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The apical annuli of Toxoplasma gondii are composed of coiled-coil and signalling proteins embedded in the inner membrane complex sutures.

Engelberg K, Chen CT, Bechtel T, Sánchez Guzmán V, Drozda AA, Chavan S, Weerapana E, Gubbels MJ.

Cell Microbiol. 2019 Aug 30:e13112. doi: 10.1111/cmi.13112. [Epub ahead of print]


TgCep250 is dynamically processed through the division cycle and is essential for structural integrity of the Toxoplasma centrosome.

Chen CT, Gubbels MJ.

Mol Biol Cell. 2019 May 1;30(10):1160-1169. doi: 10.1091/mbc.E18-10-0608. Epub 2019 Mar 13.


A Member of the Ferlin Calcium Sensor Family Is Essential for Toxoplasma gondii Rhoptry Secretion.

Coleman BI, Saha S, Sato S, Engelberg K, Ferguson DJP, Coppens I, Lodoen MB, Gubbels MJ.

MBio. 2018 Oct 2;9(5). pii: e01510-18. doi: 10.1128/mBio.01510-18.


Toxoplasma gondii chromosomal passenger complex is essential for the organization of a functional mitotic spindle: a prerequisite for productive endodyogeny.

Berry L, Chen CT, Francia ME, Guerin A, Graindorge A, Saliou JM, Grandmougin M, Wein S, Bechara C, Morlon-Guyot J, Bordat Y, Gubbels MJ, Lebrun M, Dubremetz JF, Daher W.

Cell Mol Life Sci. 2018 Dec;75(23):4417-4443. doi: 10.1007/s00018-018-2889-6. Epub 2018 Jul 26.


Two Phosphoglucomutase Paralogs Facilitate Ionophore-Triggered Secretion of the Toxoplasma Micronemes.

Saha S, Coleman BI, Dubey R, Blader IJ, Gubbels MJ.

mSphere. 2017 Nov 29;2(6). pii: e00521-17. doi: 10.1128/mSphere.00521-17. eCollection 2017 Nov-Dec.


Differential Roles for Inner Membrane Complex Proteins across Toxoplasma gondii and Sarcocystis neurona Development.

Dubey R, Harrison B, Dangoudoubiyam S, Bandini G, Cheng K, Kosber A, Agop-Nersesian C, Howe DK, Samuelson J, Ferguson DJP, Gubbels MJ.

mSphere. 2017 Oct 18;2(5). pii: e00409-17. doi: 10.1128/mSphere.00409-17. eCollection 2017 Sep-Oct.


Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1.

Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ.

Mol Microbiol. 2017 Feb;103(4):618-634. doi: 10.1111/mmi.13577. Epub 2016 Dec 23.


Migratory activation of parasitized dendritic cells by the protozoan Toxoplasma gondii 14-3-3 protein.

Weidner JM, Kanatani S, Uchtenhagen H, Varas-Godoy M, Schulte T, Engelberg K, Gubbels MJ, Sun HS, Harrison RE, Achour A, Barragan A.

Cell Microbiol. 2016 Nov;18(11):1537-1550. doi: 10.1111/cmi.12595. Epub 2016 May 6.


The FIKK kinase of Toxoplasma gondii is not essential for the parasite's lytic cycle.

Skariah S, Walwyn O, Engelberg K, Gubbels MJ, Gaylets C, Kim N, Lynch B, Sultan A, Mordue DG.

Int J Parasitol. 2016 May;46(5-6):323-32. doi: 10.1016/j.ijpara.2016.01.001. Epub 2016 Feb 6.


A MORN1-associated HAD phosphatase in the basal complex is essential for Toxoplasma gondii daughter budding.

Engelberg K, Ivey FD, Lin A, Kono M, Lorestani A, Faugno-Fusci D, Gilberger TW, White M, Gubbels MJ.

Cell Microbiol. 2016 Aug;18(8):1153-71. doi: 10.1111/cmi.12574. Epub 2016 Mar 9.


The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence.

Berry L, Chen CT, Reininger L, Carvalho TG, El Hajj H, Morlon-Guyot J, Bordat Y, Lebrun M, Gubbels MJ, Doerig C, Daher W.

Cell Microbiol. 2016 Aug;18(8):1106-1120. doi: 10.1111/cmi.12571. Epub 2016 Feb 22.


Compartmentalized Toxoplasma EB1 bundles spindle microtubules to secure accurate chromosome segregation.

Chen CT, Kelly M, Leon Jd, Nwagbara B, Ebbert P, Ferguson DJ, Lowery LA, Morrissette N, Gubbels MJ.

Mol Biol Cell. 2015 Dec 15;26(25):4562-76. doi: 10.1091/mbc.E15-06-0437. Epub 2015 Oct 14.


Lytic Cycle of Toxoplasma gondii: 15 Years Later.

Blader IJ, Coleman BI, Chen CT, Gubbels MJ.

Annu Rev Microbiol. 2015;69:463-85. doi: 10.1146/annurev-micro-091014-104100. Epub 2015 Aug 28. Review.


Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans.

Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT.

Cell Host Microbe. 2015 Jul 8;18(1):49-60. doi: 10.1016/j.chom.2015.06.003. Epub 2015 Jun 25.


Apicomplexan cell cycle flexibility: centrosome controls the clutch.

Chen CT, Gubbels MJ.

Trends Parasitol. 2015 Jun;31(6):229-30. doi: 10.1016/ Epub 2015 Apr 19.


Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases.

Brown KM, Suvorova E, Farrell A, McLain A, Dittmar A, Wiley GB, Marth G, Gaffney PM, Gubbels MJ, White M, Blader IJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004180. doi: 10.1371/journal.ppat.1004180. eCollection 2014 Jun.


Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii.

Farrell A, Coleman BI, Benenati B, Brown KM, Blader IJ, Marth GT, Gubbels MJ.

BMC Genomics. 2014 May 10;15:354. doi: 10.1186/1471-2164-15-354.


The Toxoplasma gondii kinetochore is required for centrosome association with the centrocone (spindle pole).

Farrell M, Gubbels MJ.

Cell Microbiol. 2014 Jan;16(1):78-94. doi: 10.1111/cmi.12185. Epub 2013 Sep 10.


The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival.

Morlon-Guyot J, Berry L, Chen CT, Gubbels MJ, Lebrun M, Daher W.

Cell Microbiol. 2014 Jan;16(1):95-114. doi: 10.1111/cmi.12186. Epub 2013 Sep 9.


Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains.

Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, Marth GT, Gubbels MJ, Saeij JP.

BMC Genomics. 2013 Jul 10;14:467. doi: 10.1186/1471-2164-14-467.


The Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutant.

Chen CT, Gubbels MJ.

J Cell Sci. 2013 Aug 1;126(Pt 15):3344-55. doi: 10.1242/jcs.123364. Epub 2013 May 31.


Evolution of apicomplexan secretory organelles.

Gubbels MJ, Duraisingh MT.

Int J Parasitol. 2012 Nov;42(12):1071-81. doi: 10.1016/j.ijpara.2012.09.009. Epub 2012 Oct 13. Review.


Targeted proteomic dissection of Toxoplasma cytoskeleton sub-compartments using MORN1.

Lorestani A, Ivey FD, Thirugnanam S, Busby MA, Marth GT, Cheeseman IM, Gubbels MJ.

Cytoskeleton (Hoboken). 2012 Dec;69(12):1069-85. doi: 10.1002/cm.21077. Epub 2012 Oct 11.


β-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria.

Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J.

MBio. 2012 Sep 25;3(5). pii: e00258-12. doi: 10.1128/mBio.00258-12. Print 2012.


Cytoskeleton assembly in Toxoplasma gondii cell division.

Anderson-White B, Beck JR, Chen CT, Meissner M, Bradley PJ, Gubbels MJ.

Int Rev Cell Mol Biol. 2012;298:1-31. doi: 10.1016/B978-0-12-394309-5.00001-8. Review.


Toxoplasma ISP4 is a central IMC sub-compartment protein whose localization depends on palmitoylation but not myristoylation.

Fung C, Beck JR, Robertson SD, Gubbels MJ, Bradley PJ.

Mol Biochem Parasitol. 2012 Aug;184(2):99-108. doi: 10.1016/j.molbiopara.2012.05.002. Epub 2012 May 30.


Cactin is essential for G1 progression in Toxoplasma gondii.

Szatanek T, Anderson-White BR, Faugno-Fusci DM, White M, Saeij JP, Gubbels MJ.

Mol Microbiol. 2012 May;84(3):566-77. doi: 10.1111/j.1365-2958.2012.08044.x. Epub 2012 Apr 9.


A genetic screen to isolate Toxoplasma gondii host-cell egress mutants.

Coleman BI, Gubbels MJ.

J Vis Exp. 2012 Feb 8;(60). pii: 3807. doi: 10.3791/3807.


A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.

Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ.

Science. 2012 Jan 13;335(6065):218-21. doi: 10.1126/science.1210829. Erratum in: Science. 2012 Apr 13;336(6078):155.


An insertional trap for conditional gene expression in Toxoplasma gondii: identification of TAF250 as an essential gene.

Jammallo L, Eidell K, Davis PH, Dufort FJ, Cronin C, Thirugnanam S, Chiles TC, Roos DS, Gubbels MJ.

Mol Biochem Parasitol. 2011 Feb;175(2):133-43. doi: 10.1016/j.molbiopara.2010.10.007. Epub 2010 Oct 28.


A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis.

Lorestani A, Sheiner L, Yang K, Robertson SD, Sahoo N, Brooks CF, Ferguson DJ, Striepen B, Gubbels MJ.

PLoS One. 2010 Aug 19;5(8):e12302. doi: 10.1371/journal.pone.0012302.


A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii.

Anderson-White BR, Ivey FD, Cheng K, Szatanek T, Lorestani A, Beckers CJ, Ferguson DJ, Sahoo N, Gubbels MJ.

Cell Microbiol. 2011 Jan;13(1):18-31. doi: 10.1111/j.1462-5822.2010.01514.x.


Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.

Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS.

PLoS Pathog. 2010 Mar 19;6(3):e1000815. doi: 10.1371/journal.ppat.1000815.


Development of a screen to dissect Toxoplasma gondii egress.

Eidell KP, Burke T, Gubbels MJ.

Mol Biochem Parasitol. 2010 Jun;171(2):97-103. doi: 10.1016/j.molbiopara.2010.03.004. Epub 2010 Mar 21.


Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.

Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J.

Eukaryot Cell. 2010 Feb;9(2):228-41. doi: 10.1128/EC.00197-09. Epub 2009 Sep 25.


Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes.

Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, Grotenbreg GM.

J Infect Dis. 2008 Dec 1;198(11):1625-33. doi: 10.1086/593019.


Chemogenomics and parasitology: small molecules and cell-based assays to study infectious processes.

Muskavitch MA, Barteneva N, Gubbels MJ.

Comb Chem High Throughput Screen. 2008 Sep;11(8):624-46. Review.


The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?

Gubbels MJ, White M, Szatanek T.

Int J Parasitol. 2008 Oct;38(12):1343-58. doi: 10.1016/j.ijpara.2008.06.004. Epub 2008 Jul 24. Review.


MORN1 has a conserved role in asexual and sexual development across the apicomplexa.

Ferguson DJ, Sahoo N, Pinches RA, Bumstead JM, Tomley FM, Gubbels MJ.

Eukaryot Cell. 2008 Apr;7(4):698-711. doi: 10.1128/EC.00021-08. Epub 2008 Feb 29.


Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii.

Gubbels MJ, Lehmann M, Muthalagi M, Jerome ME, Brooks CF, Szatanek T, Flynn J, Parrot B, Radke J, Striepen B, White MW.

PLoS Pathog. 2008 Feb 8;4(2):e36. doi: 10.1371/journal.ppat.0040036.


Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.

Frickel EM, Quesada V, Muething L, Gubbels MJ, Spooner E, Ploegh H, Artavanis-Tsakonas K.

Cell Microbiol. 2007 Jun;9(6):1601-10. Epub 2007 Feb 16.


CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes.

Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS.

J Clin Invest. 2006 Sep;116(9):2366-77.


Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection.

Dalton JE, Cruickshank SM, Egan CE, Mears R, Newton DJ, Andrew EM, Lawrence B, Howell G, Else KJ, Gubbels MJ, Striepen B, Smith JE, White SJ, Carding SR.

Gastroenterology. 2006 Sep;131(3):818-29.


A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus.

Gubbels MJ, Vaishnava S, Boot N, Dubremetz JF, Striepen B.

J Cell Sci. 2006 Jun 1;119(Pt 11):2236-45. Epub 2006 May 9.


A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology.

Egan CE, Dalton JE, Andrew EM, Smith JE, Gubbels MJ, Striepen B, Carding SR.

J Immunol. 2005 Dec 15;175(12):8191-9.


Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice.

Gubbels MR, Jørgensen TN, Metzger TE, Menze K, Steele H, Flannery SA, Rozzo SJ, Kotzin BL.

J Immunol. 2005 Nov 1;175(9):6190-6.


Studying the cell biology of apicomplexan parasites using fluorescent proteins.

Gubbels MJ, Striepen B.

Microsc Microanal. 2004 Oct;10(5):568-79. Review.


New insights into disease pathogenesis from mouse lupus genetics.

Jørgensen TN, Gubbels MR, Kotzin BL.

Curr Opin Immunol. 2004 Dec;16(6):787-93. Review.


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