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Items: 1 to 50 of 72

1.

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E.

Cancer Cell. 2019 Aug 12;36(2):194-209.e9. doi: 10.1016/j.ccell.2019.07.003.

PMID:
31408619
2.

Author Correction: The regulation, functions and clinical relevance of arginine methylation.

Guccione E, Richard S.

Nat Rev Mol Cell Biol. 2019 Sep;20(9):567. doi: 10.1038/s41580-019-0166-7.

PMID:
31375791
3.

The role of GRHL2 and epigenetic remodeling in epithelial-mesenchymal plasticity in ovarian cancer cells.

Chung VY, Tan TZ, Ye J, Huang RL, Lai HC, Kappei D, Wollmann H, Guccione E, Huang RY.

Commun Biol. 2019 Jul 24;2:272. doi: 10.1038/s42003-019-0506-3. eCollection 2019.

4.

The regulation, functions and clinical relevance of arginine methylation.

Guccione E, Richard S.

Nat Rev Mol Cell Biol. 2019 Jul 26. doi: 10.1038/s41580-019-0155-x. [Epub ahead of print] Review. Erratum in: Nat Rev Mol Cell Biol. 2019 Sep;20(9):567.

PMID:
31350521
5.

CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.

Palmer N, Talib SZA, Ratnacaram CK, Low D, Bisteau X, Lee JHS, Pfeiffenberger E, Wollmann H, Tan JHL, Wee S, Sobota R, Gunaratne J, Messerschmidt DM, Guccione E, Kaldis P.

J Cell Biol. 2019 Jul 26. pii: jcb.201903125. doi: 10.1083/jcb.201903125. [Epub ahead of print]

PMID:
31350280
6.

Phenotype-based screens with conformation-specific inhibitors reveal p38 gamma and delta as targets for HCC polypharmacology.

Yu JX, Craig AJ, Duffy ME, Villacorta-Martin C, Miguela V, Ruiz de Galarreta M, Scopton AP, Silber L, Maldonado AY, Rialdi A, Guccione E, Lujambio A, Villanueva A, Dar AC.

Mol Cancer Ther. 2019 Jun 18. pii: molcanther.0571.2018. doi: 10.1158/1535-7163.MCT-18-0571. [Epub ahead of print]

PMID:
31213506
7.

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity.

Musiani D, Bok J, Massignani E, Wu L, Tabaglio T, Ippolito MR, Cuomo A, Ozbek U, Zorgati H, Ghoshdastider U, Robinson RC, Guccione E, Bonaldi T.

Sci Signal. 2019 Apr 2;12(575). pii: eaat8388. doi: 10.1126/scisignal.aat8388.

PMID:
30940768
8.

The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.

Seah MKY, Wang Y, Goy PA, Loh HM, Peh WJ, Low DHP, Han BY, Wong E, Leong EL, Wolf G, Mzoughi S, Wollmann H, Macfarlan TS, Guccione E, Messerschmidt DM.

Development. 2019 Jul 10;146(19). pii: dev170266. doi: 10.1242/dev.170266.

9.

Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma.

Bhat AV, Palanichamy Kala M, Rao VK, Pignata L, Lim HJ, Suriyamurthy S, Chang KT, Lee VK, Guccione E, Taneja R.

Cancer Res. 2019 May 1;79(9):2232-2243. doi: 10.1158/0008-5472.CAN-18-2676. Epub 2019 Mar 4.

PMID:
30833420
10.

Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

Tan AT, Yang N, Lee Krishnamoorthy T, Oei V, Chua A, Zhao X, Tan HS, Chia A, Le Bert N, Low D, Tan HK, Kumar R, Irani FG, Ho ZZ, Zhang Q, Guccione E, Wai LE, Koh S, Hwang W, Chow WC, Bertoletti A.

Gastroenterology. 2019 May;156(6):1862-1876.e9. doi: 10.1053/j.gastro.2019.01.251. Epub 2019 Jan 31.

11.

MBNL1 alternative splicing isoforms play opposing roles in cancer.

Tabaglio T, Low DH, Teo WKL, Goy PA, Cywoniuk P, Wollmann H, Ho J, Tan D, Aw J, Pavesi A, Sobczak K, Wee DKB, Guccione E.

Life Sci Alliance. 2018 Sep 7;1(5):e201800157. doi: 10.26508/lsa.201800157. eCollection 2018 Oct.

12.

Influenza virus infection causes global RNAPII termination defects.

Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I.

Nat Struct Mol Biol. 2018 Sep;25(9):885-893. doi: 10.1038/s41594-018-0124-7. Epub 2018 Sep 3.

PMID:
30177761
13.

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Bonday ZQ, Cortez GS, Grogan MJ, Antonysamy S, Weichert K, Bocchinfuso WP, Li F, Kennedy S, Li B, Mader MM, Arrowsmith CH, Brown PJ, Eram MS, Szewczyk MM, Barsyte-Lovejoy D, Vedadi M, Guccione E, Campbell RM.

ACS Med Chem Lett. 2018 Apr 23;9(7):612-617. doi: 10.1021/acsmedchemlett.8b00014. eCollection 2018 Jul 12.

14.

PRMT5-mediated regulation of developmental myelination.

Scaglione A, Patzig J, Liang J, Frawley R, Bok J, Mela A, Yattah C, Zhang J, Teo SX, Zhou T, Chen S, Bernstein E, Canoll P, Guccione E, Casaccia P.

Nat Commun. 2018 Jul 19;9(1):2840. doi: 10.1038/s41467-018-04863-9.

15.

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J.

Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007.

16.

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.

Chiang K, Zielinska AE, Shaaban AM, Sanchez-Bailon MP, Jarrold J, Clarke TL, Zhang J, Francis A, Jones LJ, Smith S, Barbash O, Guccione E, Farnie G, Smalley MJ, Davies CC.

Cell Rep. 2017 Dec 19;21(12):3498-3513. doi: 10.1016/j.celrep.2017.11.096.

17.

Chromatin dependencies in cancer and inflammation.

Marazzi I, Greenbaum BD, Low DHP, Guccione E.

Nat Rev Mol Cell Biol. 2018 Apr;19(4):245-261. doi: 10.1038/nrm.2017.113. Epub 2017 Nov 29. Review.

PMID:
29184195
18.

Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability.

Guccione EJ, Kendall JJ, Hitchcock A, Garg N, White MA, Mulholland F, Poole RK, Kelly DJ.

Environ Microbiol. 2017 Oct;19(10):4326-4348. doi: 10.1111/1462-2920.13930. Epub 2017 Oct 2.

19.

Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.

20.

PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling.

Mzoughi S, Zhang J, Hequet D, Teo SX, Fang H, Xing QR, Bezzi M, Seah MKY, Ong SLM, Shin EM, Wollmann H, Wong ESM, Al-Haddawi M, Stewart CL, Tergaonkar V, Loh YH, Dunn NR, Messerschmidt DM, Guccione E.

Nat Genet. 2017 Sep;49(9):1354-1363. doi: 10.1038/ng.3922. Epub 2017 Jul 24.

PMID:
28740264
21.

Emi2 Is Essential for Mouse Spermatogenesis.

Gopinathan L, Szmyd R, Low D, Diril MK, Chang HY, Coppola V, Liu K, Tessarollo L, Guccione E, van Pelt AMM, Kaldis P.

Cell Rep. 2017 Jul 18;20(3):697-708. doi: 10.1016/j.celrep.2017.06.033.

22.

[Androgen receptors in breast cancer: Expression, value and therapeutic prospects].

Héquet D, Mzoughi S, Rouzier R, Guccione E.

Bull Cancer. 2017 Apr;104(4):363-369. doi: 10.1016/j.bulcan.2017.01.005. Epub 2017 Feb 16. Review. French.

PMID:
28216075
23.

Discovery and characterisation of the automethylation properties of PRDM9.

Koh-Stenta X, Poulsen A, Li R, Wee JL, Kwek PZ, Chew SY, Peng J, Wu L, Guccione E, Joy J, Hill J.

Biochem J. 2017 Mar 7;474(6):971-982. doi: 10.1042/BCJ20161067.

PMID:
28126738
24.

Loss of maternal Trim28 causes male-predominant early embryonic lethality.

Sampath Kumar A, Seah MK, Ling KY, Wang Y, Tan JH, Nitsch S, Lim SL, Lorthongpanich C, Wollmann H, Low DH, Guccione E, Messerschmidt DM.

Genes Dev. 2017 Jan 1;31(1):12-17. doi: 10.1101/gad.291195.116. Epub 2017 Jan 23.

25.

Histone arginine methylation in cocaine action in the nucleus accumbens.

Damez-Werno DM, Sun H, Scobie KN, Shao N, Rabkin J, Dias C, Calipari ES, Maze I, Pena CJ, Walker DM, Cahill ME, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis CD, Guccione E, Turecki G, Defilippi P, Neve RL, Hurd YL, Shen L, Nestler EJ.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.

26.

The role of PRDMs in cancer: one family, two sides.

Mzoughi S, Tan YX, Low D, Guccione E.

Curr Opin Genet Dev. 2016 Feb;36:83-91. doi: 10.1016/j.gde.2016.03.009. Epub 2016 May 7. Review.

PMID:
27153352
27.

GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification.

Chung VY, Tan TZ, Tan M, Wong MK, Kuay KT, Yang Z, Ye J, Muller J, Koh CM, Guccione E, Thiery JP, Huang RY.

Sci Rep. 2016 Feb 18;6:19943. doi: 10.1038/srep19943.

28.

Targeting MYC in cancer therapy: RNA processing offers new opportunities.

Koh CM, Sabò A, Guccione E.

Bioessays. 2016 Mar;38(3):266-75. doi: 10.1002/bies.201500134. Epub 2016 Jan 18. Review.

29.

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.

Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo SX, Low DH, Koh CM, Rambow F, Fiers M, Rogiers A, Radaelli E, Al-Haddawi M, Tan SY, Hermans E, Amant F, Yan H, Lakshmanan M, Koumar RC, Lim ST, Derheimer FA, Campbell RM, Bonday Z, Tergaonkar V, Shackleton M, Blattner C, Marine JC, Guccione E.

J Clin Invest. 2016 Jan;126(1):68-84. doi: 10.1172/JCI82534. Epub 2015 Nov 23.

30.

Transcription and imprinting dynamics in developing postnatal male germline stem cells.

Hammoud SS, Low DH, Yi C, Lee CL, Oatley JM, Payne CJ, Carrell DT, Guccione E, Cairns BR.

Genes Dev. 2015 Nov 1;29(21):2312-24. doi: 10.1101/gad.261925.115.

31.

Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress.

Giannakakis A, Zhang J, Jenjaroenpun P, Nama S, Zainolabidin N, Aau MY, Yarmishyn AA, Vaz C, Ivshina AV, Grinchuk OV, Voorhoeve M, Vardy LA, Sampath P, Kuznetsov VA, Kurochkin IV, Guccione E.

Sci Rep. 2015 May 29;5:9737. doi: 10.1038/srep09737.

32.

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis.

Koh CM, Bezzi M, Low DH, Ang WX, Teo SX, Gay FP, Al-Haddawi M, Tan SY, Osato M, Sabò A, Amati B, Wee KB, Guccione E.

Nature. 2015 Jul 2;523(7558):96-100. doi: 10.1038/nature14351. Epub 2015 May 11.

PMID:
25970242
33.

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity.

Koh CM, Khattar E, Leow SC, Liu CY, Muller J, Ang WX, Li Y, Franzoso G, Li S, Guccione E, Tergaonkar V.

J Clin Invest. 2015 May;125(5):2109-22. doi: 10.1172/JCI79134. Epub 2015 Apr 20.

34.

Nasal Inoculation of the Commensal Neisseria lactamica Inhibits Carriage of Neisseria meningitidis by Young Adults: A Controlled Human Infection Study.

Deasy AM, Guccione E, Dale AP, Andrews N, Evans CM, Bennett JS, Bratcher HB, Maiden MC, Gorringe AR, Read RC.

Clin Infect Dis. 2015 May 15;60(10):1512-20. doi: 10.1093/cid/civ098. Epub 2015 Mar 25.

PMID:
25814628
35.

Trained immunity in newborn infants of HBV-infected mothers.

Hong M, Sandalova E, Low D, Gehring AJ, Fieni S, Amadei B, Urbani S, Chong YS, Guccione E, Bertoletti A.

Nat Commun. 2015 Mar 25;6:6588. doi: 10.1038/ncomms7588.

36.

Modeling cerebrovascular pathophysiology in amyloid-β metabolism using neural-crest-derived smooth muscle cells.

Cheung C, Goh YT, Zhang J, Wu C, Guccione E.

Cell Rep. 2014 Oct 9;9(1):391-401. doi: 10.1016/j.celrep.2014.08.065. Epub 2014 Oct 2.

37.

Multiplexed analysis of protein-ligand interactions by fluorescence anisotropy in a microfluidic platform.

Cheow LF, Viswanathan R, Chin CS, Jennifer N, Jones RC, Guccione E, Quake SR, Burkholder WF.

Anal Chem. 2014 Oct 7;86(19):9901-8. doi: 10.1021/ac502605f. Epub 2014 Sep 25.

PMID:
25207435
38.

Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.

Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M, Verrecchia A, Tonelli C, Fagà G, Bianchi V, Ronchi A, Low D, Müller H, Guccione E, Campaner S, Amati B.

Nature. 2014 Jul 24;511(7510):488-492. doi: 10.1038/nature13537. Epub 2014 Jul 9.

39.

NUCKS is a positive transcriptional regulator of insulin signaling.

Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akıncılar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W, Tergaonkar V.

Cell Rep. 2014 Jun 26;7(6):1876-86. doi: 10.1016/j.celrep.2014.05.030. Epub 2014 Jun 12.

40.

Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis.

Hammoud SS, Low DH, Yi C, Carrell DT, Guccione E, Cairns BR.

Cell Stem Cell. 2014 Aug 7;15(2):239-53. doi: 10.1016/j.stem.2014.04.006. Epub 2014 May 15.

41.

The core and conserved role of MAL is homeostatic regulation of actin levels.

Salvany L, Muller J, Guccione E, Rørth P.

Genes Dev. 2014 May 15;28(10):1048-53. doi: 10.1101/gad.237743.114.

42.

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.

Koh-Stenta X, Joy J, Poulsen A, Li R, Tan Y, Shim Y, Min JH, Wu L, Ngo A, Peng J, Seetoh WG, Cao J, Wee JL, Kwek PZ, Hung A, Lakshmanan U, Flotow H, Guccione E, Hill J.

Biochem J. 2014 Jul 15;461(2):323-34. doi: 10.1042/BJ20140374.

PMID:
24785241
43.

Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line.

Loh SL, Teh C, Muller J, Guccione E, Hong W, Korzh V.

Sci Rep. 2014 Mar 6;4:4289. doi: 10.1038/srep04289.

44.

Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.

Wang X, Zhao Z, Muller J, Iyu A, Khng AJ, Guccione E, Ruan Y, Ingham PW.

Biol Open. 2013 Sep 9;2(11):1203-13. doi: 10.1242/bio.20136262. eCollection 2013.

45.

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME.

Cell Rep. 2013 Nov 14;5(3):687-701. doi: 10.1016/j.celrep.2013.09.044. Epub 2013 Oct 31.

46.

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery.

Bezzi M, Teo SX, Muller J, Mok WC, Sahu SK, Vardy LA, Bonday ZQ, Guccione E.

Genes Dev. 2013 Sep 1;27(17):1903-16. doi: 10.1101/gad.219899.113.

47.

PRMT5 modulates the metabolic response to fasting signals.

Tsai WW, Niessen S, Goebel N, Yates JR 3rd, Guccione E, Montminy M.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8870-5. doi: 10.1073/pnas.1304602110. Epub 2013 May 13.

48.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.

Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.

49.

p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.

Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok WC, Low DH, Thike AA, Kuznetsov VA, Tan PH, Voorhoeve PM, Guccione E.

Nucleic Acids Res. 2012 Oct;40(19):9534-42. doi: 10.1093/nar/gks858. Epub 2012 Sep 16.

50.

Hairless promotes PPARγ expression and is required for white adipogenesis.

Kumpf S, Mihlan M, Goginashvili A, Grandl G, Gehart H, Godel A, Schmidt J, Müller J, Bezzi M, Ittner A, Guccione E, Wolfrum C, Ricci R.

EMBO Rep. 2012 Nov 6;13(11):1012-20. doi: 10.1038/embor.2012.133. Epub 2012 Sep 11.

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