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Items: 1 to 50 of 78

1.

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.

Tobias AM, Toska D, Lange K, Eck T, Bhat R, Janson CA, Rotella DP, Gubler U, Goodey NM.

PLoS One. 2018 May 22;13(5):e0197173. doi: 10.1371/journal.pone.0197173. eCollection 2018.

2.

Expression, purification and enzymatic characterization of Brugia malayi dihydrofolate reductase.

Perez-Abraham R, Sanchez KG, Alfonso M, Gubler U, Siekierka JJ, Goodey NM.

Protein Expr Purif. 2016 Dec;128:81-5. doi: 10.1016/j.pep.2016.08.012. Epub 2016 Aug 18.

PMID:
27544923
3.

Allosteric antibody inhibition of human hepsin protease.

Koschubs T, Dengl S, Dürr H, Kaluza K, Georges G, Hartl C, Jennewein S, Lanzendörfer M, Auer J, Stern A, Huang KS, Packman K, Gubler U, Kostrewa D, Ries S, Hansen S, Kohnert U, Cramer P, Mundigl O.

Biochem J. 2012 Mar 15;442(3):483-94. doi: 10.1042/BJ20111317.

PMID:
22132769
4.

Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.

Goodnow RA Jr, Hicks A, Sidduri A, Kowalczyk A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Tilley J, Cohen N, Choudhry S, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Tare NS, Oh H, Lamb M, Kurylko G, Hamid R, Wright MB, Pamidimukkala A, Egan T, Gubler U, Hoffman AF, Wei X, Li YL, O'Neil J, Marcano R, Pozzani K, Molinaro T, Santiago J, Singer L, Hargaden M, Moore D, Catala AR, Chao LC, Hermann G, Venkat R, Mancebo H, Renzetti LM.

J Med Chem. 2010 May 13;53(9):3502-16. doi: 10.1021/jm1001919.

PMID:
20380377
5.

Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates.

Hicks A, Goodnow R Jr, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Lora JM, Satjawatcharaphong J, Brovarney M, Dabbagh K, Tare NS, Oh H, Lamb M, Sidduri A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Kowalczyk A, Kurylko G, Hamid R, Wright MB, Pamidimukkala A, Egan T, Gubler U, Hoffman AF, Wei X, Li YL, O'Neil J, Marcano R, Pozzani K, Molinaro T, Santiago J, Singer L, Hargaden M, Moore D, Catala AR, Chao LC, Benson J, March T, Venkat R, Mancebo H, Renzetti LM.

Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):33-43. doi: 10.1016/j.prostaglandins.2010.02.003. Epub 2010 Mar 7.

PMID:
20214997
6.

Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.

Robinson RT, Khader SA, Martino CA, Fountain JJ, Teixeira-Coelho M, Pearl JE, Smiley ST, Winslow GM, Woodland DL, Walter MJ, Conejo-Garcia JR, Gubler U, Cooper AM.

J Exp Med. 2010 Mar 15;207(3):591-605. doi: 10.1084/jem.20091085. Epub 2010 Mar 8. Erratum in: J Exp Med. 2010 Apr 12;207(4):897.

7.

Scaling law for second-order hyperpolarizability in poly(triacetylene) molecular wires.

Gubler U, Bosshard C, Günter P, Balakina MY, Cornil J, Brédas JL, Martin RE, Diederich F.

Opt Lett. 1999 Nov 15;24(22):1599-601.

PMID:
18079876
8.

Photochromic polymers for the optical homodyne detection of ultrasonic surface displacements.

Gubler U, Wright D, Moerner WE, Klein MB.

Opt Lett. 2002 Mar 1;27(5):354-6.

PMID:
18007801
9.

A place for high-throughput electrophysiology in cardiac safety: screening hERG cell lines and novel compounds with the ion works HTTM system.

Guthrie H, Livingston FS, Gubler U, Garippa R.

J Biomol Screen. 2005 Dec;10(8):832-40. Epub 2005 Oct 18.

PMID:
16234341
10.

Optical waveguides structured with photoaligning polymers.

Stump A, Gubler U, Bosshard C.

Opt Lett. 2005 Jun 1;30(11):1333-5.

PMID:
15981524
11.

Optical materials: A new twist for nonlinear optics.

Gubler U, Bosshard C.

Nat Mater. 2002 Dec;1(4):209-10. No abstract available.

PMID:
12618776
12.

Pt-tetraethynylethene molecular scaffolding: synthesis and characterization of a novel class of organometallic molecular rods.

Siemsen P, Gubler U, Bosshard C, Günter P, Diederich F.

Chemistry. 2001 Mar 16;7(6):1333-41.

PMID:
11322561
13.

Synthesis and physical investigation of donor-donor and acceptor-acceptor end-functionalized monodisperse poly(triacetylene) oligomers.

Martin RE, Gubler U, Boudon C, Bosshard C, Gisselbrecht JP, Günter P, Gross M, Diederich F.

Chemistry. 2000 Dec 1;6(23):4400-12.

PMID:
11140971
14.

Monodisperse poly(triacetylene) oligomers extending from monomer to hexadecamer: joint experimental and theoretical investigation of physical properties

Martin RE, Gubler U, Cornil J, Balakina M, Boudon C, Bosshard C, Gisselbrecht JP, Diederich F, Gunter P, Gross M, Bredas JL.

Chemistry. 2000 Oct 2;6(19):3622-35.

PMID:
11072828
15.

T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases.

Murphy KM, Ouyang W, Szabo SJ, Jacobson NG, Guler ML, Gorham JD, Gubler U, Murphy TL.

Curr Top Microbiol Immunol. 1999;238:13-26. Review.

PMID:
10087648
16.

Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.

Gorham JD, Güler ML, Fenoglio D, Gubler U, Murphy KM.

J Immunol. 1998 Aug 15;161(4):1664-70.

17.

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses.

Gately MK, Renzetti LM, Magram J, Stern AS, Adorini L, Gubler U, Presky DH.

Annu Rev Immunol. 1998;16:495-521. Review.

PMID:
9597139
18.

Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex.

Presky DH, Minetti LJ, Gillessen S, Wilkinson VL, Wu CY, Gubler U, Chizzonite R, Gately MK.

J Immunol. 1998 Mar 1;160(5):2174-9.

19.
20.

Selective expression of an interleukin-12 receptor component by human T helper 1 cells.

Rogge L, Barberis-Maino L, Biffi M, Passini N, Presky DH, Gubler U, Sinigaglia F.

J Exp Med. 1997 Mar 3;185(5):825-31.

21.
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23.

Regulation of IL-12 receptor expression in early T-helper responses implies two phases of Th1 differentiation: capacitance and development.

Murphy KM, Murphy TL, Szabo SJ, Jacobson NG, Guler ML, Gorham JD, Gubler U.

Chem Immunol. 1997;68:54-69. Review. No abstract available.

PMID:
9329216
24.

Structural and functional aspects of the IL-12 receptor complex.

Stern AS, Gubler U, Presky DH, Magram J.

Chem Immunol. 1997;68:23-37. Review. No abstract available.

PMID:
9329214
25.

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, Wu CY, Gately MK, Gubler U.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14002-7.

26.

Evidence for multiple sites of interaction between IL-12 and its receptor.

Presky DH, Minetti LJ, Gillessen S, Gubler U, Chizzonite R, Stern AS, Gately MK.

Ann N Y Acad Sci. 1996 Oct 31;795:390-3.

PMID:
8958964
27.

Molecular biology of interleukin-12 receptors.

Gubler U, Presky DH.

Ann N Y Acad Sci. 1996 Oct 31;795:36-40.

PMID:
8958915
28.

Low-Temperature Thermodynamic and Thermal-Transport Properties of Decagonal Al65Cu20Co15.

Edagawa K, Chernikov MA, Bianchi AD, Felder E, Gubler U, Ott HR.

Phys Rev Lett. 1996 Aug 5;77(6):1071-1074. No abstract available.

PMID:
10062983
29.

Biological function and distribution of human interleukin-12 receptor beta chain.

Wu CY, Warrier RR, Carvajal DM, Chua AO, Minetti LJ, Chizzonite R, Mongini PK, Stern AS, Gubler U, Presky DH, Gately MK.

Eur J Immunol. 1996 Feb;26(2):345-50.

PMID:
8617302
30.

Cloning and characterization of a mouse IL-12 receptor-beta component.

Chua AO, Wilkinson VL, Presky DH, Gubler U.

J Immunol. 1995 Nov 1;155(9):4286-94.

PMID:
7594587
31.

IL12 receptors and receptor antagonists.

Presky DH, Gubler U, Chizzonite RA, Gately MK.

Res Immunol. 1995 Sep-Oct;146(7-8):439-45. Review. No abstract available.

PMID:
8839143
32.

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

Tahara H, Zitvogel L, Storkus WJ, Zeh HJ 3rd, McKinney TG, Schreiber RD, Gubler U, Robbins PD, Lotze MT.

J Immunol. 1995 Jun 15;154(12):6466-74.

PMID:
7759882
33.

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM.

Immunity. 1995 Jun;2(6):665-75.

34.

Structure-function analysis of the p35 subunit of mouse interleukin 12.

Zou JJ, Schoenhaut DS, Carvajal DM, Warrier RR, Presky DH, Gately MK, Gubler U.

J Biol Chem. 1995 Mar 17;270(11):5864-71.

35.

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist.

Gillessen S, Carvajal D, Ling P, Podlaski FJ, Stremlo DL, Familletti PC, Gubler U, Presky DH, Stern AS, Gately MK.

Eur J Immunol. 1995 Jan;25(1):200-6.

PMID:
7843232
36.

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

Ling P, Gately MK, Gubler U, Stern AS, Lin P, Hollfelder K, Su C, Pan YC, Hakimi J.

J Immunol. 1995 Jan 1;154(1):116-27.

PMID:
7527811
37.

Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases.

Gately MK, Gubler U, Brunda MJ, Nadeau RR, Anderson TD, Lipman JM, Sarmiento U.

Ther Immunol. 1994 Jun;1(3):187-96. Review.

PMID:
7584494
38.

Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo.

Tahara H, Zeh HJ 3rd, Storkus WJ, Pappo I, Watkins SC, Gubler U, Wolf SF, Robbins PD, Lotze MT.

Cancer Res. 1994 Jan 1;54(1):182-9.

39.

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.

Kiniwa M, Gately M, Gubler U, Chizzonite R, Fargeas C, Delespesse G.

J Clin Invest. 1992 Jul;90(1):262-6.

40.

Cloning and expression of murine IL-12.

Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, Familletti PC, Gately MK, Gubler U.

J Immunol. 1992 Jun 1;148(11):3433-40.

PMID:
1350290
41.

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

Gately MK, Desai BB, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Familletti PC, Sinigaglia F, Chizonnite R, Gubler U, et al.

J Immunol. 1991 Aug 1;147(3):874-82.

PMID:
1713608
42.

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

Gubler U, Chua AO, Schoenhaut DS, Dwyer CM, McComas W, Motyka R, Nabavi N, Wolitzky AG, Quinn PM, Familletti PC, et al.

Proc Natl Acad Sci U S A. 1991 May 15;88(10):4143-7.

43.

Two distinct tumour necrosis factor receptors--members of a new cytokine receptor gene family.

Loetscher H, Brockhaus M, Dembic Z, Gentz R, Gubler U, Hohmann HP, Lahm HW, Van Loon AP, Pan YC, Schlaeger EJ, et al.

Oxf Surv Eukaryot Genes. 1991;7:119-42. Review. No abstract available.

PMID:
1661597
44.

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences.

Dembic Z, Loetscher H, Gubler U, Pan YC, Lahm HW, Gentz R, Brockhaus M, Lesslauer W.

Cytokine. 1990 Jul;2(4):231-7.

PMID:
1966549
45.

Characterization of mouse IL-1 receptors: evidence for IL-1 receptor heterogeneity.

Kilian PL, Stern AS, Gubler U, Chizzonite RA.

Prog Clin Biol Res. 1990;349:251-7. Review. No abstract available.

PMID:
2144638
46.

Sequence of the cDNA for the human fibroblast type interleukin-1 receptor.

Chua AO, Gubler U.

Nucleic Acids Res. 1989 Dec 11;17(23):10114. No abstract available.

47.

Two high-affinity interleukin 1 receptors represent separate gene products.

Chizzonite R, Truitt T, Kilian PL, Stern AS, Nunes P, Parker KP, Kaffka KL, Chua AO, Lugg DK, Gubler U.

Proc Natl Acad Sci U S A. 1989 Oct;86(20):8029-33.

48.

A sensitive technique to monitor gene transfer and expression in bone marrow stem cells.

Narayanan R, Tare NS, Benjamin WR, Gubler U.

Exp Hematol. 1989 Aug;17(7):832-5.

PMID:
2666145
49.

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