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Items: 1 to 50 of 92

1.

Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice.

de Souza-Neto FP, Silva MME, Santuchi MC, de Alcântara-Leonídio TC, Motta-Santos D, Oliveira AC, Melo MB, Canta GN, de Souza LE, Irigoyen MCC, Campagnole-Santos MJ, Guatimosim S, Santos RAS, da Silva RF.

Clin Sci (Lond). 2019 Mar 1;133(5):629-643. doi: 10.1042/CS20180547. Print 2019 Mar 15.

PMID:
30737255
2.

Increased oxidative stress and CaMKII activity contribute to electro-mechanical defects in cardiomyocytes from a murine model of Huntington's disease.

Joviano-Santos JV, Santos-Miranda A, Botelho AFM, de Jesus ICG, Andrade JN, de Oliveira Barreto T, Magalhães-Gomes MPS, Valadão PAC, Cruz JDS, Melo MM, Guatimosim S, Guatimosim C.

FEBS J. 2019 Jan;286(1):110-123. doi: 10.1111/febs.14706. Epub 2018 Dec 20.

PMID:
30451379
3.

Resistance exercise mediates remote ischemic preconditioning by limiting cardiac eNOS uncoupling.

Santana MNS, Souza DS, Miguel-Dos-Santos R, Rabelo TK, Vasconcelos CML, Navia-Pelaez JM, Jesus ICG, Silva-Neto JAD, Lauton-Santos S, Capettini LDSA, Guatimosim S, Rogers RG, Santos MRVD, Santana-Filho VJ, Mesquita TRR.

J Mol Cell Cardiol. 2018 Dec;125:61-72. doi: 10.1016/j.yjmcc.2018.10.016. Epub 2018 Oct 16.

PMID:
30339842
4.

Genetic deletion of the alamandine receptor MRGD leads to dilated cardiomyopathy in mice.

Oliveira AC, Melo MB, Motta-Santos D, Peluso AA, Souza-Neto F, da Silva RF, Almeida JFQ, Canta G, Reis AM, Goncalves G, Cerri G, Coutinho D, Guedes de Jesus IC, Guatimosim S, Linhares ND, Alenina N, Bader M, Campagnole-Santos MJ, Santos RAS.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H123-H133. doi: 10.1152/ajpheart.00075.2018. Epub 2018 Oct 19.

PMID:
30339496
5.

Endurance training restores spatially distinct cardiac mitochondrial function and myocardial contractility in ovariectomized rats.

Morra EA, Rodrigues PL, Jesus ICG, Do Val Lima PR, Ávila RA, Zanardo TÉC, Nogueira BV, Bers DM, Guatimosim S, Stefanon I, Ribeiro Júnior RF.

Free Radic Biol Med. 2019 Jan;130:174-188. doi: 10.1016/j.freeradbiomed.2018.10.406. Epub 2018 Oct 10.

PMID:
30315935
6.

Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor.

Guo Y, Jardin BD, Zhou P, Sethi I, Akerberg BN, Toepfer CN, Ai Y, Li Y, Ma Q, Guatimosim S, Hu Y, Varuzhanyan G, VanDusen NJ, Zhang D, Chan DC, Yuan GC, Seidman CE, Seidman JG, Pu WT.

Nat Commun. 2018 Sep 21;9(1):3837. doi: 10.1038/s41467-018-06347-2.

7.

Fast and slow-twitching muscles are differentially affected by reduced cholinergic transmission in mice deficient for VAChT: A mouse model for congenital myasthenia.

Magalhães-Gomes MPS, Motta-Santos D, Schetino LPL, Andrade JN, Bastos CP, Guimarães DAS, Vaughan SK, Martinelli PM, Guatimosim S, Pereira GS, Coimbra CC, Prado VF, Prado MAM, Valdez G, Guatimosim C.

Neurochem Int. 2018 Nov;120:1-12. doi: 10.1016/j.neuint.2018.07.002. Epub 2018 Jul 9.

8.

Corrigendum to "Neuromuscular synapse degeneration without muscle function loss in the diaphragm of a murine model for Huntington's Disease" [Neurochem. Int. 116 (2018) 30-42].

Valadão PAC, Gomes MPSM, Aragão BC, Rodrigues HA, Andrade JN, Garcias R, Joviano-Santos JV, Luiz MA, Camargo WL, Naves LA, Kushmerick C, Cavalcante WLG, Gallacci M, de Jesus ICG, Guatimosim S, Guatimosim C.

Neurochem Int. 2018 Sep;118:264. doi: 10.1016/j.neuint.2018.05.002. Epub 2018 May 24. No abstract available.

PMID:
29803294
9.

Neuromuscular synapse degeneration without muscle function loss in the diaphragm of a murine model for Huntington's Disease.

Valadão PAC, Gomes MPSM, Aragão BC, Rodrigues HA, Andrade JN, Garcias R, Joviano-Santos JV, Luiz MA, Camargo WL, Naves LA, Kushmerick C, Cavalcante WLG, Gallacci M, de Jesus ICG, Guatimosim S, Guatimosim C.

Neurochem Int. 2018 Jun;116:30-42. doi: 10.1016/j.neuint.2018.03.007. Epub 2018 Mar 10. Erratum in: Neurochem Int. 2018 Sep;118:264.

PMID:
29530757
10.

Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes.

Jesus ICG, Scalzo S, Alves F, Marques K, Rocha-Resende C, Bader M, Santos RAS, Guatimosim S.

Am J Physiol Cell Physiol. 2018 Jun 1;314(6):C702-C711. doi: 10.1152/ajpcell.00153.2017. Epub 2018 Feb 14.

PMID:
29443552
11.

Ghrelin potentiates cardiac reactivity to stress by modulating sympathetic control and beta-adrenergic response.

Camargo-Silva G, Turones LC, da Cruz KR, Gomes KP, Mendonça MM, Nunes A, de Jesus IG, Colugnati DB, Pansani AP, Pobbe RLH, Santos R, Fontes MAP, Guatimosim S, de Castro CH, Ianzer D, Ferreira RN, Xavier CH.

Life Sci. 2018 Mar 1;196:84-92. doi: 10.1016/j.lfs.2018.01.019. Epub 2018 Feb 3.

PMID:
29366747
12.

Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms.

Britto RM, Silva-Neto JAD, Mesquita TRR, Vasconcelos CML, de Almeida GKM, Jesus ICG, Santos PHD, Souza DS, Miguel-Dos-Santos R, de Sá LA, Dos Santos FSM, Pereira-Filho RN, Albuquerque-Júnior RLC, Quintans-Júnior LJ, Guatimosim S, Lauton-Santos S.

Food Chem Toxicol. 2018 Jan;111:557-566. doi: 10.1016/j.fct.2017.12.003. Epub 2017 Dec 5.

13.

Neonatal cardiomyocyte hypertrophy induced by endothelin-1 is blocked by estradiol acting on GPER.

Goncalves GK, Scalzo S, Alves AP, Agero U, Guatimosim S, Reis AM.

Am J Physiol Cell Physiol. 2018 Mar 1;314(3):C310-C322. doi: 10.1152/ajpcell.00060.2017. Epub 2017 Nov 22.

14.

Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation.

Zhang D, Li Y, Heims-Waldron D, Bezzerides V, Guatimosim S, Guo Y, Gu F, Zhou P, Lin Z, Ma Q, Liu J, Wang DZ, Pu WT.

Circ Res. 2018 Jan 5;122(1):74-87. doi: 10.1161/CIRCRESAHA.117.311349. Epub 2017 Oct 11.

15.

Exercise Training Protects Cardiomyocytes from Deleterious Effects of Palmitate.

Alves MNM, Roman-Campos D, Parreira AB, Almeida PWM, Cruz JS, Guatimosim S, Dias-Peixoto MF.

Int J Sports Med. 2017 Nov;38(12):949-953. doi: 10.1055/s-0043-118010. Epub 2017 Sep 18.

PMID:
28922681
16.

HDR brachytherapy decreases proliferation rate and cellular progression of a radioresistant human squamous cell carcinoma in vitro.

Geraldo JM, Scalzo S, Reis DS, Leão TL, Guatimosim S, Ladeira LO, Andrade LM.

Int J Radiat Biol. 2017 Sep;93(9):958-966. doi: 10.1080/09553002.2017.1341661. Epub 2017 Jul 4.

PMID:
28609167
17.

Testosterone deficiency prevents left ventricular contractility dysfunction after myocardial infarction.

Ribeiro Júnior RF, Ronconi KS, Jesus ICG, Almeida PWM, Forechi L, Vassallo DV, Guatimosim S, Stefanon I, Fernandes AA.

Mol Cell Endocrinol. 2018 Jan 15;460:14-23. doi: 10.1016/j.mce.2017.06.011. Epub 2017 Jun 9. Review.

PMID:
28606867
18.

Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure.

Campos JC, Queliconi BB, Bozi LHM, Bechara LRG, Dourado PMM, Andres AM, Jannig PR, Gomes KMS, Zambelli VO, Rocha-Resende C, Guatimosim S, Brum PC, Mochly-Rosen D, Gottlieb RA, Kowaltowski AJ, Ferreira JCB.

Autophagy. 2017 Aug 3;13(8):1304-1317. doi: 10.1080/15548627.2017.1325062.

19.

Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway.

Mesquita TRR, de Jesus ICG, Dos Santos JF, de Almeida GKM, de Vasconcelos CML, Guatimosim S, Macedo FN, Dos Santos RV, de Menezes-Filho JER, Miguel-Dos-Santos R, Matos PTD, Scalzo S, Santana-Filho VJ, Albuquerque-Júnior RLC, Pereira-Filho RN, Lauton-Santos S.

Front Pharmacol. 2017 May 11;8:220. doi: 10.3389/fphar.2017.00220. eCollection 2017.

20.

(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts.

Gondim ANS, Lara A, Santos-Miranda A, Roman-Campos D, Lauton-Santos S, Menezes-Filho JER, de Vasconcelos CML, Conde-Garcia EA, Guatimosim S, Cruz JS.

Eur J Pharmacol. 2017 Jul 15;807:56-63. doi: 10.1016/j.ejphar.2017.04.022. Epub 2017 Apr 20.

PMID:
28435092
21.

Analysis of Cardiac Myocyte Maturation Using CASAAV, a Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo.

Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT.

Circ Res. 2017 Jun 9;120(12):1874-1888. doi: 10.1161/CIRCRESAHA.116.310283. Epub 2017 Mar 29. Review.

22.

Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels.

Rocha-Resende C, Guedes de Jesus IC, Roman-Campos D, Miranda AS, Alves F, Resende RR, Dos Santos Cruz J, Machado FS, Guatimosim S.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C478-C486. doi: 10.1152/ajpcell.00004.2016. Epub 2017 Jan 25.

23.

Dissection of the Effects of Quercetin on Mouse Myocardium.

Santos MS, Oliveira ED, Santos-Miranda A, Cruz JS, Gondim ANS, Menezes-Filho JER, Souza DS, Pinho-da-Silva L, Jesus ICG, Roman-Campos D, Guatimosim S, Lara A, Conde-Garcia EA, Vasconcelos CML.

Basic Clin Pharmacol Toxicol. 2017 Jun;120(6):550-559. doi: 10.1111/bcpt.12743. Epub 2017 Mar 14.

24.

Cardiorespiratory alterations in rodents experimentally envenomed with Hadruroides lunatus scorpion venom.

Costal-Oliveira F, Guerra-Duarte C, Oliveira MS, Castro KL, Lopes-de-Sousa L, Lara A, Gomes ER, Bonilla C, Guatimosim S, Melo MM, Chávez-Olórtegui C.

J Venom Anim Toxins Incl Trop Dis. 2016 Jul 15;23:2. doi: 10.1186/s40409-016-0076-5. eCollection 2017.

25.

Severe Calorie Restriction Reduces Cardiometabolic Risk Factors and Protects Rat Hearts from Ischemia/Reperfusion Injury.

Melo DS, Costa-Pereira LV, Santos CS, Mendes BF, Costa KB, Santos CF, Rocha-Vieira E, Magalhães FC, Esteves EA, Ferreira AJ, Guatimosim S, Dias-Peixoto MF.

Front Physiol. 2016 Apr 8;7:106. doi: 10.3389/fphys.2016.00106. eCollection 2016.

26.

Functionalized nanomaterials: are they effective to perform gene delivery to difficult-to-transfect cells with no cytotoxicity?

Tonelli FM, Lacerda SM, Paiva NC, Pacheco FG, Scalzo Junior SR, de Macedo FH, Cruz JS, Pinto MC, Corrêa Junior JD, Ladeira LO, França LR, Guatimosim S, Resende RR.

Nanoscale. 2015 Nov 21;7(43):18036-43. doi: 10.1039/c5nr04173b.

PMID:
26486874
27.

Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions.

Roy A, Dakroub M, Tezini GC, Liu Y, Guatimosim S, Feng Q, Salgado HC, Prado VF, Prado MA, Gros R.

FASEB J. 2016 Feb;30(2):688-701. doi: 10.1096/fj.15-277046. Epub 2015 Oct 19.

28.

Autonomic cardiocirculatory control in mice with reduced expression of the vesicular acetylcholine transporter.

Durand MT, Becari C, Tezini GC, Fazan R Jr, Oliveira M, Guatimosim S, Prado VF, Prado MA, Salgado HC.

Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H655-62. doi: 10.1152/ajpheart.00114.2015. Epub 2015 Jun 19.

29.

Beneficial effects of angiotensin-(1-7) against deoxycorticosterone acetate-induced diastolic dysfunction occur independently of changes in blood pressure.

de Almeida PW, Melo MB, Lima Rde F, Gavioli M, Santiago NM, Greco L, Jesus IC, Nocchi E, Parreira A, Alves MN, Mitraud L, Resende RR, Campagnole-Santos MJ, Dos Santos RA, Guatimosim S.

Hypertension. 2015 Aug;66(2):389-95. doi: 10.1161/HYPERTENSIONAHA.114.04893. Epub 2015 Jun 15.

PMID:
26077567
30.

Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.

Aguiar CJ, Rocha-Franco JA, Sousa PA, Santos AK, Ladeira M, Rocha-Resende C, Ladeira LO, Resende RR, Botoni FA, Barrouin Melo M, Lima CX, Carballido JM, Cunha TM, Menezes GB, Guatimosim S, Leite MF.

Cell Commun Signal. 2014 Dec 24;12:78. doi: 10.1186/s12964-014-0078-2.

31.

Cholinergic activity as a new target in diseases of the heart.

Roy A, Guatimosim S, Prado VF, Gros R, Prado MA.

Mol Med. 2015 Jan 26;20:527-37. doi: 10.2119/molmed.2014.00125. Review.

32.

Basal and β-adrenergic cardiomyocytes contractility dysfunction induced by dietary protein restriction is associated with downregulation of SERCA2a expression and disturbance of endoplasmic reticulum Ca2+ regulation in rats.

Penitente AR, Novaes RD, Silva ME, Silva MF, Quintão-Júnior JF, Guatimosim S, Cruz JS, Chianca DA Jr, Natali AJ, Neves CA.

Cell Physiol Biochem. 2014;34(2):443-54. doi: 10.1159/000363013. Epub 2014 Jul 30.

33.

Cholinergic signaling exerts protective effects in models of sympathetic hyperactivity-induced cardiac dysfunction.

Gavioli M, Lara A, Almeida PW, Lima AM, Damasceno DD, Rocha-Resende C, Ladeira M, Resende RR, Martinelli PM, Melo MB, Brum PC, Fontes MA, Souza Santos RA, Prado MA, Guatimosim S.

PLoS One. 2014 Jul 3;9(7):e100179. doi: 10.1371/journal.pone.0100179. eCollection 2014.

34.

Scale/topography of substrates surface resembling extracellular matrix for tissue engineering.

Resende RR, Fonseca EA, Tonelli FM, Sousa BR, Santos AK, Gomes KN, Guatimosim S, Kihara AH, Ladeira LO.

J Biomed Nanotechnol. 2014 Jul;10(7):1157-93. Review.

PMID:
24804539
35.

Response.

Roy A, Fields WC, Rocha-Resende C, Resende RR, Guatimosim S, Prado VF, Gros R, Prado MA.

FASEB J. 2014 Jan;28(1):2-3. doi: 10.1096/fj.14-0102LTE. No abstract available.

PMID:
24385569
36.

Protein restriction after weaning modifies the calcium kinetics and induces cardiomyocyte contractile dysfunction in rats.

Penitente AR, Novaes RD, Chianca DA Jr, da Silva MF, Silva ME, Souza AM, Guatimosim S, Almeida PW, Alves MN, Felix LB, Neves CA, Natali AJ.

Cells Tissues Organs. 2013;198(4):311-7. doi: 10.1159/000355943. Epub 2013 Nov 12.

PMID:
24247000
37.

Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart.

Roy A, Fields WC, Rocha-Resende C, Resende RR, Guatimosim S, Prado VF, Gros R, Prado MA.

FASEB J. 2013 Dec;27(12):5072-82. doi: 10.1096/fj.13-238279. Epub 2013 Sep 9.

38.

Effects of severe caloric restriction from birth on the hearts of adult rats.

Melo DS, Riul TR, Esteves EA, Moraes PL, Ferreira FO, Gavioli M, Alves MN, Almeida PW, Guatimosim S, Ferreira AJ, Dias Peixoto MF.

Appl Physiol Nutr Metab. 2013 Aug;38(8):879-85. doi: 10.1139/apnm-2012-0387. Epub 2013 Feb 11.

PMID:
23855276
39.

Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice.

Vanzelli AS, Medeiros A, Rolim N, Bartholomeu JB, Cunha TF, Bechara LR, Gomes ER, Mattos KC, Sirvente R, Salemi VM, Mady C, Negrao CE, Guatimosim S, Brum PC.

PLoS One. 2013 May 1;8(5):e62452. doi: 10.1371/journal.pone.0062452. Print 2013. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/ae03273e-5ed4-4c8f-a985-b39503b2e7e5. Salemi, Vera [corrected to Salemi, Vera Maria Cury]. PLoS One. 2013;8(7). doi:10.1371/annotation/f82c53c5-e15c-470c-b5e7-7732e1435cda. Bechara, Luiz G [corrected to Bechara, Luiz R G].

40.

Cardiomyocyte dysfunction during the chronic phase of Chagas disease.

Roman-Campos D, Sales-Júnior P, Duarte HL, Gomes ER, Guatimosim S, Ropert C, Gazzinelli RT, Cruz JS.

Mem Inst Oswaldo Cruz. 2013 Apr;108(2):243-5.

41.

Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus.

Resende RR, Andrade LM, Oliveira AG, Guimarães ES, Guatimosim S, Leite MF.

Cell Commun Signal. 2013 Feb 21;11(1):14. doi: 10.1186/1478-811X-11-14.

42.

Cardiovascular effects of angiotensin A: a novel peptide of the renin-angiotensin system.

Coutinho DC, Foureaux G, Rodrigues KD, Salles RL, Moraes PL, Murça TM, De Maria ML, Gomes ER, Santos RA, Guatimosim S, Ferreira AJ.

J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):480-6. doi: 10.1177/1470320312474856. Epub 2013 Feb 5.

PMID:
23386282
43.

Cardiac dysfunction in rats prone to audiogenic epileptic seizures.

Damasceno DD, Savergnini SQ, Gomes ER, Guatimosim S, Ferreira AJ, Doretto MC, Almeida AP.

Seizure. 2013 May;22(4):259-66. doi: 10.1016/j.seizure.2013.01.006. Epub 2013 Jan 20.

44.

Cell apoptosis induced by hookworm antigens: a strategy of immunomodulation.

Gazzinelli-Guimarães PH, Souza-Fagundes EM, Cancado GG, Martins VG, Dhom-Lemos LC, Ricci ND, Fiuza JA, Bueno LL, Miranda RR, Guatimosim S, Gazzinelli A, Correa-Oliveira R, Bartholomeu DC, Fujiwara RT.

Front Biosci (Elite Ed). 2013 Jan 1;5:662-75.

PMID:
23277021
45.

Functional cross-talk between aldosterone and angiotensin-(1-7) in ventricular myocytes.

de Almeida PW, de Freitas Lima R, de Morais Gomes ER, Rocha-Resende C, Roman-Campos D, Gondim AN, Gavioli M, Lara A, Parreira A, de Azevedo Nunes SL, Alves MN, Santos SL, Alenina N, Bader M, Resende RR, dos Santos Cruz J, Souza dos Santos RA, Guatimosim S.

Hypertension. 2013 Feb;61(2):425-30. doi: 10.1161/HYPERTENSIONAHA.111.199539. Epub 2012 Dec 10.

PMID:
23232646
46.

Novel insights into the development of chagasic cardiomyopathy: role of PI3Kinase/NO axis.

Roman-Campos D, Sales-Junior P, Duarte HL, Gomes ER, Lara A, Campos P, Rocha NN, Resende RR, Ferreira A, Guatimosim S, Gazzinelli RT, Ropert C, Cruz JS.

Int J Cardiol. 2013 Sep 10;167(6):3011-20. doi: 10.1016/j.ijcard.2012.09.020. Epub 2012 Sep 29.

47.

Carbon nanotube interaction with extracellular matrix proteins producing scaffolds for tissue engineering.

Tonelli FM, Santos AK, Gomes KN, Lorençon E, Guatimosim S, Ladeira LO, Resende RR.

Int J Nanomedicine. 2012;7:4511-29. doi: 10.2147/IJN.S33612. Epub 2012 Aug 14. Review.

48.

An analysis of the myocardial transcriptome in a mouse model of cardiac dysfunction with decreased cholinergic neurotransmission.

Roy A, Lara A, Guimarães D, Pires R, Gomes ER, Carter DE, Gomez MV, Guatimosim S, Prado VF, Prado MA, Gros R.

PLoS One. 2012;7(6):e39997. doi: 10.1371/journal.pone.0039997. Epub 2012 Jun 29.

49.

Nuclear inositol 1,4,5-trisphosphate is a necessary and conserved signal for the induction of both pathological and physiological cardiomyocyte hypertrophy.

Arantes LA, Aguiar CJ, Amaya MJ, Figueiró NC, Andrade LM, Rocha-Resende C, Resende RR, Franchini KG, Guatimosim S, Leite MF.

J Mol Cell Cardiol. 2012 Oct;53(4):475-86. doi: 10.1016/j.yjmcc.2012.06.017. Epub 2012 Jul 2.

PMID:
22766271
50.

Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.

Esper L, Roman-Campos D, Lara A, Brant F, Castro LL, Barroso A, Araujo RR, Vieira LQ, Mukherjee S, Gomes ER, Rocha NN, Ramos IP, Lisanti MP, Campos CF, Arantes RM, Guatimosim S, Weiss LM, Cruz JS, Tanowitz HB, Teixeira MM, Machado FS.

Am J Pathol. 2012 Jul;181(1):130-40. doi: 10.1016/j.ajpath.2012.03.042. Epub 2012 May 29.

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