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Strand-specific Dual RNA-seq of Bronchial Epithelial cells Infected with Influenza A/H3N2 Viruses Reveals Splicing of Gene Segment 6 and Novel Host-Virus Interactions.

Fabozzi G, Oler AJ, Liu P, Chen Y, Mindaye S, Dolan MA, Kenney H, Gucek M, Zhu J, Rabin RL, Subbarao K.

J Virol. 2018 Jul 5. pii: JVI.00518-18. doi: 10.1128/JVI.00518-18. [Epub ahead of print]


Rapid Classification and Identification of Multiple Microorganisms with Accurate Statistical Significance via High-Resolution Tandem Mass Spectrometry.

Alves G, Wang G, Ogurtsov AY, Drake SK, Gucek M, Sacks DB, Yu YK.

J Am Soc Mass Spectrom. 2018 Jun 5. doi: 10.1007/s13361-018-1986-y. [Epub ahead of print]


Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes.

Ulmer BM, Stoehr A, Schulze ML, Patel S, Gucek M, Mannhardt I, Funcke S, Murphy E, Eschenhagen T, Hansen A.

Stem Cell Reports. 2018 Mar 13;10(3):834-847. doi: 10.1016/j.stemcr.2018.01.039. Epub 2018 Mar 1.


Identification and functional analysis of SOX10 phosphorylation sites in melanoma.

Cronin JC, Loftus SK, Baxter LL, Swatkoski S, Gucek M, Pavan WJ.

PLoS One. 2018 Jan 9;13(1):e0190834. doi: 10.1371/journal.pone.0190834. eCollection 2018.


MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells.

Van Itallie CM, Tietgens AJ, Aponte A, Gucek M, Cartagena-Rivera AX, Chadwick RS, Anderson JM.

J Cell Sci. 2018 Feb 2;131(3). pii: jcs210237. doi: 10.1242/jcs.210237.


GCN5L1 modulates cross-talk between mitochondria and cell signaling to regulate FoxO1 stability and gluconeogenesis.

Wang L, Scott I, Zhu L, Wu K, Han K, Chen Y, Gucek M, Sack MN.

Nat Commun. 2017 Sep 12;8(1):523. doi: 10.1038/s41467-017-00521-8.


A Genoproteomic Approach to Detect Peptide Markers of Bacterial Respiratory Pathogens.

Wang H, Drake SK, Yong C, Gucek M, Lyes MA, Rosenberg AZ, Soderblom E, Arthur Moseley M, Dekker JP, Suffredini AF.

Clin Chem. 2017 Aug;63(8):1398-1408. doi: 10.1373/clinchem.2016.269647. Epub 2017 Jun 6.


Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.

Freeman LA, Demosky SJ Jr, Konaklieva M, Kuskovsky R, Aponte A, Ossoli AF, Gordon SM, Koby RF, Manthei KA, Shen M, Vaisman BL, Shamburek RD, Jadhav A, Calabresi L, Gucek M, Tesmer JJG, Levine RL, Remaley AT.

J Pharmacol Exp Ther. 2017 Aug;362(2):306-318. doi: 10.1124/jpet.117.240457. Epub 2017 Jun 2.


Peptide Markers for Rapid Detection of KPC Carbapenemase by LC-MS/MS.

Wang H, Drake SK, Youn JH, Rosenberg AZ, Chen Y, Gucek M, Suffredini AF, Dekker JP.

Sci Rep. 2017 May 31;7(1):2531. doi: 10.1038/s41598-017-02749-2.


Peptide affinity analysis of proteins that bind to an unstructured region containing the transactivating domain of the osmoprotective transcription factor NFAT5.

Dumond JF, Zhang X, Izumi Y, Ramkissoon K, Wang G, Gucek M, Wang X, Burg MB, Ferraris JD.

Physiol Genomics. 2016 Nov 1;48(11):835-849. doi: 10.1152/physiolgenomics.00100.2016. Epub 2016 Oct 7.


Structural Insights into Substrate Recognition and Catalysis in Outer Membrane Protein B (OmpB) by Protein-lysine Methyltransferases from Rickettsia.

Abeykoon AH, Noinaj N, Choi BE, Wise L, He Y, Chao CC, Wang G, Gucek M, Ching WM, Chock PB, Buchanan SK, Yang DC.

J Biol Chem. 2016 Sep 16;291(38):19962-74. doi: 10.1074/jbc.M116.723460. Epub 2016 Jul 29.


A Novel Peptidomic Approach to Strain Typing of Clinical Acinetobacter baumannii Isolates Using Mass Spectrometry.

Wang H, Drake SK, Yong C, Gucek M, Tropea M, Rosenberg AZ, Dekker JP, Suffredini AF.

Clin Chem. 2016 Jun;62(6):866-75. doi: 10.1373/clinchem.2015.253468. Epub 2016 Apr 26.


Prolyl hydroxylation regulates protein degradation, synthesis, and splicing in human induced pluripotent stem cell-derived cardiomyocytes.

Stoehr A, Yang Y, Patel S, Evangelista AM, Aponte A, Wang G, Liu P, Boylston J, Kloner PH, Lin Y, Gucek M, Zhu J, Murphy E.

Cardiovasc Res. 2016 Jun 1;110(3):346-58. doi: 10.1093/cvr/cvw081. Epub 2016 Apr 19.


The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication.

Zhang Y, Chen Y, Gucek M, Xu H.

EMBO J. 2016 May 17;35(10):1045-57. doi: 10.15252/embj.201592994. Epub 2016 Apr 6.


Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation.

Sun J, Aponte AM, Menazza S, Gucek M, Steenbergen C, Murphy E.

Cardiovasc Res. 2016 May 1;110(1):96-106. doi: 10.1093/cvr/cvw037. Epub 2016 Feb 17.


Identification of Microorganisms by High Resolution Tandem Mass Spectrometry with Accurate Statistical Significance.

Alves G, Wang G, Ogurtsov AY, Drake SK, Gucek M, Suffredini AF, Sacks DB, Yu YK.

J Am Soc Mass Spectrom. 2016 Feb;27(2):194-210. doi: 10.1007/s13361-015-1271-2. Epub 2015 Oct 28.


Molecular Signature of Nitroso-Redox Balance in Idiopathic Dilated Cardiomyopathies.

Menazza S, Aponte A, Sun J, Gucek M, Steenbergen C, Murphy E.

J Am Heart Assoc. 2015 Sep 22;4(9):e002251. doi: 10.1161/JAHA.115.002251.


Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury.

Boylston JA, Sun J, Chen Y, Gucek M, Sack MN, Murphy E.

J Mol Cell Cardiol. 2015 Nov;88:73-81. doi: 10.1016/j.yjmcc.2015.09.005. Epub 2015 Sep 24.


A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.

Dai C, Yao X, Gordon EM, Barochia A, Cuento RA, Kaler M, Meyer KS, Keeran KJ, Nugent GZ, Jeffries KR, Qu X, Yu ZX, Aponte A, Gucek M, Dagur PK, McCoy JP, Levine SJ.

Mucosal Immunol. 2016 May;9(3):702-17. doi: 10.1038/mi.2015.94. Epub 2015 Sep 16.


Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.

Chung YW, Lagranha C, Chen Y, Sun J, Tong G, Hockman SC, Ahmad F, Esfahani SG, Bae DH, Polidovitch N, Wu J, Rhee DK, Lee BS, Gucek M, Daniels MP, Brantner CA, Backx PH, Murphy E, Manganiello VC.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2253-62. doi: 10.1073/pnas.1416230112. Epub 2015 Apr 15.


Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.

Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu D, Smith JL, Yuen G, Yue J, Ann DK, Simpson RM, Creighton CJ, Figg WD, Gucek M, Luo J.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1724-33. doi: 10.1073/pnas.1415569112. Epub 2015 Mar 24.


Exosomes released from breast cancer carcinomas stimulate cell movement.

Harris DA, Patel SH, Gucek M, Hendrix A, Westbroek W, Taraska JW.

PLoS One. 2015 Mar 23;10(3):e0117495. doi: 10.1371/journal.pone.0117495. eCollection 2015.


Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks.

Fredriksson K, Van Itallie CM, Aponte A, Gucek M, Tietgens AJ, Anderson JM.

PLoS One. 2015 Mar 19;10(3):e0117074. doi: 10.1371/journal.pone.0117074. eCollection 2015.


A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice.

Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H.

Cell Metab. 2015 Mar 3;21(3):455-67. doi: 10.1016/j.cmet.2015.02.004.


Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network.

Artym VV, Swatkoski S, Matsumoto K, Campbell CB, Petrie RJ, Dimitriadis EK, Li X, Mueller SC, Bugge TH, Gucek M, Yamada KM.

J Cell Biol. 2015 Feb 2;208(3):331-50. doi: 10.1083/jcb.201405099.


Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.

Lu Z, Chen Y, Aponte AM, Battaglia V, Gucek M, Sack MN.

J Biol Chem. 2015 Jan 23;290(4):2466-76. doi: 10.1074/jbc.M114.606228. Epub 2014 Dec 12.


Reply to "Tn4401 carrying blaKPC is inserted within another insertion in pKpQIL and related plasmids".

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Dec;52(12):4450. doi: 10.1128/JCM.02614-14. No abstract available.


Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain.

Han MH, Hu Z, Chen CY, Chen Y, Gucek M, Li Z, Markey SP.

J Proteome Res. 2014 Nov 7;13(11):4567-80. doi: 10.1021/pr500656z. Epub 2014 Sep 19.


Global discovery of high-NaCl-induced changes of protein phosphorylation.

Wang R, Ferraris JD, Izumi Y, Dmitrieva N, Ramkissoon K, Wang G, Gucek M, Burg MB.

Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C442-54. doi: 10.1152/ajpcell.00379.2013. Epub 2014 Jun 25.


A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single-plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae.

Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP.

J Clin Microbiol. 2014 Aug;52(8):2804-12. doi: 10.1128/JCM.00694-14. Epub 2014 May 21.


Biochemical and biological properties of cortexillin III, a component of Dictyostelium DGAP1-cortexillin complexes.

Liu X, Shu S, Yu S, Lee DY, Piszczek G, Gucek M, Wang G, Korn ED.

Mol Biol Cell. 2014 Jul 1;25(13):2026-38. doi: 10.1091/mbc.E13-08-0457. Epub 2014 May 7.


PhosSA: Fast and accurate phosphorylation site assignment algorithm for mass spectrometry data.

Saeed F, Pisitkun T, Hoffert JD, Rashidian S, Wang G, Gucek M, Knepper MA.

Proteome Sci. 2013 Nov 7;11(Suppl 1):S14. doi: 10.1186/1477-5956-11-S1-S14. Epub 2013 Nov 7.


Multimethylation of Rickettsia OmpB catalyzed by lysine methyltransferases.

Abeykoon A, Wang G, Chao CC, Chock PB, Gucek M, Ching WM, Yang DC.

J Biol Chem. 2014 Mar 14;289(11):7691-701. doi: 10.1074/jbc.M113.535567. Epub 2014 Feb 4.


Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion.

Van Itallie CM, Tietgens AJ, Aponte A, Fredriksson K, Fanning AS, Gucek M, Anderson JM.

J Cell Sci. 2014 Feb 15;127(Pt 4):885-95. doi: 10.1242/jcs.140475. Epub 2013 Dec 11.


The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T.

Nat Cell Biol. 2013 Dec;15(12):1464-72. doi: 10.1038/ncb2868. Epub 2013 Nov 10.


Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.

Klebba JE, Buster DW, Nguyen AL, Swatkoski S, Gucek M, Rusan NM, Rogers GC.

Curr Biol. 2013 Nov 18;23(22):2255-2261. doi: 10.1016/j.cub.2013.09.019. Epub 2013 Oct 31.


Cyclophilin D modulates mitochondrial acetylome.

Nguyen TT, Wong R, Menazza S, Sun J, Chen Y, Wang G, Gucek M, Steenbergen C, Sack MN, Murphy E.

Circ Res. 2013 Dec 6;113(12):1308-19. doi: 10.1161/CIRCRESAHA.113.301867. Epub 2013 Sep 23.


The novel caspase-3 substrate Gap43 is involved in AMPA receptor endocytosis and long-term depression.

Han MH, Jiao S, Jia JM, Chen Y, Chen CY, Gucek M, Markey SP, Li Z.

Mol Cell Proteomics. 2013 Dec;12(12):3719-31. doi: 10.1074/mcp.M113.030676. Epub 2013 Sep 10.


Restricted mitochondrial protein acetylation initiates mitochondrial autophagy.

Webster BR, Scott I, Han K, Li JH, Lu Z, Stevens MV, Malide D, Chen Y, Samsel L, Connelly PS, Daniels MP, McCoy JP Jr, Combs CA, Gucek M, Sack MN.

J Cell Sci. 2013 Nov 1;126(Pt 21):4843-9. doi: 10.1242/jcs.131300. Epub 2013 Sep 4.


Proteomic serum profile of fatigued men receiving localized external beam radiation therapy for non-metastatic prostate cancer.

Lukkahatai N, Patel S, Gucek M, Hsiao CP, Saligan LN.

J Pain Symptom Manage. 2014 Apr;47(4):748-756.e4. doi: 10.1016/j.jpainsymman.2013.05.016. Epub 2013 Jul 31.


Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.

Um JH, Brown AL, Singh SK, Chen Y, Gucek M, Lee BS, Luckey MA, Kim MK, Park JH, Sleckman BP, Gellert M, Chung JH.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9873-8. doi: 10.1073/pnas.1307928110. Epub 2013 May 28.


High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase.

Topanurak S, Ferraris JD, Li J, Izumi Y, Williams CK, Gucek M, Wang G, Zhou X, Burg MB.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7482-7. doi: 10.1073/pnas.1305220110. Epub 2013 Apr 15.


The N and C termini of ZO-1 are surrounded by distinct proteins and functional protein networks.

Van Itallie CM, Aponte A, Tietgens AJ, Gucek M, Fredriksson K, Anderson JM.

J Biol Chem. 2013 May 10;288(19):13775-88. doi: 10.1074/jbc.M113.466193. Epub 2013 Apr 3.


Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans.

Yu P, Pisitkun T, Wang G, Wang R, Katagiri Y, Gucek M, Knepper MA, Geller HM.

PLoS One. 2013;8(3):e59285. doi: 10.1371/journal.pone.0059285. Epub 2013 Mar 18.


An Efficient Dynamic Programming Algorithm for Phosphorylation Site Assignment of Large-Scale Mass Spectrometry Data.

Saeed F, Pisitkun T, Hoffert JD, Wang G, Gucek M, Knepper MA.

Proceedings (IEEE Int Conf Bioinformatics Biomed). 2012 Oct 4:618-625.


CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism.

Menazza S, Wong R, Nguyen T, Wang G, Gucek M, Murphy E.

J Mol Cell Cardiol. 2013 Mar;56:81-90. doi: 10.1016/j.yjmcc.2012.12.004. Epub 2012 Dec 19.


Proteomics approaches to fibrotic disorders.

Gucek M.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S10. doi: 10.1186/1755-1536-5-S1-S10. eCollection 2012.


Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.

Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo J.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3659-67. doi: 10.1073/pnas.1207673110. Epub 2012 Dec 10.


The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.

Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T.

Nature. 2012 Dec 13;492(7428):199-204. doi: 10.1038/nature11700. Epub 2012 Nov 28. Retraction in: Nature. 2014 Feb 27;506(7489):516.


Two protein lysine methyltransferases methylate outer membrane protein B from Rickettsia.

Abeykoon AH, Chao CC, Wang G, Gucek M, Yang DC, Ching WM.

J Bacteriol. 2012 Dec;194(23):6410-8. doi: 10.1128/JB.01379-12. Epub 2012 Sep 21.

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