.7554/eLife.09347.


Mechanical phenotyping of primary human skeletal stem cells in heterogeneous populations by real-time deformability cytometry.

Xavier M, Rosendahl P, Herbig M, Kräter M, Spencer D, Bornhäuser M, Oreffo RO, Morgan H, Guck J, Otto O.

Integr Biol (Camb). 2016 May 16;8(5):616-23. doi: 10.1039/c5ib00304k. Epub 2016 Mar 16.


3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments.

Taubenberger AV, Bray LJ, Haller B, Shaposhnykov A, Binner M, Freudenberg U, Guck J, Werner C.

Acta Biomater. 2016 May;36:73-85. doi: 10.1016/j.actbio.2016.03.017. Epub 2016 Mar 10.


Real-time deformability cytometry as a label-free indicator of cell function.

Otto O, Rosendahl P, Golfier S, Mietke A, Herbig M, Jacobi A, Topfner N, Herold C, Klaue D, Girardo S, Winzi M, Fischer-Friedrich E, Guck J.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:1861-4. doi: 10.1109/EMBC.2015.7318744.


Extracting Cell Stiffness from Real-Time Deformability Cytometry: Theory and Experiment.

Mietke A, Otto O, Girardo S, Rosendahl P, Taubenberger A, Golfier S, Ulbricht E, Aland S, Guck J, Fischer-Friedrich E.

Biophys J. 2015 Nov 17;109(10):2023-36. doi: 10.1016/j.bpj.2015.09.006.


ODTbrain: a Python library for full-view, dense diffraction tomography.

Müller P, Schürmann M, Guck J.

BMC Bioinformatics. 2015 Nov 4;16:367. doi: 10.1186/s12859-015-0764-0.

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